Concomitant atypical knee gout and seronegative rheumatoid arthritis:A case report

BACKGROUND Gout and seronegative rheumatoid arthritis(SNRA)are two distinct inflammatory joint diseases whose co-occurrence is relatively infrequently reported.Limited information is available regarding the clinical management and prognosis of these combined diseases.CASE SUMMARY A 57-year-old woman with a 20-year history of joint swelling,tenderness,and morning stiffness who was negative for rheumatoid factor and had a normal uric acid level was diagnosed with SNRA.The initial regimen of methotrexate,leflunomide,and celecoxib alleviated her symptoms,except for those associated with the knee.After symptom recurrence after medication cessation,her regimen was updated to include iguratimod,methotrexate,methylprednisolone,and folic acid,but her knee issues persisted.Minimally invasive needle-knife scope therapy revealed proliferating pannus and needle-shaped crystals in the knee,indicating coexistent SNRA and atypical knee gout.After postarthroscopic surgery to remove the synovium and urate crystals,and following a tailored regimen of methotrexate,leflunomide,celecoxib,benzbromarone,and allopurinol,her knee symptoms were significantly alleviated with no recurrence observed over a period of more than one year,indicating successful management of both conditions.CONCLUSION This study reports the case of a patient concurrently afflicted with atypical gout of the knee and SNRA and underscores the significance of minimally invasive joint techniques as effective diagnostic and therapeutic tools in the field of rheumatology and immunology.

Metastatic Rectal Adenocarcinoma of the Hip and Knee Joints: A Case Series

Two cases are presented of patients with a history of metastatic rectal adenocarcinoma presenting with a painful joint effusion. Both cases are potential examples of metastasis to periarticular bone with local infiltration to the synovium, which is one proposed mechanism of intrasynovial metastasis. While skeletal metastases are a relatively common occurrence in metastatic adenocarcinoma, intraarticular metastasis is extremely rare. These cases highlight the need to consider metastasis in the differential of joint swelling in the setting of a history of adenocarcinoma.

Clinical effect of sodium hyaluronate joint cavity filling combined with exercise therapy on patients with post-traumatic knee arthritis

Objective:To research the sodium hyaluronate joint cavity filling combined with exercise therapy on the indicator of pain,motor function,and levels of inflammatory factors in joint fluid in patients with post-traumatic knee arthritis.Method Totally 100 patients(Department of Orthopaedics,The second Affiliated Hospital to Liaoning University of Chinese Medicine,2013.10-2018.8)with post-traumatic knee arthritis were selected,then they were divided into observation group(n=50)and control group(n=50).The control group was given glucosamine sulfate and sodium hyaluronate joint cavity filling,the observation group was given leg press with visual feedback,they were treated 4 weeks.Assessing the pain degree through visual analog scale(VAS),hospital for special surgery knee score(HSS)as the indicator of motor function,inflammatory factor(TNF-α,IL-6,and IL-8)in the joint fluid.Results The score of VAS were lower than pretherapy(P<0.05),the degree of VAS of observation group were lower than control group(P<0.05).The score of HSS were higher than pretherapy(P<0.05),the degree of VAS of observation group were higher than control group(P<0.05).The inflammatory factor(TNF-α,IL-6,and CRP)in the joint fluid were lower than pretherapy(P<0.05),and the observation group were lower than control group(P<0.05).Conclusions Giving sodium hyaluronate joint cavity filling combined with exercise therapy can improve the function of joint.

Association of vitamin D and knee osteoarthritis in younger individuals

BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease trend.This study was designed to look for the association of serum vitamin D among these young arthritic patients.AIM To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)patients.METHODS In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.RESULTS Both the groups were comparable in terms of age and sex.The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients.However,the clinical and radiological severities have no association with serum vitamin D level.

