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Implications of Elevated Serum Cortisol in the Onset of Postoperative Delirium Following Off-Pump Coronary Artery Bypass Grafting: Insights from a Bangladesh-Based Single Center Experience
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作者 Vivek Kumar Jha Md Abir Tazim Chowdhury +6 位作者 Munama Magdum Manoj Tiwari Md Abul Bashar Maruf Md Saiful Islam Khan Priyanka Sinha Rajesh Naryan Kapar Md. Rezwanul Hoque 《World Journal of Cardiovascular Diseases》 CAS 2024年第4期252-267,共16页
Background: Following coronary artery bypass grafting (CABG), delirium emerges as a prevalent complication. This study aimed to assess the correlation between elevated serum cortisol levels and the occurrence of posto... Background: Following coronary artery bypass grafting (CABG), delirium emerges as a prevalent complication. This study aimed to assess the correlation between elevated serum cortisol levels and the occurrence of postoperative delirium subsequent to off-pump CABG. Methods: Conducted in the Department of Cardiac Surgery at BSMMU from October 2020 to September 2022, this comparative cross-sectional study included a total of 44 participants. Subjects, meeting specific criteria, were purposefully assigned to two groups based on off-pump CABG. Group A (n = 22) consisted of patients with normal serum cortisol levels, while Group B (n = 22) comprised individuals with high serum cortisol levels on the first postoperative day. Delirium onset was assessed at the bedside in the ICU on the 1st, 2nd, 3rd, 4th, and 5th postoperative days using standard tools, namely the Richmond Agitation Sedation score (RASS) and The Confusion Assessment Method (CAM-ICU). Data were collected based on the presence or absence of delirium. Statistical analysis utilized SPSS version 26.0, employing an independent Student’s t-test for continuous data and chi-square and Fischer’s exact test for categorical data. A p-value ≤ 0.05 was considered statistically significant. Results: Group-A had a mean age of 54.50 ± 17.97, and Group-B had a mean age of 55.22 ± 15.45, both with a male predominance (81.81% and 86.36% respectively). The mean serum cortisol level was significantly higher in Group B (829.71 ± vs. 389.98 ± 68.77). Postoperative delirium occurred in 27.3% of Group B patients, statistically significant compared to the 4.5% in Group A. However, patients in Group B who developed delirium experienced significantly longer postoperative ICU and hospital stays (79.29 ± 12.27 vs. 11.44 ± 2.85, p ≤ 0.05). There was one mortality in Group B, which was statistically not significant. Conclusion: This study observed a significant association between elevated serum cortisol levels in the postoperative period and the occurrence of postoperative delirium after off-pump coronary artery bypass grafting. 展开更多
关键词 Coronary Artery Bypass grafting (CABG) Serum Cortisol Postoperative Delirium BANGLADESH
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“Grafting from”法制备高载量大孔弱阳离子交换层析介质
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作者 郭旺 姜泽平 +6 位作者 马磊 乔娟 莫文清 靳海波 何广湘 黄永东 张荣月 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2024年第3期64-72,共9页
针对大孔聚合物层析介质孔径大、比表面积低而导致的蛋白结合容量低的问题,采用“graftingfrom”策略,以大孔聚丙烯酸酯微球为基质,通过氧化还原引发甲基丙烯酸在微球表面接枝聚合,制备了高载量弱阳离子交换层析介质.研究了单体浓度、... 针对大孔聚合物层析介质孔径大、比表面积低而导致的蛋白结合容量低的问题,采用“graftingfrom”策略,以大孔聚丙烯酸酯微球为基质,通过氧化还原引发甲基丙烯酸在微球表面接枝聚合,制备了高载量弱阳离子交换层析介质.研究了单体浓度、过硫酸钾浓度及反应温度等因素对蛋白结合容量的影响.所得介质的蛋白静态结合容量和动态结合容量分别达到252.21和157.25mg/mL;同时发现具有一定离子交换容量的该类介质能够在0.2 mol/L NaCl缓冲液中保持100 mg/mL的蛋白结合容量.将该层析介质用于鸡卵清中溶菌酶的纯化,获得了较高的纯化效率. 展开更多
关键词 弱阳离子交换层析介质 大孔聚合物 蛋白结合容量 grafting from法 分离纯化
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A nursing protocol targeting risk factors for reducing postoperative delirium in patients following coronary artery bypass grafting:Results of a prospective before-after study 被引量:6
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作者 Weiying Zhang Yan Sun +4 位作者 Yang Liu Wenjuan Qiu Xiaofei Ye Guihong Zhang Lingjuan Zhang 《International Journal of Nursing Sciences》 2017年第2期81-87,共7页
Objective: The results of postoperative delirium (POD) warrant testing for prevention. The purpose of this study was to determine whether a nursing intervention targeting risk factors could decrease the inci-dence of ... Objective: The results of postoperative delirium (POD) warrant testing for prevention. The purpose of this study was to determine whether a nursing intervention targeting risk factors could decrease the inci-dence of POD among patients who had coronary artery bypass grafting (CABG) in China.Methods: A prospective before-after study was conducted between April 2014 and April 2015. A nursing delirium intervention protocol targeting risk factors for delirium was performed for 141 patients un-dergoing CABG in a cardiothoracic ICU from November 2014 to April 2015. Intervention consisted of screening for delirium risk factors, followed by targeted risk factor modification, including pain control, early catheter removal, patient orientation using the 5W1H procedure, increased family visits, mini-mizing care-related interruptions, comfortable nursing and monitoring for sleeping difficulties. Out-comes of the Intervention Group were compared with those of the Control Group for 137 CABG patients from April 2014 to October 