The safety of Chuangyuling (CYL) dressing—a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional...The safety of Chuangyuling (CYL) dressing—a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional Chinese medicine (TCM) extract solution was compounded with scaffolds (gelatin and Bletilla hyacinthine gum), and then frozen and dried to form spongy and porous material CYL. According to the standard of biological evaluation of medical devices that was instituted by the ministry of health of China \, the biological evaluation of CYL dressing was conducted. The results showed that all the contents of biological evaluation test consisting of acute toxicity, skin irritation, sensitization and cytotoxicity met the requirement of standards. It was concluded that the biomaterial carrying TCM (CYL dressing) is safe for application of wound healing.展开更多
Objective:This article uses the method of network pharmacology to study the related mechanism of Guilu Erxian Gum in the treatment of osteoporosis.Methods:Based on the TCMSP database,ETCM database,chemistry database,a...Objective:This article uses the method of network pharmacology to study the related mechanism of Guilu Erxian Gum in the treatment of osteoporosis.Methods:Based on the TCMSP database,ETCM database,chemistry database,and DrugBank database,the potential active ingredients and related targets of Guilu Erxian Gum were obtained.The known therapeutic targets of osteoporosis were obtained from OMIM and Genecards databases,and the STRING database was used.A protein interaction network(PPI)of active ingredients-disease targets was established,and the topological parameters of the network were analyzed using Cytoscape 3.8.0 software to obtain key active ingredients and their targets.In R4.0.2,the Bioconductor data package was used to analyze the GO biological function and KEGG pathway analysis of key targets,and obtain the effective ingredients and targets of Guilu Erxian Gum for treating osteoporosis.Results:The prediction results show that Guilu Erxian Gum has 87 active ingredients and 2305 targets,and there are 4141 known therapeutic targets for osteoporosis.The two act together to obtain a total of 71 PPI core genes.The GO biological process analysis yielded 95 entries,and the KEGG pathway analysis yielded 115 pathways.Conclusion:The analysis results show that Guilu Erxian Gum may play an anti-osteoporosis effect by regulating inflammatory factors,promoting osteoblast differentiation,inhibiting osteoclast formation,and improving microcirculation.The pathways involved include TNF signaling pathways,IL-17 signaling pathway,NF-κB signaling pathway,HIF-1 signaling pathway,MAPK signaling pathway,PI3K-Akt signaling pathway,etc.This study provides a theoretical basis for further elucidating the pharmacological mechanism of Guilu Erxian Gum in the treatment of osteoporosis.展开更多
目的探讨腹部中药外敷结合咀嚼对食管癌(esophageal carcinoma,EC)术后消化道功能恢复的影响.方法选取2014-03/2016-08在宁海县第一医院接受手术治疗的EC患者108例,依据随机数表法分为观察组(腹部中药外敷结合口香糖咀嚼)和对照组(常规...目的探讨腹部中药外敷结合咀嚼对食管癌(esophageal carcinoma,EC)术后消化道功能恢复的影响.方法选取2014-03/2016-08在宁海县第一医院接受手术治疗的EC患者108例,依据随机数表法分为观察组(腹部中药外敷结合口香糖咀嚼)和对照组(常规治疗、护理),比较2组患者的疗效、胃肠功能恢复情况及胃泌素、胃动素水平.结果观察组54例,总有效率为94.44%,对照组54例,总有效率为85.19%,差异具有统计学意义(χ~2=6.635,P<0.05).观察组患者的首次排便时间、肛门排气时间、肠鸣音恢复时间及住院时间均明显低于对照组,差异具有统计学意义(49.27 h±4.82 h vs 65.83 h±5.26 h,31.45 h±3.72 h vs 59.26 h±4.01 h,18.43 h±2.83 h vs24.05 h±3.26 h,8.72 h±1.26 h vs 11.45 h±2.74 h,P<0.05).治疗前,2组患者的胃泌素、胃动素无显著差异(P>0.05).治疗后,观察组的胃泌素和胃动素均明显高于对照组,差异具有统计学意义(108.24 ng/L±21.36 ng/L vs91.38 ng/L±22.36 ng/L,612.79 ng/L±42.35 ng/L vs 506.23 ng/L±51.25 ng/L,P<0.05).结论腹部中药外敷结合口香糖咀嚼能够明显改善EC术后患者临床症状和体征,促进患者胃肠功能恢复,值得临床推广.展开更多
文摘The safety of Chuangyuling (CYL) dressing—a multifunctional medicine carrying biomaterial was evaluated in order to provide foundation for the application of CYL as material used in the wound healing. The traditional Chinese medicine (TCM) extract solution was compounded with scaffolds (gelatin and Bletilla hyacinthine gum), and then frozen and dried to form spongy and porous material CYL. According to the standard of biological evaluation of medical devices that was instituted by the ministry of health of China \, the biological evaluation of CYL dressing was conducted. The results showed that all the contents of biological evaluation test consisting of acute toxicity, skin irritation, sensitization and cytotoxicity met the requirement of standards. It was concluded that the biomaterial carrying TCM (CYL dressing) is safe for application of wound healing.
