Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This s...Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity.After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects.The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.展开更多
To maximize the size and structural advantages of nanomaterials in electrooxidation of ethanol, we herein report the synthesis of core–shell gold(Au)@Palladium(Pd) nanoparticles smaller than 3 nm in an ionic liquid, ...To maximize the size and structural advantages of nanomaterials in electrooxidation of ethanol, we herein report the synthesis of core–shell gold(Au)@Palladium(Pd) nanoparticles smaller than 3 nm in an ionic liquid, which combines the advantages of ionic liquids in preparing fine metal nanoparticles with the benefits of core–shell nanostructures. This synthetic strategy relies on the use of an ionic liquid(1-(2'-aminoethyl)-3-methyl-imidazolum tetrafluoroborate) as a stabilizer to produce Au particles with an average size of ca. 2.41 nm, which are then served as seeds for the formation of tiny core–shell Au@Pd nanoparticles with different Au/Pd molar ratios. The strong electronic coupling between Au core and Pd shell endows the Pd shell with an electronic structure favorable for the ethanol oxidation reaction. In specific, the ionic liquidderived core–shell Au@Pd nanoparticles at an Au/Pd molar ratio of 1/1 exhibit the highest mass-and area-based activities, approximately 11 times than those of commercial Pd/C catalyst for ethanol electrooxidation.展开更多
Bimetallic gold-silver core-shell nanoparticles were prepared by chemical reduction in aqueous solution, following a method that was friendly to the environment, allowing us to use this for medicinal purposes. Gold na...Bimetallic gold-silver core-shell nanoparticles were prepared by chemical reduction in aqueous solution, following a method that was friendly to the environment, allowing us to use this for medicinal purposes. Gold nanoparticles were synthesized, and silver cations were then reduced on the nanoparticles. Using the optical properties of metallic nanoparticles, surface plasmon resonance was determined by UV-Vis spectroscopy, and the values obtained for gold and silver were approximately 520 nm and 400 nm in wavelength, respectively. The absorption peaks of the surface plasmon band show a clear red-shift due to size effect in the case of the silver surface, and a plasmon coupling effect, in the case of gold. To obtain a better understanding of the coating conditions, high resolution transmission electron microscopy was used. The average hydrodynamic size and the size distribution of the synthesized nanoparticles were obtained by dynamic light scattering. The development of this process, which is benign for the environment, opens the possibility for many applications in the areas of renewable energy, medicine and biology.展开更多
Nanostructural gold/polyaniline core/shell composite particles on conducting electrode ITO were successfully prepared via electrochemical polymerization of aniline based on 4-aminothiophenol (4-ATP) capped Au nanopart...Nanostructural gold/polyaniline core/shell composite particles on conducting electrode ITO were successfully prepared via electrochemical polymerization of aniline based on 4-aminothiophenol (4-ATP) capped Au nanoparticles. The new approach to the fabrication included three steps: preparation of gold nanoparticles as core by pulse electrodeposition; formation of ATP monolayer on the gold particle surface, which served as a binder and an initiator; polymerization of aniline monomer initiated by ATP molecules under controlled voltage lower than the voltammetric threshold of aniline polymerization, which assured the formation of polyaniline shell film occurred on gold particles selectively. Topographic images were also studied by AFM, which indicated the diameter of gold nanoparticles were around 250 nm. Coulometry characterization confirmed the shell thickness of polyaniline film was about 30 nm. A possible formation mechanism of the Au/polyaniline core-shell nanocomposites was also proposed. The novel as-prepared core-shell nanoparticles have potential application in constructing biosensor when bioactive enzymes are absorbed or embedded in polyaniline shell film.展开更多
In this paper, AuNRs colloids with SPRL located at ~810 nm and ~1100 nm were synthesized using an improved seed method. Based on the NIR lasers available, photothermal conversion of AuNRs were systematically studied c...In this paper, AuNRs colloids with SPRL located at ~810 nm and ~1100 nm were synthesized using an improved seed method. Based on the NIR lasers available, photothermal conversion of AuNRs were systematically studied compared with that of water. Under low power irradiation, the highest temperature is obtained when the SPRL wavelength of AuNRs is equal to the laser wavelength, and temperature of colloid increases from ~20°C to ~65°C. With increasing laser power (such as 6 W), the AuNRs colloid boils within a few minutes, and nanorods undergo a shape deformation from rod to spherical particle and even fusion, and the SPRL disappears. For further investigation, the obtained AuNRs were coated with SiO2 shell to form a core-shell nanostructure (Au@SiO2). The surface coating can be used not only in keeping the stability of AuNRs for further treatment, but also in increasing plasmonic property and biocompatibility. This work will be useful for designing plasmonic photothermal properties and further applications in nanomedicine.展开更多
