Association mapping(as opposed to population mapping) is becoming more important in establishing associations between a phenotype and a genotype.The major advantage of association mapping,
Ⅰ. HGP AND HUMAN GENOME SCIENCE IN CHINA The HGP, standing for "human genome project," is one of the basic research programs of vital importance in life science, now underway in a worldwide scope. Its signi...Ⅰ. HGP AND HUMAN GENOME SCIENCE IN CHINA The HGP, standing for "human genome project," is one of the basic research programs of vital importance in life science, now underway in a worldwide scope. Its significance is never to be overestimated when we place any stress on it. As a matter of fact, it will provide an invaluable tool to reveal the essence of human life by展开更多
Gastric cancer(GC) is a highly aggressive and life-threatening malignancy.Even with radical surgical removal and front-line chemotherapy,more than half of GCs locally relapse and metastasize at a distant site.The dism...Gastric cancer(GC) is a highly aggressive and life-threatening malignancy.Even with radical surgical removal and front-line chemotherapy,more than half of GCs locally relapse and metastasize at a distant site.The dismal outcomes reflect the ineffectiveness of a one-size fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex molecular underpinnings.The recent comprehensive genomic and molecular profiling has led to our deepened understanding of GC.The emerging molecular classification schemes based on the genetic,epigenetic,and molecular signatures are providing great promise for the development of more effective therapeutic strategies in a more personalized and precise manner.To this end,the Cancer Genome Atlas(TCGA) research network conducted a comprehensive molecular evaluation of primary GCs and proposed a new molecular classification dividing GCs into four subtypes:Epstein-Barr virus-associated tumors,microsatellite unstable tumors,genomically stable tumors,and tumors with chromosomal instability.This review primarily focuses on the TCGA molecular classification of GCs and discusses the implications on novel targeted therapy strategies.We believe that these fundamental findings will support the future application of targeted therapies and will guide our efforts to develop more efficacious drugs to treat human GCs.展开更多
The first sequenced diploid cotton genome was published in2012 by the group led by the Institute of Cotton Research,Chinese Academy of Agricultural Sciences.Cotton genomics research subsequently entered a period of ra...The first sequenced diploid cotton genome was published in2012 by the group led by the Institute of Cotton Research,Chinese Academy of Agricultural Sciences.Cotton genomics research subsequently entered a period of rapid development.展开更多
文摘Association mapping(as opposed to population mapping) is becoming more important in establishing associations between a phenotype and a genotype.The major advantage of association mapping,
文摘Ⅰ. HGP AND HUMAN GENOME SCIENCE IN CHINA The HGP, standing for "human genome project," is one of the basic research programs of vital importance in life science, now underway in a worldwide scope. Its significance is never to be overestimated when we place any stress on it. As a matter of fact, it will provide an invaluable tool to reveal the essence of human life by
基金supported by the National Natural Science Foundation of China(No.81502523)
文摘Gastric cancer(GC) is a highly aggressive and life-threatening malignancy.Even with radical surgical removal and front-line chemotherapy,more than half of GCs locally relapse and metastasize at a distant site.The dismal outcomes reflect the ineffectiveness of a one-size fits-all approach for a highly heterogeneous disease with diverse etiological causes and complex molecular underpinnings.The recent comprehensive genomic and molecular profiling has led to our deepened understanding of GC.The emerging molecular classification schemes based on the genetic,epigenetic,and molecular signatures are providing great promise for the development of more effective therapeutic strategies in a more personalized and precise manner.To this end,the Cancer Genome Atlas(TCGA) research network conducted a comprehensive molecular evaluation of primary GCs and proposed a new molecular classification dividing GCs into four subtypes:Epstein-Barr virus-associated tumors,microsatellite unstable tumors,genomically stable tumors,and tumors with chromosomal instability.This review primarily focuses on the TCGA molecular classification of GCs and discusses the implications on novel targeted therapy strategies.We believe that these fundamental findings will support the future application of targeted therapies and will guide our efforts to develop more efficacious drugs to treat human GCs.
基金supported by the Funds for Creative Research Groups of China(31621005)Young Elite Scientist Sponsorship Program by CAST
文摘The first sequenced diploid cotton genome was published in2012 by the group led by the Institute of Cotton Research,Chinese Academy of Agricultural Sciences.Cotton genomics research subsequently entered a period of rapid development.
