Extended finite element-based cohesive zone method for modeling simultaneous hydraulic fracture height growth in layered reservoirs

In this study,a fully coupled hydromechanical model within the extended finite element method(XFEM)-based cohesive zone method(CZM)is employed to investigate the simultaneous height growth behavior of multi-cluster hydraulic fractures in layered porous reservoirs with modulus contrast.The coupled hydromechanical model is first verified against an analytical solution and a laboratory experiment.Then,the fracture geometry(e.g.height,aperture,and area)and fluid pressure evolutions of multiple hydraulic fractures placed in a porous reservoir interbedded with alternating stiff and soft layers are investigated using the model.The stress and pore pressure distributions within the layered reservoir during fluid injection are also presented.The simulation results reveal that stress umbrellas are easily to form among multiple hydraulic fractures’tips when propagating in soft layers,which impedes the simultaneous height growth.It is also observed that the impediment effect of soft layer is much more significant in the fractures suppressed by the preferential growth of adjoining fractures.After that,the combined effect of in situ stress ratio and fracturing spacing on the multi-fracture height growth is presented,and the results elucidate the influence of in situ stress ratio on the height growth behavior depending on the fracture spacing.Finally,it is found that the inclusion of soft layers changes the aperture distribution of outmost and interior hydraulic fractures.The results obtained from this study may provide some insights on the understanding of hydraulic fracture height containment observed in filed.

Study of the Effects of Glucocorticoid on Growth and Adult Final Height in Children with Primary Nephrotic Syndrome

Objective: To analyze the epidemiological characteristics of growth, as well as factors associated with growth retardation in children with primary nephrotic syndrome (PNS), and to investigate the effect of glucocorticoid (GC) use duration on growth retardation in these children. Methods: Clinical and laboratory data of 353 PNS children treated at our hospital from July 2014 to June 2015 were collected through the medical record management system. Height, weight, and GC usage were recorded. Follow-up assessments were conducted in August 2022 for the original group, recording height, weight, and GC usage. Height and weight were evaluated using standard deviation scores (SDS). Categorical data were analyzed using chi-square test while continuous measurement data were analyzed using t-test or rank-sum test. Linear regression was used to assess the association between two single independent variables, and logistic regression analysis was used to screen for risk factors related to growth retardation in children with PNS. Results: Among the 353 PNS children enrolled in this study, male-to-female ratio of 2.64:1 (256 males vs 97 females). A total of 119 children exhibited growth retardation, incidence rate of 33.71%. The duration of GC usage among those with growth retardation was significantly longer compared to those without it (762.81 ± 934.50 days vs 263.77 ± 420.49 days;p Conclusion: PNS children treated with GC have a high incidence of growth retardation, and a high proportion of short stature in adulthood, especially in children with growth retardation in childhood, most of them have short stature after grown up. Time of GC usage is a risk factor for growth retardation in children with PNS.

Study on height growth model of Pinus koraiensis

Growth model is an efficient way to study growing process of some factors of plants quantitatively. Height growth of Korean pine (Pinus koraiensis) was studied by using Hyperbola equation, Logistic equation, Richards equation with three parameters, and Richards equation with four parameters in this paper. The results showed that Richards equation with four parameters was the most suitable and could be turned into other theoretical equations when some parameters were given different value. The maximum height of trees could be given in advance when using Richards equation with four parameters, and it was even more corresponding to reality. In addition, a height growth model with real height of fixed age as a parameter was discussed in this paper. This kind of growth model could be used to calculate height growth of a given tree effectively.

