Gastroprotective Effects of Ascaridole on Gastric Ulcer in Rats

Objective To evaluate the gastroprotective activity of ascaridole. Methods The gastroprotective effect of ascaridole was evaluated on ulcer healing in rats with acetic acid-induced chronic gastric ulcer, pylorus ligation- and Aspirin-induced gastric ulcer. Ascaridole was ig administered with the dosages of 10 and 20 mg/kg once daily for 7 d. Results Ascaridole showed the significant anti-ulcer effects. In acetic acid-induced gastric ulcer rats, the ulcer areas after 10 and 20 mg/kg of ascaridole treatment were (65.1 ± 20.0) and (50.6 ± 11.0) mm2, respectively, which were significant lower (P < 0.01) than that of the control group [(116.7 ± 35.8) mm2]. For pylorus ligation model, ascaridole showed a gastric ulcer healing effect in a dose-dependent manner. Ascaridole at the dose of 20 mg/kg showed 50% ulcer protection and had a significant (P < 0.05) gastroprotective activity since it decreased the total acidity and pepsin activity. Compared to the control group, the two dosages of ascaridole showed the significant reduction (P < 0.05) in the ulcer index on Aspirin-induced ulcer. Conclusion This study provides evidence that ascaridole shows potential efficacy on the healing of gastric ulcers induced by acetic acid, Aspirin, and pylorus ligation.

Phytochemical composition and gastroprotective effect of Feijoa sellowiana Berg fruits from Sicily

Objective:To assess the fruit of Feijoa sellowiana Berg var.coolidge and gorgiona,cultured in Sicily,for its gastroprotective effect,in association with performing phytochemical evaluation.Methods:The gastroprotective effect was investigated on ethanol-induced ulcers in rats,with sucralfate as reference drug.Samples of gastric mucosae,stained by periodic acid-Shiff and haematoxylin/eosin,were observed by light microscopy.Results:By means of HPLC,vitamin E complex and polyphenol compounds were determined.identified,while δ was only in var.coolidge.In whole fruit of two varieties,catechin,eriodictyol,eriocitrin,pyrocatechol,quercetin,rutin,ellagic,gallic and syringic acid were determined.The fruit showed gastroprotective effect(ulcer index:var.coolidge=1.07,var.gorgiona=1.02).The efficacy was comparable to that of sucralfate(ulcer index 1.10).Histological examination confirmed the inhibition of ulcerogenic activity of the ethanol.Conclusions:In pulp and peel samples of both varieties of fruit α,β and γ tocopherols were and show beneficial effects on various diseases,particularly those caused by oxidative processes resulting in cell damage.The amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit,grown in pedoclimatic condition very different from the origin area.Active principles of Feijoa sellowiana can play an important role in human diet and show beneficial effects on various diseases,particularly those caused by oxidative processes resulting in cell damage.The amount of polyphenols and vitamin E complex confirms the nutritional value of this fruit,grown in pedoclimatic condition very different from the origin area.