Primary total knee arthroplasty(TKA)is a widespread procedure to address end stage osteoarthritis with good results,clinical outcomes,and long-term survivorship.Although it is frequently performed in elderly,an increa...Primary total knee arthroplasty(TKA)is a widespread procedure to address end stage osteoarthritis with good results,clinical outcomes,and long-term survivorship.Although it is frequently performed in elderly,an increased demand in young and active people is expected in the next years.However,a considerable dissatisfaction rate has been reported by highly demanding patients due to the intrinsic limitations provided by the TKA.Bicruciate-retaining(BCR)TKA was developed to mimic knee biomechanics,through anterior cruciate ligament preservation.First-generation BCR TKA has not gained popularity due to its being a challenging technique and having poor survival outcomes.Thanks to implant design improvement and surgeon-friendly instrumentation,secondgeneration BCR TKA has seen renewed interest.This review will focus on surgical indications,kinematical basis,clinical results and latest developments of secondgeneration BCR TKA.展开更多
In recent years, large language models have achieved breakthroughs on a wide range of benchmarks in natural language processing and continue to increase in performance. Recently, the advances of large language models ...In recent years, large language models have achieved breakthroughs on a wide range of benchmarks in natural language processing and continue to increase in performance. Recently, the advances of large language models have raised interest outside the natural language processing community and could have a large impact on daily life. In this paper, we pose the question: How will large language models and other foundation models shape the future product development process? We provide the reader with an overview of the subject by summarizing both recent advances in natural language processing and the use of information technology in the engineering design process. We argue that discourse should be regarded as the core of engineering design processes, and therefore should be represented in a digital artifact. On this basis, we describe how foundation models such as large language models could contribute to the design discourse by automating parts thereof that involve creativity and reasoning, and were previously reserved for humans. We describe how simulations, experiments, topology optimizations, and other process steps can be integrated into a machine-actionable, discourse-centric design process. As an example, we present a design discourse on the optimization of wind turbine blades. Finally, we outline the future research that will be necessary for the implementation of the conceptualized framework.展开更多
Monodisperse aerosols are essential in many applications, such as filter testing, aerosol instrument calibration, and experiments for validating models. This paper describes the design principle, construction, and per...Monodisperse aerosols are essential in many applications, such as filter testing, aerosol instrument calibration, and experiments for validating models. This paper describes the design principle, construction, and performance of a monodisperse-aerosol generation system that comprises an atomizer, virtual impactor, microcontroller-based isokinetic probe, wind tunnel, and velocity measurement device. The size distribution of the produced monodisperse aerosols was determined by an optical particle counter. The effects of atomizer characteristics, the rates of minor and major flow, and solution criteria were investigated. It was found that all these parameters affect the generation of monodisperse aerosol. Finally, the expected geometric standard deviation （〈1.25） of monodisperse aerosol particles was obtained with the most suitable atomizer for 10% oleic acid in ethyl alcohol solution with 5%-15% minor flow, where the ratio between the nozzle-to-probe distance and acceleration-nozzle-exit diameter was 0.66. The con- structed monodisperse-aerosol-generation system can be used for instrumental calibration and aerosol research.展开更多
文摘Primary total knee arthroplasty(TKA)is a widespread procedure to address end stage osteoarthritis with good results,clinical outcomes,and long-term survivorship.Although it is frequently performed in elderly,an increased demand in young and active people is expected in the next years.However,a considerable dissatisfaction rate has been reported by highly demanding patients due to the intrinsic limitations provided by the TKA.Bicruciate-retaining(BCR)TKA was developed to mimic knee biomechanics,through anterior cruciate ligament preservation.First-generation BCR TKA has not gained popularity due to its being a challenging technique and having poor survival outcomes.Thanks to implant design improvement and surgeon-friendly instrumentation,secondgeneration BCR TKA has seen renewed interest.This review will focus on surgical indications,kinematical basis,clinical results and latest developments of secondgeneration BCR TKA.
基金the German Research Foundation(DFG)–project number:442146713.
文摘In recent years, large language models have achieved breakthroughs on a wide range of benchmarks in natural language processing and continue to increase in performance. Recently, the advances of large language models have raised interest outside the natural language processing community and could have a large impact on daily life. In this paper, we pose the question: How will large language models and other foundation models shape the future product development process? We provide the reader with an overview of the subject by summarizing both recent advances in natural language processing and the use of information technology in the engineering design process. We argue that discourse should be regarded as the core of engineering design processes, and therefore should be represented in a digital artifact. On this basis, we describe how foundation models such as large language models could contribute to the design discourse by automating parts thereof that involve creativity and reasoning, and were previously reserved for humans. We describe how simulations, experiments, topology optimizations, and other process steps can be integrated into a machine-actionable, discourse-centric design process. As an example, we present a design discourse on the optimization of wind turbine blades. Finally, we outline the future research that will be necessary for the implementation of the conceptualized framework.
文摘Monodisperse aerosols are essential in many applications, such as filter testing, aerosol instrument calibration, and experiments for validating models. This paper describes the design principle, construction, and performance of a monodisperse-aerosol generation system that comprises an atomizer, virtual impactor, microcontroller-based isokinetic probe, wind tunnel, and velocity measurement device. The size distribution of the produced monodisperse aerosols was determined by an optical particle counter. The effects of atomizer characteristics, the rates of minor and major flow, and solution criteria were investigated. It was found that all these parameters affect the generation of monodisperse aerosol. Finally, the expected geometric standard deviation （〈1.25） of monodisperse aerosol particles was obtained with the most suitable atomizer for 10% oleic acid in ethyl alcohol solution with 5%-15% minor flow, where the ratio between the nozzle-to-probe distance and acceleration-nozzle-exit diameter was 0.66. The con- structed monodisperse-aerosol-generation system can be used for instrumental calibration and aerosol research.