2014. Delirium was assessed using the confusion assessment method for the intensive care unit (CAM-ICU). The sample size was justified by PASS2000, based on previous data of delirium incidence in our institution (30%). Main results: Delirium incidence during the first seven postoperative days was significantly lower in the Intervention Group at 13.48%(19/141) vs. 29.93%(41/137) for the Control Group (x2=11.112, P=0.001). In addition, POD in the Intervention Group occurred between the 3rd and 6th postoperative days, while POD in the Control Group mainly occurred on the first three days postoperatively. Delirium in the Intervention Group occurred later than delirium in the Control Group (x2=12.743, P<0.001). Length of ICU stay was reduced significantly (Z= -6.026, P<0.001). Conclusion: The application of a nursing protocol targeting risk factors in this study seems to be asso-ciated with a lower incidence of POD in patients after CABG. This finding suggests that managing the predictors properly is one of the effective strategies to prevent delirium. 展开更多
关键词 Postoperative delirium Coronary artery bypass grafting Risk factors Nursing protocol
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Histological, physio-biochemical, and transcriptomic analyses reveal the potential limiting factors for successful grafting of pecan
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作者 Zhenghai Mo Xufeng Yang +2 位作者 Longjiao Hu Min Zhai Jiping Xuan 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第6期317-327,共11页
Budding is an important grafting technique to asexually propagate pecan(Carya illinoinensis(Wangenh.)K.Koch).To determine factors that might hamper success-ful budding of the species,a representative easy-to-survive c... Budding is an important grafting technique to asexually propagate pecan(Carya illinoinensis(Wangenh.)K.Koch).To determine factors that might hamper success-ful budding of the species,a representative easy-to-survive cultivar‘Pawnee’and a typical difficult-to-survive culti-var‘Jinhua’were used for comprehensive analysis.Mor-phological observation showed that cells surrounding the secretory cells or sieve tube had collapsed in‘Jinhua’but not in‘Pawnee’during grafting.‘Jinhua’might suffer more hypoxia stress than‘Pawnee’as‘Jinhua’had higher catalase,superoxide dismutase,polyphenol oxidase,pyruvate decar-boxylase(PDC),alcohol dehydrogenase(ADH)activities during grafting and contained greater levels of hydrogen per-oxide 12 days after grafting(DAG).Transcriptions of PDC and ADH were also up-regulated significantly in‘Jinhua’whereas they were not significantly affected in‘Pawnee’.Phenylalanine ammonia-lyase activities of‘Jinhua’were consistently lower than that of‘Pawnee’.Initial phenol con-tents were similar between the two cultivars.Graft-promot-ing substances,including soluble sugar,soluble protein,and gibberellin(GA)were incompletely recovered in‘Jinhua’12 DAG while fully restored in‘Pawnee’.Increased levels of trans-zeatin riboside in‘Jinhua’were much smaller than in‘Pawnee’3 DAG.The contents of indole-3-acetic acid were similar,and the dynamics of abscisic acid were the same between the two genotypes.Results suggest that hypoxia stress and shortages of sugar,protein,GA,and cytokinin during the healing process might be key factors limiting successful budding of pecan.The degree of scion-rootstock compatibility and the content of phenols might be excluded as constraints for successful budding. 展开更多
关键词 PECAN grafting HISTOLOGY BIOCHEMISTRY Transcriptome analysis
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Improvement of ionic conductivity of solid polymer electrolyte based on Cu-Al bimetallic metal-organic framework fabricated through molecular grafting
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作者 Liu-bin SONG Tian-yuan LONG +5 位作者 Min-zhi XIAO Min LIU Ting-ting ZHAO Yin-jie KUANG Lin JIANG Zhong-liang XIAO 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第9期2943-2958,共16页
A composite solid electrolyte comprising a Cu-Al bimetallic metal-organic framework(CAB),lithium salt(LiTFSI)and polyethylene oxide(PEO)was fabricated through molecular grafting to enhance the ionic conductivity of th... A composite solid electrolyte comprising a Cu-Al bimetallic metal-organic framework(CAB),lithium salt(LiTFSI)and polyethylene oxide(PEO)was fabricated through molecular grafting to enhance the ionic conductivity of the PEO-based electrolytes.Experimental and molecular dynamics simulation results indicated that the electrolyte with 10 wt.%CAB(PL-CAB-10%)exhibits high ionic conductivity(8.42×10~(-4)S/cm at 60℃),high Li+transference number(0.46),wide electrochemical window(4.91 V),good thermal stability,and outstanding mechanical properties.Furthermore,PL-CAB-10%exhibits excellent cycle stability in both Li-Li symmetric battery and Li/PL-CAB-10%/LiFePO4 asymmetric battery setups.These enhanced performances are primarily attributable to the introduction of the versatile CAB.The abundant metal sites in CAB can react with TFSI~-and PEO through Lewis acid-base interactions,promoting LiTFSI dissociation and improving ionic conductivity.Additionally,regular pores in CAB provide uniformly distributed sites for cation plating during cycling. 展开更多
关键词 polyethylene oxide Cu−Al bimetallic metal-organic framework solid lithium metal battery molecular grafting ionic conductivity