The Pathognomic Radiologic Features of Gout in the Fingers and Review of the Literature, Including the Latest Drug Therapy

Gout is one of the most common inflammatory arthritides that predominantly affects the first metatarsophalangeal joint. The underlying inflammatory process is elicited by the deposition of monosodium urate (MSU) crystals in the affected joint that are termed tophi and which may in the course of chronic gout progress into subcutaneous depositions of tophi. In this case report, we present a patient (PID: 6925981) who was seen in our outpatient department with a first episode of tophaceous gout in the finger, an infrequently seen condition that mostly affects older men with long-term gout. We discuss the case in view of the current literature on diagnosis and treatment of tophaceous gout.

Arthroscopic Minimally Invasive Surgery for Knee Joint Gouty Arthritis

Objective:To analyse the efficacy of arthroscopic minimally invasive surgery in patients with knee joint gouty arthritis.Methods:A retrospective analysis method was carried out on randomly selected 56 patients with knee gouty arthritis from early July 2018 to the end of June 2019.All patients underwent arthroscopic minimally invasive surgery.Results:In this study,the patients were followed for 10 months.The Lysholm score of knee function was found to be significantly higher after treatment compared to the scores before treatment(P<0.05).Conclusion:Arthroscopic minimally invasive surgery is a promising method to treat for knee joint gouty arthritis.

Comparison of Three Experimental Models for Rat Osteoarthritis Induction

Background: Osteoarthritis is a slowly progressive and debilitating disease with high prevalence in adult population. Knee is one of the joints most affected by this disorder. There are several models for animals’ osteoarthritis induction, however it is not identified any paper that compares these techniques. The present study was aimed to define the most appropriate model for rats osteoarthritis induction. Material and Methods: 40 Wistar rats were distributed into 4 groups of 10 animals each: normality group (NG);meniscectomy group (MG);quinolone group (QG) and iodoacetate group (IG). Radiographic images of the rat’s knees were analyzed as well as the amount of chondrocytes in the epiphyseal and articular cartilage. Results: In the radiographic analysis, there was a low correlation between the raters. Regarding the amount of chondrocytes in the epiphyseal cartilage, it was noticed that the IG and QG groups had fewer chondrocytes than NG, in contrast to MG that reported similar results to normality (p > 0.05). There was no significant difference between IG and QG groups (p > 0.05). Regarding the amount of chondrocytes in articular cartilage, it was noticed that the IG group showed fewer chondrocytes than NG (p 0.05). There was no significant difference between QG and MG groups (p > 0.05). Conclusion: Intraarticular injection of iodoacetate in rats is the model with greatest effect on reduction of chondrocytes amount.

Observation on the therapeutic effect of modified sparrow-pecking moxibustion for 60 cases of osteoarthritis of knee

Objective To observe the therapeutic effect of modified sparrow-pecking moxibustion for osteoarthritis of knee. Methods Sixty cases of patients with osteoarthritis of knee were divided randomly into a treatment group and a control group. The treatment group was treated by modified sparrow- pecking moxibustion, and the control group by traditional sparrow-pecking moxibustion. It was given once a day and 10 times were one course, and the efficacy was observed after two courses of treatment. Results the total effective rate in the treatment group was 90.00% （27/30）, that in the control group was 76.67% （23/30）, the efficacy in the treatment group was better than that in the control group （P〈O.05）. Conclusion Modified sparrow-pecking moxibustion has obvious effect on the treatment of osteoarthritis of knee and it is worthy of being studied and promoted.

Clinical Application of Double-hand Needling Manipulation

Double-hand manipulation is a needling technique, with which No. 30 filiform needles of various lengths are selected and inserted into the affected part of the body in opposite directions or symmetrically upward-downward, rightward- leftward, anteriorly-posteriorly to the point, followed by needle twirling with both hands. When the two opposite needle tips are twirled to a certain degree, the soreness, warm, numbness, and distending needling sensation tends be connected in a line, forming a rather strong needling sensation. After such manipulation for some time, the needles are retained for 30 min., during which the needle manipulation is given 3-5 times at intervals. This needling treatment is given once daily. The author of this article has adopted this manipulation method in the acupuncture treatment of various diseases with quite satisfactory results. Some of the sample cases are listed as follows.

