Gender Differences in the Incidence and Related Factors of Low Social Support among Adolescents with Subthreshold Depression

Background:Social support is related to depression,but the gender differences and related factors that contribute to low social support among adolescents with subthreshold depression remain to be elucidated.This study explores the relationship between social support and depression,in addition to the gender difference in the incidence of low social support among adolescents with subthreshold depression and its related factors.Methods:A total of 371 Chinese adolescents with subthreshold depression were recruited.All subjects were rated on the Social Support Scale for Adolescents,the Response Style Scale,the Self-Perception Profile for Children,the Individualism-collectivism scale.Results:Binary logistic regression indicated that the stability dimension of cognitive style,the generality dimension of the Cognitive Style Questionnaire,and the social acceptance dimension of the Self-Perception Profile for Children scale were significantly correlated with social support level in male adolescents with subthreshold depression.In contrast,the total score of the Self-Perception Profile for Children scale,the social acceptance of the Self-Perception Profile for Children scale,total individualism,and total collectivism were significantly correlated with social support level in female adolescents with subthreshold depression.Limitations:This study is a cross-sectional study,and its effectiveness in explaining factors that influence levels of social support is limited.Conclusions:The gender difference between low social support among adolescents with subthreshold depression is related to cognitive style,self-perception,and collectivism–individualism.

A Study on Gender Differences in Speech Interaction Behaviors of Preschool Teachers-Based on the Improved Flanders Interactive Analysis System(iFIAS)

The issue of the extremely imbalanced gender ratio in preschool teachers has received widespread attention,and there are few studies on teacher-child verbal interaction behavior based on gender differences in preschool teachers.This article takes the“Little Light Bulb Is On”,a scientific exploration activity done by 5-6 years old kindergarten students as an example,and uses the improved Flanders Interaction Analysis System(iFIAS)as a tool to analyze the speech interaction behavior of male and female preschool teachers.The research results indicate that there are gender differences in teacher child language interaction between male and female teachers in terms of the atmosphere,the teaching structure,the teaching tendency,the way of raising questions,and the overall trend of interaction.

Gender differences in ghrelin, nociception genes, psychological factors and quality of life in functional dyspepsia

AIM to evaluate gender differences in the aspect of ghrelin,nociception-related genes and psychological aspects and the quality of life(Qo L) in Korean functional dyspepsia(FD) patients.METHODS Total of 191 persons were prospectively enrolled between March 2013 and May 2016 in Seoul National Bundang Hospital,and classified into control and FD group based on ROME Ⅲ criteria. Questionnaire included assessment for dyspepsia symptoms,Qo L and anxiety or depression. Preproghrelin and nociception genes in the gastric mucosa and plasma acyl/des-acyl ghrelin were measured. RESULTS Lower level of plasma acyl ghrelin in FD patients compared to control was significant only in male(15.9 fmol/m L vs 10.4 fmol/m L,P = 0.017). Significantly higher m RNA expressions of nerve growth factor and transient receptor potential vanilloid receptor 1 were observed in male(P = 0.002 and P = 0.014,respectively) than in female. In contrast,female FD patients had a higher anxiety and depression score than male FD(P = 0.029),and anxiety score was correlated with epigastric pain only in female FD patients(female: Spearman rho = 0.420,P = 0.037). The impairment of overall Qo L was more prominent in female FD patients than male patients(5.4 ± 0.3 vs 6.5 ± 0.3,P = 0.020). CONCLUSION Gender differences of ghrelin and nociception-related genes in male and psychological factors in female underlie FD symptoms. More careful assessment of psychological or emotional status is required particularly for the female FD patients.

Gender difference in the neuroprotective effect of rat bone marrow mesenchymal cells against hypoxiainduced apoptosis of retinal ganglion cells

Bone marrow mesenchymal stem cells can reduce retinal ganglion cell death and effectively prevent vision loss. Previously, we found that during differentiation, female rhesus monkey bone marrow mesenchymal stem cells acquire a higher neurogenic potential compared with male rhesus monkey bone marrow mesenchymal stem cells. This suggests that female bone marrow mesenchymal stem cells have a stronger neuroprotective effect than male bone marrow mesenchymal stem cells. Here, we first isolated and cultured bone marrow mesenchymal stem cells from female and male rats by density gradient centrifugation. Retinal tissue from newborn rats was prepared by enzymatic digestion to obtain primary retinal ganglion cells. Using the transwell system, retinal ganglion cells were co-cultured with bone marrow mesenchymal stem cells under hypoxia. Cell apoptosis was detected by flow cytometry and caspase-3 activity assay. We found a marked increase in apoptotic rate and caspase-3 activity of retinal ganglion cells after 24 hours of hypoxia compared with normoxia. Moreover, apoptotic rate and caspase-3 activity of retinal ganglion cells significantly decreased with both female and male bone marrow mesenchymal stem cell co-culture under hypoxia compared with culture alone, with more significant effects from female bone marrow mesenchymal stem cells. Our results indicate that bone marrow mesenchymal stem cells exert a neuroprotective effect against hypoxia-induced apoptosis of retinal ganglion cells, and also that female cells have greater neuroprotective ability compared with male cells.

Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

Gender differences in the efficacy of cardiovascular rehabilitation in patients after cardiac surgery procedures

Cardiac rehabilitation （CR） programs are well known to improve patients＇ functional status after cardiac surgery and are recommended by current guideline. In fact, they pro- mote not only structured physical exercises but also a complete secondary prevention determining an overall reduction in recurrent cardiac events and an improvement in functional, psychosocial status and survival.

Gender differences in adolescent dry eye disease:a health problem in girls

AIM： To evaluate the signs and symptoms of dry eye disease（DED） in adolescents. METHODS： This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms： dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS： Of the 323 adolescents recruited, 70（21.7%） were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time（BUT; ≤5s; P=0.000） and superficial punctate keratopathy（SPK; staining score ≥3; P=0.000）. Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION： We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group.

A Socio-pragmatic Analysis of Gender Differences in Gossip Girl

The paper employs the method of discourse analysis to analyze males' and females' differences in cross-gender conversations in Gossip Girl from the perspective of Searle's Indirect Speech Act Theory, Grice's Cooperative Principle, and Leech's Politeness Principle. The study found that females tend to abide by Cooperative Principle, while males are more likely to fl out the CP, and that female characters are used to making requests or suggestions by raising question in a euphemistic way; while males concern less about courtesy, women always attach a great deal of importance to saving others' face in daily conversation. The paper contributed to reducing misunderstanding in cross-gender communication.

Gender differences in challenging behaviors,management and outcomes in elderly patients with delirium

BACKGROUND： Gender differences have been reported in some common mental disorders. However, few studies have monitored gender differences in individuals with delirium. OBJECTIVE： To explore gender differences in challenging behaviors, management and outcomes in age-matched elderly patients with delirium.DESIGN, TIME AND SETTING： A retrospective cohort study was performed in the Bankstown-Lidcombe Hospital, Sydney, Australia, from October 2008 to April 2009. METHODS： Patients, aged 65-90 years, diagnosed with delirium according to the International Classification of Diseases （ICD）-10 in the Psychogeriatric Unit of Bankstown Lidcombe Hospital from January 2002 to October 2008 were reviewed. All the patients were measured according to the Confusion Assessment Method upon admission. Those who developed delirium during hospitalization were excluded.MAIN OUTCOME MEASURES： Cause of delirium, wandering, aggression, duration of delirium, physical restraint, use of antipsychotic medicine, recovery from delirium, discharge back home, length of stay, one-to-one nursing care, falls and absconding rate.RESULTS： The 131 age-matched delirious patients comprised 54 males and 77 females. The behavioral disorders of wandering [odds ration （OR） = 2.612, 95% confidence interval （CI） = 1.26 -5.413, P = 0.009] and aggression （OR = 2.243, 95% CI = 1.028 - 4.891, P= 0.04） were more frequent in males than in females. More males received one-to-one nursing care （OR = 4.114, 95% CI = 1.355 - 12.491, P = 0.008）, were more likely to receive antipsychotic medications （OR = 2.24, 95% CI = 1.095-4.583, P = 0.021） and more likely to be physically restrained （OR = 2.07, 95% CI = 1.02-1.02, P = 0.043） compared with female patients. All absconding patients （3/131, 2.3%） were male. In addition, male patients displayed a greater falling rate compared with females （OR = 4.57, 95% CI= 1.519-13.722, P = 0.004）.CONCLUSION： There are gender differences in challenging behaviors, management and outcomes in elderly delirious patients. Males with delirium display more challenging behaviors that require physical restraint and pharmacological management including wandering and aggression; males also abscond and have a higher rate of falls compared with female patients.