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Efficient and selective removal of Pb(Ⅱ) from landfill leachate using L-serine-modified polyethylene/polypropylene nonwoven fabric synthesized via radiation grafting technique
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作者 Xin-Xin Feng Cheng Li +6 位作者 Xuan-Zhi Mao Wan-Ning Ren Yang Gao Yu-Long He Zhe Xing Rong Li Guo-Zhong Wu 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第4期144-155,共12页
In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl me... In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl methacrylate and subsequent L-serine modification.The effect of the absorbed dose was investigated in the range of 5–50 kGy.NWF-serine was characterized by Fourier transform infrared spectroscopy,thermogravimetric analysis,and scanning electron microscopy.Batch adsorption tests were conducted to investigate the influences of pH,adsorption time,temperature,initial concentration,and sorbent dosage on the Pb(Ⅱ) adsorption performance of NWF-serine.The results indicated that Pb(Ⅱ) adsorption onto NWF-serine was an endothermic process,following the pseudo-second-order kinetic model and Langmuir isotherm model.The saturated adsorption capacity was 198.1 mg/g.NWF-serine exhibited Pb(Ⅱ) removal rates of 99.8% for aqueous solutions with initial concentrations of 100 mg/L and 82.1% for landfill leachate containing competitive metal ions such as Cd,Cu,Ni,Mn,and Zn.Furthermore,NWF-serine maintained 86% of its Pb(Ⅱ) uptake after five use cycles.The coordination of the carboxyl and amino groups with Pb(Ⅱ) was confirmed using X-ray photoelectron spectroscopy and extended X-ray absorption fine structure analysis. 展开更多
关键词 Landfill leachate Radiation grafting Polyethylene/polypropylene nonwoven fabric Pb(Ⅱ)removal
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Outcomes of surgical correction of Peyronie’s disease with plaque excision and grafting: Comparison of testicular tunica vaginalis graft versus bovine pericardium graft
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作者 Ali Eslahi Faisal Ahmed +5 位作者 Mohammad Reza Askarpour Hossein-Ali Nikbakht Iman Shamohammadi Payam Ghasemi Hanieh Alimardani Bahareh Ebrahimi 《Asian Journal of Urology》 CSCD 2024年第3期497-503,共7页
Objective:Peyronie’s disease(PD)is an abnormal wound healing in the penile tunica albuginea.After fibrotic plaque excision,different graft materials have been used to repair the defects,but the optimal graft remains ... Objective:Peyronie’s disease(PD)is an abnormal wound healing in the penile tunica albuginea.After fibrotic plaque excision,different graft materials have been used to repair the defects,but the optimal graft remains unknown.This study aimed to compare the functional outcomes of testicular tunica vaginalis grafts and bovine pericardium grafts in patients with severe PD.Methods:A retrospective comparative study was conducted on 33 PD patients undergoing partial plaque excision and grafting from September 2015 to May 2021.The patients were divided into two groups depending on the type of graft used.For 15 patients in Group B,testicular tunica vaginalis grafts were used to repair the defect,while for 18 patients in Group A,bovine pericardium grafts were used.Data of the patient’s age,comorbidities,sexual function,penile curvature,postoperative complications,need for further treatment,change in penile length,and satisfaction were gathered and compared between the groups.Sexual function was evaluated using the 5-item version of the International Index of Erectile Function(IIEF-5),and a functional less than 20-degree penile curvature after surgery was considered a successful intervention.Results:There was no difference in age,comorbidities,degree of curvature,perioperative IIEF-5,operative time,plaque size,or complication rates.After surgery,a statistically significant improvement in curvature degree(p<0.05)and satisfactory penile appearance(p<0.05)were seen in both groups without any superiority between the two groups(p=0.423 and p=0.840,respectively).With a 30-month follow-up,the IIEF-5 was consistent in both groups,with no statistical significance between the groups(p=0.492).The main change in penile length during the operation was increased and still positive in the last follow-up in both groups without statistical significance(p=0.255 and p=0.101,respectively).Conclusion:Partial plaque excision and corporoplasty with both testicular tunica vaginalis or bovine pericardium grafts are equally effective in treating males with clinically significant PD. 展开更多
关键词 Peyronie's disease Plaque excision Testicular tunica vaginalis graft Bovine pericardium graft
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Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil-water separation
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作者 Ying Sun Wen-Rui Wang +7 位作者 Dan-Yi Li Si-Yi Xu Lin Lin Man-Li Lu Kai Fan Chen-Yang Xing Lin-Fan Li Ji-Hao Li 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第9期103-114,共12页