Mining Applicable Elite Alleles of Growth Duration, Plant Height and Panicle Number per Plant by Conditional QTL Mapping in Japonica Rice

Unconditional and conditional QTL mapping were conducted for growth duration (GD), plant height (PH) and effective panicle number per plant (PN) using a recombinant inbred line (RIL) population derived from a cross between two japonica rice varieties Xiushui 79 and C Bao. The RIL population consisted of 254 lines was planted in two environments, Nanjing and Sihong, Jiangsu Province, China. Results showed that additive effects were major in all of QTLs for GD, PH and PN detected by the two methods, and the epistatic effects explained a small proportion of phenotypic variation. No interactions were detected between additive QTL and environment, and between epistatic QTL pairs and environment. After growth duration was adjusted to an identical level, RM80-160bp was detected as an applicable elite allele for PN, with an additive effect of 0.71. When effective panicle number per plant was adjusted to an identical level, RM448-240bp was detected as an applicable elite allele for GD, with an additive effect of 4.64. After plant height was adjusted to an identical level, RM80-160bp was detected as an applicable elite allele for PN, with an additive effect of 0.62, and RM448-240bp was detected as an applicable elite allele for GD, with an additive effect of 3.89. These applicable elite alleles could be used to improve target traits without influencing the other two traits.

Response of photosynthesis,growth,and acorn mass of pedunculate oak to diff erent levels of nitrogen in wet and dry growing seasons

The objective was to examine the effects of optimal leaf nitrogen levels>2.0%and suboptimal levels<2.0%,nitrogen nutrition on net photo synthetic rate,stem diameter increment,height growth increment and acorn mass of pedunculate oak during 2010 in the absence of drought stress and during 2011 under the impact of moderate drought stress.According to the results,moderate drought stress significantly reduced net photo synthetic rate,stem diameter increment and height growth increment,while acorn mass was not affected.Suboptimal nitrogen nutrition significantly reduced the net photo synthetic rate and stem diameter increment only in the wet year,acorn mass in both wet and dry years,while height growth increment was not significantly reduced by suboptimal nitrogen nutrition in either year.The results indicate that optimal nitrogen levels can stimulate photo synthetic rate and stem diameter increment of pedunculate oak only in the absence of moderate drought stress.Moreover,the results show that moderate drought stress is a more dominant stressor for photosynthesis and growth of pedunculate oak than suboptimal nitrogen nutrition,while for acorn development,it is the more dominant stressor.

Height/Length and Weight Growth Curves and Growth References of Children Aged 0 - 7 in Chongqing by GAMLSS

Aim: Using the generalised additive model for location, the scale and shape (GAMLSS), the standard of height (length), weight and percentage curve of children were formulated to understand the growth law in Chongqing and to provide a reference for clinical and preventive health care work of paediatrics in West China. Methods: Data were collected from the health clinic dataset of children aged 0 - 7 years in the Department of Child Health Care of a Third-Class A hospital in Chongqing from 2010 to 2017. By applying the GAMLSS technology and taking D(μ, σ, ν, τ) as the specific distribution form, BCT as the link function, P-spline function and cubic splines function as the smoothing function, the unit value of age-specific standard deviation of height (length) and weight were obtained, and the percentile map was drawn. Results: Based on the principle of minimum AIC and SBC values, BCT distribution was chosen as the model of the link function. Fitting results of height (length) and weight parameters of boys and girls, standard deviation tables of age and percentile curves were obtained. Conclusions: This study was an exploration of using GAMLSS method to establish a reference value range in the field of children’s growth and development in China. It could supplement the relevant data of Chongqing area for Reference standard for growth and development of children under 7 years of age in China, and also provide a reference for the rational diagnosis of children’s short stature and malnutrition in Chongqing.

Comparative Analyses of Height Growth Velocities of School Boys in South Korea and Japan in the Past 50 Years

