Background Domestic goose breeds are descended from either the Swan goose(Anser cygnoides)or the Greylag goose(Anser anser),exhibiting variations in body size,reproductive performance,egg production,feather color,and ...Background Domestic goose breeds are descended from either the Swan goose(Anser cygnoides)or the Greylag goose(Anser anser),exhibiting variations in body size,reproductive performance,egg production,feather color,and other phenotypic traits.Constructing a pan-genome facilitates a thorough identification of genetic variations,thereby deepening our comprehension of the molecular mechanisms underlying genetic diversity and phenotypic variability.Results To comprehensively facilitate population genomic and pan-genomic analyses in geese,we embarked on the task of 659 geese whole genome resequencing data and compiling a database of 155 RNA-seq samples.By constructing the pan-genome for geese,we generated non-reference contigs totaling 612 Mb,unveiling a collection of 2,813 novel genes and pinpointing 15,567 core genes,1,324 softcore genes,2,734 shell genes,and 878 cloud genes in goose genomes.Furthermore,we detected an 81.97 Mb genomic region showing signs of genome selection,encompassing the TGFBR2 gene correlated with variations in body weight among geese.Genome-wide association studies utilizing single nucleotide polymorphisms(SNPs)and presence-absence variation revealed significant genomic associations with various goose meat quality,reproductive,and body composition traits.For instance,a gene encoding the SVEP1 protein was linked to carcass oblique length,and a distinct gene-CDS haplotype of the SVEP1 gene exhibited an association with carcass oblique length.Notably,the pan-genome analysis revealed enrichment of variable genes in the“hair follicle maturation”Gene Ontology term,potentially linked to the selection of feather-related traits in geese.A gene presence-absence variation analysis suggested a reduced frequency of genes associated with“regulation of heart contraction”in domesticated geese compared to their wild counterparts.Our study provided novel insights into gene expression features and functions by integrating gene expression patterns across multiple organs and tissues in geese and analyzing population variation.Conclusion This accomplishment originates from the discernment of a multitude of selection signals and candidate genes associated with a wide array of traits,thereby markedly enhancing our understanding of the processes underlying domestication and breeding in geese.Moreover,assembling the pan-genome for geese has yielded a comprehensive apprehension of the goose genome,establishing it as an indispensable asset poised to offer innovative viewpoints and make substantial contributions to future geese breeding initiatives.展开更多
To reduce the negative effects that conventional modes of transportation have on the environment,researchers are working to increase the use of electric vehicles.The demand for environmentally friendly transportation ...To reduce the negative effects that conventional modes of transportation have on the environment,researchers are working to increase the use of electric vehicles.The demand for environmentally friendly transportation may be hampered by obstacles such as a restricted range and extended rates of recharge.The establishment of urban charging infrastructure that includes both fast and ultra-fast terminals is essential to address this issue.Nevertheless,the powering of these terminals presents challenges because of the high energy requirements,whichmay influence the quality of service.Modelling the maximum hourly capacity of each station based on its geographic location is necessary to arrive at an accurate estimation of the resources required for charging infrastructure.It is vital to do an analysis of specific regional traffic patterns,such as road networks,route details,junction density,and economic zones,rather than making arbitrary conclusions about traffic patterns.When vehicle traffic is simulated using this data and other variables,it is possible to detect limits in the design of the current traffic engineering system.Initially,the binary graylag goose optimization(bGGO)algorithm is utilized for the purpose of feature selection.Subsequently,the graylag goose optimization(GGO)algorithm is utilized as a voting classifier as a decision algorithm to allocate demand to charging stations while taking into consideration the cost variable of traffic congestion.Based on the results of the analysis of variance(ANOVA),a comprehensive summary of the components that contribute to the observed variability in the dataset is provided.The results of the Wilcoxon Signed Rank Test compare the actual median accuracy values of several different algorithms,such as the voting GGO algorithm,the voting grey wolf optimization algorithm(GWO),the voting whale optimization algorithm(WOA),the voting particle swarm optimization(PSO),the voting firefly algorithm(FA),and the voting genetic algorithm(GA),to the theoretical median that would be expected that there is no difference.展开更多
