Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can...Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.展开更多
Background:Since the completion of the Human Genome Project,health science has been strongly influenced by the advances in genetics and genomics.However,the progress of embracing genetics and genomics into nursing dis...Background:Since the completion of the Human Genome Project,health science has been strongly influenced by the advances in genetics and genomics.However,the progress of embracing genetics and genomics into nursing discipline is limited.One of the main barriers is lack of understanding on the relevancy of genetics and genomics to nursing discipline.Objectives:This paper aims to synthesize and develop a theoretical framework for the interaction of nursing discipline with genetics and genomics.Methods:Through content analysis and constant comparative method,a theoretical framework was developed from synthesis of the studies regarding nursing and genetics/genomics indexed in multiple English and Chinese databases.Results:Four main theoretical statements were constructed in the framework:1)There are three ways to show how genetics and genomics can influence nursing discipline:a new specialty,new technologies and a new lens;2)The significant contribution of nursing discipline to genetics and genomics lies in how nurses could focus on the association between human responses and genes and how nurses could advocate for their clients in the genetic and genomic era;3)A paradigm shift occurs after a constant interaction of nursing discipline with genetics and genomics;4)Implementation strategies could be used to facilitate the integration of genetics and genomics to nursing discipline and advance the paradigm shift.Conclusions:The framework will help to understand the relationship between nursing discipline and genetics and genomics and implicate the future studies integrating genetics and genomic science into nursing discipline.展开更多
(Started in 1974, Monthly)WWW.jgenetgenomics.org (Free electronic papers published in 1974-2005)Journal of Genetics and Genomics (JGG) is one of China’s leading journals in the life science. JGG covers all areas of
The genetic base that cotton breeders commonly use to improve Upland cultivars is very narrow.The AD-genome species Gossypium barbadense,G.tomentosum,and G.mustelinum are part of
Cotton fiber is a commodity of key economic importance in both developed and developing countries.The two cultivated species,Gossypium hirsutum and G.barbadense,are
Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive response.We previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously boun...Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive response.We previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay PASSPORT-seq.The AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT transcription.The independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related phenotypes.Methods We used in silico,in vitro,in vivo,and retrospective models to test this hypothesis.Results In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT mRNA.Unexpectedly,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression model.Genotype-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>T.However,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with HTN.Conclusions We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White participants.Further studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>G.Studies like this will help clinicians move beyond the use of race as a surrogate for genotype.展开更多
The Association of Chinese Geneticists in America （ACGA） and the Hong Kong Society of Medical Genetics （HKSMG） held their first joint Conference on Genetic and Genomic Medicine in Hong Kong from June 9-11 in 2008 ...The Association of Chinese Geneticists in America （ACGA） and the Hong Kong Society of Medical Genetics （HKSMG） held their first joint Conference on Genetic and Genomic Medicine in Hong Kong from June 9-11 in 2008 at the Cheung Kung Hai Conference Center, William MW Mong Block, Li Ka Shing Faculty of Medicine, the University of Hong Kong. Other co-organizers included the University of Hong Kong and Chinese Society of Medical Genetics. A satellite conference ＂ACGA-WZMC International Symposium of Genetics and Translational Medicine＂, co-organized with Wenzhou Medical College and Chinese Society of Medical Genetics, was held from June 12-14, 2008 at Wenzhou, Zhejiang Province of China.展开更多
Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing ...Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing grain/forage legume studies,展开更多
Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing ...Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing grain/forage legume studies,as well as research on model legume plants such as Lotus japonicus and Medicago truncatula.The aims are to feature innovative research findings in the basic and applied fields of展开更多
Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative r...Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative research findings in the basic and applied fields of rice molecular genetics and novel techniques for improvement,展开更多
Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chos...Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chosen for publication should be innovative research work in the field of Triticeae genomics and Triticeae genetics,展开更多
Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative r...Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative research findings in the basic and applied fields of rice molecular genetics and novel techniques for improvement,as well as applications of molecular enhanced products.For the authors who have financial展开更多
Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chos...Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chosen for publication should be innovative research work in the field of Triticeae genomics and Triticeae genetics,including classical genetics analysis,structural and functional analysis of Triticeae genome,isolation展开更多
Review Small but influential： the role of microRNAs on gene regulatory network and 3＇UTR evolution……Rui Zhang, Bing Su（1） Research Articles Molecular characterization and expression analysis of a chicken-type ly...Review Small but influential： the role of microRNAs on gene regulatory network and 3＇UTR evolution……Rui Zhang, Bing Su（1） Research Articles Molecular characterization and expression analysis of a chicken-type lysozyme gene from housefly （Musca domestica）……Qian Ren, Xiaofan Zhao, Jinxing Wang（7）展开更多
Disclaimer No responsibility is assumed by the Sponsors, Publishers and Editors for errors or any consequences arising from the use of information contained in the Journal; the views and opinions expressed do not refl...Disclaimer No responsibility is assumed by the Sponsors, Publishers and Editors for errors or any consequences arising from the use of information contained in the Journal; the views and opinions expressed do not reflect those of the Sponsors, Publishers and Editors, neither does the publication of advertisements constitute any endorsement of the products advertised by the Sponsors, Publishers and Editors.展开更多
基金Supported in part by NIH Heart,Lung,and Blood Institute(No.HLO74815)Institute of Neurological Disorders and Stroke(No.NS-084823)
文摘Past 25 y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our eyes. Based on these findings, it is becoming clear that an early diagnosis employing genetic testing can help evaluate patients＇ conditions for instituting treatment plan（s） and follow-up care to avoid vision complications later. For example, knowing family history becomes crucial for inherited eye diseases as it can benefit members in family who may have similar eye diseases or predispositions. Therefore, gathering information from an elaborate examination along with complete assessment of past medical illness by ophthalmologists followed by consultation with geneticists can help create a roadmap for making diagnosis and treatment precise and beneficial. In this review, we present an update on ocular genomic medicine that we believe has tremendous potential towards unraveling genetic implications in ocular diseases and patients＇ susceptibilities. We also discuss translational aspects of genetic ophthalmology and genome engineering that may help advance molecular diagnostics and therapeutics.
基金This study was funded by Shanghai Jiaotong University Multidisciplinary Research Grant,17JCYA14.The first author(Hu)was supported by Ontario Trillium Scholarship in a PhD program at the University of Ottawa
文摘Background:Since the completion of the Human Genome Project,health science has been strongly influenced by the advances in genetics and genomics.However,the progress of embracing genetics and genomics into nursing discipline is limited.One of the main barriers is lack of understanding on the relevancy of genetics and genomics to nursing discipline.Objectives:This paper aims to synthesize and develop a theoretical framework for the interaction of nursing discipline with genetics and genomics.Methods:Through content analysis and constant comparative method,a theoretical framework was developed from synthesis of the studies regarding nursing and genetics/genomics indexed in multiple English and Chinese databases.Results:Four main theoretical statements were constructed in the framework:1)There are three ways to show how genetics and genomics can influence nursing discipline:a new specialty,new technologies and a new lens;2)The significant contribution of nursing discipline to genetics and genomics lies in how nurses could focus on the association between human responses and genes and how nurses could advocate for their clients in the genetic and genomic era;3)A paradigm shift occurs after a constant interaction of nursing discipline with genetics and genomics;4)Implementation strategies could be used to facilitate the integration of genetics and genomics to nursing discipline and advance the paradigm shift.Conclusions:The framework will help to understand the relationship between nursing discipline and genetics and genomics and implicate the future studies integrating genetics and genomic science into nursing discipline.