关节腔内注射肿瘤坏死因子受体抗体融合蛋白对难治性类风湿关节炎患者关节积液情况、膝关节功能及ACPA水平的影响

目的 探讨关节腔内注射肿瘤坏死因子受体抗体融合蛋白[rhTNFR:Fc,益赛普(etanercept)]对难治性类风湿关节炎(RA)患者关节积液情况、膝关节功能及抗瓜氨酸肽抗体(ACPA)水平的影响。方法 选取我院收治的难治性RA患者为研究对象,分为两组。对照组患者给予甲氨蝶呤片等常规基础治疗,研究组在对照组基础上于患者关节腔内注射rhTNFR:Fc治疗,观察治疗后两组患者关节积液情况、膝关节功能及ACPA水平的变化。结果 研究组治疗有效率高于对照组(P<0.05)。治疗后,研究组患者关节积液深度、滑膜厚度低于对照组(P<0.05);VAS评分低于对照组(P<0.05);Lysholm膝关节功能评分高于对照组(P<0.05);血沉(ESR)、C反应蛋白(CRP)、ACPA水平低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 于难治性RA患者关节腔内注射rhTNFR:Fc疗效明显,能够减少关节积液量,改善膝关节功能,延缓病情发展。

关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的临床研究

目的:探究关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的临床效果。方法:回顾性选取九江市第一人民医院2022年6月—2023年9月收治的80例早期类风湿关节炎膝关节病变患者,根据治疗方案将其分为联合组(n=47)和对照组(n=33),对照组采用临床常规治疗方案,即采用曲安奈德进行关节腔注射治疗,联合组采用关节腔靶向注射臭氧联合中药外敷治疗。均治疗3周。比较两组疗效;比较两组治疗前后的C反应蛋白(CRP)、抗环瓜氨酸多肽抗体(ACCP)、类风湿因子(RF)和甘露聚糖结合凝集素(MBL)水平;比较两组治疗前后的视觉模拟评分法(VAS)评分及关节超声评估情况。结果:联合组总有效率为93.62%,高于对照组的72.73%,差异有统计学意义(P<0.05)。治疗后,两组血清RF、CRP、ACCP水平均低于治疗前,且联合组均低于对照组;两组血清MBL水平均高于治疗前,且联合组高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组髌上囊积液深度、髌上囊滑膜厚度、VAS评分均低于治疗前,且联合组均低于对照组,差异均有统计学意义(P<0.05)。结论:关节腔靶向注射臭氧联合中药外敷治疗早期类风湿关节炎膝关节病变的效果较好,可以显著改善患者的血清学指标和疼痛程度,并减轻膝关节病变。

MSUS和X线检查对类风湿性关节炎膝关节病变的临床诊断价值

目的 探讨肌骨超声(MSUS)和X线检查对类风湿性关节炎(RA)膝关节病变的临床诊断价值,以指导RA的诊断和治疗。方法 选取2020年11月至2023年11月安徽医科大学第一附属医院收治的49例RA患者,所有患者均接受双侧膝关节的MSUS和X线检查。通过回顾性分析,比较MSUS和X线在膝关节病变声像特征方面的差异。结果 MSUS检查对滑膜炎、关节腔/髌上囊积液、骨侵蚀、半月板损伤、腘窝囊肿的检出率高于X线检查,差异具有统计学意义(P<0.05);MSUS检查对骨赘/骨质增生、骨质疏松、周围软组织肿胀的检出率低于X线检查,差异具有统计学意义(P<0.05);MSUS和X线检查对关节间隙狭窄的检出率无明显差异(P>0.05)。结论 MSUS和X线检查在RA膝关节病变的诊断中各有优势。MSUS对软组织结构病变更敏感,而X线在骨性结构改变的检测上更为准确。两种检查方法在声像特征上互补,结合使用可以为RA的诊疗提供更全面、可靠的影像学依据。建议在临床实践中综合运用这两种检查手段,以获得更精确的诊断和更有效的治疗策略,通过这种多模态影像诊断方法,医生可以更好地评估RA患者的病情,制定个性化的治疗计划。

