Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina:Two case reports

It is well known that calcium channel blockers(CCBs) are the first line of therapy for vasospastic angina(VSA). Here, we report two cases of VSA with an increase in the frequency of angina attacks after switching from a brand-name to a generic CCB. In both cases, angina recurred upon switching from a brand-name CCB to a generic CCB during follow-up. The patients' condition improved upon switching back to the original CCB. Both cases involved a high severity of VSA, based on the results of spasm provocation testing. These findings suggest that, in some patients with severe VSA, the frequency of angina attacks increases when switching from a brand-name CCB to a generic CCB. Cardiologists should consider this factor when prescribing drugs for angina.

High performance“non-local”generic face reconstruction model using the lightweight Speckle-Transformer(SpT)UNet

Significant progress has been made in computational imaging(CI),in which deep convolutional neural networks(CNNs)have demonstrated that sparse speckle patterns can be reconstructed.However,due to the limited“local”kernel size of the convolutional operator,for the spatially dense patterns,such as the generic face images,the performance of CNNs is limited.Here,we propose a“non-local”model,termed the Speckle-Transformer(SpT)UNet,for speckle feature extraction of generic face images.It is worth noting that the lightweight SpT UNet reveals a high efficiency and strong comparative performance with Pearson Correlation Coefficient(PCC),and structural similarity measure(SSIM)exceeding 0.989,and 0.950,respectively.

STL中Generic算法的扩展

Generic程序设计是实现软件重用的重要方法之一。文章介绍了generic程序设计与C++标准模板库（STL），探讨了STL中generic算法的扩展方法。

C++对Generic程序设计技术的支持

介绍了 generic程序设计技术 ,探讨了 generic程序设计在 C+ +中的应用 ,说明了 C+ +标准模板库的组成 。

从R^n到R^3的光滑映射的generic奇点

本文的目的在于用微分拓扑的方法讨论从Ｒｎ 到Ｒ３的光滑映射的ｇｅｎｅｒｉｃ 奇点的分类问题，我们证明这样的映射只有三类奇点：折点、尖点和燕尾点，并给出了它们的标准型．这推广了Ｊ． Ｍａｒｔｉｎｅｔ［１］ 的结果．

平凡扩张代数A∝M的Generic模

通过函子-A(A∝M)由代数A的Generic模构造A∝M的Generic模,讨论Generic A-模与Generic A∝M-模之间的关系.

对偶扩张代数的分裂挠理论与Generic模

设A是一个有限维代数,R是A的对偶扩张代数.MA是一个A-模.给定一个倾斜R-模M（?）AR,我们知道MA一定是一个倾斜A-模 设（TM（?）AR,FM（?）AR）与（TM,FM）是分别由M（?）AR和MR导出的挠理论.本文讨论挠理论的分裂性以及GenericA-模与GenericR-模之间的关系.

形式Generic流形的型

本文讨论形式Generic流形上的型．利用加权坐标系先对齐权流形给出计算型的一般步骤并把结 果推广到一般的形式Generic流形．

Efficacy and Safety of Generic Dasatinib as a Second-line Treatment for Patients with Chronic Myeloid Leukemia:a Multicenter Retrospective Study in Hubei Province,China

Dasatinib is a second-generation tyrosine kinase inhibitor (TKI)and it could be used as a second-line treatment for patients with chronic myeloid leukemia (CML).Yinishu,a generic dasatinib made in China,was approved by the China Food and Drug Administration in 2013 and it costs much less than the patented dasatinib SPRYCEL.The present study aimed to examine the efficacy and safety of Yinishu as a second-line treatment for CML by comparing the baseline clinical characteristics,rates of adverse events and efficacy between Yinishu and SPRYCEL groups. The results showed that there were no significant differences in the rates of optimal response between Yinishu and SPRYCEL for patients who started second-line treatment because of treatment failure.For patients who started second-line treatment because of intolerance of first-line treatment, their levels of BCR-ABL1/ABL1 on the international scale (BCR-ABL^IS)was maintained very low throughout the course of Yinishu treatment.Drug-related adverse events occurred with the same frequency in these two groups.It was confirmed that Yinishu was effective and safe as a second- line treatment for CML patients.Yinishu may be more suitable for patients who are economically unable to pay for the patented dasatinib SPRYCEL.

