Preparation of Ephedra houttuynia Granule and Its Therapeutic Mechanism of Anti-Mycoplasma gallisepticum Infection Based on Network Pharmacology

The use of Chinese herbal medicines can replace antibiotics that cause drug-resistance problems,which are currently necessary for disease control.In this paper,a traditional Chinese medicine compound named Ephedra houttuynia granule for the treatment of Mycoplasma galliscepticum(MG)infection was prepared.Furthermore,its action mechanism was explored through network pharmacology.The optimal extraction and granulation processes of the compound were determined by high performance liquid chromatography(HPLC)method and L9 orthogonal test,and in the treatment experiment,Ephedra houttuynia granule showed a significant therapeutic effect on MG infection.In the study of network pharmacology,the results showed that the core targets of Ephedra houttuynia granule against MG infection were vascular endothelial growth factor(VEGFA),fos proto-oncogene(FOS),prepro-coagulation factor II(F2),etc.,the gene ontology/kyoto encyclopedia of genes and genomes(GO/KEGG)analysis results indicated that the signaling pathways of neuroactive ligand receptor interaction,cAMP,IL-17,T cell receptor,and tumor necrosis factor(TNF)might involve in anti-MG infection.In conclusion,this study would provide a new idea for elucidating the action mechanism of other diseases in veterinary clinic,which had a certain guiding significance.

Effects of Post-expanding Lower Temperature Granulating Process on Growth Performance of Piglets

[Objective] The paper was to compare the effects of traditional granulating process and post-expanding lower temperature granulating process on starch gelatinization degree and in vitro protein digestibility of conversation feed, and growth performance of piglets. [Method] Sixty weaned piglets, 25 days old, were randomly divided into two groups, six replicates each group, and each replicate contained five piglets. Piglets in control group were fed with the conversation feed developed by traditional granulating process, and those in experimental group were fed with the conservation feed developed by post-expanding lower temperature granulating process. The trial lasted 28 d. [Result] Compared to traditional granulating process, post-expanding lower temperature granulating process significantly enhanced starch gelatinization degree of conservation feed by56.9%（P〈0.05）, and significantly improved in vitro protein digestibility of conservation feed by 11.48%（P〈0.05）. Compared to the control group, the feed intake of piglets in experimental group was increased by 21.63%（P〈0.05）; the average daily gain was increased by 27.61%（P〈0.05）; the diarrhea rate was lowered; and the feed gain ratio was improved by 4.51%（P〉0.05）. The results suggested that post-expanding lower temperature granulating process effectively enhanced feed digestion and absorption of piglets. [Conclusion] The paper provides a theoretical basis and practical reference for improvement of production process of conservation feed.

Analysis of aerobic granular sludge formation based on grey system theory

Based on grey entropy analysis, the relational grade of operational parameters with aerobic granular sludge＇s granulation indicators was studied. The former consisted of settling time （ST）, aeration time （AT）, superficial gas velocity （SGV）, height/diameter （H/D） ratio and organic loading rates （OLR）, the latter included sludge volume index （SVI） and set-up time. The calculated result showed that for SVI and set-up time, the influence orders and the corresponding grey entropy relational grades （GERG） were： SGV （0.9935） 〉 AT （0.9921） 〉 OLR （0.9894） 〉 ST （0.9876） 〉 H/D （0.9857） and SGV （0.9928） 〉 H/D （0.9914） 〉 AT （0.9909） 〉 OLR （0.9897） 〉 ST （0.9878）. The chosen parameters were all key impact factors as each GERG was larger than 0.98. SGV played an important role in improving SVI transformation and facilitating the set-up process. The influence of ST on SVI and set-up time was relatively low due to its dual functions. SVI transformation and rapid set-up demanded different optimal I-I/D ratio scopes （10-20 and 16-20）. Meanwhile, different functions could be obtained through adjusting certain factors＇ scope.

The ultimate goal of modeling—Simulation of system and plant performance

Modern production processes in chemical, pharmaceutical and biological industries are characterized by complex process structures, which consist of different apparatuses and process steps. Modeling the entire process requires simulating all units altogether, while taking into account interconnections between them, Nevertheless, in the area of solids processing, there is nowadays an unfilled gap from the side of computer support of process modeling in allowing effective optimization and prediction of the behavior of the whole plant, This paper presents a tool for flowsheet simulation which allows the simulation of the stationary behavior of complex processes dealing with solids and its extension towards dynamic modeling, Also, a new simulation concept is proposed on the basis of the multiscale approach. On the macroscale, fiowsheet simulation is performed with the help of the SolidSim system. Parameters for the macromodels in Solid-Sim are predicted by microscale simulation. The models for the two scales are then coupled by inter-scale communication laws. Application of the proposed modeling concept is shown by an example of fluidized bed granulation.