痛风性膝关节炎关节镜术后谨防痛风急性发作和术后感染的误诊误治

目的:比较痛风性膝关节炎行关节镜术后痛风急性发作与术后感染临床特征差异。方法:自2017年1月至2022年12月共收治235例痛风性膝关节炎患者,并接受关节镜下膝关节痛风病灶清理。35例术后发热≥38°C,手术关节发生红、肿、热、痛急性炎症反应,男29例,女6例,年龄17~81(41.48±13.90)岁。23例确诊为痛风急性发作(急性发作组),男18例,女5例,年龄17~81(41.95±14.99)岁,予秋水仙碱、泼尼松龙治疗;12例确诊为术后关节感染(感染组),男11例,女1例,年龄18~61(40.57±11.10)岁,予抗感染治疗及关节腔清理冲洗。比较两组手术情况、血液学、关节液、临床特征。结果:急性发作组起热时间多发生于48 h内,明显早于术后感染组(P=0.037)。急性发作组VAS峰值疼痛(5.32±1.38)分,高于感染组(2.45±0.68)分(P=0.000),其中14例痛风急性发作患者伴发其他关节剧痛。血液学方面,两组白细胞计数及比例等指标均有所上升。炎症指标方面,两组红细胞沉降率、白细胞介素-6(interleukin-6,IL-6)、降钙素原等炎症指标比较,差异无统计学意义(P>0.05);而术后感染组C反应蛋白(220.97±116.30)mg·L^(-1),高于急性发作组(120.67±82.45)mg·L^(-1)(P=0.006)。急性发作组血尿酸(316.55±112.84)μmol·L^(-1),高于感染组(159.14±126.92)μmol·L^(-1)(P=0.001)。感染组关节液检查糖代谢指标低于急性发作组(P=0.001)。术后感染组5例细菌培养阳性。结论:痛风性膝关节炎关节镜术后发生急性炎症反应需谨慎鉴别痛风急性发作和术后感染。二者诊断与鉴别诊断应结合临床体征、血液学和关节液检查结果综合判断,并给予针对性治疗,从而避免误诊误治导致严重并发症发生。

易误诊的膝骨性关节炎临床分析

目的分析膝骨性关节炎(KOA)早期误诊的原因,以提高该病诊断准确性。方法选取2021年2月至2022年4月3例初诊为其他疾病的KOA患者的临床资料进行回顾分析。结果1例因右膝关节晨僵和肿胀就诊,初步诊断为类风湿关节炎,误诊时间11 d;进一步超声检查显示关节内无滑膜增生,但存在明显的软骨磨损,磁共振成像显示关节软骨退行性变,最终明确诊断为KOA,给予控制疼痛和抗炎治疗后恢复良好。1例初诊时表现为突发左膝关节肿胀疼痛,通过X线检查后,初步诊断为半月板损伤,误诊时间9 d;接受口服非甾体类抗炎药治疗后症状未改善,磁共振成像示关节软骨退行性变和骨赘形成,随后明确诊断为KOA,接受物理治疗和关节镜手术后,症状显著改善。1例因右膝关节红肿热痛就诊,有痛风病史,初步诊断为痛风,误诊时间10 d;接受相关治疗病情未见好转,进一步超声检查示关节内无尿酸盐结晶,但关节软骨退行性变明显,最终明确诊断为KOA,改用物理治疗和关节保护措施,症状逐渐缓解。结论KOA由于症状与其他关节疾病相似,易导致误诊,通过提高医生警觉性、完善诊断流程,能够显著减少误诊,提高诊断准确性和治疗效果,改善患者预后。

