Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion cha...Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.展开更多
Shape optimization of mechanical components is one of the issues that have been considered in recent years. Different methods were presented such as adaptive biological for reducing costs and increasing accuracy. The ...Shape optimization of mechanical components is one of the issues that have been considered in recent years. Different methods were presented such as adaptive biological for reducing costs and increasing accuracy. The effects of step factor, the number of control points and the definition way of control points coordinates in convergence rate were studied. A code was written using ANSYS Parametric Design Language (APDL) which receives the studied parameters as input and obtains the optimum shape for the components. The results show that for achieving successful optimization, step factor should be in a specific range. It is found that the use of any coordinate system in defining control points coordinates and selection of any direction for stimulus vector of algorithm will also result in optimum shape. Furthermore, by increasing the number of control points, some non-uniformities are created in the studied boundary. Achieving acceptable accuracy seems impossible due to the creation of saw form at the studied boundary which is called "saw position".展开更多
We simulated the asymmetrical growth of cube-shaped nanoparticles by applying the Monte Carlo method.The influence of the specific mechanisms on the crystal growth of nanoparticles has been phenomenologically describe...We simulated the asymmetrical growth of cube-shaped nanoparticles by applying the Monte Carlo method.The influence of the specific mechanisms on the crystal growth of nanoparticles has been phenomenologically described by efficient growth possibilities along different directions(or crystal faces).The roles of the thermodynamic and kinetic factors have been evaluated in three phenomenological models.The simulation results would benefit the understanding about the cause and manner of the asymmetrical growth of nanoparticles.展开更多
Based on statistical analysis on morphological data of nebkhas surveyed in the Hotan River Basin,Xinjiang, the changing regularity and characters of nebkhas’ morphology in different development stageshave been discus...Based on statistical analysis on morphological data of nebkhas surveyed in the Hotan River Basin,Xinjiang, the changing regularity and characters of nebkhas’ morphology in different development stageshave been discussed. Results indicate that there exist better correlation among length, width and altitudeof all kinds of nebkhas, but there are certain various shape characters in different nebkhas and the sametype of nebkhas in differential development stages. On account of analysis on mathematical imitation ofnebkhas’ shape characters, regional ecological environmental and aeolian characters, the development ofthe nebkha can be divided into a growing stage, a stabilizing stage and a declining stage.展开更多
Tetrapod-shaped ZnO whiskers and microrods were synthesized in one crucible by thermal evaporation of Zn/C mixtures at 930 ℃ in air without any catalyst.The digital camera,optical microscopy,scanning electron microsc...Tetrapod-shaped ZnO whiskers and microrods were synthesized in one crucible by thermal evaporation of Zn/C mixtures at 930 ℃ in air without any catalyst.The digital camera,optical microscopy,scanning electron microscopy,energy dispersive X-ray spectroscopy,and X-ray diffraction techniques were used to study the morphologies and crystal structures of these tetrapod-shaped ZnO microcrystals.The results show that these two types of ZnO tetrapods are grown at different heights within the same crucible.The legs of these tetrapod-shaped ZnO crystals are hexagonally faceted.Some tetrapod-shaped ZnO whiskers show hierarchical structures.A short button-like hexagonal ZnO microcrystal is observed at the triple junctions of some tetrapod-shaped ZnO whiskers.The tetrapod-shaped ZnO microrods are capped by two sets of hexagonal pyramids with two different groups of crystal planes for the surfaces.These two types of tetrapod-shaped ZnO microcrystals have different side faces and aspect ratio,which are believed to be the result of their different growth behaviors.The octa-twin model was used to discuss the different growth behaviors of these two types of ZnO tetrapods.The crystal planes of the legs and the pyramids were determined.展开更多
Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped...Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped varying trend of TE increasing rate more accurately, first, two S-shaped testing-effort functions(TEFs), i.e.,delayed S-shaped TEF(DS-TEF) and inflected S-shaped TEF(IS-TEF), are proposed. Then these two TEFs are incorporated into various types(exponential-type, delayed S-shaped and inflected S-shaped) of non-homogeneous Poisson process(NHPP)SRGMs with two forms of ID respectively for obtaining a series of new NHPP SRGMs which consider S-shaped TEFs as well as ID. Finally these new SRGMs and several comparison NHPP SRGMs are applied into four real failure data-sets respectively for investigating the fitting and prediction power of these new SRGMs.The experimental results show that:(i) the proposed IS-TEF is more suitable and flexible for describing the consumption of TE than the previous TEFs;(ii) incorporating TEFs into the inflected S-shaped NHPP SRGM may be more effective and appropriate compared with the exponential-type and the delayed S-shaped NHPP SRGMs;(iii) the inflected S-shaped NHPP SRGM considering both IS-TEF and ID yields the most accurate fitting and prediction results than the other comparison NHPP SRGMs.展开更多
