Modern medicine believes that the incidence and detection rate of chronic atrophic gastritis(CAG)are positively correlated with age.Early detection,monitoring and intervention are helpful to reduce the incidence and m...Modern medicine believes that the incidence and detection rate of chronic atrophic gastritis(CAG)are positively correlated with age.Early detection,monitoring and intervention are helpful to reduce the incidence and mortality of gastric cancer.Non-drug therapy has many unique methods,wide range of application,simple operation,easy to popularize characteristics.In the process of using non-drug therapy to treat CAG syndrome differentiation,the principle of"treating the same disease with different methods"and"treating different diseases with the same method"must be followed.In recent years,in order to improve the quality of life of CAG patients and optimize treatment methods,some research progress has been made in the treatment of chronic atrophic gastritis with non-drug therapy.This paper summarized mainly from the basic function principle and the characteristic of Chinese medicine non-drug therapy,the mechanism of various kinds of non-drug therapy treatment of chronic atrophic gastritis and its respective application.展开更多
Objective:Shugan Hewei therapy(SHT)acts to soothe the liver and harmonize the stomach.It is a classical traditional Chinese medicine method widely used in China to treat chronic atrophic gastritis(CAG)due to liver qi ...Objective:Shugan Hewei therapy(SHT)acts to soothe the liver and harmonize the stomach.It is a classical traditional Chinese medicine method widely used in China to treat chronic atrophic gastritis(CAG)due to liver qi invading the stomach.However,the clinical effects of SHT remain unclear.We aimed to evaluate the overall clinical effective rate and safety of SHT in treating CAG.Methods:We used the Jadad scale and Cochrane Collaboration risk of bias tool to evaluate the methodological quality of studies investigating SHT.Eight medical databases were searched to identify relevant studies.After data extraction and quality evaluation,27 randomized controlled trials,including 2,441 patients,were considered eligible for analysis.No serious heterogeneity or publication bias was observed across the included studies.We used Revman 5.3 statistical software to evaluate the general clinical effective rate and safety of SHT.Results:The results showed that SHT was more effective(RR=1.25;95%CI[1.20,1.29];P<0.01)and safer(MD=0.24,95%CI[0.08,0.75];P<0.01)than control interventions comprising western medicine,Chinese patent medicine,and/or western medicine+Chinese patent medicine.Compared with the control interventions,SHT resulted in greater improvements in the symptom scores for stomach distension and stomachache,serum gastrin level,histopathologic changes,Helicobacter pylori(HP)inhibition rate,and gastric mucosal inflammation.Conclusion:SHT was more effective and safer than control interventions for CAG.展开更多
Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive...Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.展开更多
Objective:To analyze the features and patterns of acupoint selection in acupuncture-moxibustion treatment of chronic atrophic gastritis(CAG)by data mining technique.Methods:Relevant clinical studies published before 2...Objective:To analyze the features and patterns of acupoint selection in acupuncture-moxibustion treatment of chronic atrophic gastritis(CAG)by data mining technique.Methods:Relevant clinical studies published before 25 June,2017 were searched in databases including PubMed,EMBASE,Cochrane library,Chinese Biomedical Literature Database(CBM),China National Knowledge infrastructure(CNKI),and Wanfang Academic Journal Full-text Database(Wanfang).Results:A total of 122 papers were included,involving 69 points.It was found that the top three points on the frequency list were Zusanli(ST 36),Zhongwan(CV 12)and Weishu(BL 21).The points selected were distributed in 11 meridians,in which the Stomach Meridian of Foot Yangming,Conception Vessel,and Bladder Meridian of Foot Taiyang ranked the top and accounted for 74.0%of the total frequency.Of the involved specific points,Five Shu-Transmitting points,crossing points and Back-Shu points ranked the top,accounting for 47.1%.The analysis of association pattern has shown that Zusanli(ST 36)and Zhongwan(CV 12)won the highest support rate in the paired groups;Zusanli(ST 36),Weishu(BL 21)and Zhongwan(CV 12)had the highest support rate among the point groups.The Five Shu-Transmitting points and the Lower He-Sea points had the highest support rate among the specific point groups.Conclusion:The data mining results of the studies on acupuncture-moxibustion for CAG are substantially in line with the acupuncture-moxibustion treatment theories in traditional Chinese medicine.The results can reflect the acupoint selection patterns in treatment of CAG and provide reference for acupuncture-moxibustion treatment of CAG in clinic.展开更多