MXene is a new type of layered two-dimensional transition metal carbide materials differing from graphene, demonstrating intriguing chemical/physical properties. Here the chemical modification of MXene and next fabric...MXene is a new type of layered two-dimensional transition metal carbide materials differing from graphene, demonstrating intriguing chemical/physical properties. Here the chemical modification of MXene and next fabrication of core-shell MXene-COOH@(PEI/PAA)_n composites have been investigated. The obtained MXene-based composites were treated with gold nanoparticles to form MXene—COOH@(PEI/PAA)_n@AuNPs nanocomposites, and their catalytic properties for nitro-compounds were studied. The prepared nanocomposites demonstrated good catalytic activity and reproducibility, showing potential applications in composite catalysts and environmental fields.展开更多
In this paper, we describe the synthesis of gold coated spindle-type iron nanoparticles and its surface modification by a thiolated fluorescently-labelled polyethylene glycol (PEG) polymer. A forced hydrolysis of ferr...In this paper, we describe the synthesis of gold coated spindle-type iron nanoparticles and its surface modification by a thiolated fluorescently-labelled polyethylene glycol (PEG) polymer. A forced hydrolysis of ferric salts in the presence of phosphate ions was used to produce α-Fe2O3 spindle-type particles. The oxide powders were first reduced to α-iron under high temperature and controlled dihydrogen atmosphere. Then, the resulting magnetic spindle-type particles were covered by a shell of gold. The formation of the core@shell structure was driven by a redox-transmetalation reaction between iron(0) at the surface of particles and a gold(III) salt. Protected against oxidation, the Fe@Au core@shell nanoparticles were then grafted with a water soluble fluorescent-PEG-thiol. TEM, XRD, EDX and measurements of magnetic properties of particles confirm 1) the conversion of hematite into iron and 2) their subsequent surface protection with a gold shell. Furthermore, the functionalization of the gold nanoparticle surface with a PEG carrying a fluorescent dye was unambiguously attested by confocal laser scanning microscopy.展开更多
We prepared Au/Ag core-shell nanoparticles by growing Ag shell onto 12 nm Au core, using silver nitrate and sodium citrate as the reactants. By changing the molar ratio of Ag to Au, the shell thickness and thus the si...We prepared Au/Ag core-shell nanoparticles by growing Ag shell onto 12 nm Au core, using silver nitrate and sodium citrate as the reactants. By changing the molar ratio of Ag to Au, the shell thickness and thus the size of bimetallic particles could be controlled in convenient way. The formation of core-shell structure was proved by UV-Vis spectra, transmission electron microscopy(TEM), etc.. The core-shell particles showed a more narrow size distribution than Ag colloid prepared without Au core. The SERS activity of the core-shell particles was investigated by using 2,4-dimethylpyridine as the probe, which strongly indicated their potential application in SERS substrate materials.展开更多
基金supported by National Research Foundation of Korea(NRF) grants funded by the Korea Government(MSIP)a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI) funded by the Ministry of Health&Welfare,Republic of Korea(HI16C1501)+1 种基金a grant from the Medical Cluster R&D Support Project through the Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF) funded by the Ministry of Health and Welfare(HT16C0001,HT16C0002,HT17C0009)a National Research Foundation of Korea(NRF) Grant funded by the Korea Government(MSIP)(2014R1A1A1003323,2017R1D1A1B03028340,2018R1D1AB07047417)
文摘Plasmonic nanostructure-mediated photothermal therapy(PTT) has proven to be a promising approach for cancer treatment,and new approaches for its effective delivery to tumor lesions are currently being developed.This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells(124I-Au@AuCBs) as a theranostic nanoplatform.124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity.After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors,intensive signals were observed at tumor lesions,and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects.The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.