Solid-state characterization and impurities determination of fluconazol generic products marketed in Morocco

In this paper, we report the results of quality control based in pbysicochemical characteriza- tion and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were supplied by different pharmaceuticals companies. The sample A, as the discovered product, was supplied by Pfizer, while samples B and C （generics）, were manufactured by two different Indian industries. Solid-state characterization of the three samples was realized with different physicochemical methods as： X-ray powder diffraction, Fourier-transformation infrared spectroscopy, differential scanning calorimetry. High performance liquid chromatography was used to quantify the impurities in the different samples. The results from the physicochemical methods cited above, showed difference in polymorph structure of the three drug substances. Sample A consisted in pure polymorph II1, sample B consisted in pure polymorph I1, sample C consisted in a mixture of fluconazole Form Ili, form II and the monohydrate. This result was confirmed by differential scanning calorimetry. Also it was demonstrated that solvents used during the re-crystallization step were among the origins of these differences in the structure form. On the other hand, the result of the stability study under humidity and temperature showed that fluconazole polymorphic transformation could be owed to the no compliance with the conditions of storage. The HPLC analysis of these compounds showed the presence of specific

A generic method for rock mass classification

Rock mass classification(RMC) is of critical importance in support design and applications to mining,tunneling and other underground excavations. Although a number of techniques are available, there exists an uncertainty in application to complex underground works. In the present work, a generic rock mass rating(GRMR) system is developed. The proposed GRMR system refers to as most commonly used techniques, and two rock load equations are suggested in terms of GRMR, which are based on the fact that whether all the rock parameters considered by the system have an influence or only few of them are influencing. The GRMR method has been validated with the data obtained from three underground coal mines in India. Then, a semi-empirical model is developed for the GRMR method using artificial neural network(ANN), and it is validated by a comparative analysis of ANN model results with that by analytical GRMR method.

Generic Regular Decompositions for Parametric Polynomial Systems

This paper presents a generalization of the authors＇ earlier work. In this paper, the two concepts, generic regular decomposition （GRD） and regular-decomposition-unstable （RDU） variety introduced in the authors＇ previous work for generic zero-dimensional systems, are extended to the case where the parametric systems are not necessarily zero-dimensional. An algorithm is provided to compute GRDs and the associated RDU varieties of parametric systems simultaneously on the basis of the algorithm for generic zero-dimensional systems proposed in the authors＇ previous work. Then the solutions of any parametric system can be represented by the solutions of finitely many regular systems and the decomposition is stable at any parameter value in the complement of the associated RDU variety of the parameter space. The related definitions and the results presented in the authors＇ previous work are also generalized and a further discussion on RDU varieties is given from an experimental point of view. The new algorithm has been implemented on the basis of DISCOVERER with Maple 16 and experimented with a number of benchmarks from the literature.

THE LARGE TIME GENERIC FORM OF THE SOLUTION TO HAMILTON-JACOBI EQUATIONS

We use Hopf-Lax formula to study local regularity of solution to Hamilton- Jacobi （HJ） equations of multi-dimensional space variables with convex Hamiltonian. Then we give the large time generic form of the solution to HJ equation, i.e. for most initial data there exists a constant T 〉 0, which depends only on the Hamiltonian and initial datum, for t 〉 T the solution of the IVP （1.1） is smooth except for ~ smooth n-dimensional hypersurface, across which Du（x, t） is discontinuous. And we show that the hypersurface 1 tends asymptotically to a given hypersurface with rate t-1/4.