Growing actin networks provide the driving force for the motility of cells and intracellular pathogens. Based on the molecular-level processes of actin polymerization, branching, capping, and depolymerization, we have...Growing actin networks provide the driving force for the motility of cells and intracellular pathogens. Based on the molecular-level processes of actin polymerization, branching, capping, and depolymerization, we have developed a modeling framework to simulate the stochastic and cooperative behaviors of growing actin networks in propelling obstacles, with an emphasis on the size and shape effects on work capacity and filament orientation in the growing process. Our results show that the characteristic size of obstacles changes the protrusion power per unit length, without influencing the orientation distribution of actin filaments in growing networks. In contrast, the geometry of obstacles has a profound effect on filament patterning, which influences the orientation of filaments differently when the drag coefficient of environment is small, intermediate, or large. We also discuss the role of various parameters, such as the aspect ratio of obstacles, branching rate, and capping rate, in affecting the protrusion power of network growth.展开更多
A lot of changes have transpired in the global economy, in China, as well as in South Africa since the bilateral relations between South Africa, Africa's most industrialized country, and China, Asia's powerhouse, we...A lot of changes have transpired in the global economy, in China, as well as in South Africa since the bilateral relations between South Africa, Africa's most industrialized country, and China, Asia's powerhouse, were established on January 1, 1998. As the global economy finds its feet 10 years after the global financial crisis, China is now in its "new normal" featuring medium and low economic growth and South Africa is preoccupied with various political and economic challenges in a subdued African growth environment. What then has transpired in this commercial corridor over the past two decades?展开更多
Diamond single crystal was epitaxially grown on the surface of diamond seeds with rough planes at high pressure and high temperature(HPHT)conditions.Fe80Ni20alloy powder was used as catalyst/solvent and natural flake-...Diamond single crystal was epitaxially grown on the surface of diamond seeds with rough planes at high pressure and high temperature(HPHT)conditions.Fe80Ni20alloy powder was used as catalyst/solvent and natural flake-like graphite was used as carbon source.Diamond single crystals were grown on the diamond seeds at 4.8GPa and 1500K.The morphology of the samples was observed by SEM.The mechanism of diamond growth with smooth planes from original seed with rough planes was studied.展开更多
Crystal shape distribution, i.e. the multidimensional size distribution of crystals, is of great importance to their down-stream processing such as in filtration as well as to the end-use properties including the diss...Crystal shape distribution, i.e. the multidimensional size distribution of crystals, is of great importance to their down-stream processing such as in filtration as well as to the end-use properties including the dissolution rate and bioavailability for crystalline pharmaceuticals. Engineering crystal shape and shape distribution requires knowledge about the growth behavior of different crystal facets under varied operational conditions e.g. supersaturations. Measurement of the facet growth rates and growth kinetics of static crystals in a crystallizer without stirring has been reported previously. Here attention is given to study on real-time characterization of the 3D facet growth behavior of crystals in a stirred tank where crystals are constantly moving and rotating. The measurement technique is stereo imaging and the crystal shape reconstruction is based on a stereo imaging camera model. By reference to a case study on potash alum crystallization, it is demonstrated that the crystal size and shape distributions (CSSD) of moving and rotating potash alum crystals in the solution can be reconstructed. The moving window approach was used to correlate 3D face growth kinetics with supersaturation (in the range 0.04 - 0.12) given by an ATR FTIR probe. It revealed that {100} is the fastest growing face, leading to a rapid reduction of its area, while the {111} face has the slowest growth rate, reflected in its area continuously getting larger.展开更多
文摘Calcium is a critical second messenger molecule in all cells and is vital in neurons for synaptic transmission.Given this importance,calcium ions are tightly controlled by a host of molecular players including ion channels,sensors,and buffering proteins.Calcium can act directly by binding to signaling molecules or calcium’s effects can be indirect,for example by altering nuclear histones.
