Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney prescriptions/herbs are widely used in Traditional Chinese Medicine(TCM). However...Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney prescriptions/herbs are widely used in Traditional Chinese Medicine(TCM). However, the exact biological basis of kidney governing bone theory in the context of new advances in biology is still not fully established. In this paper, the content of kidney governing bone theory in biology has been fully demonstrated from different aspects. We first propose that bone and kidney mutually affect each other in pathology and physiology, particularly through homeostasis of calcium, phosphorus and fibroblast growth factor-23(FGF-23). Next, we identify that tonifying kidney prescriptions/herbs exert bone protective effects, thus treating osteoporosis by regulating bone formation and bone resorption.Furthermore, the exact molecular mechanisms of tonifying kidney prescriptions, herbs and their effective components in treating osteoporosis have been systematically reviewed. Finally, we come into the conclusion that kidney regulating bone mineral homeostasis, bone protective effects of tonifying kidney herbs and regulatory effects on bone homeostasis are all the manifestations of kidney governing bone theory.Therefore, the new insights into kidney governing bone theory in biology will promote the development of clinical practices, and drugs discovery in treating osteoporosis.展开更多
In this paper,the buckling behaviors of axially functionally graded and non-uniform Timoshenko beams were investigated.Based on the auxiliary function and power series,the coupled governing equations were converted in...In this paper,the buckling behaviors of axially functionally graded and non-uniform Timoshenko beams were investigated.Based on the auxiliary function and power series,the coupled governing equations were converted into a system of linear algebraic equations.With various end conditions,the characteristic polynomial equations in the buckling loads were obtained for axially inhomogeneous beams.The lower and higher-order eigenvalues were calculated simultaneously from the multi-roots due to the fact that the derived characteristic equation was a polynomial one.The computed results were in good agreement with those analytical and numerical ones in literature.展开更多
基金supported by grants from Shanghai Yangfan Program (15YF1412200)Longhua Medical Team Project (LYTD-23)+4 种基金Longhua natural science program (14YR03)the Independent Innovation Program Supported by Science and Technology Innovation of the "085" First-class Disciplines Construction of Shanghai University of TCM (085ZY1217)the National Natural Science foundation of major international cooperation projects (81220108027)the Program of Natural Science Foundation of China (81202708, 81072831, 81102605, 81102606, 81373667, 81102606, 81202708)the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT, IRT1270)
文摘Kidney governing bone theory plays an important role in treating bone metabolic disease such as osteoporosis, and many tonifying kidney prescriptions/herbs are widely used in Traditional Chinese Medicine(TCM). However, the exact biological basis of kidney governing bone theory in the context of new advances in biology is still not fully established. In this paper, the content of kidney governing bone theory in biology has been fully demonstrated from different aspects. We first propose that bone and kidney mutually affect each other in pathology and physiology, particularly through homeostasis of calcium, phosphorus and fibroblast growth factor-23(FGF-23). Next, we identify that tonifying kidney prescriptions/herbs exert bone protective effects, thus treating osteoporosis by regulating bone formation and bone resorption.Furthermore, the exact molecular mechanisms of tonifying kidney prescriptions, herbs and their effective components in treating osteoporosis have been systematically reviewed. Finally, we come into the conclusion that kidney regulating bone mineral homeostasis, bone protective effects of tonifying kidney herbs and regulatory effects on bone homeostasis are all the manifestations of kidney governing bone theory.Therefore, the new insights into kidney governing bone theory in biology will promote the development of clinical practices, and drugs discovery in treating osteoporosis.
基金Project supported by the Funds of the Natural Science Foundation of Guangdong Province(Nos.S2013010012463 and S2013010014485)the Excellent Teacher Scheme in Guangdong Higher Education Institutions(No.Yq2014332)the Funds of the Guangdong college discipline construction(Nos.2013KJCX0189 and 2014KZDXM063)
文摘In this paper,the buckling behaviors of axially functionally graded and non-uniform Timoshenko beams were investigated.Based on the auxiliary function and power series,the coupled governing equations were converted into a system of linear algebraic equations.With various end conditions,the characteristic polynomial equations in the buckling loads were obtained for axially inhomogeneous beams.The lower and higher-order eigenvalues were calculated simultaneously from the multi-roots due to the fact that the derived characteristic equation was a polynomial one.The computed results were in good agreement with those analytical and numerical ones in literature.