系统性健康教育结合康复指导在类风湿性关节炎患者中的应用价值

目的探究系统性健康教育结合康复指导策略在类风湿性关节炎患者中的应用价值。方法对2022年1月至2023年1月江苏省苏北人民医院收治的104例类风湿性关节炎患者实施前瞻性研究,按信封法将患者随机分成2组,各52例。对照组实施常规健康教育和护理,观察组实施系统性健康教育结合康复指导策略。对2组的病情恢复情况等进行比较。结果出院3个月后,观察组的关节肿胀数和关节压痛数均比对照组少,晨僵时间比对照组短,双手平均握力和治疗依从性调查表评分均优于对照组(P均<0.05),且2组均优于干预前(P均<0.05)。2组在干预3 d、出院时和出院3个月后的视觉模拟评分法评分均较干预前更低(P均<0.05),观察组在上述时间点的评分均较同期对照组更低(P均<0.05)。出院时和出院3个月后,2组的膝关节损伤及骨性关节炎结果评分调查问卷各项评分均较干预前更高(P均<0.05),且观察组均比同期对照组更高(P均<0.05)。结论系统性健康教育结合康复指导可促进类风湿性关节炎患者病情的好转,改善其膝关节功能和治疗依从性,减轻其疼痛程度。

电针调控HIF-1α/VEGF信号通路对类风湿性关节炎模型踝关节病理学改变的影响

目的探讨电针通过调控HIF-1α/VEGF信号通路活性对类风湿性关节炎(RA)大鼠踝关节病理损伤的影响。方法选取50只SD大鼠,随机分为Sham组(空白对照)、RA组(大鼠构建RA模型)、电针组(RA组大鼠给予电针治疗)、CAY10585组(RA大鼠腹腔内注射HIF-1α/VEGF信号通路抑制剂)、电针+CAY10585组(电针组大鼠腹腔注射HIF-1α/VEGF信号通路抑制剂),每组10只。模型建立后观察各组大鼠基本形态;8周后处死大鼠,比较治疗后大鼠踝关节直径;取大鼠踝关节行HE染色,观察整体病理形态及踝关节病理特征(滑膜细胞增殖、细胞侵蚀、血管翳形成、炎性细胞浸润、骨侵蚀)病理评分;酶联免疫吸附法(ELISA)检测5组大鼠血清炎性因子肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平;Western-blot检测大鼠踝关节组织内软骨基质因子Ⅱ型胶原(CollagenⅡ)、C端肽(CTXⅡ)、Ⅱ型胶原C前肽(CPⅡ)蛋白表达。结果与Sham组比较,RA模型建立可以上调大鼠踝关节直径,踝关节滑膜细胞增殖、细胞侵蚀、血管翳形成、炎性细胞浸润、骨侵蚀病理评分,血清炎性因子(TNF-α、IL-6)水平均明显提升(P<0.05),关节滑膜上皮复层出现增生、间质水肿以及炎性细胞浸润的现象;电针干预可以下调大鼠踝关节直径、踝关节滑膜细胞增殖、细胞侵蚀、血管翳形成、炎性细胞浸润、骨侵蚀病理评分,血清炎性因子(TNF-α、IL-6)水平(P<0.05),同时踝关节病理形态明显得到缓解;CAY10585干预再次增加RA大鼠病理形态,破骨细胞明显增加,骨质出现侵蚀、溶解骨层及炎性细胞浸润的现象,踝关节直径、踝关节滑膜细胞增殖、细胞侵蚀、血管翳形成、炎性细胞浸润、骨侵蚀病理评分,血清炎性因子(TNF-α、IL-6)水平再次提升(P<0.05);电针干预可以逆转CAY10585组大鼠趋势,再次下调大鼠踝关节直径、踝关节滑膜细胞增殖、细胞侵蚀、血管翳形成、炎性细胞浸润、骨侵蚀病理评分(P<0.05);与Sham组比较,RA组大鼠踝关节组织内CTXⅡ表达提升,CollagenⅡ、CPⅡ表达降低(P<0.05);电针干预可以下调CTXⅡ表达,上调CollagenⅡ、CPⅡ、HIF-1α、VEGF表达(P<0.05);CAY10585干预则体现出相反趋势,再次上调CTXⅡ表达,下调CollagenⅡ、CPⅡ、HIF-1α、VEGF表达(P<0.05);电针干预可以逆转CAY10585组大鼠软骨基质及HIF-1α、VEGF表达(P<0.05)。结论电针治疗可以改善RA大鼠踝关节的病理学表现,降低炎性反应,保护软骨损伤,其分子机制可能与激活HIF-1α/VEG信号通路有关。