文摘Shape optimization of mechanical components is one of the issues that have been considered in recent years. Different methods were presented such as adaptive biological for reducing costs and increasing accuracy. The effects of step factor, the number of control points and the definition way of control points coordinates in convergence rate were studied. A code was written using ANSYS Parametric Design Language (APDL) which receives the studied parameters as input and obtains the optimum shape for the components. The results show that for achieving successful optimization, step factor should be in a specific range. It is found that the use of any coordinate system in defining control points coordinates and selection of any direction for stimulus vector of algorithm will also result in optimum shape. Furthermore, by increasing the number of control points, some non-uniformities are created in the studied boundary. Achieving acceptable accuracy seems impossible due to the creation of saw form at the studied boundary which is called "saw position".
基金Project supported by the National Natural Science Foundation of China(Grant No.51406111)the Major Program of the National Natural Science Foundation of China(Grant No.51590902)+2 种基金the Natural Science Foundation of Shanghai,China(Grant No.14ZR1417000)the Scientific Innovation Project of Shanghai Education Committee,China(Grant No.15ZZ100)Young Eastern Scholar of Shanghai,China(Grant No.QD2015052)
文摘We simulated the asymmetrical growth of cube-shaped nanoparticles by applying the Monte Carlo method.The influence of the specific mechanisms on the crystal growth of nanoparticles has been phenomenologically described by efficient growth possibilities along different directions(or crystal faces).The roles of the thermodynamic and kinetic factors have been evaluated in three phenomenological models.The simulation results would benefit the understanding about the cause and manner of the asymmetrical growth of nanoparticles.
基金Supported by the National Natural Science of China (No.40461002,40861008)the Key Project of the Ministry of Education (No. 209141 )Doctoral Scientific and Technological Initial Funds of Xinjiang Normal University.
文摘Based on statistical analysis on morphological data of nebkhas surveyed in the Hotan River Basin,Xinjiang, the changing regularity and characters of nebkhas’ morphology in different development stageshave been discussed. Results indicate that there exist better correlation among length, width and altitudeof all kinds of nebkhas, but there are certain various shape characters in different nebkhas and the sametype of nebkhas in differential development stages. On account of analysis on mathematical imitation ofnebkhas’ shape characters, regional ecological environmental and aeolian characters, the development ofthe nebkha can be divided into a growing stage, a stabilizing stage and a declining stage.
基金Project(0061)supported by the Doctorate Foundation of Nanchang University,ChinaProject(2006015)supported by the Center for Analysis and Testing,Nanchang University,China
文摘Tetrapod-shaped ZnO whiskers and microrods were synthesized in one crucible by thermal evaporation of Zn/C mixtures at 930 ℃ in air without any catalyst.The digital camera,optical microscopy,scanning electron microscopy,energy dispersive X-ray spectroscopy,and X-ray diffraction techniques were used to study the morphologies and crystal structures of these tetrapod-shaped ZnO microcrystals.The results show that these two types of ZnO tetrapods are grown at different heights within the same crucible.The legs of these tetrapod-shaped ZnO crystals are hexagonally faceted.Some tetrapod-shaped ZnO whiskers show hierarchical structures.A short button-like hexagonal ZnO microcrystal is observed at the triple junctions of some tetrapod-shaped ZnO whiskers.The tetrapod-shaped ZnO microrods are capped by two sets of hexagonal pyramids with two different groups of crystal planes for the surfaces.These two types of tetrapod-shaped ZnO microcrystals have different side faces and aspect ratio,which are believed to be the result of their different growth behaviors.The octa-twin model was used to discuss the different growth behaviors of these two types of ZnO tetrapods.The crystal planes of the legs and the pyramids were determined.
