The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic mac...The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0).展开更多
为全面评价生态气候因子对湖北省烟叶生长发育的影响,利用2008—2020年中国气象局陆面数据同化系统(CMA land data assimilation system,CLDAS)数据集和其他环境因子,基于最大熵模型(MaxEnt),利用湖北省西部烟区实际种植点位模拟湖北省...为全面评价生态气候因子对湖北省烟叶生长发育的影响,利用2008—2020年中国气象局陆面数据同化系统(CMA land data assimilation system,CLDAS)数据集和其他环境因子,基于最大熵模型(MaxEnt),利用湖北省西部烟区实际种植点位模拟湖北省烟区的潜在适宜性分布,并评估影响适宜性分布的主导环境因子。结果显示:MaxEnt模型对烟草适宜性分布的模拟预测精度较高(AUC=0.854)。海拔(650~1750 m)、土壤类型(黄壤)、团棵期平均最低气温(8.9~15.0℃)、旺长期平均气温(16.0~22.9℃)、成熟期平均气温(18.8~25.6℃)是影响湖北烟草分布的主导环境因子。烟草的高适生区主要分布在恩施、十堰和襄阳南部及宜昌东南部,占湖北省总面积的18.2%,80%区域的海拔为700~1350 m、团棵期平均最低气温11.2~14.5℃、旺长期平均气温19.2~22.8℃、成熟期平均气温22.0~25.4℃。在所有环境因子中,海拔高度起决定性作用,温度则是影响烟草生长发育的重要气象因子。研究表明,本研究结果与湖北烟区实际空间分布基本相符。展开更多
AIM: To study the role of connective tissue growth factor (CTGF) antibody in inhibiting bleb scarring after glaucoma filtration surgery (GFS) in rabbit model. METHODS: GFS was performed on both eyes in five rabbits. O...AIM: To study the role of connective tissue growth factor (CTGF) antibody in inhibiting bleb scarring after glaucoma filtration surgery (GFS) in rabbit model. METHODS: GFS was performed on both eyes in five rabbits. One eye of each rabbit was chosen randomly as antibody group and received subconjunctival injection of 0.1mL CTGF antibody (50mg/L) immediately after GFS applied and on the 5 th day after GFS. The other eye of each rabbit as control group was received subconjunctival injection of 0.1mL PBS at the same time as antibody group. On postoperative days 1, 3, 5, 7, 10, and 14, the appearance of filtrating blebs was observed under slit lamp, the area and the intraocular pressure (IOP) were measured with micrometer and applanation tonometer, respectively. RESULTS: On postoperative days 1, 3, 5, 7, 10, and 14, areas of filtrating blebs in antibody group were all larger comparing with the control group (P<0.05) and IOPs of antibody group were lower than the control group(P<0.05). CONCLUSION: Subconjunctival injection of CTGF antibody can maintain larger bleb area and lower IOP after GFS in rabbit.展开更多
In recent years,retinal ischemia such as that which occurs in diabetic retinopathy(DR)and retinal vein occlusion(RVO)has become a hotspot of ischemic retinopathy research.High levels of vascular endothelial growth fac...In recent years,retinal ischemia such as that which occurs in diabetic retinopathy(DR)and retinal vein occlusion(RVO)has become a hotspot of ischemic retinopathy research.High levels of vascular endothelial growth factor(VEGF)are recognized as a major cause of macular edema(ME)in DR and RVO.High concentrations of VEGF in the vitreous can lead to serious retinal ischemia and hypoxia and form retinal nonperfusion areas(NPAs).Different levels of retinal ischemia can represent disease severity and progression.Anti-VEGF therapy as the first-line treatment for ME has been found to be effective in improving vision,but there are still disputes about whether anti-VEGF therapy could improve retinal ischemia and achieve reper fusion of previously developed retinal NPAs.Here,we review and summarize studies of the effects of anti-VEGF drugs on retinal ischemia,especially NPAs.展开更多
Objective We aimed to determine the epidermal growth factor receptor （EGFR） mutation status and treatment survival of patients with stage IV lung adenocarcinoma living in the Ordos area of Inner Mongolia, China. Met...Objective We aimed to determine the epidermal growth factor receptor （EGFR） mutation status and treatment survival of patients with stage IV lung adenocarcinoma living in the Ordos area of Inner Mongolia, China. Methods EGFR testing and first-line tyrosine kinase inhibitor （TKI） treatment rates of patients with stage IV lung adenocarcinoma were analyzed from June 2012 to June 2016. Kaplan-Meier survival curves were constructed to compare patients who received different treatment strategies and those harboring different EGFR mutation statuses. Results EGFR testing and mutation rates were 65.60% and 52.90%, respectively, and improved continuously from June 2012 to June 2016. Among patients with EGFR mutations, 38.9% had EGFR 19 del, 48.2% had L858R, 4.2% had co-existing mutations in exons 19 and 21, and 8.4% had uncommon mutations. The median overall survival （OS） was 29.5, 26.5, and 16.0 months for patients receiving both TKI and chemotherapy, TKI alone, and chemotherapy alone, respectively （P = 0.047）. The OS was 26.5 and 30.0 months for patients harboring EGFR 19 del and L858R mutations, respectively （P = 0.096）. Conclusion The high OS rates of stage IV lung adenocarcinoma patients living in the Ordos area may be attributed to continuous improvements in EGFR testing and first-line TKI treatment rates. In the era of TKIs, chemotherapy for increasing OS times should be emphasized.展开更多
基金supported by Science and Technology Research Project of Jilin Provincial Department of Education,No.JJKH20220072KJ(to XL)Science and Technology Development Program of Jilin Province,No.20200201495JC(to YL)。
文摘The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.The trial protocol was approved by the Medical Ethics Committee of the Affiliated Hospital of Beihua University with approval No.(2023)(26)on April 25,2023,and was registered with the Chinese Clinical Trial Registry(registration number:ChiCTR2300072478,June 14,2023,protocol version:2.0).
