In recent years,distributed photovoltaics(DPV)has ushered in a good development situation due to the advantages of pollution-free power generation,full utilization of the ground or roof of the installation site,and ba...In recent years,distributed photovoltaics(DPV)has ushered in a good development situation due to the advantages of pollution-free power generation,full utilization of the ground or roof of the installation site,and balancing a large number of loads nearby.However,under the background of a large-scale DPV grid-connected to the county distribution network,an effective analysis method is needed to analyze its impact on the voltage of the distribution network in the early development stage of DPV.Therefore,a DPV orderly grid-connected method based on photovoltaics grid-connected order degree(PGOD)is proposed.This method aims to orderly analyze the change of voltage in the distribution network when large-scale DPV will be connected.Firstly,based on the voltagemagnitude sensitivity(VMS)index of the photovoltaics permitted grid-connected node and the acceptance of grid-connected node(AoGCN)index of other nodes in the network,thePGODindex is constructed to determine the photovoltaics permitted grid-connected node of the current photovoltaics grid-connected state network.Secondly,a photovoltaics orderly grid-connected model with a continuous updating state is constructed to obtain an orderly DPV grid-connected order.The simulation results illustrate that the photovoltaics grid-connected order determined by this method based on PGOD can effectively analyze the voltage impact of large-scale photovoltaics grid-connected,and explore the internal factors and characteristics of the impact.展开更多
To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and obj...To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)method.Based on the traditional distribution network evaluation system,a comprehensive evaluation system has been constructed.It fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid connection.The analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment methods.The subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum entropy.Calculate the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different scenarios.By setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.展开更多
For a standalone PV (photovoltaic) power generation system, the author previously proposed a new MPPT (maximum power point tracking) control method in which the I-V characteristics are scanned with a detection int...For a standalone PV (photovoltaic) power generation system, the author previously proposed a new MPPT (maximum power point tracking) control method in which the I-V characteristics are scanned with a detection interval control that operates at specified intervals and monitors the maximum power point. The author has obtained satisfactory results using this new MPPT control method. This paper investigates the application of the new MPPT control method for a PCS (power conditioning system) in a grid-connected type PV power generation system. The experimental results clearly demonstrate that the developed PCS offers outstanding effectiveness in tracking the maximum power point in partially shaded environments.展开更多
Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not complet...Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.展开更多
Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close rel...Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms.Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological processes.The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.展开更多
Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in viv...Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause CMT2.Mutations located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)model.In addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive control.Of these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut allele.We found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in Drosophila.Flies heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal morphology.These Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.展开更多
Dynamic equivalence of the wind farm is a fundamental problem in the simulation of a power system connected with wind farms because it is unpractical to model every generator in a wind farm in detail. In this paper, a...Dynamic equivalence of the wind farm is a fundamental problem in the simulation of a power system connected with wind farms because it is unpractical to model every generator in a wind farm in detail. In this paper, an Equivalence Method based on the Output Characteristics (EMOC) is proposed, with which the wind farm composed of Squirrel-Cage Induction Generators (SCIGs) can be equivalent to one generator. By considering the diversity of wind generators and special operating characteristics of a wind farm, the equivalent generator based on EMOC responds accurately in various faults. No matter whether the wind farm is integrated in grid or just programmed, EMOC can be used to acquire an accurate equivalent generator. Simulation of the dynamic equivalence of an SCIG wind farm validated the method.展开更多
This paper proposes a robust dichotomy-based model predictive control(DS-MPC)with a fixed switching frequency for the grid-connected inverter(GCI).The proposed fast dichotomy algorithm can select and deduce the optima...This paper proposes a robust dichotomy-based model predictive control(DS-MPC)with a fixed switching frequency for the grid-connected inverter(GCI).The proposed fast dichotomy algorithm can select and deduce the optimal voltage vector dynamically through the space vector plane.Therefore,the proposed DS-MPC strategy could ensure dynamic performance and steady-state performance as well.Also,the current control robustness can be improved through DS-MPC with disturbance observer(DO)based on the extended Kalman filter(EKF).The novelty of this control is that the current control with fast dynamic response can be realized in the weak grid,even if the grid voltages are greatly distorted.Simulation and hardware experiments on the weak grid validate the effectiveness of the proposed DS-MPC with the EKF observer approach.展开更多