Drug-abusing Offenders with Co-morbid Mental Disorders:Gender Differences in Problem Severity,Treatment Participation,and Recidivism

Objective This study examined the gender differences in drug‐related problems and predictors of recidivism among a sample of 1444 offenders with co‐morbid drug abuse and mental disorders participating in California＇s Proposition 36 Program.Methods Background characteristics and problem severity in multiple key life areas were assessed at intake by using Addiction Severity Index,and drug treatment participation,mental health diagnoses and arrests were based on official records.Results Women demonstrated greater problem severity than men in family relationships,health,psychological health,and sexual and physical abuse history.Men on the other hand had greater criminal history,high rates of attention disorder,and psychotic disorder.More men than women were rearrested during the year after treatment admission.Logistic regression analyses showed that for the combined sample,male,young age,cocaine use（relative to methamphetamine）,drug abuse severity,methadone treatment,arrest history and fewer prior treatment history were associated with higher recidivism at 12‐month follow‐up;lower education,cocaine use,and arrest history were related to women＇s recidivism,while young age,outpatient treatment,and arrest history were predictors of men＇s recidivism.Conclusion Although the specific type of mental disorder did not seem to be predictive of recidivism,the high rates of mental health disorder and arrest of this population is problematic.Intervention strategies taking into consideration gender‐specific problems and needs can improve outcomes for both.

Gender differences in the etiology of heart failure： A systematic review

Background Heart failure （HF） is an increasing problem for the aging population, specifically among women. The etiology of HF influences both the selection and outcome of the treatment. There are variations between genders in morbidity and mortality in different studies, possibly reflecting etiology. The objective of this study was to examine the strength of evidence available for gender differences in the etiology of chronic heart failure. Methods Computer-assisted searches from 1980-2009 for gender differences in the etiology of heart failure were performed （Medline, EMBASE and PubMed）. From 2347 abstracts reviewed based on inclusion criteria, 35 original articles were chosen for review. Data extraction was based on observational studies （prospective/retrospective cohort or cross sectional） with a mean follow up of 3 months. There was no interrater variability between the 2 reviewers on data-extraction. Results Ventricular systolic dysfunction being more associated with male sex, but female sex was more reported to be associated with preserved left ventricular function. Ischemic etiology and associated coronary heart disease were strongly correlated with male sex. The risk for HF was dramatically more elevated for women with systolic hypertension but the association for diabetes mellitus as the etiology of HF was somewhat equal between males and females. Conclusions One of the limitations in reaching conclusions about gender differences in cardiovascular disease is that many major clinical trials do not include a gender analysis nor they are powered to do so as women are under-represented in most of the HF studies. The need remains for a well designed prospective study of sufficient numbers of male and female patients with and without heart failure and analyzing etiology and risk factors based on the sex differences.

Gender Difference in Circulatory Associated Multi-Morbidity among the Elderly in Rural Southwest China

Aim: This study examined the prevalence of four chronic circulatory system diseases (hypertension, CHD, hyperlipemia, Stroke) and associated multi-morbidity in order to identify the risk factors among the elderly in Yunnan province. Methods: A cross-sectional survey including 2299 consenting adults aged ≥ 60 years from rural places was conducted in 2018. Data of demographic parameters and clinical characteristics were acquired from questionnaire and health examination. Categorical variables were presented as counts and percentages. Multivariable logistic regression analysis was used to analyze the association between individual SES and lifestyle variables and multimorbidity of the four chronic cardiovascular and cerebrovascular diseases. All analyses were conducted with SPSS 17.0 software. Results: Our study suggested that the prevalence of hypertension, CHD, hyperlipemia, Stroke was 57.1%, 4.2%, 5.9% and 5.3%, respectively and the prevalence of multimorbidity was 10.3%. Females had a higher prevalence of family history of chronic cardiovascular and cerebrovascular diseases, obesity, central obesity and illiteracy than males (P < 0.01), whereas males had a markedly higher prevalence of drinking, smoking and good sleeping quality than females (P < 0.01). The family genetic history, obesity, smoking, education, and diabetes were positively and drinking was negatively correlated with the prevalence of circulatory associated multimorbidity in elderly. Interestingly, some of the above associations were only observed in male/female but not the other sex. Conclusions: The prevalence of circulatory disease associated multimorbidity is relatively high among elderly population in rural places of Yunan province and the risk factors are different between females and males.

