Selenium concentration in hair are sorted out into three classes, i.e. low (<110 ppb), medium (110-520 ppb) and high (>520 ppb) according to the principle of multiple normal distribution and a map of classificat...Selenium concentration in hair are sorted out into three classes, i.e. low (<110 ppb), medium (110-520 ppb) and high (>520 ppb) according to the principle of multiple normal distribution and a map of classification of selenium concentration in hair from children and youngsters in China has been drawn. Selenium insufficiency in relation to Keshan disease and Kashin-Beck's disease is expounded. Geographical differentiation of hair selenium concentrations and its causes are explained.展开更多
Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The e...Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions.展开更多
文摘Selenium concentration in hair are sorted out into three classes, i.e. low (<110 ppb), medium (110-520 ppb) and high (>520 ppb) according to the principle of multiple normal distribution and a map of classification of selenium concentration in hair from children and youngsters in China has been drawn. Selenium insufficiency in relation to Keshan disease and Kashin-Beck's disease is expounded. Geographical differentiation of hair selenium concentrations and its causes are explained.
基金This work was supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA24010104-2).
文摘Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this association.The effects of TaSus1 on grain number per spike(GNS)also are largely unknown.Our previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome editing.The triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type plants.In 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to GNS.Introgression of the two alleles into a wheat genetic background confirmed their effects.The alleles differed in geographical distribution among the accessions.
