A conceptually novel,trifunctional sulfoximine-mediatedγ-functionalization of unactivated C(sp^(3))–H bonds has been achieved.The reaction is initiated by the photo-induced homolytic cleavage of an N–S bond in the ...A conceptually novel,trifunctional sulfoximine-mediatedγ-functionalization of unactivated C(sp^(3))–H bonds has been achieved.The reaction is initiated by the photo-induced homolytic cleavage of an N–S bond in the absence of photosensitizer,and proceeds sequentially through a cascade of 1,5-hydrogen atom transfer,1,4-functional group migration,desulfoximination and a Minisci reaction.A major feature of this approach is the use of sulfoximine as a traceless directing group.Other positive properties include mild conditions,simple operation,exclusive site-selectivity,high product diversity and the avoidance of additional photosensitizers.The protocol provides a new reaction mode for HAT-induced C(sp^(3))–H functionalization,and allows a much broader chemical space for sulfoximine studies.展开更多
A novel photoinduced intermolecular 1,2-arylheteroarylation of alkenes and the efficient synthesis of valuable polyarylalkanes are reported.The reaction is operationally simple,proceeds under mild conditions and with ...A novel photoinduced intermolecular 1,2-arylheteroarylation of alkenes and the efficient synthesis of valuable polyarylalkanes are reported.The reaction is operationally simple,proceeds under mild conditions and with no additional catalyst and reagents.The strategically designed radical cascade reaction is enabled by electron transfer,and involves cleavage of an inert C–C bond.The process features broad functional group compatibility as well as high product transformability.展开更多
基金supported by the National Natural Science Foundation of China(21971173,22001185,22171201)the Natural Science Foundation of Jiangsu Province(BK20200852)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘A conceptually novel,trifunctional sulfoximine-mediatedγ-functionalization of unactivated C(sp^(3))–H bonds has been achieved.The reaction is initiated by the photo-induced homolytic cleavage of an N–S bond in the absence of photosensitizer,and proceeds sequentially through a cascade of 1,5-hydrogen atom transfer,1,4-functional group migration,desulfoximination and a Minisci reaction.A major feature of this approach is the use of sulfoximine as a traceless directing group.Other positive properties include mild conditions,simple operation,exclusive site-selectivity,high product diversity and the avoidance of additional photosensitizers.The protocol provides a new reaction mode for HAT-induced C(sp^(3))–H functionalization,and allows a much broader chemical space for sulfoximine studies.
基金the National Natural Science Foundation of China(21971173)the Project of Scientific and Technologic Infrastructure of Suzhou(SZS201905)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。
文摘A novel photoinduced intermolecular 1,2-arylheteroarylation of alkenes and the efficient synthesis of valuable polyarylalkanes are reported.The reaction is operationally simple,proceeds under mild conditions and with no additional catalyst and reagents.The strategically designed radical cascade reaction is enabled by electron transfer,and involves cleavage of an inert C–C bond.The process features broad functional group compatibility as well as high product transformability.
