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Heshouwu decoction, a Chinese herb for tonifying kidney, ameliorates hypothalamic-pituitary-testicular axis secretion in aging rats 被引量:3
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作者 Siyun Niu Suru Kou +1 位作者 Xiaochun Zhou Liang Ding 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第21期1611-1617,共7页
An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treate... An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Epimedii, Radix Salviae Miltiorrhiae, and Poria). Heshouwu pill treated rats were the positive control group. Radioimmunoassay, immunohistochemical staining, and western blot assay showed hypothalamic gonadotropin-releasing hormone, hypothalamic substance P, and serum gonadotropin levels to be significantly increased in the model rats; the concentrations of hypothalamic ~3-endorphin, and serum levels of insulin-like growth factor I and testosterone were significantly decreased. 1713- and 3[3-hydroxysteroid dehydrogenase expression in testicular tissue was also decreased. Intragastric administration of Heshouwu decoction at high (9.6 g/mL/100 g), medium (4.8 g/mL/100 g), and low (2.4 g/mlJ100 g) doses, Heshouwu decoction pretreatment at a medium dose (4.8 g/mL/100 g), and Heshouwu pill (2.06 g/mL/100 g) significantly reversed these changes. Heshouwu decoction pretreatment and high-dose Heshouwu decoction had the greatest anti-aging effects. These experimental findings indicate that Heshouwu decoction can improve hypothalamic-pituitary-testicular axis secretion in a subacute aging rat model, and prevent and delay gonadal axis aging, with an effect superior to that of Heshouwu pill. 展开更多
关键词 Heshouwu decoction pituitary gonadal axis aging gonadotropin-releasing hormone gonadotropin hydroxysteroid dehydrogenase hypothalamic-pituitary-testicular axis neural regeneration
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A Qualitative Model of the Interaction of Sexual Behavior and Hormone Gene Transcription in Male Blue Gourami during Reproduction
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作者 Gad Degani 《Journal of Biophysical Chemistry》 2020年第4期43-50,共8页
In the present study, a model is suggested to describe hormone control in male blue gourami (<i><span style="font-family:Verdana;">Trichogaster trichopterus</span></i><span style=&... In the present study, a model is suggested to describe hormone control in male blue gourami (<i><span style="font-family:Verdana;">Trichogaster trichopterus</span></i><span style="font-family:Verdana;">) along the gonadotropic brain</span><span style="font-size:10pt;font-family:Verdana;">-</span><span style="font-size:10pt;font-family:Verdana;">pituitary</span><span style="font-size:10pt;font-family:Verdana;">- </span><span style="font-size:10pt;font-family:Verdana;">gonad axis (BPG axis) and the hypothalamic-pituitary-somatotropic axis (HPS axis). This model is based on the cloning</span><span style="font-size:10.0pt;font-family:""><span style="font-family:Verdana;"> and transcription of genes encoding hormones of the two axes involved in spermatogenesis during blue gourami reproduction. Gene transcription is affected by environmental, biological, </span><span style="font-family:Verdana;">and behavioral factors. Mature males were examined in two different stages—nonreproductive in high-density habitats and reproductive in low-density </span><span style="font-family:Verdana;">habitats. Based on gene transcription, gonadotropin-releasing hormone 1 (GnRH1) was involved in controlling spermatogenesis (spermatogonia to spermatids) via the BPG axis in nonreproductive and reproductive stages by controlling follicle-stimulating hormone (FSH), 11-ketotestosterone (11KT) and 17</span><i><span style="font-family:Verdana;">β</span></i><span style="font-family:Verdana;">-estradiol (E</span><sub><span style="font-family:Verdana;">2</span></sub><span style="font-family:Verdana;">). However, GnRH3 had a larger effect during the reproductive stage via the BPG axis (spermatids to sperm) on luteinizing hormone (LH), 11KT, and 17</span><i><span style="font-family:Verdana;">α</span></i></span><span style="font-size:10pt;font-family:Verdana;">-</span><span style="font-size:10pt;font-family:Verdana;">hydroxyprogesterone (17P). At the same time, the HPS axis was involved in spermatogenesis via pituitary adenylate cyclase-activating polypeptide (PACAP) and its related peptide PRP (formerly known as GHRH-like peptide) in the brain, and growth hormone (GH) in the pituitary affected synthesis of insulin-like growth factor 1 (IGF1) in the liver.</span> 展开更多
关键词 Qualitative Model Anabantidae HORMONE Gene Trichogaster SPERMATOGENESIS SPERM GNRH 11-Ketotestosterone gonadotropic Brain Pituitary gonad axis
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