In wind power generation system the grid-connected inverter is an important section for energy conversion and transmission, of which the performance has a direct influence on the entire wind power generation system. T...In wind power generation system the grid-connected inverter is an important section for energy conversion and transmission, of which the performance has a direct influence on the entire wind power generation system. The mathematical model of the grid-connected inverter is deduced firstly. Then, the space vector pulse width modulation (SVPWM) is analyzed. The power factor can be controlled close to unity, leading or lagging, which is realized based on H-type current controller and grid voltage vector-oriented control. The control strategy is verified by the simulation and experimental results with a good sinusoidal current, a small harmonic component and a fast dynamic response.展开更多
A novel topology of the current-source grid-connected inverter is proposed based on the immittance converter theory. A control strategy of sine-sine pulse width modulation (PWM) is studied. Compared with the traditi...A novel topology of the current-source grid-connected inverter is proposed based on the immittance converter theory. A control strategy of sine-sine pulse width modulation (PWM) is studied. Compared with the traditional current-source inverter, the power frequency inductors and power frequency transformer are replaced with high frequency inductors and a high frequency transformer. Thus, the proposed inverter has advantages of small volume, low cost, low total harmonic distortion (THD), low power losses, high power factor (PF) and simple control. Furthermore, grid voltage cannot influence output current of the grid-connected inverter and the current-source inverter with a high PF that approaches one has been realized. Finally, validity of the theory analysis and feasibility of the control scheme are shown by simulation and experimental results.展开更多
For multiple grid-connected inverters with active filter function,it makes sense to regulate every unit to output maximum active power from photovoltaic arrays,as well as eliminate the harmonic due to the non-linear l...For multiple grid-connected inverters with active filter function,it makes sense to regulate every unit to output maximum active power from photovoltaic arrays,as well as eliminate the harmonic due to the non-linear loads connected to the electric networks.Naturally,a centralized control coordination strategy was proposed for the purpose of high facility utilization,good harmonic compensation ability and unwanted overcompensation condition.Based on a vector decoupling control scheme and generalized instantaneous reactive power theory,the solution was to allocate the harmonic eliminating task for every inverter according to the instantaneous power margin of each.The grid current always keeps sinusoidal in spite of non-linear load change and output active power change for any inverter.The simulation results validate the efficacy of the proposed coordination strategy.展开更多
In this paper, an optimized model is proposed to find the best values for decision variables to optimize the grid connected hybrid renewable energy system which consists of photovoltaic panels, wind turbines and batte...In this paper, an optimized model is proposed to find the best values for decision variables to optimize the grid connected hybrid renewable energy system which consists of photovoltaic panels, wind turbines and battery bank for electrification to North-east region of Afghanistan to meet winter power shortages of the area. In the proposed model, there are three decision variables namely, the total area occupied by the set of PV panels, total swept area by the rotating turbines' blades, and the number of batteries. GA (genetic algorithm) is defined to find the optimal values of the decision variables. The objective of this research is to minimize the LCC (life cycle cost) of the hybrid renewable energy system, and ensuring at the same time systems reliability level which is measured in terms of LPSP (loss of power supply probability).展开更多
Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Th...Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Then,parameters of PI controller were calculated on the basis of an equivalent controlled object.Finally,Norton equivalent circuit for the current control loop of grid-connected system was derived by integrating one control equation,which connected the PWM inverter output voltage and the LCL inverter-side current,with two circuit equations,separately using the LCL inverter-side current and the injected current as loop currents.With the induced Norton equivalent circuit,system-level resonant and unstable issues on real grid-connected system applied in weak distributed power systems can be easily analyzed.The validity of substituting Norton equivalent circuit for grid-connected system is verified by simulation and experiment.展开更多
This paper proposes a cascade repetitive control strategy based on odd internal mode,and combines it with proportional-integral(PI)control to establish a compound repetitive control system for improving the quality of...This paper proposes a cascade repetitive control strategy based on odd internal mode,and combines it with proportional-integral(PI)control to establish a compound repetitive control system for improving the quality of grid connected current of LCL grid connected inverter.More specifically,the proposed method could effectively improve the control effect of grid-connected current of LCL inverter,restrain current harmonics and reduce the distortion rate of grid-connected current.Simulation experiment is conducted to verify the proposed repetitive control strategy,and the verification results show that,compared with traditional PI control,the proposed improved compound repetitive control strategy has a higher response speed,and the steady-state and dynamic performance have also been significantly improved.展开更多