The paper compares the height growth velocities of male schoolchildren in South Korea and Japan over the period 1961-2018. Growth in height was measured with the same birth cohorts, not by comparing mean height of ascending ages in the same year. Starting from a lower economic base and mean height in the 1960s, high school males aged 17 in South Korea became 3 cm taller in mean height than their Japanese peers in the mid-2000s versus 2 - 3 cm shorter in the 1960s through 1970s. Children in Japan ceased to grow taller by the end of the 1980s, not because they quit taking more animal-sourced foods, meat and milk, but because they had drastically steered away from fruit and vegetables in their diets since the end of the 1970s. Having largely converged economically with Japan, South Korean children ceased to grow any taller in the mid-2000s. More importantly, it was discovered in this study that successive cohorts in South Korea started to fall gradually but steadily in height growth velocity from 1st graders in middle school, aged 12 years to 3rd graders in high school, and aged 17 years, to be once again 3 cm below their Japanese peers in the early-2010s. Analysis of Korea Household Expenditure Surveys classified by age groups of household head, decomposed by the author, revealed that children under 20 years of age in South Korea began to steer away from fruit and, particularly, vegetables in their at-home consumption in the mid-1990s, to average only 15% of the level of older adults in their 50s in the mid-2010s. These results lend supports to the importance of fruit and vegetables as determinants in height and its growth velocities in two genetically similar nations over time and stages of economic growth.

Impacts of Primo MAXX Growth Regulator on the Growth of Bermuda Grass

[Objective] The aim was to investigate the effects of Primo MAXX growth regulator on growth of Bermuda grass,explore appropriate application concentration of Primo MAXX on Bermuda grass,and provide basis for the application of Primo MAXX in Bermuda meadow.[Method]The height,leaf colour and the aerial part＇s fresh weight of Bermuda grass treated with different concentrations were researched using single factor random block test.[Result]Primo MAXX application effectively reduced the height in all treatment without significant difference;appropriate application of Primo MAXX can enrich the color;and 35 days after application,Bermuda grass roots were become thicker.[Conclusion]The application of Primo MAXX with effective dose of 150-300 g/hm2 on Bermuda grass in southern China is more appropriate.

南疆阿拉尔垦区密植棉花株高模拟研究

【目的】探讨新疆阿拉尔垦区密植条件下不同模型对棉花株高的预测效果。【方法】以株型差异较大的新陆中81号和塔河2号为试验材料,在阿拉尔垦区16000株·hm^(-2)密植条件下开展大田试验,用Python语言建立株高生长的逻辑斯谛(logistic)、冈珀茨(Gompertz)、理查德(Richards)方程和决策树机器学习预测模型,并对模型的预测精度进行分析。【结果】Logistic、Gompertz和Richards模型中,新陆中81号株高的均方根误差(root mean square error,RMSE)分别为8.38%、7.49%和7.52%,平均绝对误差(mean absolute error,MAE)分别为6.80%、5.79%和5.82%;塔河2号株高的RMSE分别为6.09%、4.77%和4.85%,MAE分别为4.52%、3.34%和3.36%。决策树机器学习方法中,新陆中81号与塔河2号株高的RMSE分别为6.91%和3.27%,MAE分别为5.04%和2.16%。Logistic、Gompertz和Richards生长方程以及决策树机器学习方法均能较好地预测密植条件下棉花株高的生长,但在预测精度上决策树机器学习方法总体上优于生长方程。【结论】基于决策树的机器学习方法不需要用数理统计知识解释模型,训练模型需要的数据量也较少,模拟精度更高,在模拟棉花株高方面有一定优势,是对传统生长方程的有益补充。

适于GlobalAllomeTree国际数据平台的标准化中国主要树种树高-胸径方程研建

GlobalAllomeTree作为共享异速方程的国际网络平台,逐渐受到全球高度关注。当前,为促进该项国际合作,针对当前该平台缺乏中国主要树种生长异速方程的现状,系统性更新标准化中国主要树种树高-胸径方程。由于树冠和下部灌木及草丛遮挡,树高相对于胸径测量具有一定的难度,因此需要使用数学工具进行计算。选取了36个树种为材料构建树高-胸径关系方程,以全国主要树种的二元材积模型、各地区一元材积表为基础材料,以取样径阶为1 cm间隔所生成1692组树高-胸径数据作为建立方程样本,1238组外业调查数据为验证样本。建模结果表明:36个主要树种的1692组树高-胸径数据建立的全国通用性树高-胸径方程拟合相关系数(R2)为0.801,方程拟合结果较好,说明可以通过测定胸径,带入树高(H,m)-胸径(D,cm)方程(H=aDb)预估树高;对36个主要树种的树高-胸径方程进行拟合,决定系数R2值均大于0.916,平均误差(ME)、平均绝对误差(MAE)和均方根误差(RMSE)相对较小,方程整体精度较高,可广泛推广;将外业采集的1238组树高-胸径数据,根据36个主要树种树高-胸径方程拟合公式及参数估计值a、b进行方程精度验证,方程预测的平均相对误差为16.86%,在误差允许范围内,并且模型形式规范,可为GlobalAllomeTree平台用户提供科学参考。