This paper presents a superhydrophobic melamine(ME)sponge(ME-g-PLMA)prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA)onto an ME sponge for efficient oil... This paper presents a superhydrophobic melamine(ME)sponge(ME-g-PLMA)prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA)onto an ME sponge for efficient oil–water separation.The obtained ME-g-PLMA sponge had an excellent pore structure with superhydrophobic(water contact angle of 154°)and superoleophilic properties.It can absorb various types of oils up to 66–168 times its mass.The ME-g-PLMA sponge can continuously separate oil slicks in water by connecting a pump or separating oil underwater with a gravity-driven device.In addition,it maintained its highly hydrophobic properties even after long-term immersion in different corrosive solutions and repeated oil adsorption.The modified ME-g-PLMA sponge exhibited excellent separation properties and potential for oil spill cleanup. 展开更多
关键词 Radiation-induced graft polymerization Oil–water separation SPONGE SUPERHYDROPHOBIC
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Clinical effect of botulinum toxin type A combined with autologous fat grafting in patients with nasolabial fold depression
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作者 Ru-Jie Wang Ying Wang +1 位作者 Jin-Fang Wu Ting-Ting Si 《World Journal of Clinical Cases》 SCIE 2024年第22期4973-4982,共10页
BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin ... BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin A(BTX-A)injection(AFG+BTX-A injection)has been gradually applied in the treatment of patients with NLF depression.Although studies have been conducted on the efficacy and safety of AFG+BTX-A injection in treating NLF depression,the experimental design,observational indicators,and sample enrollment criteria vary remarkably,making it difficult to draw convincing and consistent conclusions.Thus,further relevant research is warranted.AIM To assess the esthetic improvement,efficacy,and safety of AFG+BTX-A injections in patients with NLF depression.METHODS This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021.These patients were categorized into control(n=30)and observation(n=30)groups.The observation group received AFG+BTX-A injection,whereas the control group underwent AFG only.All patients were evaluated using the wrinkle severity rating scale(WSRS)and global aesthetic improvement scale.The compactness of facial contours,skin evaluation indexes,adverse reactions,and satisfaction of the two groups were evaluated 3 months postoperatively.RESULTS The WSRS scores of the observation group at 1,3,and 6 months postoperatively were lower than those of the control group(P<0.05).Three months postoperatively,facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group(P<0.05).The compactness of facial contours was better in the observation group than in the control group(P<0.05).In addition,no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness,facial asymmetry,facial bruising,and facial concavity inequality(P>0.05).CONCLUSION AFG+BTX-A injection is a highly safe,cost-effective,effective,and long-lasting treatment for NLF depression with high esthetic value,which should be promoted in the future. 展开更多
关键词 Nasolabial fold depression Botulinum toxin A Autologous fat grafting ESTHETICS SAFETY
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Impact of specialized nursing outpatient case management on postcoronary artery bypass grafting patients
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作者 Tong Li Fang-Hui Lu Qing Zhao 《World Journal of Clinical Cases》 SCIE 2024年第17期3035-3044,共10页
BACKGROUND Some patients with coronary atherosclerotic heart disease experience major adverse cardiac events(MACE)and require readmission after Coronary Artery Bypass Grafting(CABG)surgery.This is often attributed to ... BACKGROUND Some patients with coronary atherosclerotic heart disease experience major adverse cardiac events(MACE)and require readmission after Coronary Artery Bypass Grafting(CABG)surgery.This is often attributed to patients'unhealthy lifestyles and dietary habits,inadequate understanding of the disease,and poor disease management compliance.Thus,searching for more targeted nursing intervention models that can enhance patients'self-management abilities and reduce the risk of readmission after CABG surgery is significant.AIM To observe the impact of specialized nursing outpatient case management on patients after CABG surgery.METHODS A total of 103 patients who underwent CABG surgery in our hospital between April 2021 and April 2022 comprised the study sample.The patients were divided into two groups using an odd-even number grouping method.The control group received routine nursing care,while the case management group received specialized nursing outpatient case management.The differences in psychological status,adherence to medical treatment,self-care ability,knowledge mastery,quality of life scores,and the occurrence rate of MACE were compared between the two groups.RESULTS After the intervention,the case management group had lower scores on the selfrating depression scale and self-rating anxiety scale and lower MACE rate,as well as higher scores for adherence to a healthy diet,medication adherence,good lifestyle habits,regular exercise,and timely follow-up,higher scores on the Coronary Heart Disease Self-Management Scale,higher scores for managing adverse habits,symptoms,emotional cognition,emergency response,disease knowledge,general lifestyle,and treatment adherence,higher scores for understanding coronary heart disease,recognizing the importance of medication adherence,understanding selfcare points after CABG surgery,and being aware of post-CABG precautions,higher scores for physical well-being,disease condition,general health,social-psychological well-being,and work-related aspects(P<0.05).CONCLUSION Specialized nursing outpatient case management can enhance patient adherence to medical treatment,knowledge mastery,psychological well-being,and overall quality of life in patients after CABG surgery. 展开更多