To realize the efficient transient simulation of a grid-connected power generation system based on multiple inverters, this paper proposes a hybrid simulation method integrating the models of electromagnetic transient...To realize the efficient transient simulation of a grid-connected power generation system based on multiple inverters, this paper proposes a hybrid simulation method integrating the models of electromagnetic transient and dynamic phasors. Based on a demonstration of the concepts and properties of dynamic phasors, the models of single-phase and three-phase inverters described by dynamic phasors are established first. Considering the numerical compatibility problem between dynamic phasors and instantaneous values, an interface scheme between dynamic phasors and instantaneous values is designed, and the efficiency and precision differences of various transformation methods are compared in detail.Finally, by utilizing MATLAB/Simulink, a hybrid simulation platform of a multi-inverter grid-connected system is built, and the efficiency and accuracy of the hybrid simulation are validated via comparison with the full electromagnetic transient simulation.展开更多
Nowadays,the single state inverter for the grid-connected photovoltaic(PV)systems is becoming more and more popular as they can reduce circuit complexity resulting in less power losses of the inverter.This paper focus...Nowadays,the single state inverter for the grid-connected photovoltaic(PV)systems is becoming more and more popular as they can reduce circuit complexity resulting in less power losses of the inverter.This paper focuses on the use of model predictive control(MPC)to control a 3-phase and 2-level single-state grid-connected inverter in order to regulate the PV maximum power point(MPP).The algorithm of MPC scheme was done to measure the simultaneous current signal including predicting the next sampling current flow.The reference current(Id∗)was used to control the distribution of electrical power from the solar cell to the grid.To be able to control the maximum power point tracking(MPPT)when the sunlight suddenly changes,so that a developing MPPT based on estimation current perturbation and observation(ECP&O-MPPT)technique was used to control the reference current.This concept was experimented by using MATLAB/Simulink software package.The proposed technique was tested and compared with the old technique.The simulation results showed that the developed MPPT technique can track the MPP faster when the light changes rapidly under 1,000W/m2,25℃ standard climatic conditions.The MPPT time was 0.015 s.The total harmonic distortion(THD)was 2.17%and the power factor was 1.展开更多
As to the concrete topology of three-phase LCL type grid-connected inverter with damping resistance, mathematical model was deduced in detail, using method of equivalent transformation to the structure diagram, dampin...As to the concrete topology of three-phase LCL type grid-connected inverter with damping resistance, mathematical model was deduced in detail, using method of equivalent transformation to the structure diagram, damping resistance was virtualized, mathematical model under the DQ frame that can realize decoupling control was established, a dual-loop control strategy for grid-connected inverter with LCL filter was proposed, the system stability was analyzed and the design method of controller was given. The proposed method overcame the flaws of loss increase, efficiency reduce and cost increase which were caused by damping resistance in LCL type grid-connected inverter, the system efficiency and power supply quality of the output were improved. Feasibility and effectiveness of the new method were validated by simulation and experimental results.展开更多
Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a populat...Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort study.Methods:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK Biobank.Sleep duration(short:<6 h/day;normal:6-8 h/day;long:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and 2015.PA was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death registries.Results:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were documented.Compared with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes risk.This increased risk among short sleepers seems to be protected against by PA.Compared with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did not.Conclusion:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.展开更多
BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cas...BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM.展开更多
As the proportion of renewable energy power generation continues to increase,the number of grid-connected microgrids is gradually increasing,and geographically adjacent microgrids can be interconnected to form a Micro...As the proportion of renewable energy power generation continues to increase,the number of grid-connected microgrids is gradually increasing,and geographically adjacent microgrids can be interconnected to form a Micro-Grid Community(MGC).In order to reduce the operation and maintenance costs of a single micro grid and reduce the adverse effects caused by unnecessary energy interaction between the micro grid and the main grid while improving the overall economic benefits of the micro grid community,this paper proposes a bi-level energy management model with the optimization goal of maximizing the social welfare of the micro grid community and minimizing the total electricity cost of a single micro grid.The lower-level model optimizes the output of each equipment unit in the system and the exchange power between the system and the external grid with the goal of minimizing the operating cost of each microgrid.The upper-level model optimizes the goal ofmaximizing the socialwelfare of themicrogrid.Taking amicrogrid community with four microgrids as an example,the simulation analysis shows that the proposed optimization model is beneficial to reduce the operating cost of a single microgrid,improve the overall revenue of the microgrid community,and reduce the power interaction pressure on the main grid.展开更多
基金supported by North China Electric Power Research Institute’s Self-Funded Science and Technology Project“Research on Distributed Energy Storage Optimal Configuration and Operation Control Technology for Photovoltaic Promotion in the Entire County”(KJZ2022049).