关于改善中枢性性早熟患儿身高获益的思考

随着遗传和环境等多种因素的改变,儿童性早熟的发病率逐渐增加,以改善身高为目的的性早熟治疗是临床关注的重点问题之一。目前,促性腺激素释放激素类似物(gonadotropin-releasing hormone analogs,GnRHa)仍是首选治疗药物,但其对身高的改善作用受多种因素影响,可能导致身高获益低于预期。联合重组人生长激素(recombinant human growth hormone,rhGH)治疗是提高GnRHa疗效的可选治疗策略,然而联用时机等尚无明确推荐。基于性早熟治疗现状,重新审视单用GnRHa及联合rhGH治疗对身高的改善作用至关重要。该文探索了联合治疗适应证等策略,以期指导临床用药,帮助性早熟患儿实现更理想的身高获益。

水稻籼粳中间型杂交组合若干性状的遗传效应分析

【目的】水稻籼粳亚种间杂交具有强大的杂种优势已成为当前水稻育种关注的焦点,本研究旨在为籼粳交水稻育种实践以及水稻关键性状的遗传研究提供理论依据。【方法】按照NC-II不完全双列杂交方式,选择14个亲本材料并配组48个杂交组合,采用植物数量性状的加性-显性遗传模型(A-D模型)分析生育期、株高与粒形相关性状等共计5个农艺性状的遗传效应、杂种优势及性状之间的相关性。【结果】籼粳亚种间杂交稻生育期、株高、粒长、粒宽及长宽比等的加性方差分量占遗传主效应比率(V_(A)/V_(P))比值分别为69.2%、 74.2%、 58.9%、66.0%和63.5%。广义遗传率(H^(2)B)和狭义遗传率(H^(2)N)的变幅分别为59.0%~99.6%和69.2%~98.9%,均达显著或极显著水平,主要受加性效应控制,且受环境影响小,在育种上早期选择有效。大多数的籼粳亚种间杂种一代的生育期、株高和粒形性状均呈负向中亲优势和负向超亲优势,杂交后代的生育期缩短、株高降低,长宽比介于双亲之间。籼粳亚种间杂交稻生育期是一个独立遗传的品种特性,株高与粒形具呈显著正相关。【结论】在籼粳交育种上应关注生育期、株高,粒形等性状间的协调,有效利用杂种优势,培育强优势亚种间杂交稻新组合。

利用异速生长模型和博弈论解析藏川杨主干动态生长的遗传调控机制

【目的】高度与直径是树木生命历程中的2个重要生长性状,本文通过量化藏川杨主干高度和直径之间的相互作用,探究这2个性状的生长过程和生长模式,揭示藏川杨主干动态生长的遗传调控机制。【方法】基于异速生长模型和博弈论构建藏川杨高度与直径性状的动态生长互作微分方程,利用系统作图构建藏川杨主干生长遗传解析的统计模型。进一步以藏川杨自然群体作为研究材料,调查其在温室内的生长动态数据,结合本群体的高通量分子标记数据,开展藏川杨的全基因组基因定位工作。【结果】藏川杨主干高度和直径的整体生长曲线符合Logistic生长曲线,拆分整体生长曲线发现,藏川杨主干的直径生长对高度生长具有抑制作用,而高度生长对直径生长具有促进作用。所有藏川杨高度和直径的个体拟合优度> 0.90,且2个性状拟合的残差均服从随机分布,说明使用广义Lotka-Volterra微分方程来拟合藏川杨高度和直径效果很好。基于功能作图方法共定位到78个显著位点,可注释到52个候选基因。以2号染色体上最显著的SNP为例,对藏川杨高度和直径进行遗传解析,发现该SNP的3种基因型(AA、AC、CC)具有相似的高度–直径相互作用模式。该SNP对整体生长、独立生长和依赖生长发挥了不同方式的遗传效应。对定位到的显著位点进行功能注释,可将这些位点所在的基因分为:与木质素/细胞壁合成相关基因、与生长发育相关基因、与抗病抗逆性相关基因、与光合作用相关基因这4类。【结论】结合异速生长模型和博弈理论的基因定位模型,可检测基因如何通过合作或竞争策略来调控藏川杨主干的大小,识别树干动态生长的过程和模式,相关模型也可为其他物种重要性状之间的深层次遗传解析提供借鉴。