We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons...We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH shifts.Based on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.展开更多
In the contemporary world of highly efficient technological development,fifth-generation technology(5G)is seen as a vital step forward with theoretical maximum download speeds of up to twenty gigabits per second(Gbps)...In the contemporary world of highly efficient technological development,fifth-generation technology(5G)is seen as a vital step forward with theoretical maximum download speeds of up to twenty gigabits per second(Gbps).As far as the current implementations are concerned,they are at the level of slightly below 1 Gbps,but this allowed a great leap forward from fourth generation technology(4G),as well as enabling significantly reduced latency,making 5G an absolute necessity for applications such as gaming,virtual conferencing,and other interactive electronic processes.Prospects of this change are not limited to connectivity alone;it urges operators to refine their business strategies and offers users better and improved digital solutions.An essential factor is optimization and the application of artificial intelligence throughout the general arrangement of intricate and detailed 5G lines.Integrating Binary Greylag Goose Optimization(bGGO)to achieve a significant reduction in the feature set while maintaining or improving model performance,leading to more efficient and effective 5G network management,and Greylag Goose Optimization(GGO)increases the efficiency of the machine learningmodels.Thus,the model performs and yields more accurate results.This work proposes a new method to schedule the resources in the next generation,5G,based on a feature selection using GGO and a regression model that is an ensemble of K-Nearest Neighbors(KNN),Gradient Boosting,and Extra Trees algorithms.The ensemble model shows better prediction performance with the coefficient of determination R squared value equal to.99348.The proposed framework is supported by several Statistical analyses,such as theWilcoxon signed-rank test.Some of the benefits of this study are the introduction of new efficient optimization algorithms,the selection of features and more reliable ensemble models which improve the efficiency of 5G technology.展开更多
Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant ener...Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully comprehended.Results In this study, geese exhibited more pronounced changes in the liver index and triglyceride(TG) content following the consumption of the high-fat diet(HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues(5 HFD, 5 normal), including generating highresolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat deposition and hepatic fat regulation in geese under conditions of excessive energy intake.Conclusions We examined the dynamic modifications in three-dimensional chromatin architecture and gene expression induced by an HFD in goose liver tissues. We conducted a cross-species analysis comparing that of mice. Our results contribute significant insights into the chromatin architecture of goose liver tissues, offering a novel perspective for investigating mammal liver diseases.展开更多
基金funding from several sources,including the Chongqing Scientific Research Institution Performance Incentive Project(grant number cstc2022jxjl80007)the Earmarked Fund for China Agriculture Research System(grant number CARS-42-51)+5 种基金the Chongqing Scientific Research Institution Performance Incentive Project(grant number 22527 J)the Key R&D Project in Agriculture and Animal Husbandry of Rongchang(grant number No.22534C-22)Natural Science Foundation of Chongqing Project,grant number CSTB2022NSCQ-MSX0434Natural Science Foundation of Sichuan Project,grant number 2022NSFSC0605Natural Science Foundation of Sichuan Project,grant number 2021YFS0379the Chongqing Technology Innovation and Application Development Project(grant number No.cstc2021ycjh-bgzxm0248)。
文摘Background Domestic goose breeds are descended from either the Swan goose(Anser cygnoides)or the Greylag goose(Anser anser),exhibiting variations in body size,reproductive performance,egg production,feather color,and other phenotypic traits.Constructing a pan-genome facilitates a thorough identification of genetic variations,thereby deepening our comprehension of the molecular mechanisms underlying genetic diversity and phenotypic variability.Results To comprehensively facilitate population genomic and pan-genomic analyses in geese,we embarked on the task of 659 geese whole genome resequencing data and compiling a database of 155 RNA-seq samples.By constructing the pan-genome for geese,we generated non-reference contigs totaling 612 Mb,unveiling a collection of 2,813 novel genes and pinpointing 15,567 core genes,1,324 softcore genes,2,734 shell genes,and 878 cloud genes in goose genomes.Furthermore,we detected an 81.97 Mb genomic region showing signs of genome selection,encompassing the TGFBR2 gene