文摘In recent years,distributed photovoltaics(DPV)has ushered in a good development situation due to the advantages of pollution-free power generation,full utilization of the ground or roof of the installation site,and balancing a large number of loads nearby.However,under the background of a large-scale DPV grid-connected to the county distribution network,an effective analysis method is needed to analyze its impact on the voltage of the distribution network in the early development stage of DPV.Therefore,a DPV orderly grid-connected method based on photovoltaics grid-connected order degree(PGOD)is proposed.This method aims to orderly analyze the change of voltage in the distribution network when large-scale DPV will be connected.Firstly,based on the voltagemagnitude sensitivity(VMS)index of the photovoltaics permitted grid-connected node and the acceptance of grid-connected node(AoGCN)index of other nodes in the network,thePGODindex is constructed to determine the photovoltaics permitted grid-connected node of the current photovoltaics grid-connected state network.Secondly,a photovoltaics orderly grid-connected model with a continuous updating state is constructed to obtain an orderly DPV grid-connected order.The simulation results illustrate that the photovoltaics grid-connected order determined by this method based on PGOD can effectively analyze the voltage impact of large-scale photovoltaics grid-connected,and explore the internal factors and characteristics of the impact.
基金support of the project“State Grid Corporation Headquarters Science and Technology Program(5108-202299258A-1-0-ZB)”.
文摘To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)method.Based on the traditional distribution network evaluation system,a comprehensive evaluation system has been constructed.It fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid connection.The analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment methods.The subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum entropy.Calculate the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different scenarios.By setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.
文摘For a standalone PV (photovoltaic) power generation system, the author previously proposed a new MPPT (maximum power point tracking) control method in which the I-V characteristics are scanned with a detection interval control that operates at specified intervals and monitors the maximum power point. The author has obtained satisfactory results using this new MPPT control method. This paper investigates the application of the new MPPT control method for a PCS (power conditioning system) in a grid-connected type PV power generation system. The experimental results clearly demonstrate that the developed PCS offers outstanding effectiveness in tracking the maximum power point in partially shaded environments.
基金supported by UniversitàCattolica(D1 intramural funds to RP)Italian Ministry of University and Research(PRIN 2022ZYLB7B,P2022YW7BP funds to CG).
文摘Several experimental evidence suggests a link between brain Herpes simplex virus type-1 infection and the occurrence of Alzheimer’s disease.However,the molecular mechanisms underlying this association are not completely understood.Among the molecular mediators of synaptic and cognitive dysfunction occurring after Herpes simplex virus type-1 infection and reactivation in the brain neuroinflammatory cytokines seem to occupy a central role.Here,we specifically reviewed literature reports dealing with the impact of neuroinflammation on synaptic dysfunction observed after recurrent Herpes simplex virus type-1 reactivation in the brain,highlighting the role of interleukins and,in particular,interleukin 1βas a possible target against Herpes simplex virus type-1-induced neuronal dysfunctions.
基金support from Region Stockholm,ALF-project(FoUI-960041)Open Access funding is provided by Karolinska Institute(both to IM)。
文摘Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relationship between these two aging-related diseases have resulted in the investigation of shared pathophysiological molecular mechanisms.Impaired insulin signaling in the brain has gained increasing attention during the last decade and has been suggested to contribute to the development of Parkinson's disease through the dysregulation of several pathological processes.The contribution of type 2 diabetes mellitus and insulin resistance in neurodegeneration in Parkinson's disease,with emphasis on brain insulin resistance,is extensively discussed in this article and new therapeutic strategies targeting this pathological link are presented and reviewed.
基金supported by the Natural Science Foundation of Fujian Province,No.2020J02027the National Natural Science Foundation of China,No.31970461the Foundation of NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate,Fujian Maternity and Child Health Hospital,No.2022-NHP-05(all to WC).