1985—2019年新疆维吾尔族中小学生生长发育的长期趋势

目的:了解新疆维吾尔自治区1985—2019年7~18岁维吾尔族中小学生生长发育情况,为制定健康促进策略提供理论依据。方法:选取1985、2000、2010和2019年4次全国学生体质与健康调研中具有完整身高、体质量和体重指数(body mass index, BMI)数据的18 591例7~18岁新疆维吾尔族中小学生为研究对象,计算各年龄组每相邻两调查年之间的增幅和每十年增速,对各形态指标平均值进行t检验分析年份间的差异。结果:34年来,除17~18岁女生身高外,其余各年龄组维吾尔族男女生身高和体质量显著增长(P值均<0.01),男女生身高增长范围为2.06~9.89 cm和-0.03~6.86 cm;体质量增长范围为2.39~10.2 kg和2.57~8.05 kg;2000—2019年大部分年龄组BMI增加,男女生BMI增长范围分别为-0.94~0.86 kg/m^(2)和0.08~1.34 kg/m^(2),男生形态指标增幅大于女生。前15年男生身高和男女生体质量增速最快,中间10年多数年龄组身高和少数年龄组体质量、BMI下降,后9年除男生体质量外总体均转为积极生长趋势,且女生身高增速达到各时期最高。女生身高最大发育年龄(maximum increase/growth age, MIA)提前较体质量和BMI的MIA提前的明显;男生身高MIA无明显变化,但体质量和BMI的MIA提前明显。结论:34年间新疆7~18岁维吾尔族中小学生总体身体形态呈增长趋势,存在性别差异,总体生长情况尚处于生长长期趋势的初期阶段,需要重点关注男女生的体质量状况,预防不正常营养状态的出现。

升温情境中叶损对树木幼苗生长的影响

为探究升温能否在一定程度上抵消虫害叶损造成的负面影响,该研究采用控制变量法比较不同叶损程度下落叶松(Larix gmelinii)、红松(Pinus koraiensis)和冷杉(Abies fabri)幼苗当年的高生长以及来年不同温度下的萌芽情况。结果表明,当叶损程度达到50%时,落叶松幼苗当年的高生长会受到显著影响;而红松和冷杉在叶损程度达到75%时才会受到显著影响。室温下(13℃~18℃)落叶松来年的萌芽物候比20℃和25℃提前且高生长情况较好;红松和冷杉在室温下叶损75%会导致萌芽物候推迟且高生长受到影响,在20℃或25℃时,叶损造成的不利影响则会被削弱。因此,在未来变暖的情境中,推测红松和冷杉因虫害叶损造成的不利影响在一定程度上会被抵消,且对于虫害的抵抗和恢复亦明显高于落叶松。