文摘为全面评价生态气候因子对湖北省烟叶生长发育的影响,利用2008—2020年中国气象局陆面数据同化系统(CMA land data assimilation system,CLDAS)数据集和其他环境因子,基于最大熵模型(MaxEnt),利用湖北省西部烟区实际种植点位模拟湖北省烟区的潜在适宜性分布,并评估影响适宜性分布的主导环境因子。结果显示:MaxEnt模型对烟草适宜性分布的模拟预测精度较高(AUC=0.854)。海拔(650~1750 m)、土壤类型(黄壤)、团棵期平均最低气温(8.9~15.0℃)、旺长期平均气温(16.0~22.9℃)、成熟期平均气温(18.8~25.6℃)是影响湖北烟草分布的主导环境因子。烟草的高适生区主要分布在恩施、十堰和襄阳南部及宜昌东南部,占湖北省总面积的18.2%,80%区域的海拔为700~1350 m、团棵期平均最低气温11.2~14.5℃、旺长期平均气温19.2~22.8℃、成熟期平均气温22.0~25.4℃。在所有环境因子中,海拔高度起决定性作用,温度则是影响烟草生长发育的重要气象因子。研究表明,本研究结果与湖北烟区实际空间分布基本相符。
基金Natural Science Foundation of Shaanxi Province,China(No.2001SM66)
文摘AIM: To study the role of connective tissue growth factor (CTGF) antibody in inhibiting bleb scarring after glaucoma filtration surgery (GFS) in rabbit model. METHODS: GFS was performed on both eyes in five rabbits. One eye of each rabbit was chosen randomly as antibody group and received subconjunctival injection of 0.1mL CTGF antibody (50mg/L) immediately after GFS applied and on the 5 th day after GFS. The other eye of each rabbit as control group was received subconjunctival injection of 0.1mL PBS at the same time as antibody group. On postoperative days 1, 3, 5, 7, 10, and 14, the appearance of filtrating blebs was observed under slit lamp, the area and the intraocular pressure (IOP) were measured with micrometer and applanation tonometer, respectively. RESULTS: On postoperative days 1, 3, 5, 7, 10, and 14, areas of filtrating blebs in antibody group were all larger comparing with the control group (P<0.05) and IOPs of antibody group were lower than the control group(P<0.05). CONCLUSION: Subconjunctival injection of CTGF antibody can maintain larger bleb area and lower IOP after GFS in rabbit.
文摘In recent years,retinal ischemia such as that which occurs in diabetic retinopathy(DR)and retinal vein occlusion(RVO)has become a hotspot of ischemic retinopathy research.High levels of vascular endothelial growth factor(VEGF)are recognized as a major cause of macular edema(ME)in DR and RVO.High concentrations of VEGF in the vitreous can lead to serious retinal ischemia and hypoxia and form retinal nonperfusion areas(NPAs).Different levels of retinal ischemia can represent disease severity and progression.Anti-VEGF therapy as the first-line treatment for ME has been found to be effective in improving vision,but there are still disputes about whether anti-VEGF therapy could improve retinal ischemia and achieve reper fusion of previously developed retinal NPAs.Here,we review and summarize studies of the effects of anti-VEGF drugs on retinal ischemia,especially NPAs.
基金Supported by a grant from the Inner Mongolia Health Planning Committee Sciences Foundation(No.201303164)Wu Jie Ping Funding(No.320675014017)
文摘Objective We aimed to determine the epidermal growth factor receptor （EGFR） mutation status and treatment survival of patients with stage IV lung adenocarcinoma living in the Ordos area of Inner Mongolia, China. Methods EGFR testing and first-line tyrosine kinase inhibitor （TKI） treatment rates of patients with stage IV lung adenocarcinoma were analyzed from June 2012 to June 2016. Kaplan-Meier survival curves were constructed to compare patients who received different treatment strategies and those harboring different EGFR mutation statuses. Results EGFR testing and mutation rates were 65.60% and 52.90%, respectively, and improved continuously from June 2012 to June 2016. Among patients with EGFR mutations, 38.9% had EGFR 19 del, 48.2% had L858R, 4.2% had co-existing mutations in exons 19 and 21, and 8.4% had uncommon mutations. The median overall survival （OS） was 29.5, 26.5, and 16.0 months for patients receiving both TKI and chemotherapy, TKI alone, and chemotherapy alone, respectively （P = 0.047）. The OS was 26.5 and 30.0 months for patients harboring EGFR 19 del and L858R mutations, respectively （P = 0.096）. Conclusion The high OS rates of stage IV lung adenocarcinoma patients living in the Ordos area may be attributed to continuous improvements in EGFR testing and first-line TKI treatment rates. In the era of TKIs, chemotherapy for increasing OS times should be emphasized.
