Conventional vs. polyethylene glycol (PEG)-fusion tech- nologies to repair severed spinal axons: Most spinal cord injuries (SCIs) involve cutor crush-severance of spinal tract axons in the central nervous system ...Conventional vs. polyethylene glycol (PEG)-fusion tech- nologies to repair severed spinal axons: Most spinal cord injuries (SCIs) involve cutor crush-severance of spinal tract axons in the central nervous system (CNS). Clinical out- comes after CNS axonal severance is very poor because proximal segments of CNS axons lack a suitable environment for outgrowth (Kakulas, 1999; Fitch and Silver, 2008; Rowland et al., 2008; Kwon et al., 2010) and therefore do not naturally regenerate (Ramon y Caial, 1928). Current strategies to try to increase behavioral recovery after SCI are focused on en- hancing the environment for axonal outgrowth.展开更多
Some biological uses of polyethylene glycol(PEG):The use of PEG as a membrane fusogen was first reported in 1976with the creation of cell hybrids,formed by suspending two cell lines in a 50%w/w solution of PEG in w...Some biological uses of polyethylene glycol(PEG):The use of PEG as a membrane fusogen was first reported in 1976with the creation of cell hybrids,formed by suspending two cell lines in a 50%w/w solution of PEG in water.展开更多
基金supported by grants from the Lone Star Paralysis Foundation to GDB and JDPby an NIH grant R01 NS081063 to GD
文摘Conventional vs. polyethylene glycol (PEG)-fusion tech- nologies to repair severed spinal axons: Most spinal cord injuries (SCIs) involve cutor crush-severance of spinal tract axons in the central nervous system (CNS). Clinical out- comes after CNS axonal severance is very poor because proximal segments of CNS axons lack a suitable environment for outgrowth (Kakulas, 1999; Fitch and Silver, 2008; Rowland et al., 2008; Kwon et al., 2010) and therefore do not naturally regenerate (Ramon y Caial, 1928). Current strategies to try to increase behavioral recovery after SCI are focused on en- hancing the environment for axonal outgrowth.
基金supported by grants from the Lone Star Paralysis Foundationan NIH grant R01 NS081063 to GDB
文摘Some biological uses of polyethylene glycol(PEG):The use of PEG as a membrane fusogen was first reported in 1976with the creation of cell hybrids,formed by suspending two cell lines in a 50%w/w solution of PEG in water.