文摘Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in vivo models to study the role of Na^(+)/K^(+)-ATPase in these diseases,we modified the Drosophila gene homolog,Atpα,to mimic the human ATP1A1 gene mutations that cause CMT2.Mutations located within the helical linker region of human ATP1A1(I592T,A597T,P600T,and D601F)were simultaneously introduced into endogenous Drosophila Atpαby CRISPR/Cas9-mediated genome editing,generating the Atpα^(TTTF)model.In addition,the same strategy was used to generate the corresponding single point mutations in flies(Atpα^(I571T),Atpα^(A576T),Atpα^(P579T),and Atpα^(D580F)).Moreover,a deletion mutation(Atpα^(mut))that causes premature termination of translation was generated as a positive control.Of these alleles,we found two that could be maintained as homozygotes(Atpα^(I571T)and Atpα^(P579T)).Three alleles(Atpα^(A576T),Atpα^(P579)and Atpα^(D580F))can form heterozygotes with the Atpαmut allele.We found that the Atpαallele carrying these CMT2-associated mutations showed differential phenotypes in Drosophila.Flies heterozygous for Atpα^(TTTF)mutations have motor performance defects,a reduced lifespan,seizures,and an abnormal neuronal morphology.These Drosophila models will provide a new platform for studying the function and regulation of the sodium-potassium pump.
文摘Dynamic equivalence of the wind farm is a fundamental problem in the simulation of a power system connected with wind farms because it is unpractical to model every generator in a wind farm in detail. In this paper, an Equivalence Method based on the Output Characteristics (EMOC) is proposed, with which the wind farm composed of Squirrel-Cage Induction Generators (SCIGs) can be equivalent to one generator. By considering the diversity of wind generators and special operating characteristics of a wind farm, the equivalent generator based on EMOC responds accurately in various faults. No matter whether the wind farm is integrated in grid or just programmed, EMOC can be used to acquire an accurate equivalent generator. Simulation of the dynamic equivalence of an SCIG wind farm validated the method.
文摘This paper proposes a robust dichotomy-based model predictive control(DS-MPC)with a fixed switching frequency for the grid-connected inverter(GCI).The proposed fast dichotomy algorithm can select and deduce the optimal voltage vector dynamically through the space vector plane.Therefore,the proposed DS-MPC strategy could ensure dynamic performance and steady-state performance as well.Also,the current control robustness can be improved through DS-MPC with disturbance observer(DO)based on the extended Kalman filter(EKF).The novelty of this control is that the current control with fast dynamic response can be realized in the weak grid,even if the grid voltages are greatly distorted.Simulation and hardware experiments on the weak grid validate the effectiveness of the proposed DS-MPC with the EKF observer approach.
基金supported by Delta Power Electronic Science and Education Development in 2007 (Grant No.DRES2007002)
文摘In wind power generation system the grid-connected inverter is an important section for energy conversion and transmission, of which the performance has a direct influence on the entire wind power generation system. The mathematical model of the grid-connected inverter is deduced firstly. Then, the space vector pulse width modulation (SVPWM) is analyzed. The power factor can be controlled close to unity, leading or lagging, which is realized based on H-type current controller and grid voltage vector-oriented control. The control strategy is verified by the simulation and experimental results with a good sinusoidal current, a small harmonic component and a fast dynamic response.
基金supported by the Shanghai Leading Academic Discipline Project (Grant No.T0103)
文摘A novel topology of the current-source grid-connected inverter is proposed based on the immittance converter theory. A control strategy of sine-sine pulse width modulation (PWM) is studied. Compared with the traditional current-source inverter, the power frequency inductors and power frequency transformer are replaced with high frequency inductors and a high frequency transformer. Thus, the proposed inverter has advantages of small volume, low cost, low total harmonic distortion (THD), low power losses, high power factor (PF) and simple control. Furthermore, grid voltage cannot influence output current of the grid-connected inverter and the current-source inverter with a high PF that approaches one has been realized. Finally, validity of the theory analysis and feasibility of the control scheme are shown by simulation and experimental results.
基金Project(51107111)supported by the National Natural Science Foundation of China
文摘For multiple grid-connected inverters with active filter function,it makes sense to regulate every unit to output maximum active power from photovoltaic arrays,as well as eliminate the harmonic due to the non-linear loads connected to the electric networks.Naturally,a centralized control coordination strategy was proposed for the purpose of high facility utilization,good harmonic compensation ability and unwanted overcompensation condition.Based on a vector decoupling control scheme and generalized instantaneous reactive power theory,the solution was to allocate the harmonic eliminating task for every inverter according to the instantaneous power margin of each.The grid current always keeps sinusoidal in spite of non-linear load change and output active power change for any inverter.The simulation results validate the efficacy of the proposed coordination strategy.
