Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and af...Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.展开更多
Despite serious difficulties caused by the civil war in China and the military confrontation in Korea, over 1,200 Chinese students and scholars returned from the United States （U.S.） to their homeland in the 1950s. ...Despite serious difficulties caused by the civil war in China and the military confrontation in Korea, over 1,200 Chinese students and scholars returned from the United States （U.S.） to their homeland in the 1950s. While the effort made by the returnees and the Communist regime has been studied, the role played by the U.S. government remains unclear. Relying mostly on archived government documents and published individual recollections, this paper shows that Washington provided most of its assistance to the Chinese students through the emergency aid program, which not only covered all the educational costs for about three quarters of them, but also paid travel expenses for about two thirds of the returnees. In addition, Washington assisted many students in obtaining visas from the British government for their transfer in Hong Kong and offered them room, board, and other services while they were waiting for their transportation in San Francisco. The examination of the helping hand extended by Washington to these returning Chinese students can enhance our understanding of the complex and dynamic nature of Sino-American relations during the Cold War.展开更多
基金supported by American Diabetes Association,American Heart Association,NIH NIEHS,NIH NIA,NIH NINDS,and NIH ARRA
文摘Throughout the globe,diabetes mellitus（DM） is increasing in incidence with limited therapies presently available to prevent or resolve the significant complications of this disorder.DM impacts multiple organs and affects all components of the central and peripheral nervous systems that can range from dementia to diabetic neuropathy.The mechanistic target of rapamycin（m TOR） is a promising agent for the development of novel regenerative strategies for the treatment of DM.m TOR and its related signaling pathways impact multiple metabolic parameters that include cellular metabolic homeostasis,insulin resistance,insulin secretion,stem cell proliferation and differentiation,pancreatic β-cell function,and programmed cell death with apoptosis and autophagy.m TOR is central element for the protein complexes m TOR Complex 1（m TORC1） and m TOR Complex 2（m TORC2） and is a critical component for a number of signaling pathways that involve phosphoinositide 3-kinase（PI 3-K）,protein kinase B（Akt）,AMP activated protein kinase（AMPK）,silent mating type information regulation 2 homolog 1（Saccharomyces cerevisiae）（SIRT1）,Wnt1 inducible signaling pathway protein 1（WISP1）,and growth factors.As a result,m TOR represents an exciting target to offer new clinical avenues for the treatment of DM and the complications of this disease.Future studies directed to elucidate the delicate balance m TOR holds over cellular metabolism and the impact of its broad signaling pathways should foster the translation of these targets into effective clinical regimens for DM.
文摘Despite serious difficulties caused by the civil war in China and the military confrontation in Korea, over 1,200 Chinese students and scholars returned from the United States （U.S.） to their homeland in the 1950s. While the effort made by the returnees and the Communist regime has been studied, the role played by the U.S. government remains unclear. Relying mostly on archived government documents and published individual recollections, this paper shows that Washington provided most of its assistance to the Chinese students through the emergency aid program, which not only covered all the educational costs for about three quarters of them, but also paid travel expenses for about two thirds of the returnees. In addition, Washington assisted many students in obtaining visas from the British government for their transfer in Hong Kong and offered them room, board, and other services while they were waiting for their transportation in San Francisco. The examination of the helping hand extended by Washington to these returning Chinese students can enhance our understanding of the complex and dynamic nature of Sino-American relations during the Cold War.