金亚蓓运用齐氏脐针治疗青少年身高增长缓慢的临床体会

[目的]总结浙江省名中医金亚蓓教授运用齐氏脐针治疗青少年身高增长缓慢的临床经验与体会。[方法]通过临床跟诊、整理、回顾、分析的方式,从病因病机、辨证论治和特色选穴等方面总结金师运用脐针治疗青少年身高增长缓慢的临床经验,并附验案两则。[结果]金师认为,青少年身高增长缓慢内在核心病机为“脾虚不运,五脏不坚”,与“肾虚不充,骨髓化生乏源”“肝失疏泄,横克脾土”关系密切。临床常将患者分为脾肾两虚型和肝郁脾虚型两类,脾肾两虚型患者的脐针治疗以“震位、巽位、离位、坤位”为主方,肝郁脾虚型则以“左升四针”为主,治疗过程中注重调畅情志,随证调整针方。文末所举验案中,其一患者属脾肾两虚型,用脐针益气健脾、补肾培元为治,兼顾患者负面情绪,辅以疏肝、祛邪、固脱,邪去正复后改为“左升四针”助阳升发而使身高得长;其二患者属肝郁脾虚型,系学业压力重大、肝失疏泄、横克脾土所致,以“左升四针”疏肝解郁、升发阳气,辅以宣肺理气,最终五脏调和而身高自长。[结论]金师运用齐氏脐针治疗青少年身高增长缓慢,严谨辨证,分型论治,关注患者心理状态,注重调畅情志,临床特色鲜明,治疗效果显著,其经验值得推广学习。

1985—2019年中国18个少数民族17岁学生身高长期趋势分析

目的:分析1985—2019年我国18个少数民族17岁学生身高生长长期变化趋势。方法:提取7次中国学生体质与健康调研报告(除1991年)中蒙古族、回族、维吾尔族、壮族、朝鲜族、藏族、苗族、布依族、侗族、白族、土家族、哈尼族、傣族、傈僳族、佤族、纳西族、土族、羌族等18个少数民族学生身高均值进行研究。结果:34年间各少数民族男生17岁身高均值显著增长(P<0.05)。2019年18个少数民族17岁男学生中,回族男生身高均值最高(173.09 cm),苗族男生身高均值最低(162.66 cm),每10年身高增长>1 cm的民族有侗族(1.96 cm/10年)、白族(1.96 cm/10年)、土家族(1.95 cm/10年)、羌族(1.80 cm/10年)、回族(1.80 cm/10年)、蒙古族(1.79 cm/10年)、土族(1.72 cm/10年)、维吾尔族(1.63 cm/10年)、藏族(1.61 cm/10年)、布依族(1.55 cm/10年)、纳西族(1.52 cm/10年)、傣族(1.35 cm/10年)、傈僳族(1.29 cm/10年)、哈尼族(1.25 cm/10年)、壮族(1.16 cm/10年)、佤族(1.06 cm/10年);每10年身高增长<1 cm的民族是苗族(0.95 cm/10年)。2019年,18个少数民族17岁女学生中,回族女生身高均值最高(161.71 cm),布依族女生身高均值最低(151.63 cm),每10年身高增长>1 cm的民族分别是土家族(1.80 cm/10年)、回族(1.52 cm/10年)、土族(1.25 cm/10年)、白族(1.23 cm/10年)、侗族(1.18 cm/10年)、朝鲜族(1.12 cm/10年)、羌族(1.04 cm/10年);34年间除维吾尔族、苗族女生外,其余少数民族女生身高增长显著(P<0.05)。结论:我国少数民族男生均出现了较为明显的生长长期趋势,大部分少数民族女生出现了较为明显的生长长期趋势,各民族男女生身高增长不平衡,证明我国不同地区、不同少数民族学生生长潜力得以发挥,对于身高增长较慢的民族需要给予更高的关注,而对于那些身高增长较快的民族也要预防其带来的负面效应。