Gender Difference of Cadmium- induced Renal Tubular Dysfunction for Inhabitants in Toyama,Japan

Objective The aim of the present study mas to compare the gender difference for cadmium-induced renal tubular dysfunction between the male and female inhabitants. Methods Urinary β2-microglobulin was measured in 299 male (94%) and 342 female (92%) inhabitants aged 54-72 years,and the development of renal tubular dysfunction for 11 years was studied in the 62 married couples from them. Results A significantly higher cumulative incidence was found in both men and women in cadmium-polluted area,showing 68. 4% in men and 64. 8% in women compared to 15. 3% in men and 5. 9% in women in the reference areas. Relative risk of renal tubular dysfunction in females (11. 0) was higher than males (4. 5). The ratios of urinary β2-microglobulin and glucose were higher in women than those in men in both the cadmium-polluted areas and the reference areas. Conclusion Although almost identical incidences were detected between men and women, the changes in excretion of β2-microglobulin and glucose was greater in women than those in men. These findings suggest that renal tubular dysfunction might be more progressive in women than that in men.

Gender Differences in Gastrointestinal, Hepatobiliary and Pancreatic Surgery and Perceived Relevance on Outcomes <br/>—A Single Center 22-Year Observational Study in India (1996-2018)

Introduction: Gender differences are still quite prevalent in the present time. Although there is literature regarding gender differences in healthcare expenditure in India, there is no data regarding gender differences in hospital stay, hospital seeking behaviors and mortality. Aim: To evaluate the Gender differences in a hospital seeking behavior, mortality and hospital stay. Methods: We prospectively analyzed, from a retrospective database, all patients who underwent surgical gastrointestinal, hepato-biliary, pancreatic and splenic surgeries from 1996 to 2018 in our unit. Patients were divided into groups based on gender, admission time period and priority of admission i.e., elective or emergency. Both the gender groups were compared with respect to total procedures done, hospital stay and mortality. Organ specific mortality was calculated as proportions, was analyzed and compared between the groups. Time trends of the same were observed and compared. Results: Of 12,411 patients, 7979 (64.3%) were males and 4432 (35.7%) were females. 9191 (74.1%) patients underwent elective procedures whereas 3220 (25.9%) had emergency procedures (p ≤ 0.001). Overall mortality was higher in males (n = 473, 5.92%) in comparison to females (n = 185, 4.17%) (p ≤ 0.001). Majority of surgeries in males were of small intestine (22.5%) in which small bowel resection was most commonly done (5.4%), whereas, gallbladder and biliary surgeries (27.4%) were the most common in females in which laparoscopic cholecystectomy was most commonly done (5.8%). Median hospital stay was higher in males (10 days vs 9 days), (p ≤ 0.001). Mortality was higher in females in all organ categories except in liver (6.34% vs 2.7%), pancreas (37.3% Vs 18.3%) and spleen (3.38% Vs 1.62%) where mortality was higher for male gender. Highest mortality for females was in small intestinal surgery (34%) and for males, it was pancreatic surgery (37.3%). Highest mortality in males was emergency open pancreatic necrosectomy (21.6%) and that in females was emergency small intestinal surgery (11.9%). Although the number of surgeries in females increased over time (380 in 1996-1999 Vs 951 in 2016-2018), the proportion remained constant (36.3% Vs 38.3% in 1996-1999 and 2016-2018 respectively). Conclusion: We conclude that mortality is found to be higher in males after gastrointestinal surgery, which may be explained by the fact that hospital seeking behavior is more in males though it is fairly increasing in females in the recent years.

Gender Differences in Quality of Attachment to God, Forgiveness, Altruism, and Mental Health in College and Seminary School Students

The aim of the current study was to investigate gender differences in quality of attachment to God, forgiveness, altruism and mental health in college and seminary school students as well. To fulfil the stated goal 993 individuals were selected by means of stratified sampling procedures and the following measures were distributed among them： Muslim-Spiritual Attachment Scale, Kin Altruism, Reciprocal Altruism Enright Forgiveness Inventory, and Symptom Checklist-90 Revised. Analysis of data using t test revealed significant differences between male and female students （/9 〈 0.01）. Moreover, data indicated that interpersonal sensitivity was higher in male students while somatization complains was higher among female students. Analysis of data showed that quality of secure attachment in female students were higher than male students （P 〈 0.01）. Moreover, female students were higher in altruism, especially in domain of compassion （P 〈 0.05）. In addition female students were higher in perceiving God as a Safe Haven and providing them with comfort and tranquility. Moreover, females students were higher in altruism （p 〈 0.05）, and forgiveness （p 〈 0.01）. The analysis of data revealed that female students were higher in the secure attachment to God, sympathy toward others and they scored higher in somatization complain while male students were higher in the interpersonal sensitivity. Theoretical implication and practical application of findings have been discussed in the original paper. Findings in this project were consistent with body of research findings. Theoretical implication and practical usage of the current study was described in the original paper. Data revealed that female student were higher in secure attachment to God, altruism and forgiveness. Showing emotional stability and higher spirituality.

