Rubidate is a phenolic compound. The present investigation was designed to establishwhether rubidate protects the heart muscle against tlie deleterious effects of ttie oxygen free radicals pro-deced by isoproterenol (...Rubidate is a phenolic compound. The present investigation was designed to establishwhether rubidate protects the heart muscle against tlie deleterious effects of ttie oxygen free radicals pro-deced by isoproterenol (ISO)-indiJced myocardial ischemia in mice. ISO treatment (30 mg ·kg-1 subcuta-neous injection once daily for 2 days) caused widespread and severe myocardial cell damage- decreased my-ocardial glutathione peroxidase (GSH-Px) , superoxide dismutase (SOD) activities and increased myocardialmalondialdehyde I MDA) content. Rubidate pretreatment 500 mg· kg-1 , 2000 mg· kg-1 x 7d protected GSH-Px, SOD activity in the tiearts of ISO-treated mice. Rubidate 2000 mg . kg` diminished MDA production.However, rubidate 500 mg·kg-1 did not show such an effect. This study demonstrated that rubidate inhibitedIipid peroxidation (LPO, expressed by malondialdehyde formation) , scavenged.O2 and H2O2.It may beconcluded that rubidate exhibits an antioxidative activity via scavenging free radicals.展开更多
文摘Rubidate is a phenolic compound. The present investigation was designed to establishwhether rubidate protects the heart muscle against tlie deleterious effects of ttie oxygen free radicals pro-deced by isoproterenol (ISO)-indiJced myocardial ischemia in mice. ISO treatment (30 mg ·kg-1 subcuta-neous injection once daily for 2 days) caused widespread and severe myocardial cell damage- decreased my-ocardial glutathione peroxidase (GSH-Px) , superoxide dismutase (SOD) activities and increased myocardialmalondialdehyde I MDA) content. Rubidate pretreatment 500 mg· kg-1 , 2000 mg· kg-1 x 7d protected GSH-Px, SOD activity in the tiearts of ISO-treated mice. Rubidate 2000 mg . kg` diminished MDA production.However, rubidate 500 mg·kg-1 did not show such an effect. This study demonstrated that rubidate inhibitedIipid peroxidation (LPO, expressed by malondialdehyde formation) , scavenged.O2 and H2O2.It may beconcluded that rubidate exhibits an antioxidative activity via scavenging free radicals.