能谱CT检测下肢关节周围尿酸盐结晶沉积的应用研究

目的:探讨应用能谱CT成像技术检测下肢关节周围尿酸盐(MSU)结晶沉积的临床价值。方法:选取90例拟诊断为痛风性关节炎(GA)的患者作为研究对象,均接受下肢关节能谱CT成像技术及常规实验室检查,以后者检查结果为准,分析能谱CT成像技术对GA的诊断价值。结果:应用能谱CT成像技术检查,有77例见MSU结晶沉积,其与常规实验室检查的一致性较强(Kappa=0.732)。77例GA患者中检查出膝关节44例(218处MSU结晶沉积区),足踝关节48例(162处MSU结晶沉积区)。77例GA患者重度MSU沉积组(n=11)、中度MSU沉积组(n=36)、轻度MSU沉积组(n=30)间的MSU结晶数积分和临床症状积分均有统计学差异(P<0.05),均表现为重度MSU沉积组>中度MSU沉积组>轻度MSU沉积组(P<0.05)。Pearson分析显示,GA患者MSU结晶计数与临床症状正相关(r=0.739,P<0.05)。结论:能谱CT成像技术对下肢关节周围MSU结晶沉积有较高显示率,在GA早期诊断中具有重要价值。

成年男性增负荷后的步态及膝关节运动参数特征研究

目的:研究成年男性增负荷后的步态及膝关节运动参数运动特征,探讨增负荷行走对膝关节的影响。方法:选择82名健康男性大学生为研究对象,按照增负荷程度不同将对象分为0%BW组和15%BW组,每组各41名。0%BW组以自身体重的0%负荷行走;15%BW组以自身体重的15%负荷行走。使用Vicon Nexus 1.5.2三维光学运动捕捉系统(英国OML)采集不同负荷前后步态参数和膝关节运动学数据,包括步长、步宽、步频、支撑相占比、摆动相占比、膝关节支撑相角度和摆动相角度最大值及最小值、力矩最大值、力矩最小值,对得到的数据进行比较。结果:15%BW组步频和摆动相均高于0%BW组,支撑相低于0%BW组(P<0.05);矢状面角度最大值(屈膝最大角度)和最大力矩均大于0%BW组(P<0.05);矢状面角度最小值(屈膝最小角度)和最小力矩均少于0%BW组(P<0.05);两组研究对象步长和步宽比较,差异均无统计学意义(P>0.05)。结论:在增负荷状态下,人体会增大膝关节力矩及膝关节屈曲角度,增大支撑相占比,胫骨平台应力峰值增大,长期负重行走可能会诱发膝关节相关疾病。

血友病病人膝关节功能评估工具的研究进展

综述血友病病人膝关节功能相关评估工具的内容、特点、应用现状及局限性,提示医务人员在使用工具时应依据不同疾病的发展阶段和治疗情况选择评估工具,也可同时使用多个量表达到全面评估的目的。此外,现有的评估工具均来自国外,尚未检索到我国本土化的血友病病人关节功能和生活质量的相关评估工具,建议研究者开发适合我国国情的、具有良好信效度的评估工具,不断完善我国血友病关节功能的评估。

等速肌力测定分析高原膝骨关节炎对膝关节屈伸肌群的影响

目的检测世居藏族重度膝骨关节炎(KOA)患者膝关节等速肌力特征,并比较其与健康者的差异。方法通过等速肌力测试与训练系统,对20例单膝右侧发病KOA患者(观察组)和20例健康者(对照组)进行膝关节不同角速度(60°/S和180°/S)等速向心肌力测试,对观察指标比较分析。结果在不同角速度下,观察组右膝(患侧)膝关节屈、伸肌群峰力矩均低于左膝(健侧)和对照组,组间差异有统计学意义(P<0.05)。两组受试者在180°/s屈、伸肌群PT、峰力矩体质量比较均低于60°/s屈、伸肌群,组间差异有统计学意义(P<0.05)。结论患者健、患侧膝关节肌肉功能均比健康人差,患侧膝关节肌肉功能的下降以屈肌最为显著。