Impact of Gender Difference on Characteristics and Outcome of Chronic Hepatitis C

Gender difference in chronic hepatitis C (CHC) infection is not previously well studied. We aimed to analyze the effect of gender difference on the risk factors of CHC, disease progression, and outcome after oral direct acting antiviral (DAA) therapy. The study was conducted at Tropical Medicine and Gastroenterology Department, Sohag University, Egypt, in the period between 2018 and 2020. 775 patients were evaluated for hepatitis C virus (HCV) risk factors. Laboratory investigations, abdominal ultrasound and liver Shear wave elastography (SWE) were done. The patients were given antiviral therapy and followed up to assess the response and side effects of DAA therapy. 434 (56%) of study patients were males and 341 (44%) were females. Catching infection from blood transfusion and intravenous (IV) injection of tarter emetic was significantly higher in males, while catching infection from surgical operation was significantly higher in females. Hepatic fibrosis was significantly more extensive in males. Side effects were reported more in females. Sustained virological response (SVR) 12 was reported in 98.6%. Females had a slightly better SVR12 than males (99.4% versus 97.9%). In conclusion males were different from females in exposure to HCV risk factors. After introduction of blood screening and stoppage of parenteral anti-bilharzial therapy the risk of HCV infection could be greatly prevented in males, while the exposure of females to obstetric procedure is increasing nowadays which hides a risk of ongoing infection in females. So, HCV surveillance programs in females retain their importance in early detection and management of CHC. Although hepatic fibrosis progression was more in males, females were more liable to adverse events of DAA therapy. So, researchers should consider the gender of their patients in drug design and administration.

Gender Differences in Motivation and Learning Preferences of Pharmacists in Lifelong Learning

Objectives： To analyse motivation and preferences of pharmacists who participate in CE （continuing education） to develop suitable lifelong learning programmes for pharmacists. Methods： An online questionnaire, which explored the motivation and preferences of the pharmacists to lifelong learning, was sent to all members of the Royal Dutch Pharmaceutical Society （4321） in the Netherlands. The data were analysed using a non-hierarchical clustering technique. Key findings： Two clusters of pharmacists were discovered. Cluster A pharmacists （n = 474） were more motivated by credit points （63.5% vs. 47.2%）, personal interest （84.1% vs. 56.3%）, updating knowledge （73.8% vs. 56.8%） and topicality of CE courses （47.7% vs. 26.1%）. Cluster B pharmacists （n = 199） were predominantly motivated by the aspect ＂duty as a care-giver＂ （97.0% vs. 0 % in cluster A）. Pharmacists who belonged to cluster A tended to be women （60.5%）, often worked part-time （29.3%） and mostly preferred lectures （71.1%）. Cluster B pharmacists consisted of statistically significantly more male pharmacists （52.8%, p = 0.001）, worked more full time （77.4%, p = 0.009） and mostly preferred blended learning （62.3%, p = 0.047）. Conclusions： These results suggest the use of different education formats for different kinds of pharmacists to participate in CE activities.

On Gender Difference of Language in Emma

Many findings suggest that gender has a great influence on the using of language. The thesis attempts to discuss the gender difference of language in Emma by analyzing certain selected sections of the novel from the perspective of, lexicon, syntax,and discourse with the knowledge of linguistics and pragmatics, so as to draw a general conclusion on the gender difference in lexicon, syntax, and in the application of conversational principles. Through the analysis of gender difference of language in Emma,the thesis expects to help the readers acknowledge the difference in women's speech and men's speech, so as to reduce the barriers of cross-gender communication, and promote the harmonious communication between men and women.

Personality Styles,Psychological Adjustment and Gender Differences in Parents of Children with Congenital Disabilities

The present study analyzes the psychological adaptation of parents with children having congenital disabilities. The study included 83 men and 96 women, who were parents of children with severe spina bifida, cerebral palsy, cleft lip and cleft palate. The Millon Index of Personality Styles was used to identify the most distinctive personality styles of parents caring for a child with a chronic disability and parental psychological adjustment. We also investigated if personality profiles differ by gender, and educational and socioeconomic level. The personality styles identified may serve as indicators of the way parents adapt to the child with a congenital disability. The results also suggest that a child’s disability has a differential impact on men and women. Gender issues are evaluated, as well as any repercussions these may have on women.

Effect of gender differences in distal femoral geometry on the clinical outcomes of total knee arthroplasty

Objective To investigate the effect of gender differences in distal femoral geometry on the clinical outcomes of total knee arthroplasty (TKA).Methods From March 2003 to October 2006,213 cases with 294 osteoarthritic knees who