基金supported by the Pre-research Foundation of CPLA General Equipment Department
文摘Testing-effort(TE) and imperfect debugging(ID) in the reliability modeling process may further improve the fitting and prediction results of software reliability growth models(SRGMs). For describing the S-shaped varying trend of TE increasing rate more accurately, first, two S-shaped testing-effort functions(TEFs), i.e.,delayed S-shaped TEF(DS-TEF) and inflected S-shaped TEF(IS-TEF), are proposed. Then these two TEFs are incorporated into various types(exponential-type, delayed S-shaped and inflected S-shaped) of non-homogeneous Poisson process(NHPP)SRGMs with two forms of ID respectively for obtaining a series of new NHPP SRGMs which consider S-shaped TEFs as well as ID. Finally these new SRGMs and several comparison NHPP SRGMs are applied into four real failure data-sets respectively for investigating the fitting and prediction power of these new SRGMs.The experimental results show that:(i) the proposed IS-TEF is more suitable and flexible for describing the consumption of TE than the previous TEFs;(ii) incorporating TEFs into the inflected S-shaped NHPP SRGM may be more effective and appropriate compared with the exponential-type and the delayed S-shaped NHPP SRGMs;(iii) the inflected S-shaped NHPP SRGM considering both IS-TEF and ID yields the most accurate fitting and prediction results than the other comparison NHPP SRGMs.
基金supported by the National Natural Science Foundation of China (Grants 11321202, 11672268)the Zhejiang Provincial Natural Science Foundation of China (Grant LR16A020001)
文摘Growing actin networks provide the driving force for the motility of cells and intracellular pathogens. Based on the molecular-level processes of actin polymerization, branching, capping, and depolymerization, we have developed a modeling framework to simulate the stochastic and cooperative behaviors of growing actin networks in propelling obstacles, with an emphasis on the size and shape effects on work capacity and filament orientation in the growing process. Our results show that the characteristic size of obstacles changes the protrusion power per unit length, without influencing the orientation distribution of actin filaments in growing networks. In contrast, the geometry of obstacles has a profound effect on filament patterning, which influences the orientation of filaments differently when the drag coefficient of environment is small, intermediate, or large. We also discuss the role of various parameters, such as the aspect ratio of obstacles, branching rate, and capping rate, in affecting the protrusion power of network growth.
文摘A lot of changes have transpired in the global economy, in China, as well as in South Africa since the bilateral relations between South Africa, Africa's most industrialized country, and China, Asia's powerhouse, were established on January 1, 1998. As the global economy finds its feet 10 years after the global financial crisis, China is now in its "new normal" featuring medium and low economic growth and South Africa is preoccupied with various political and economic challenges in a subdued African growth environment. What then has transpired in this commercial corridor over the past two decades?
文摘Diamond single crystal was epitaxially grown on the surface of diamond seeds with rough planes at high pressure and high temperature(HPHT)conditions.Fe80Ni20alloy powder was used as catalyst/solvent and natural flake-like graphite was used as carbon source.Diamond single crystals were grown on the diamond seeds at 4.8GPa and 1500K.The morphology of the samples was observed by SEM.The mechanism of diamond growth with smooth planes from original seed with rough planes was studied.
文摘Crystal shape distribution, i.e. the multidimensional size distribution of crystals, is of great importance to their down-stream processing such as in filtration as well as to the end-use properties including the dissolution rate and bioavailability for crystalline pharmaceuticals. Engineering crystal shape and shape distribution requires knowledge about the growth behavior of different crystal facets under varied operational conditions e.g. supersaturations. Measurement of the facet growth rates and growth kinetics of static crystals in a crystallizer without stirring has been reported previously. Here attention is given to study on real-time characterization of the 3D facet growth behavior of crystals in a stirred tank where crystals are constantly moving and rotating. The measurement technique is stereo imaging and the crystal shape reconstruction is based on a stereo imaging camera model. By reference to a case study on potash alum crystallization, it is demonstrated that the crystal size and shape distributions (CSSD) of moving and rotating potash alum crystals in the solution can be reconstructed. The moving window approach was used to correlate 3D face growth kinetics with supersaturation (in the range 0.04 - 0.12) given by an ATR FTIR probe. It revealed that {100} is the fastest growing face, leading to a rapid reduction of its area, while the {111} face has the slowest growth rate, reflected in its area continuously getting larger.