基金supported by the National Natural Science Foundation of China(21573240,21706265,21776292)National Natural Science Foundation of Beijing(2173062)+1 种基金the Center for Mesoscience,Institute of Process Engineering,Chinese Academy of Sciences(MPCS-2017-A-02)State Key Laboratory of Multiphase Complex Systems,Institute of Process Engineering,Chinese Academy of Sciences(MPCS2019-A-09)。
文摘To maximize the size and structural advantages of nanomaterials in electrooxidation of ethanol, we herein report the synthesis of core–shell gold(Au)@Palladium(Pd) nanoparticles smaller than 3 nm in an ionic liquid, which combines the advantages of ionic liquids in preparing fine metal nanoparticles with the benefits of core–shell nanostructures. This synthetic strategy relies on the use of an ionic liquid(1-(2'-aminoethyl)-3-methyl-imidazolum tetrafluoroborate) as a stabilizer to produce Au particles with an average size of ca. 2.41 nm, which are then served as seeds for the formation of tiny core–shell Au@Pd nanoparticles with different Au/Pd molar ratios. The strong electronic coupling between Au core and Pd shell endows the Pd shell with an electronic structure favorable for the ethanol oxidation reaction. In specific, the ionic liquidderived core–shell Au@Pd nanoparticles at an Au/Pd molar ratio of 1/1 exhibit the highest mass-and area-based activities, approximately 11 times than those of commercial Pd/C catalyst for ethanol electrooxidation.
文摘Bimetallic gold-silver core-shell nanoparticles were prepared by chemical reduction in aqueous solution, following a method that was friendly to the environment, allowing us to use this for medicinal purposes. Gold nanoparticles were synthesized, and silver cations were then reduced on the nanoparticles. Using the optical properties of metallic nanoparticles, surface plasmon resonance was determined by UV-Vis spectroscopy, and the values obtained for gold and silver were approximately 520 nm and 400 nm in wavelength, respectively. The absorption peaks of the surface plasmon band show a clear red-shift due to size effect in the case of the silver surface, and a plasmon coupling effect, in the case of gold. To obtain a better understanding of the coating conditions, high resolution transmission electron microscopy was used. The average hydrodynamic size and the size distribution of the synthesized nanoparticles were obtained by dynamic light scattering. The development of this process, which is benign for the environment, opens the possibility for many applications in the areas of renewable energy, medicine and biology.
基金Project supported by the Start up Fund for Returned Overseas Chinese Scholars at CSU, China
文摘Nanostructural gold/polyaniline core/shell composite particles on conducting electrode ITO were successfully prepared via electrochemical polymerization of aniline based on 4-aminothiophenol (4-ATP) capped Au nanoparticles. The new approach to the fabrication included three steps: preparation of gold nanoparticles as core by pulse electrodeposition; formation of ATP monolayer on the gold particle surface, which served as a binder and an initiator; polymerization of aniline monomer initiated by ATP molecules under controlled voltage lower than the voltammetric threshold of aniline polymerization, which assured the formation of polyaniline shell film occurred on gold particles selectively. Topographic images were also studied by AFM, which indicated the diameter of gold nanoparticles were around 250 nm. Coulometry characterization confirmed the shell thickness of polyaniline film was about 30 nm. A possible formation mechanism of the Au/polyaniline core-shell nanocomposites was also proposed. The novel as-prepared core-shell nanoparticles have potential application in constructing biosensor when bioactive enzymes are absorbed or embedded in polyaniline shell film.