关键词 Specialized nursing Case management Coronary artery bypass grafting Adherence to medical treatment Knowledge mastery Psychological status
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Negative pressure device-assisted autologous fat grafting: A case report
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作者 Rao Fu Jiaqi Qin +2 位作者 Fangzhou Xie Xintao Wang Yun Xie 《Chinese Journal of Plastic and Reconstructive Surgery》 2024年第1期34-36,共3页
This report describes a novel technique for improving depressed scars using negative pressure suction-assisted autologous fat grafting.A 35-year-old woman presented with a 20-year history of bilateral central buttock ... This report describes a novel technique for improving depressed scars using negative pressure suction-assisted autologous fat grafting.A 35-year-old woman presented with a 20-year history of bilateral central buttock con-cavities,causing aesthetic concerns.To maximize fat graft survival and enhance tissue volume,we implemented intermittent negative pressure suction on the recipient area for one month preoperatively.The patient expressed satisfaction with the cosmetic outcome,and a three-month follow-up confirmed a significantly improved fat graft survival rate.This minimally invasive,cost-effective,and easily reproducible technique offers a promising clinical strategy for treating depressed scars. 展开更多
关键词 Negative pressure Autologous fat grafting Depressed scars ADHESION
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Surgical Treatment of Osteonecrosis of the Femoral Head Using Minimally Invasive Surgical Drilling and Cancellous Grafting at Brazzaville University Hospital
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作者 Kevin Parfait Bienvenu Bouhelo-Pam Marius Monka +4 位作者 Arnauld Sledje Wilfrid Bilongo Bouyou Regis Perry Massouama Paul Yèlai Ikounga Roger Bertrand Sah Mbou Armand Moyikoua 《Open Journal of Orthopedics》 2024年第2期122-132,共11页
Introduction: Osteonecrosis of the femoral head (ONTF) is a debilitating condition. Several treatments have been proposed with controversial results. The aim of our study was to evaluate treatment by surgical drilling... Introduction: Osteonecrosis of the femoral head (ONTF) is a debilitating condition. Several treatments have been proposed with controversial results. The aim of our study was to evaluate treatment by surgical drilling coupled with in situ cancellous grafting. Materials and methods: Our study was a case-control study conducted at Brazzaville University Hospital from 1st January 2018 to 31 December 2023. It compared two groups of patients with ONTF: non-operated (13 patients, 20 hips) and operated (22 patients, 35 hips). We used the visual digital scale (VDS) for pain assessment, the Merle D’Aubigne-Postel (MDP) scoring system for clinical and functional assessment, and the evolution of necrosis. Results: The group of non-operated patients had a mean age of 35.69 ± 3.4 years, no improvement in pain with an EVN above seven at the last recoil and a mean global MDP score falling from 12.7 before offloading to 10.13 at one year. The group of patients operated on had a mean age of 37.86 ± 7.02 years, a significant reduction in pain (p = 0.00004) and a significantly increased MDP score (p = 0.0034). A comparison of the two groups of patients showed significant stabilization of the necrotic lesions in the operated patients (p = 0.00067), with better satisfaction in the same group. Conclusion: Surgical drilling combined with grafting in the treatment of early-stage ONTF has improved progress in our series. The technique is reproducible and less invasive. It has made it possible to delay unfavorable progression and, consequently, hip replacement surgery. 展开更多
关键词 HIP Osteonecrosis of the Femoral Head Conservative Treatment Surgical Drilling Bone grafting
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Off-Pump Coronary Artery Bypass Grafting in Patients with Left Ventricular Dysfunction: Short-Term Results from a Single Center in Bangladesh
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作者 Muhit Abdullah Md. Abir Tazim Chowdhury +9 位作者 Satyajit Sharma Rehana Akther Munama Magdum Munjerin Refat Synthee Md. Zafar-Al-Nimari Saikat Das Gupta Saleh Ahmed Samir Kumar Biswas M. Quamrul Islam Talukder Farooque Ahmed 《World Journal of Cardiovascular Surgery》 2024年第9期145-156,共12页
