Fluence of Glucosidorum Tripterygii Totorum on joint and serum soluble interleukin-2 receptor in patients with ankylosing spondylitis

Objective The current study was designed to find out the effect of Glucosidorum Tripterygii Totorum (GTT) on the serum level of soluble interleukin-2 receptor (sIL-2R) in patient with ankylosing spondylitis (AS). Method 29 patients with active AS were selected to take GTT (1mg per kg) three times a day for one year. After that, its curative effect was evaluated. The serum level of sIL-2R of these patients was measured by sandwich ELISA method and was compared with that of normal subjects. Result The serum level of sIL-2R in active AS patients was obviously higher than that of the non-active AS patients. (P<0.01). The total effective rate of GTT on AS was 89.6%, while clinical relief rate 27.6%, obvious effective rate 44.8%, effective rate 17.2% and non-effective rate 10.4%. The patients’ serum level of sIL-2R after therapy was significantly lower than that before therapy except patients with no effect. (P<0.05). Conclusion GTT has positive curative effect on active AS patients and could cause obvious decrease of the serum level of sIL-2R. The serum level of sIL-2R can be used as an important index of activity of AS and as a guide of therapy.

Treabment of 36 Patiente ot Corticosteroid-DependentType ot Aspirin-Induced Asthma withGlucosidorum Tripterygii Totorum

This paper reports that Glucosidorurn Tripterygii Totorum(GTT) , 20 mg, three times daily wasused as a substitute for cortical hormone to treat corticosteroid-dependent type of aspirin-inducod asthma.The results showed that the total effective rate was 100 % , with 31 cases of rnarked effectiveness t 86. 11 % )and 5 cases of effectiveness (13. 89% ) . Plasma cortisol was signiticantly elevated to normal level aftertreatment (P< 0. 001 ) . Cushing's syndrome disappeared gradually. The blood glucose in the 9 patients whowere complicated with diabetes mellitus returned to normal and their glucosuria test became negative . Thevalue of peak expiratory flow (PEF) increased to different degreesf P < 0 . 01 for male, P < 0 . 05 for female) .The increment of PEF in the patients complicated with emphysema was not so much as in those patients notcomplicated with emphysema, but compared with premedication value, the elevation of PEF was significant(P< 0. 05) . There were no side-effects during treatment and the side-effects of cortical hormone could beavoided . Thus, the treatment proved valuable.

雷公藤多甙治疗激素依赖型阿斯匹林性哮喘36例

３６例自身对照以雷公藤多甙片每日６０ｍｇ，分３次口服，替代皮质激素治疗激素依赖型阿斯匹林性哮喘。结果显示：显效３１例（８６．１１％），有效５例（１３．８９％），总有效率１００％。治疗后血总皮质醇上升达正常范围（Ｐ＜０．００１），柯兴氏综合征逐渐消失，９例合并糖尿病者血糖正常，尿糖阴性。治疗后最大呼气流量值有不同程度上升（男Ｐ＜０．０１，女Ｐ＜０．０５），无合并肺气肿者上升幅度较大，合并肺气肿者上升幅度较小，但与治疗前比较仍有显著性差异，Ｐ＜０．０５。治疗期间无明显副作用，且可避免皮质激素引起的副作用，是一种可取的治疗方法。

雷公藤多甙水溶性及醇溶性成分对淋巴细胞的作用

应用单克隆抗体,流式细胞仪等方法,观察雷公藤多甙片水溶性及醇溶性成分对外周血淋巴细胞的作用。结果表明,雷公藤多甙片水溶性成分及醇溶性成分在体外,对人外周血 CD_4、CD_8的作用一致,使 CD_4、CD_8阳性细胞增多(P<0.05),且二者都能增强PHA 对CD_(25)表达的诱导作用(P<0.05);雷公藤多甙片醇溶性成分为200μg/ml 对静止期淋巴细胞有促分裂作用,而当其浓度达1mg/ml 时,能抑制 PHA 对静止期淋巴细胞的促分裂作用。结果提示:雷公藤多甙片中的水溶性成分在体外对淋巴细胞有免疫增强作用,而醇溶性成分在小剂量时有免疫促进作用,但大剂量时则为免疫抑制作用。

雷公藤多甙为主治疗口腔粘膜下纤维性变的临床观察

目的 :口腔粘膜下纤维性变近期的研究 ,提出来是自身免疫性疾病。除早期的以外 ,采用了以雷公藤多甙为主的治疗方案 ,观察疗效。方法 :戒除咀嚼槟榔的嗜好 ,禁烟、酒、辣椒等。早期患者不给任何药物 ,中、晚期患者服用以雷公藤多甙为主的药物 ,张口受限患者 ,在口腔粘膜瘢痕部位再注射地塞米松。结果 :早期患者半年后 ,病变完全消退。中、晚期患者的亦收到了较好的效果。结论 :该方法可在临床工作中使用。