Objective: To observe the clinical efficacy of combining acupuncture and medication in treating chronic atrophic gastritis(CAG) due to spleen-stomach deficiency. Methods: Totally 176 patients with CAG were randomized ...Objective: To observe the clinical efficacy of combining acupuncture and medication in treating chronic atrophic gastritis(CAG) due to spleen-stomach deficiency. Methods: Totally 176 patients with CAG were randomized into two groups by the random number table. The 91 subjects in the treatment group were intervened by acupuncture and oral Chinese patent medication; the other 85 subjects were by oral Chinese patent medication alone. The clinical efficacies were compared at the end of intervention. Results: After a treatment course, the total effective rate was 87.9% in the treatment group versus 75.3% in the control group; according to the gastroscopy and pathological biopsy examinations, the total effective rate was 85.7% in the treatment group versus 74.1% in the control group. There were significant differences in comparing the clinical efficacy, gastroscopy and pathological examinations between the two groups(P<0.05). Conclusion: Combining acupuncture and medication can produce a better therapeutic efficacy than medication alone in treating CAG due to spleen-stomach deficiency.展开更多
基金Specialized Disease Evidence-Based Ability Improvement Project for Dominate Diseases in the Field of TCM Digestion(Chronic Atrophic Gastritis)(2019XZZX-XH011)Natural Science Foundation of Shaanxi Provincial Administration of Science and Technology(2020JM-591)Shaanxi University of Chinese Medicine First-Class Discipline Innovation Team Project(Shaan Zhong Da Xue Ke Ban[2019]No.2,2019-YL04)。
文摘Modern medicine believes that the incidence and detection rate of chronic atrophic gastritis(CAG)are positively correlated with age.Early detection,monitoring and intervention are helpful to reduce the incidence and mortality of gastric cancer.Non-drug therapy has many unique methods,wide range of application,simple operation,easy to popularize characteristics.In the process of using non-drug therapy to treat CAG syndrome differentiation,the principle of"treating the same disease with different methods"and"treating different diseases with the same method"must be followed.In recent years,in order to improve the quality of life of CAG patients and optimize treatment methods,some research progress has been made in the treatment of chronic atrophic gastritis with non-drug therapy.This paper summarized mainly from the basic function principle and the characteristic of Chinese medicine non-drug therapy,the mechanism of various kinds of non-drug therapy treatment of chronic atrophic gastritis and its respective application.
基金This study was financed by grants from the National Natural Science Foundation of China(No.81873236,81270050)the Key Laboratory of Health Identification and Assessment in Shanghai(No.13DZ2261000).
文摘Objective:Shugan Hewei therapy(SHT)acts to soothe the liver and harmonize the stomach.It is a classical traditional Chinese medicine method widely used in China to treat chronic atrophic gastritis(CAG)due to liver qi invading the stomach.However,the clinical effects of SHT remain unclear.We aimed to evaluate the overall clinical effective rate and safety of SHT in treating CAG.Methods:We used the Jadad scale and Cochrane Collaboration risk of bias tool to evaluate the methodological quality of studies investigating SHT.Eight medical databases were searched to identify relevant studies.After data extraction and quality evaluation,27 randomized controlled trials,including 2,441 patients,were considered eligible for analysis.No serious heterogeneity or publication bias was observed across the included studies.We used Revman 5.3 statistical software to evaluate the general clinical effective rate and safety of SHT.Results:The results showed that SHT was more effective(RR=1.25;95%CI[1.20,1.29];P<0.01)and safer(MD=0.24,95%CI[0.08,0.75];P<0.01)than control interventions comprising western medicine,Chinese patent medicine,and/or western medicine+Chinese patent medicine.Compared with the control interventions,SHT resulted in greater improvements in the symptom scores for stomach distension and stomachache,serum gastrin level,histopathologic changes,Helicobacter pylori(HP)inhibition rate,and gastric mucosal inflammation.Conclusion:SHT was more effective and safer than control interventions for CAG.