文摘In this paper, AuNRs colloids with SPRL located at ~810 nm and ~1100 nm were synthesized using an improved seed method. Based on the NIR lasers available, photothermal conversion of AuNRs were systematically studied compared with that of water. Under low power irradiation, the highest temperature is obtained when the SPRL wavelength of AuNRs is equal to the laser wavelength, and temperature of colloid increases from ~20°C to ~65°C. With increasing laser power (such as 6 W), the AuNRs colloid boils within a few minutes, and nanorods undergo a shape deformation from rod to spherical particle and even fusion, and the SPRL disappears. For further investigation, the obtained AuNRs were coated with SiO2 shell to form a core-shell nanostructure (Au@SiO2). The surface coating can be used not only in keeping the stability of AuNRs for further treatment, but also in increasing plasmonic property and biocompatibility. This work will be useful for designing plasmonic photothermal properties and further applications in nanomedicine.
基金financially supported by the National Natural Science Foundation of China (Nos.21473153 and 51771162)Support Program for the Top Young Talents of Hebei Province,China Postdoctoral Science Foundation (No.2015M580214)+1 种基金the Scientific and Technological Research and Development Program of Qinhuangdao City (No.201701B004)Undergraduate Training Programs for Innovation and Entrepreneurship of Yanshan University (No.CXXL2017227)
文摘MXene is a new type of layered two-dimensional transition metal carbide materials differing from graphene, demonstrating intriguing chemical/physical properties. Here the chemical modification of MXene and next fabrication of core-shell MXene-COOH@(PEI/PAA)_n composites have been investigated. The obtained MXene-based composites were treated with gold nanoparticles to form MXene—COOH@(PEI/PAA)_n@AuNPs nanocomposites, and their catalytic properties for nitro-compounds were studied. The prepared nanocomposites demonstrated good catalytic activity and reproducibility, showing potential applications in composite catalysts and environmental fields.
文摘In this paper, we describe the synthesis of gold coated spindle-type iron nanoparticles and its surface modification by a thiolated fluorescently-labelled polyethylene glycol (PEG) polymer. A forced hydrolysis of ferric salts in the presence of phosphate ions was used to produce α-Fe2O3 spindle-type particles. The oxide powders were first reduced to α-iron under high temperature and controlled dihydrogen atmosphere. Then, the resulting magnetic spindle-type particles were covered by a shell of gold. The formation of the core@shell structure was driven by a redox-transmetalation reaction between iron(0) at the surface of particles and a gold(III) salt. Protected against oxidation, the Fe@Au core@shell nanoparticles were then grafted with a water soluble fluorescent-PEG-thiol. TEM, XRD, EDX and measurements of magnetic properties of particles confirm 1) the conversion of hematite into iron and 2) their subsequent surface protection with a gold shell. Furthermore, the functionalization of the gold nanoparticle surface with a PEG carrying a fluorescent dye was unambiguously attested by confocal laser scanning microscopy.
文摘We prepared Au/Ag core-shell nanoparticles by growing Ag shell onto 12 nm Au core, using silver nitrate and sodium citrate as the reactants. By changing the molar ratio of Ag to Au, the shell thickness and thus the size of bimetallic particles could be controlled in convenient way. The formation of core-shell structure was proved by UV-Vis spectra, transmission electron microscopy(TEM), etc.. The core-shell particles showed a more narrow size distribution than Ag colloid prepared without Au core. The SERS activity of the core-shell particles was investigated by using 2,4-dimethylpyridine as the probe, which strongly indicated their potential application in SERS substrate materials.
