With the research on and development of Genetically Modified Food （GMF）, people＇s attitude toward GMF may fall into two divergent categories, typical- ly represented by the United States（US） and the European Unio...With the research on and development of Genetically Modified Food （GMF）, people＇s attitude toward GMF may fall into two divergent categories, typical- ly represented by the United States（US） and the European Union（EU）, respectively. The former follows a ＂sound science principle＂ and firmly objects to the precautionary principle, namely a permissive policy of positive support of and voluntary labelling on GMF; while the latter adopts a cautiously precautionary principle, requiring mandatory labelling and traceability. From the standpoint of regulatory principles, together with corresponding supervisory measures and relevant provisions, this paper compared the execution of directives and provisions on GMF from the initial policies enacted by the US and EU to current situation combined with the track and analysis of latest polic ies issued.展开更多
[Objective] This study aimed to evaluate tbe healthy risk of genetically modified （ GM ） soybeans by using a novel approach for functions and safety of food. [ Me^od] Different from traditional evaluation of substan...[Objective] This study aimed to evaluate tbe healthy risk of genetically modified （ GM ） soybeans by using a novel approach for functions and safety of food. [ Me^od] Different from traditional evaluation of substantial equivalence, three great innovations were performed in this study, involving in basic diet, evalu- ation approaches and principle, as well as the clarification of connotation differences between absolute and relative mass of organs. Hence a novel BDI-GS （Bendib Damage Index and General Score） evaluation approach was established and applied in comparative evaluation between RR GM and natural soybeans. Healthy male ICR mice during linear growth were selected; experimental mice were fed with 15% RR GM soybeans and 15% natural soybeans blending maize meal diets, and control mice were fed with single maize meal diet for 13 d; the mice were dissected after collecting blood samples and perfectly obtained nine organs or tissues to re- cord their masses and conduct statistical analyses. [Result] Plenty of matching information was obtained through simple design. The growth performance of treated mice was markedly of individual differences, some mice were thwarted due to regular intake of RR soybeans. Meanwhile, the functions and safety of RR soybeans were markedly lowered in overall nutritional and healthy effects than those of natural soybeans expressed in GS values, and presents some declines in nutrition and health of thymus, pancreas and spermary; especially, it can make thymus immune （P 〈0.05） in markedly lower level than that of natural soybeans. [ Conclusion] Therefore, major troubles and risks of RR soybeans intake are of personal risks in different degrees, in addition, it may increase sub-health and related chronic epi- demics risks, and herein it will presents certain safety issues. The creation of this novel evaluation system provides a simple and available evaluation approach for functions and potential risks revelation of food effects, and will yield far-reaching influences to safety evaluation and healthy development of GM foods, as well as public health.展开更多
目的本研究通过BDI-GS(Benefit-Damage Index&General Scores)评价新体系对比评价进口转基因(GM)大豆油与天然大豆油的食用功效及安全性。方法以处于线性生长期的健康ICR(Institute of Cancer Research)小鼠为研究对象,通过喂食实验...目的本研究通过BDI-GS(Benefit-Damage Index&General Scores)评价新体系对比评价进口转基因(GM)大豆油与天然大豆油的食用功效及安全性。方法以处于线性生长期的健康ICR(Institute of Cancer Research)小鼠为研究对象,通过喂食实验,统计9项脏器组织重量、系数及其BDI和GS等指标进行食用安全性判断。结果两种GM大豆油在小鼠生长发育方面不如天然大豆油,综合营养健康效应天然大豆油GS值均在11.0以上,而GM大豆油仅在9.0以上;部分脏器指标的BDI明显降低,主要表现在肺脏、胸腺、脾脏和性腺的营养和健康效应上,与天然大豆油比较存在显著差异(P<0.05及P<0.01)。结论表明GM大豆油在营养及健康效应方面不如国产天然大豆油,且存在农药残留问题。展开更多
文摘With the research on and development of Genetically Modified Food （GMF）, people＇s attitude toward GMF may fall into two divergent categories, typical- ly represented by the United States（US） and the European Union（EU）, respectively. The former follows a ＂sound science principle＂ and firmly objects to the precautionary principle, namely a permissive policy of positive support of and voluntary labelling on GMF; while the latter adopts a cautiously precautionary principle, requiring mandatory labelling and traceability. From the standpoint of regulatory principles, together with corresponding supervisory measures and relevant provisions, this paper compared the execution of directives and provisions on GMF from the initial policies enacted by the US and EU to current situation combined with the track and analysis of latest polic ies issued.
基金Supported by Development Fund of the Institute of Radiation Medicine(No.SF1227)Research Fund for Youth Scholars of Union Medical College(No.2012D03)Research Fund for the Doctoral Program of Higher Education of China(No.20121106120042)
文摘[Objective] This study aimed to evaluate tbe healthy risk of genetically modified （ GM ） soybeans by using a novel approach for functions and safety of food. [ Me^od] Different from traditional evaluation of substantial equivalence, three great innovations were performed in this study, involving in basic diet, evalu- ation approaches and principle, as well as the clarification of connotation differences between absolute and relative mass of organs. Hence a novel BDI-GS （Bendib Damage Index and General Score） evaluation approach was established and applied in comparative evaluation between RR GM and natural soybeans. Healthy male ICR mice during linear growth were selected; experimental mice were fed with 15% RR GM soybeans and 15% natural soybeans blending maize meal diets, and control mice were fed with single maize meal diet for 13 d; the mice were dissected after collecting blood samples and perfectly obtained nine organs or tissues to re- cord their masses and conduct statistical analyses. [Result] Plenty of matching information was obtained through simple design. The growth performance of treated mice was markedly of individual differences, some mice were thwarted due to regular intake of RR soybeans. Meanwhile, the functions and safety of RR soybeans were markedly lowered in overall nutritional and healthy effects than those of natural soybeans expressed in GS values, and presents some declines in nutrition and health of thymus, pancreas and spermary; especially, it can make thymus immune （P 〈0.05） in markedly lower level than that of natural soybeans. [ Conclusion] Therefore, major troubles and risks of RR soybeans intake are of personal risks in different degrees, in addition, it may increase sub-health and related chronic epi- demics risks, and herein it will presents certain safety issues. The creation of this novel evaluation system provides a simple and available evaluation approach for functions and potential risks revelation of food effects, and will yield far-reaching influences to safety evaluation and healthy development of GM foods, as well as public health.
文摘目的本研究通过BDI-GS(Benefit-Damage Index&General Scores)评价新体系对比评价进口转基因(GM)大豆油与天然大豆油的食用功效及安全性。方法以处于线性生长期的健康ICR(Institute of Cancer Research)小鼠为研究对象,通过喂食实验,统计9项脏器组织重量、系数及其BDI和GS等指标进行食用安全性判断。结果两种GM大豆油在小鼠生长发育方面不如天然大豆油,综合营养健康效应天然大豆油GS值均在11.0以上,而GM大豆油仅在9.0以上;部分脏器指标的BDI明显降低,主要表现在肺脏、胸腺、脾脏和性腺的营养和健康效应上,与天然大豆油比较存在显著差异(P<0.05及P<0.01)。结论表明GM大豆油在营养及健康效应方面不如国产天然大豆油,且存在农药残留问题。