correlated with variations in body weight among geese.Genome-wide association studies utilizing single nucleotide polymorphisms(SNPs)and presence-absence variation revealed significant genomic associations with various goose meat quality,reproductive,and body composition traits.For instance,a gene encoding the SVEP1 protein was linked to carcass oblique length,and a distinct gene-CDS haplotype of the SVEP1 gene exhibited an association with carcass oblique length.Notably,the pan-genome analysis revealed enrichment of variable genes in the“hair follicle maturation”Gene Ontology term,potentially linked to the selection of feather-related traits in geese.A gene presence-absence variation analysis suggested a reduced frequency of genes associated with“regulation of heart contraction”in domesticated geese compared to their wild counterparts.Our study provided novel insights into gene expression features and functions by integrating gene expression patterns across multiple organs and tissues in geese and analyzing population variation.Conclusion This accomplishment originates from the discernment of a multitude of selection signals and candidate genes associated with a wide array of traits,thereby markedly enhancing our understanding of the processes underlying domestication and breeding in geese.Moreover,assembling the pan-genome for geese has yielded a comprehensive apprehension of the goose genome,establishing it as an indispensable asset poised to offer innovative viewpoints and make substantial contributions to future geese breeding initiatives.
基金funded by the Deanship of Scientific Research,Princess Nourah bint Abdulrahman University,through the Program of Research Project Funding After Publication,Grant No.(44-PRFA-P-48).
文摘To reduce the negative effects that conventional modes of transportation have on the environment,researchers are working to increase the use of electric vehicles.The demand for environmentally friendly transportation may be hampered by obstacles such as a restricted range and extended rates of recharge.The establishment of urban charging infrastructure that includes both fast and ultra-fast terminals is essential to address this issue.Nevertheless,the powering of these terminals presents challenges because of the high energy requirements,whichmay influence the quality of service.Modelling the maximum hourly capacity of each station based on its geographic location is necessary to arrive at an accurate estimation of the resources required for charging infrastructure.It is vital to do an analysis of specific regional traffic patterns,such as road networks,route details,junction density,and economic zones,rather than making arbitrary conclusions about traffic patterns.When vehicle traffic is simulated using this data and other variables,it is possible to detect limits in the design of the current traffic engineering system.Initially,the binary graylag goose optimization(bGGO)algorithm is utilized for the purpose of feature selection.Subsequently,the graylag goose optimization(GGO)algorithm is utilized as a voting classifier as a decision algorithm to allocate demand to charging stations while taking into consideration the cost variable of traffic congestion.Based on the results of the analysis of variance(ANOVA),a comprehensive summary of the components that contribute to the observed variability in the dataset is provided.The results of the Wilcoxon Signed Rank Test compare the actual median accuracy values of several different algorithms,such as the voting GGO algorithm,the voting grey wolf optimization algorithm(GWO),the voting whale optimization algorithm(WOA),the voting particle swarm optimization(PSO),the voting firefly algorithm(FA),and the voting genetic algorithm(GA),to the theoretical median that would be expected that there is no difference.
基金Project supported by the Natural Science Foundation of Heilongjiang Province of China (Grant No.LH2020A014)the Graduate Students' Research Innovation Project of Harbin Normal University (Grant No.HSDSSCX2022-47)。
文摘We conduct a theoretical analysis of the massive and tunable Goos–Hänchen(GH) shift on a polar crystal covered with periodical black phosphorus(BP)-patches in the THz range. The surface plasmon phonon polaritons(SPPPs), which are coupled by the surface phonon polaritons(SPh Ps) and surface plasmon polaritons(SPPs), can greatly increase GH shifts.Based on the in-plane anisotropy of BP, two typical metasurface models are designed and investigated. An enormous GH shift of about-7565.58 λ_(0) is achieved by adjusting the physical parameters of the BP-patches. In the designed metasurface structure, the maximum sensitivity accompanying large GH shifts can reach about 6.43 × 10^(8) λ_(0)/RIU, which is extremely sensitive to the size, carrier density, and layer number of BP. Compared with a traditional surface plasmon resonance sensor, the sensitivity is increased by at least two orders of magnitude. We believe that investigating metasurface-based SPPPs sensors could lead to high-sensitivity biochemical detection applications.