缓释肥一次性施入对酸枣容器苗生长的影响

以酸枣容器苗为试材,通过对比酸枣容器苗在不同缓释肥施用量下的生长状况,筛选最佳缓释肥施用量,为酸枣容器育苗的精准施肥提供技术支持。结果表明,不同缓释肥施用量条件下,酸枣容器苗在生长、生理及叶绿素含量等方面均存在显著性差异,其中年施肥量75 g/袋时,酸枣苗综合表现最好。与CK 1相比,施用缓释肥可显著促进苗木生长,株高增加7.26%~29.53%,地径增加10.28%~20.46%,二次枝数量增加1.06%~26.46%,最长二次枝长度增加1.24%~14.40%。除地径外,其余3个指标均随施肥量增加呈先增后降的趋势,且在年施肥量75 g/袋时,各个指标达最高。与CK 1相比,苗木根系投影面积、根表面积、根平均直径、根体积、总鲜质量、地上部鲜质量、地下部鲜质量分别显著提高了53.81%、53.81%、60.85%、82.08%、50.73%、56.82%、53.12%,且叶片的可溶性糖含量均增加。本研究表明,以缓释肥年施用量75 g/袋为宜。

中西医结合综合治疗特发性矮小症的临床价值分析

目的探讨分析对特发性矮小症患儿采用中西医结合综合治疗的临床疗效。方法90例特发性矮小症患儿开展本次研究,将所有患儿根据数字表法分为观察组与对照组,各45例。单独给予西医治疗的为对照组,采用中西医结合综合治疗的为观察组。比较两组的身高标准差及预测成年身高,消化系统及呼吸系统疾病的发生情况,生长因子水平。结果观察组身高标准差(-1.6±0.5)cm、预测成年身高(163.4±6.9)cm均优于对照组的(-1.9±0.7)、(156.7±5.4)cm(P<0.05)。观察组消化系统疾病发生率4.44%、呼吸系统疾病发生率8.89%均低于对照组的22.22%、28.89%(P<0.05)。观察组的胰岛素样生长因子-1为(195.5±25.8)ng/ml,胰岛素样生长因子结合蛋白-3为(4.4±0.8)μg/ml;对照组的胰岛素样生长因子-1为(104.5±16.8)ng/ml,胰岛素样生长因子结合蛋白-3为(2.4±0.4)μg/ml。观察组胰岛素样生长因子-1、胰岛素样生长因子结合蛋白-3均高于对照组(t=19.828、15.000,P=0.000、0.000<0.05)。结论对特发性矮小症患儿采用中西医结合综合治疗的临床疗效更为确切,可以使患儿的身高大幅增长,并提高患儿的自身免疫力,有必要在临床上大力推广。

碳酸钙D_(3)联合重组人生长激素对身材矮小症患儿生长发育的影响

目的探究碳酸钙D_(3)联合重组人生长激素对身材矮小症患儿生长发育的影响。方法选取2018年6月至2021年11月于西部战区总医院就诊的身材矮小症患儿114例。采用随机信封法分为对照组和观察组,各57例。对照组给予重组人生长激素注射液皮下注射治疗,观察组在对照组的基础上联合碳酸钙D_(3)片口服治疗。2组患儿均连续治疗12个月。比较2组患儿治疗前后生长发育情况、骨代谢指标、生长因子水平及甲状腺功能,比较2组治疗期间不良反应总发生率。结果治疗后2组患儿身高、骨龄指数、骨龄年龄差水平均明显高于治疗前,且观察组明显高于对照组[(122±7)cm比(118±7)cm、(0.98±0.02)比(0.97±0.03)、(-0.36±0.05)比(-0.40±0.08)],差异均有统计学意义(均P<0.05)。治疗后观察组骨碱性磷酸酶、Ⅰ型原胶原氨基端前肽、25-羟基维生素D、胰岛素样生长因子1、胰岛素样生长因子结合蛋白3水平均明显高于对照组,食欲刺激素水平低于对照组,差异均有统计学意义(均P<0.05)。治疗后2组患儿促甲状腺激素、游离三碘甲腺原氨酸、游离甲状腺素水平差异均无统计学意义(均P>0.05)。2组患儿不良反应总发生率差异无统计学意义(P>0.05)。结论碳酸钙D_(3)联合重组人生长激素可有效改善各类生长因子分泌水平,提升患儿骨质代谢水平,进而促进患儿生长发育,且对患儿甲状腺功能无明显影响,具有较好的安全性。