Perceptions of Generic Drugs in the Pharmacists of Public Hospitals:A Cross-sectional Survey in Hubei Province of China

Objective:Generic drugs provide an opportunity for savings in drug expenditure since they are available at a lower cost and do not affect patients’health.A better understanding of pharmacists’knowledge,attitudes,and perception can promote the quality use of generic drugs.The objective of this study was to investigate the knowledge,attitudes,and perception of pharmacists from tertiary hospitals in China regarding generic drugs.Methods:A cross-sectional survey using a postal questionnaire was conducted,which was sent to 200 hospital pharmacists randomly selected from tertiary hospitals in Hubei Province.A total of 125 questionnaires out of 200 were received.Of the respondents,80 were female and 45 were male.Results:The majority of respondents(87.2%)could clearly distinguish between original and generic drugs.Pharmacists agreed that generic drugs were less effective(52.8%)and produced more side effects(52%).Forty-nine respondents thought that generic drug products were not adequately tested.Approximately 78% and 60% of the pharmacists indicated that generic substitution was not feasible for drugs with narrow therapeutic windows and drugs for critical diseases,respectively.Most of them supported the recommendation of generic drugs based on professional judgment.Conclusion:Our study showed that a considerable portion of Chinese hospital pharmacists hold negative perceptions of generic drugs.Interventions to improve pharmacists'knowledge of generic drugs are needed.

Short-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf

Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.

Book Announcement of L. Celentano, Robust Tracking Controllers Design with Generic References for Continuous and Discrete Uncertain Linear SISO Systems, LAP LAMBERT Academic Publishing, 2012

In this book new results on controller design techniques for the tracking of generic reference inputs are presented. They allow the design of a controller for an uncertain process, either continuous or discrete-time, without zeros, and with measurable state. The controller guarantees that the control system is Type 1 and has the desired constant gain and poles or that the control system tracks, with a specified maximum error and with a specified maximum time constant, a generic reference with bounded derivative (variation in the discrete-time case), also in the presence of a generic disturbance with bounded derivative (variation). In addition, it is considered the case in which the reference is known a priori. The utility and the efficiency of the proposed methods are illustrated with attractive and significant examples of motion control and temperature control. This book is useful for the design of control systems, especially for manufacturing systems, that are versatile, fast, precise and robust.

国家标准《功能、残疾、健康分类的康复组合评定》践行指南

《国际功能、残疾与健康分类(international classification of functioning,disability and health,ICF)》由世界卫生组织(WHO)在2001年发布[1],二十多年来,WHO一直致力于ICF在全世界的临床应用,并根据各国反馈推出了ICF的不同版本,包括了通用版(ICF generic set,ICF-GS)[2]、核心组合版(ICF core set,ICF-CS)[3]及康复组合版(ICF rehabilitation set,ICF-RS)[4]。

Successful generic drug product development:From research to marketing approval

Recently,generic drug products have played an increasingly important role in the health care system globally,especially in the developing world,as they provide for an effective and more affordable alternative for healthcare professionals.Generic drug products are proven therapeutically equivalent to the corresponding innovator’s product,and hence can be substituted in clinical practice.The objective of generic drug development is to develop a stable and bioequivalent generic drug product with desirable properties in a timely manner.This presentation is intended to summarize three important sequential stages essential for successful generic drug development based on a regulatory experience in reviewing and evaluating the Pharmaceutical Development Section(P2)of the ASEAN Common Technical Dossier(ACTD)of generic drug product applications submitted to the Food and Drug Administration,Thailand[1,2].

Generic-Model-Based Description Scheme for MPEG-7

We propose a new description scheme for MPEG-7:Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia. It uses a generic model as the description frame, which provides a simple but useful object\|based structure. The main components of the description scheme are generic model, objects and object features. The proposed description scheme is illustrated and exemplified by Extensible Markup Language. It aims at clarity and flexibility to support MPEG\|7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non\|linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.

A Generic Design Model for Evolutionary Algorithms

A generic design model for evolutionary algorithms is proposed in this paper. The model, which was described by UML in details, focuses on the key concepts and mechanisms in evolutionary algorithms. The model not only achieves separation of concerns and encapsulation of implementations by classification and abstraction of those concepts, it also has a flexible architecture due to the application of design patterns. As a result, the model is reusable, extendible, easy to understand, easy to use, and easy to test. A large number of experiments applying the model to solve many different problems adequately illustrate the generality and effec-tivity of the model.