Background: Off-pump coronary artery bypass grafting (OPCAB) is considered a safer alternative to on-pump surgery, especially in patients with left ventricular dysfunction (LVD). Objectives: This study assessed short-... Background: Off-pump coronary artery bypass grafting (OPCAB) is considered a safer alternative to on-pump surgery, especially in patients with left ventricular dysfunction (LVD). Objectives: This study assessed short-term outcomes and functional improvements in LVD patients post-OPCAB. Methods: The study included 200 coronary artery disease patients who underwent isolated off-pump coronary artery bypass grafting (OPCAB) at the National Heart Foundation Hospital and Research Institute between January 2019 and June 2020. Patients were categorized into Group 1, with a left ventricular ejection fraction (LVEF) of 30% - 39%, and Group 2, with an LVEF of 40% or higher. Echocardiographic assessments of left ventricular dimensions and ejection fraction were performed preoperatively, at discharge, and one month postoperatively. Results: In Group 1, preoperative left ventricular internal dimensions during diastole (LVIDd) and systole (LVIDs) were 53.48 ± 4.40 mm and 44.23 ± 3.93 mm, respectively, with a left ventricular ejection fraction (LVEF) of 35.28% ± 2.26%. At discharge, these values improved to 51.58 ± 4.04 mm (LVIDd), 41.23 ± 5.30 mm (LVIDs), and 39.25% ± 3.75% (LVEF). One month postoperatively, further improvements were observed: 46.29 ± 3.76 mm (LVIDd), 37.45 ± 3.68 mm (LVIDs), and 43.22% ± 4.67% (LVEF). Group 2 showed similar positive outcomes, with preoperative values of 47.09 ± 5.06 mm (LVIDd), 35.11 ± 5.25 mm (LVIDs), and 50.13% ± 7.25% (LVEF), improving to 42.37 ± 4.18 mm (LVIDd), 31.05 ± 4.19 mm (LVIDs), and 55.33% ± 7.05% (LVEF) at one month postoperatively. Both groups demonstrated significant improvements in left ventricular function and NYHA class, with most patients moving from class III/IV to I/II. Complications were minimal, and no mortality was observed. Conclusion: OPCAB is safe and effective for patients with LVEF 30% - 39% and LVEF ≥ 40%, providing significant short-term functional improvements without increased risk. 展开更多
关键词 Off-Pump Coronary Artery Bypass grafting Left Ventricular Dysfunction (LVD) Short-Term Outcomes
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Delayed Grafting as a Valid Technique in Burn Management: Experience from a Burn Unit in Oman
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作者 Taif Alsafy Joe Jacob +10 位作者 Anish Thadathil Elias Ahmed Salah El Din Salim Mohammed Ghawas Majid Tariq Saud Albusaidi Ahmed Al Jabri Al Anood Al Hadhrami Mutazz Obeid Al Khaldi Moath Abdelhamid Shummo Karim Mohamed Haridi Aml Eid Saleh Said Al-Busaidi 《Modern Plastic Surgery》 2024年第1期9-14,共6页
Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 5... Background: Early excision and grafting has been the preferred method of managing major burns around the world since 1970. Considering the advances in health care and the development of new antibiotics over the past 50 years, delayed grafting as a technique for the management of burns over 15%-20% of total body surface area (TBSA) could have comparable results to that of early excision. This study aims to highlight the outcomes of practicing delayed grafting in burn patients. Methods: A case series analysis was performed of 51 patients who were admitted to the burns unit in Sultan Qaboos Hospital Salalah with over 20% TBSA between January 2014 and December 2019. The patients received prophylactic antibiotics and silver sulphadiazine dressing until the burn eschar had completely separated, followed by grafting. Results: Two patients were lost during the entire duration of the study. The mortality rate was comparable to that of early excision, while the rate of hypertrophic scarring was lower than the range reported by other studies. Conclusion: In the management of patients with over 20% TBSA, delayed grafting after complete separation of eschar is still a valid technique. 展开更多
关键词 BURNS Burn Units Burn Management Delayed grafting Major Burns Treatment Efficacy
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A systematic review of progenitor survival and maturation in Parkinsonian models
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作者 Giulia Comini Eilís Dowd 《Neural Regeneration Research》 SCIE CAS 2025年第11期3172-3178,共7页
Stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell source.Unlike current therapeutic options for patient... Stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell source.Unlike current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to patients.The ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian brain.Because the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March 2024.After screening,76 articles were included in the analysis from which 178 separate transplant studies were identified.From these,graft survival could be assessed in 52 studies and differentiation in 129 studies.Overall,we found that graft survival ranged from<1% to 500% of cells transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients. 展开更多
关键词 cell replacement therapy DIFFERENTIATION embryonic stem cells GRAFT induced pluripotent stem cells Parkinson's disease SURVIVAL TRANSPLANT
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Physiology of in-situ arterial revascularization in coronary artery bypass grafting: Preoperative,intraoperative and postoperative factors and influences
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作者 T Bruce Ferguson Jr 《World Journal of Cardiology》 CAS 2016年第11期623-637,共15页