基金National Natural Science Foundation of China(No.81973719)Science and technology research project of Liaoning Provincial Department of Education(No.L201921)Liaoning Provincial Science And Technology Plan Project(No.2020JH2/10300068)。
文摘Objective:This article uses the method of network pharmacology to study the related mechanism of Guilu Erxian Gum in the treatment of osteoporosis.Methods:Based on the TCMSP database,ETCM database,chemistry database,and DrugBank database,the potential active ingredients and related targets of Guilu Erxian Gum were obtained.The known therapeutic targets of osteoporosis were obtained from OMIM and Genecards databases,and the STRING database was used.A protein interaction network(PPI)of active ingredients-disease targets was established,and the topological parameters of the network were analyzed using Cytoscape 3.8.0 software to obtain key active ingredients and their targets.In R4.0.2,the Bioconductor data package was used to analyze the GO biological function and KEGG pathway analysis of key targets,and obtain the effective ingredients and targets of Guilu Erxian Gum for treating osteoporosis.Results:The prediction results show that Guilu Erxian Gum has 87 active ingredients and 2305 targets,and there are 4141 known therapeutic targets for osteoporosis.The two act together to obtain a total of 71 PPI core genes.The GO biological process analysis yielded 95 entries,and the KEGG pathway analysis yielded 115 pathways.Conclusion:The analysis results show that Guilu Erxian Gum may play an anti-osteoporosis effect by regulating inflammatory factors,promoting osteoblast differentiation,inhibiting osteoclast formation,and improving microcirculation.The pathways involved include TNF signaling pathways,IL-17 signaling pathway,NF-κB signaling pathway,HIF-1 signaling pathway,MAPK signaling pathway,PI3K-Akt signaling pathway,etc.This study provides a theoretical basis for further elucidating the pharmacological mechanism of Guilu Erxian Gum in the treatment of osteoporosis.
文摘目的探讨腹部中药外敷结合咀嚼对食管癌(esophageal carcinoma,EC)术后消化道功能恢复的影响.方法选取2014-03/2016-08在宁海县第一医院接受手术治疗的EC患者108例,依据随机数表法分为观察组(腹部中药外敷结合口香糖咀嚼)和对照组(常规治疗、护理),比较2组患者的疗效、胃肠功能恢复情况及胃泌素、胃动素水平.结果观察组54例,总有效率为94.44%,对照组54例,总有效率为85.19%,差异具有统计学意义(χ~2=6.635,P<0.05).观察组患者的首次排便时间、肛门排气时间、肠鸣音恢复时间及住院时间均明显低于对照组,差异具有统计学意义(49.27 h±4.82 h vs 65.83 h±5.26 h,31.45 h±3.72 h vs 59.26 h±4.01 h,18.43 h±2.83 h vs24.05 h±3.26 h,8.72 h±1.26 h vs 11.45 h±2.74 h,P<0.05).治疗前,2组患者的胃泌素、胃动素无显著差异(P>0.05).治疗后,观察组的胃泌素和胃动素均明显高于对照组,差异具有统计学意义(108.24 ng/L±21.36 ng/L vs91.38 ng/L±22.36 ng/L,612.79 ng/L±42.35 ng/L vs 506.23 ng/L±51.25 ng/L,P<0.05).结论腹部中药外敷结合口香糖咀嚼能够明显改善EC术后患者临床症状和体征,促进患者胃肠功能恢复,值得临床推广.