基金Princess Nourah bint Abdulrahman University Researchers Supporting Project Number(PNURSP2024R 308)。
文摘In the contemporary world of highly efficient technological development,fifth-generation technology(5G)is seen as a vital step forward with theoretical maximum download speeds of up to twenty gigabits per second(Gbps).As far as the current implementations are concerned,they are at the level of slightly below 1 Gbps,but this allowed a great leap forward from fourth generation technology(4G),as well as enabling significantly reduced latency,making 5G an absolute necessity for applications such as gaming,virtual conferencing,and other interactive electronic processes.Prospects of this change are not limited to connectivity alone;it urges operators to refine their business strategies and offers users better and improved digital solutions.An essential factor is optimization and the application of artificial intelligence throughout the general arrangement of intricate and detailed 5G lines.Integrating Binary Greylag Goose Optimization(bGGO)to achieve a significant reduction in the feature set while maintaining or improving model performance,leading to more efficient and effective 5G network management,and Greylag Goose Optimization(GGO)increases the efficiency of the machine learningmodels.Thus,the model performs and yields more accurate results.This work proposes a new method to schedule the resources in the next generation,5G,based on a feature selection using GGO and a regression model that is an ensemble of K-Nearest Neighbors(KNN),Gradient Boosting,and Extra Trees algorithms.The ensemble model shows better prediction performance with the coefficient of determination R squared value equal to.99348.The proposed framework is supported by several Statistical analyses,such as theWilcoxon signed-rank test.Some of the benefits of this study are the introduction of new efficient optimization algorithms,the selection of features and more reliable ensemble models which improve the efficiency of 5G technology.
基金supported by the National Key R&D Program of China (2022YFF1000100 to Long Jin and 2023YFD1300012 to Long Jin)the Sichuan Science and Technology Program (2022JDJQ0054 to Long Jin and 2021YFYZ0009 to Mingzhou Li)the National Natural Science Foundation of China (32225046 to Mingzhou Li)。
文摘Background Goose, descendants of migratory ancestors, have undergone extensive selective breeding, resulting in their remarkable ability to accumulate fat in the liver and exhibit a high tolerance for significant energy intake. As a result, goose offers an excellent model for studying obesity, metabolic disorders, and liver diseases in mammals. Although the impact of the three-dimensional arrangement of chromatin within the cell nucleus on gene expression and transcriptional regulation is widely acknowledged, the precise functions of chromatin architecture reorganization during fat deposition in goose liver tissues still need to be fully comprehended.Results In this study, geese exhibited more pronounced changes in the liver index and triglyceride(TG) content following the consumption of the high-fat diet(HFD) than mice without significant signs of inflammation. Additionally, we performed comprehensive analyses on 10 goose liver tissues(5 HFD, 5 normal), including generating highresolution maps of chromatin architecture, conducting whole-genome gene expression profiling, and identifying H3K27ac peaks in the livers of geese and mice subjected to the HFD. Our results unveiled a multiscale restructuring of chromatin architecture, encompassing Compartment A/B, topologically associated domains, and interactions between promoters and enhancers. The dynamism of the three-dimensional genome architecture, prompted by the HFD, assumed a pivotal role in the transcriptional regulation of crucial genes. Furthermore, we identified genes that regulate chromatin conformation changes, contributing to the metabolic adaptation process of lipid deposition and hepatic fat changes in geese in response to excessive energy intake. Moreover, we conducted a cross-species analysis comparing geese and mice exposed to the HFD, revealing unique characteristics specific to the goose liver compared to a mouse. These chromatin conformation changes help elucidate the observed characteristics of fat deposition and hepatic fat regulation in geese under conditions of excessive energy intake.Conclusions We examined the dynamic modifications in three-dimensional chromatin architecture and gene expression induced by an HFD in goose liver tissues. We conducted a cross-species analysis comparing that of mice. Our results contribute significant insights into the chromatin architecture of goose liver tissues, offering a novel perspective for investigating mammal liver diseases.