Surgical revascularization with coronary artery bypass grafting(CABG) has become established as the most effective interventional therapy for patients with moderately severe and severe stable ischemic heart disease(SI... Surgical revascularization with coronary artery bypass grafting(CABG) has become established as the most effective interventional therapy for patients with moderately severe and severe stable ischemic heart disease(SIHD). This recommendation is based on traditional 5-year outcomes of mortality and avoidance of myocardial infarction leading to reintervention and/or cardiac death. However, these results are confounded in that they challenge the traditional CABG surgical tenets of completeness of anatomic revascularization, the impact of arterial revascularization on late survival, and the lesser impact of secondary prevention following CABG on late outcomes. Moreover, the emergence of physiologic-based revascularization with percutaneous cardiovascular intervention as an alternative strategy for revascularization in SIHD raises the question of whether there are similar physiologic effects in CABG. Finally, the ongoing ISCHEMIA trial is specifically addressing the importance of the physiology of moderate or severe ischemia in optimizing therapeutic interventions in SIHD. So it is time to address the role that physiology plays in surgical revascularization. The long-standing anatomic framework for surgical revascularization is no longer sufficient to explain the mechanisms for short-term and long-term outcomes in CABG. Novel intraoperative imaging technologies have generated important new data on the physiologic blood flow and myocardial perfusion responses to revascularization on an individual graft and global basis. Long-standing assumptions about technical issues such as competitive flow are brought into question by real-time visualization of the physiology of revascularization. Our underestimation of the impact of Guideline Directed Medical Therapy, or Optimal Medical Therapy, on the physiology of preoperative SIHD, and the full impact of secondary prevention on post-intervention SIHD, must be better understood. In this review, these issues are addressed through the perspective of multi-arterial revascularization in CABG, which is emerging(after 30 years) as the "standard of care" for CABG. In fact, it is the physiology of these arterial grafts that is the mechanism for their impact on long-term outcomes in CABG. Moreover, a better understanding of all of these preoperative, intraoperative and postoperative components of the physiology of revascularization that will generate the next, more granular body of knowledge about CABG, and enable surgeons to design and execute a better surgical revascularization procedure for patients in the future. 展开更多
关键词 Coronary artery bypass grafting Arterial revascularization Myocardial perfusion Surgical outcomes intraoperative imaging
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Study on Top Grafting Technology of Bare Scions of Walnut Trees in Eastern Hebei
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作者 Jinli LIU Qiuxiang YU +2 位作者 Lixian CUI Jing LIU Zhongkui BAI 《Asian Agricultural Research》 2022年第6期41-42,46,共3页
[Objectives]To accelerate the improvement of walnut varieties and change the cultivation status of low yield and poor quality.[Methods]Through experimenting on the optimization technology of walnut trees,this paper st... [Objectives]To accelerate the improvement of walnut varieties and change the cultivation status of low yield and poor quality.[Methods]Through experimenting on the optimization technology of walnut trees,this paper studied the suitable top grafting period and scientific top grafting protection measures of walnut trees in Eastern Hebei,and established the top grafting technology system of walnut.Moreover,this paper explored the impact of different time and scientific management and protection measures on the survival rate and growth of bare scion top grafting of walnut trees.[Results]The grafting time had a great impact on the growth of new shoots,and there were significant differences in the survival rate among different grafting periods.The highest grafting survival rate was 96.97%on April 27 and the lowest grafting survival rate was 66.67%on May 4;the average survival rate was 78.10%.Among them,the survival rate of top grafting was the highest on April 20 and April 27.The growth of new shoots grafted in the early stage was greater than that in the late stage.The growth of new shoots and branches on April 8 and April 20 were the largest,with lengths of 160.3 and 143.7 cm;the thickness was 1.72 and 1.43 cm;the branch lengths were 79.8 and 63.4 cm;the branch thickness was 0.98 and 0.82 cm;the growth index was also the highest on April 8 and April 20 at 10,20,30 d after grafting,which was significantly different from other time periods.[Conclusions]Walnut trees with early grafting in Eastern Hebei can quickly restore their crown growth and had higher yield,thus this technology can be widely applied in Eastern Hebei or Yanshan area. 展开更多
关键词 WALNUT top grafting Survival rate GROWTH
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Features of Management of Patients Undergoing Coronary Artery Bypass Grafting in the Early Postoperative Period
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作者 Musayev Seymur Aydin 《Journal of Pharmacy and Pharmacology》 CAS 2021年第11期364-368,共5页