文摘(Started in 1974, Monthly)WWW.jgenetgenomics.org (Free electronic papers published in 1974-2005)Journal of Genetics and Genomics (JGG) is one of China’s leading journals in the life science. JGG covers all areas of
文摘The genetic base that cotton breeders commonly use to improve Upland cultivars is very narrow.The AD-genome species Gossypium barbadense,G.tomentosum,and G.mustelinum are part of
文摘Cotton fiber is a commodity of key economic importance in both developed and developing countries.The two cultivated species,Gossypium hirsutum and G.barbadense,are
基金National Center for Research Resources,Grant/Award Number:RR020128NHGRI,National Institute of General Medical Sciences,Grant/Award Numbers:1R01GM120156-01A1,K23GM147805,R35GM131812,T32GM008425+3 种基金NHLBI,NINDS,NCI,Grant/Award Number:1R03CA223906-01NIDA,NIMH,Office of the Director of the National Institutes of Health,Indiana University School of Medicine,Grant/Award Number:NIH/NCRRRR020128NIH-NIGMS,Grant/Award Numbers:t32gm008425,r35gm131812,1r01gm120156-01a1,k23gm147805NIH-NCI,Grant/Award Number:1R03CA223906-01。
文摘Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive response.We previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay PASSPORT-seq.The AGT promoter variant rs5051 C>T is in linkage disequilibrium(LD)with rs699 A>G and increases AGT transcription.The independent effect of these variants is understudied due to their LD therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related phenotypes.Methods We used in silico,in vitro,in vivo,and retrospective models to test this hypothesis.Results In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT mRNA.Unexpectedly,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression model.Genotype-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>T.However,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with HTN.Conclusions We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White participants.Further studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>G.Studies like this will help clinicians move beyond the use of race as a surrogate for genotype.
文摘The Association of Chinese Geneticists in America （ACGA） and the Hong Kong Society of Medical Genetics （HKSMG） held their first joint Conference on Genetic and Genomic Medicine in Hong Kong from June 9-11 in 2008 at the Cheung Kung Hai Conference Center, William MW Mong Block, Li Ka Shing Faculty of Medicine, the University of Hong Kong. Other co-organizers included the University of Hong Kong and Chinese Society of Medical Genetics. A satellite conference ＂ACGA-WZMC International Symposium of Genetics and Translational Medicine＂, co-organized with Wenzhou Medical College and Chinese Society of Medical Genetics, was held from June 12-14, 2008 at Wenzhou, Zhejiang Province of China.
文摘Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing grain/forage legume studies,
文摘Legume Genomics and Genetics(ISSN 1925-1580)is an open access and peer-reviewed journal that publishes original research papers in the fields of genomics and genetics of legume plants,which is committed to publishing grain/forage legume studies,as well as research on model legume plants such as Lotus japonicus and Medicago truncatula.The aims are to feature innovative research findings in the basic and applied fields of
文摘Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative research findings in the basic and applied fields of rice molecular genetics and novel techniques for improvement,
文摘Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chosen for publication should be innovative research work in the field of Triticeae genomics and Triticeae genetics,
文摘Rice Genomics and Genetics(ISSN 1925-2021)is an international,open access,peer reviewed journal,committed to serve for rice genome research,rice genetics research and rice breeding,particularly publishing innovative research findings in the basic and applied fields of rice molecular genetics and novel techniques for improvement,as well as applications of molecular enhanced products.For the authors who have financial
文摘Triticeae Genomics and Genetics(ISSN 1925-203X)is committed to publishing and disseminating significant original achievements in the related research fields of Triticeae genomics and Triticeae genetics.All papers chosen for publication should be innovative research work in the field of Triticeae genomics and Triticeae genetics,including classical genetics analysis,structural and functional analysis of Triticeae genome,isolation
文摘Review Small but influential： the role of microRNAs on gene regulatory network and 3＇UTR evolution……Rui Zhang, Bing Su（1） Research Articles Molecular characterization and expression analysis of a chicken-type lysozyme gene from housefly （Musca domestica）……Qian Ren, Xiaofan Zhao, Jinxing Wang（7）
文摘Disclaimer No responsibility is assumed by the Sponsors, Publishers and Editors for errors or any consequences arising from the use of information contained in the Journal; the views and opinions expressed do not reflect those of the Sponsors, Publishers and Editors, neither does the publication of advertisements constitute any endorsement of the products advertised by the Sponsors, Publishers and Editors.
