Red honeybush tea(RHT)is a tea product developed from Cyclopia spp.which is endemic to South Africa.Aside refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type ...Red honeybush tea(RHT)is a tea product developed from Cyclopia spp.which is endemic to South Africa.Aside refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes.This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(P<0.05)elevation in serum insulin,pancreaticβ-cell function,HDL-C levels with concomitant decrease in AST,ALT,ALP,urea,CK-MB,fructosamine,total cholesterol,triglycerides,LDL-C,and insulin resistance in diabetic rats.RHT also signifi cantly(P<0.05)decreased MDA levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with RHT.The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.展开更多
Aims Cyclopia and Aspalathus are legumes harvested for production of Honeybush and Rooibos tea,respectively.Farmers grow these species from either seeds or cuttings over several years with continuous annual harvesting...Aims Cyclopia and Aspalathus are legumes harvested for production of Honeybush and Rooibos tea,respectively.Farmers grow these species from either seeds or cuttings over several years with continuous annual harvesting.The aims of this study were to assess the effect of plant age,plant species,toposequence,planting material and farmer practice on nitrogen(N)nutrition and water-use efficiency of two Cyclopia and Aspalathus species in the Cape fynbos.Methods The study was conducted using plants from Koksrivier farm located near Gansbaai(33°S 18°E,39 m.a.s.l),and at Kanetberg farm near Barrydale(33°S 21°E,830 m.a.s.l).The 15N natural abundance technique was used to determine N_(2)fixation,carbon(C)assimilation andδ^(13)C in shoot of Cyclopia and Aspalathus species.Important Findings Older tea plantations of C.genistoides and C.subternata derived more N from fixation and exhibited greater water-use efficiency than younger plants.At Koksrivier,Aspalathus caledonensis and A.aspalathoides showed greater water-use efficiency and derived more N from fixation than Cyclopia genistoides.Annual harvesting of C.genistoides decreased N_(2)fixation.At Kanetberg,C.subter-nata plants on the upper and middle slopes derived more N from atmospheric fixation than those on the lower slope.C.subternata plants grown from seedlings recorded greater%Ndfa than cuttings.N_(2)fixation and water-use efficiency of Cyclopia was affected by age,slope and planting material.Further,symbiotic N nutrition and water-use efficiency of Cyclopia and Aspalathus were related.展开更多
基金supported by a competitive research grant from the Research Office,University of KwaZulu-Natal(UKZN),Durbanan incentive grant for rated researchers and a grant support for women and young researchers from the National Research Foundation(NRF),Pretoria,South Africa.
文摘Red honeybush tea(RHT)is a tea product developed from Cyclopia spp.which is endemic to South Africa.Aside refreshment,RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes.This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes(T2D)model of rats.T2D was induced starting with feeding 10%fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin(40 mg/kg body weight(BW)).Five weeks of treatment of RHT led to significant(P<0.05)elevation in serum insulin,pancreaticβ-cell function,HDL-C levels with concomitant decrease in AST,ALT,ALP,urea,CK-MB,fructosamine,total cholesterol,triglycerides,LDL-C,and insulin resistance in diabetic rats.RHT also signifi cantly(P<0.05)decreased MDA levels and enhanced level of GSH,activity of SOD,catalase,GR in most of organs(pancreas,liver,kidneys,and heart).Signifi cantly(P<0.05)improved morphological changes in the islets andβ-cells were observed in rats treated with RHT.The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.
文摘Aims Cyclopia and Aspalathus are legumes harvested for production of Honeybush and Rooibos tea,respectively.Farmers grow these species from either seeds or cuttings over several years with continuous annual harvesting.The aims of this study were to assess the effect of plant age,plant species,toposequence,planting material and farmer practice on nitrogen(N)nutrition and water-use efficiency of two Cyclopia and Aspalathus species in the Cape fynbos.Methods The study was conducted using plants from Koksrivier farm located near Gansbaai(33°S 18°E,39 m.a.s.l),and at Kanetberg farm near Barrydale(33°S 21°E,830 m.a.s.l).The 15N natural abundance technique was used to determine N_(2)fixation,carbon(C)assimilation andδ^(13)C in shoot of Cyclopia and Aspalathus species.Important Findings Older tea plantations of C.genistoides and C.subternata derived more N from fixation and exhibited greater water-use efficiency than younger plants.At Koksrivier,Aspalathus caledonensis and A.aspalathoides showed greater water-use efficiency and derived more N from fixation than Cyclopia genistoides.Annual harvesting of C.genistoides decreased N_(2)fixation.At Kanetberg,C.subter-nata plants on the upper and middle slopes derived more N from atmospheric fixation than those on the lower slope.C.subternata plants grown from seedlings recorded greater%Ndfa than cuttings.N_(2)fixation and water-use efficiency of Cyclopia was affected by age,slope and planting material.Further,symbiotic N nutrition and water-use efficiency of Cyclopia and Aspalathus were related.