文摘In this paper, an optimized model is proposed to find the best values for decision variables to optimize the grid connected hybrid renewable energy system which consists of photovoltaic panels, wind turbines and battery bank for electrification to North-east region of Afghanistan to meet winter power shortages of the area. In the proposed model, there are three decision variables namely, the total area occupied by the set of PV panels, total swept area by the rotating turbines' blades, and the number of batteries. GA (genetic algorithm) is defined to find the optimal values of the decision variables. The objective of this research is to minimize the LCC (life cycle cost) of the hybrid renewable energy system, and ensuring at the same time systems reliability level which is measured in terms of LPSP (loss of power supply probability).
基金Project(51307009)supported by the National Natural Science Foundation of ChinaProject(12JJ4045)supported by Hunan Provincial Natural Science Foundation,China+2 种基金Project(2011KFJJ003)supported by the Key Laboratory for Power Technology of Renewable Energy Sources of Hunan Province,ChinaProject(2011kfj14)supported by the Fund of Key Laboratory of Hunan Province about Power System Operation and Control,ChinaProject(454.13S-20)supported by the Enterprises’Postdoctoral Funds of Pudong Area of Shanghai,China
文摘Modeling method for the current control loop of a grid-connected PWM inverter with the LCL output filter was discussed.Firstly,the current control loop with the LCL inverter-side current as feedback was established.Then,parameters of PI controller were calculated on the basis of an equivalent controlled object.Finally,Norton equivalent circuit for the current control loop of grid-connected system was derived by integrating one control equation,which connected the PWM inverter output voltage and the LCL inverter-side current,with two circuit equations,separately using the LCL inverter-side current and the injected current as loop currents.With the induced Norton equivalent circuit,system-level resonant and unstable issues on real grid-connected system applied in weak distributed power systems can be easily analyzed.The validity of substituting Norton equivalent circuit for grid-connected system is verified by simulation and experiment.
基金supported by the National Natural Science Foundation of China(No.61903291)。
文摘This paper proposes a cascade repetitive control strategy based on odd internal mode,and combines it with proportional-integral(PI)control to establish a compound repetitive control system for improving the quality of grid connected current of LCL grid connected inverter.More specifically,the proposed method could effectively improve the control effect of grid-connected current of LCL inverter,restrain current harmonics and reduce the distortion rate of grid-connected current.Simulation experiment is conducted to verify the proposed repetitive control strategy,and the verification results show that,compared with traditional PI control,the proposed improved compound repetitive control strategy has a higher response speed,and the steady-state and dynamic performance have also been significantly improved.
基金supported by the State Grid Science and Technology Project (grant no. KJ2021-069)。
文摘To realize the efficient transient simulation of a grid-connected power generation system based on multiple inverters, this paper proposes a hybrid simulation method integrating the models of electromagnetic transient and dynamic phasors. Based on a demonstration of the concepts and properties of dynamic phasors, the models of single-phase and three-phase inverters described by dynamic phasors are established first. Considering the numerical compatibility problem between dynamic phasors and instantaneous values, an interface scheme between dynamic phasors and instantaneous values is designed, and the efficiency and precision differences of various transformation methods are compared in detail.Finally, by utilizing MATLAB/Simulink, a hybrid simulation platform of a multi-inverter grid-connected system is built, and the efficiency and accuracy of the hybrid simulation are validated via comparison with the full electromagnetic transient simulation.
基金This research is supported by the MATLAB/Simulink,Rajamangala University of Technology Rattanakosin.
文摘Nowadays,the single state inverter for the grid-connected photovoltaic(PV)systems is becoming more and more popular as they can reduce circuit complexity resulting in less power losses of the inverter.This paper focuses on the use of model predictive control(MPC)to control a 3-phase and 2-level single-state grid-connected inverter in order to regulate the PV maximum power point(MPP).The algorithm of MPC scheme was done to measure the simultaneous current signal including predicting the next sampling current flow.The reference current(Id∗)was used to control the distribution of electrical power from the solar cell to the grid.To be able to control the maximum power point tracking(MPPT)when the sunlight suddenly changes,so that a developing MPPT based on estimation current perturbation and observation(ECP&O-MPPT)technique was used to control the reference current.This concept was experimented by using MATLAB/Simulink software package.The proposed technique was tested and compared with the old technique.The simulation results showed that the developed MPPT technique can track the MPP faster when the light changes rapidly under 1,000W/m2,25℃ standard climatic conditions.The MPPT time was 0.015 s.The total harmonic distortion(THD)was 2.17%and the power factor was 1.