Objectives:Coronary heart disease(CHD)is a leading cause of death and disability worldwide.Coronary artery bypass graft(CABG)is the most performed surgical procedure to treat coronary heart disease.Along with the stan... Objectives:Coronary heart disease(CHD)is a leading cause of death and disability worldwide.Coronary artery bypass graft(CABG)is the most performed surgical procedure to treat coronary heart disease.Along with the standard medical treatment,the rehabilitation program and exercise activities should be implemented in the treatment process to avoid adverse preoperative events.Methods:Of the 132 patients,30 patients received isolated CABG,30 patients-mitral valve prosthesis,and 72 patients underwent concomitant CABG+mitral valve surgery.The common drug treatments after CABG were aspirin,clopidogrel,beta-blockers,angiotensin-converting enzyme(ACE)inhibitors,statins.The rehabilitation program,including physical and psychological therapy,was initiated from the first postoperative day and continued throughout the hospital stay.Results:The duration of physical therapy was a course of 10-12 days with a further transition to the next stage of rehabilitation treatment.Of the 132 operated patients,only 37(28%)had an adequate mental state.The remaining 95(72%)patients had significant mental changes including neurosis(20 cases),anxiety-depressive state(49 cases),hypochondria(19 cases),hysteria(7 cases).Through the individual approach and medical treatment,121(91.7%)patients had an adequate mental state on days 12-14 postoperatively.The mortality was in 8.3%(11patients).Conclusions:The implementation of rehabilitation programs including physical and psychological therapy accelerates convalescence periodand return to normal life of early post-CABG patients. 展开更多
关键词 Ischemic heart disease coronary artery bypass grafting REHABILITATION
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Effects of two modification methods on the mechanical properties of wood flour/recycled plastic blends composites: addition of thermoplastic elastomer SEBS-g-MAH and in-situ grafting MAH 被引量:1
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作者 宋永明 王清文 +2 位作者 韩广平 王海刚 高华 《Journal of Forestry Research》 SCIE CAS CSCD 2010年第3期373-378,399,400,共8页
The effect of maleic anhydride grafted styrene-ethylene- buty-lene-styrene block copolymer (SEBS-g-MAH) and in-situ grafting MAH on mechanical, dynamic mechanical properties of wood flour/recycled plastic blends com... The effect of maleic anhydride grafted styrene-ethylene- buty-lene-styrene block copolymer (SEBS-g-MAH) and in-situ grafting MAH on mechanical, dynamic mechanical properties of wood flour/recycled plastic blends composites was investigated. Recycled plastic polypro-pylene (PP), high-density polyethylene (HDPE) and polystyrene (PS), were mixed with wood flour in a high speed blender and then extruded by a twin/single screw tandem extruder system to form wood flour/recycled plastic blends composites. Results show that the impact properties of the composites were improved more significantly by using SEBS-g-MAH compatibilizer than by using the mixtures of MAH and DCP via reactive blending in situ. However, contrary results were ob-served on the tensile and flexural properties of the corresponding com-posites. In General, the mechanical properties of composites made from recycled plastic blends were inferior to those made from virgin plastic blends, especially in elongation break. The morphological study verified that the interfacial adhesion or the compatibility of plastic blends with wood flour was improved by adding SEBS-g-MAH or in-situ grafting MAH. A better interfacial bonding between PP, HDPE, PS and wood flour was obtained by in-situ grafting MAH than the addition of SEBS-g-MAH. In-situ grafting MAH can be considered as a potential way of increasing the interfacial compatibility between plastic blends and wood flour. The storage modulus and damping factor of composites were also characterized through dynamic mechanical analysis (DMA). 展开更多
关键词 COMPATIBILIZER COMPOSITES in-situ grafting recycled plastic blends wood flour
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Enhance of Grafting Reaction of Acrylic Acid and Acrylamide onto Preirradiated Polypropylene Film 被引量:1
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作者 杨黎明 陈捷 +2 位作者 吴明红 刘昊晟 吕霞娟 《Advances in Manufacturing》 SCIE CAS 2000年第S1期189-192,共4页
Grafting of acrylic acid (AAc) and acrylamide (AAm) onto preirradiated PP film was performed in aqueous solution of AAc and AAm, respectively. Electron beam accelerator was used as irradiation source. The effect of f... Grafting of acrylic acid (AAc) and acrylamide (AAm) onto preirradiated PP film was performed in aqueous solution of AAc and AAm, respectively. Electron beam accelerator was used as irradiation source. The effect of ferrous sulfate, sodium nitrate, methanol and glucose on the degree of grafting was demonstrated. The function of the different additives was compared by the grafting of different monomers (AAc and AAm). The results show that the four of these additives are elective on the grafting of AAc. Only two of these additives, ferrous sulfate and methanol were effective on the grafting of AAm. 展开更多
关键词 Radiation grafting POLYPROPYLENE acrylic acid ACRYLAMIDE
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