基金The National Key Research and Development Program(No.2018YFC1704500).
文摘Objectives:To evaluate the benefits of traditional Chinese herbal medicine(TCHM)plus triple therapy(TT)in the management of Helicobacter pylori(H.pylori)-induced chronic atrophic gastritis(CAG).Methods:A comprehensive access and electronic database search were carried out from inception to June 2020.Prospective randomized trials(TCHM plus TT vs.TT)were selected to assess the eradication rate of H.pylori(ER of H.pylori),clinical symptom relief rate(SRR),treatment-related adverse reactions(TRAR)and 95%confidence intervals(CI)in the meta-analysis and cumulative meta-analysis(CMA).Meta-regression analysis was used to analyze heterogeneity between studies and publication bias.Results:33 studies contained 3,226 participants were included.Compared with the TT group,TCHM plus TT group showed a significantly higher ER of H.pylori(OR=4.14,95%CI:3.21-5.35;P=0.000)and SRR(OR=4.50,95%CI:3.59-5.64).Meanwhile,the TRAR of TCHM plus TT remedy was significantly lower than TT monopoly(RR=0.43,95%CI:0.29-0.64;P=0.000).The results of the CMA,sorted by publication year,duration of treatment,and sample size,confirmed that combined treatment remedy was superior to TT monopoly in respect of ER of H.pylori and SRR.Conclusions:The present study obtained reliable and convincing evidence suggesting that TCHM plus TT remedy was efficacious and safe in treating H.pylori-induced CAG.
文摘Objective:To analyze the features and patterns of acupoint selection in acupuncture-moxibustion treatment of chronic atrophic gastritis(CAG)by data mining technique.Methods:Relevant clinical studies published before 25 June,2017 were searched in databases including PubMed,EMBASE,Cochrane library,Chinese Biomedical Literature Database(CBM),China National Knowledge infrastructure(CNKI),and Wanfang Academic Journal Full-text Database(Wanfang).Results:A total of 122 papers were included,involving 69 points.It was found that the top three points on the frequency list were Zusanli(ST 36),Zhongwan(CV 12)and Weishu(BL 21).The points selected were distributed in 11 meridians,in which the Stomach Meridian of Foot Yangming,Conception Vessel,and Bladder Meridian of Foot Taiyang ranked the top and accounted for 74.0%of the total frequency.Of the involved specific points,Five Shu-Transmitting points,crossing points and Back-Shu points ranked the top,accounting for 47.1%.The analysis of association pattern has shown that Zusanli(ST 36)and Zhongwan(CV 12)won the highest support rate in the paired groups;Zusanli(ST 36),Weishu(BL 21)and Zhongwan(CV 12)had the highest support rate among the point groups.The Five Shu-Transmitting points and the Lower He-Sea points had the highest support rate among the specific point groups.Conclusion:The data mining results of the studies on acupuncture-moxibustion for CAG are substantially in line with the acupuncture-moxibustion treatment theories in traditional Chinese medicine.The results can reflect the acupoint selection patterns in treatment of CAG and provide reference for acupuncture-moxibustion treatment of CAG in clinic.
基金supported by Jinyang Community Health Service Center of Pudong New DistrictShanghai Jiao Tong University Affiliated Sixth People’s Hospital
文摘Objective: To observe the clinical efficacy of combining acupuncture and medication in treating chronic atrophic gastritis(CAG) due to spleen-stomach deficiency. Methods: Totally 176 patients with CAG were randomized into two groups by the random number table. The 91 subjects in the treatment group were intervened by acupuncture and oral Chinese patent medication; the other 85 subjects were by oral Chinese patent medication alone. The clinical efficacies were compared at the end of intervention. Results: After a treatment course, the total effective rate was 87.9% in the treatment group versus 75.3% in the control group; according to the gastroscopy and pathological biopsy examinations, the total effective rate was 85.7% in the treatment group versus 74.1% in the control group. There were significant differences in comparing the clinical efficacy, gastroscopy and pathological examinations between the two groups(P<0.05). Conclusion: Combining acupuncture and medication can produce a better therapeutic efficacy than medication alone in treating CAG due to spleen-stomach deficiency.