文摘As to the concrete topology of three-phase LCL type grid-connected inverter with damping resistance, mathematical model was deduced in detail, using method of equivalent transformation to the structure diagram, damping resistance was virtualized, mathematical model under the DQ frame that can realize decoupling control was established, a dual-loop control strategy for grid-connected inverter with LCL filter was proposed, the system stability was analyzed and the design method of controller was given. The proposed method overcame the flaws of loss increase, efficiency reduce and cost increase which were caused by damping resistance in LCL type grid-connected inverter, the system efficiency and power supply quality of the output were improved. Feasibility and effectiveness of the new method were validated by simulation and experimental results.
基金supported by the National Key R&D Program of China(2021YFC2501500)National Natural Science Foundation of China(82171476)。
文摘Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort study.Methods:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK Biobank.Sleep duration(short:<6 h/day;normal:6-8 h/day;long:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and 2015.PA was classified according to the median or World Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death registries.Results:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were documented.Compared with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%CI):1.03-1.41)but not long sleep duration(HR=1.01,95%CI:0.89-1.15)was associated with excessive type 2 diabetes risk.This increased risk among short sleepers seems to be protected against by PA.Compared with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%CI:1.46-2.25),not recommended(below the World Health Organization-recommended level of)MVPA(HR=1.92,95%CI:1.55-2.36),or low light-intensity PA(HR=1.49,95%CI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%CI:0.88-1.49),recommended MVPA(HR=1.02,95%CI:0.71-1.48),or high light-intensity PA(HR=1.14,95%CI:0.92-1.41)did not.Conclusion:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.
文摘BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active tuberculosis.Notably,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in nature.AIM To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with T2DM.METHODS T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR values.RESULTS A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control group.Comparison of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control group.The results of univariate analysis showed that poor glucose control,hypoproteinemia,lymphopenia,TB contact history,high infection,smoking and alcohol consumption were positively associated with PTB in T2DM patients;married,history of hypertension,treatment of oral hypoglycemic drugs plus insulin,overweight,obesity and regular exercise were negatively associated with PTB in T2DM patients.Results of multivariate stepwise regression analysis found lymphopenia(OR=17.75,95%CI:3.40-92.74),smoking(OR=12.25,95%CI:2.53-59.37),history of TB contact(OR=6.56,95%CI:1.23-35.03)and poor glycemic control(OR=3.37,95%CI:1.11-10.25)was associated with an increased risk of developing PTB in patients with T2DM,While being overweight(OR=0.23,95%CI:0.08-0.72)and obesity(OR=0.11,95%CI:0.02-0.72)was associated with a reduced risk of developing PTB in patients with T2DM.CONCLUSION T2DM-PTB patients are prone to worse glycemic control,higher infection frequency,and a higher proportion of people smoking,drinking alcohol,and lack of exercise.Lymphopenia,smoking,history of TB exposure,poor glycemic control were independent risk factors for T2DM-PTB,and overweight and obesity were associated with reduced risk of concurrent PTB in patients with T2DM.
基金This paper is supported by Science and Technology Project of State Grid(The construction of provincial energy big data ecosystem and the application practice research of data value-added service for the park,5400-202012224A-0-0-00).
文摘As the proportion of renewable energy power generation continues to increase,the number of grid-connected microgrids is gradually increasing,and geographically adjacent microgrids can be interconnected to form a Micro-Grid Community(MGC).In order to reduce the operation and maintenance costs of a single micro grid and reduce the adverse effects caused by unnecessary energy interaction between the micro grid and the main grid while improving the overall economic benefits of the micro grid community,this paper proposes a bi-level energy management model with the optimization goal of maximizing the social welfare of the micro grid community and minimizing the total electricity cost of a single micro grid.The lower-level model optimizes the output of each equipment unit in the system and the exchange power between the system and the external grid with the goal of minimizing the operating cost of each microgrid.The upper-level model optimizes the goal ofmaximizing the socialwelfare of themicrogrid.Taking amicrogrid community with four microgrids as an example,the simulation analysis shows that the proposed optimization model is beneficial to reduce the operating cost of a single microgrid,improve the overall revenue of the microgrid community,and reduce the power interaction pressure on the main grid.