Study on the mechanism of effect of Daodi Tongguan Decoction on rats with premature ovarian failure

Objective:To investigate the mechanism of the effect of Daodi Tongguan Decoction on ovarian function in rats with premature ovarian failure.Methods:Forty SD female rats with regular estrous cycle were randomly divided into the blank group,the model group,the positive group(Bujiale 0.099 mg/kg),the Daodigitongguan decoction high-dose group(1.4 g/100 g)and the Daodigitongguan decoction medium-dose group(0.7 g/100 g).The model group,positive group,Daodi Tongguan Decoction high-dose group and Daodi Tongguan decoction medium-dose group were given Tripterygium wilfordii polyglycoside tablets suspension(50 mg/kg)by continuous gavage for 14 days to establish a rat model of premature ovarian failure.After the modeling,each group was given the corresponding intervention agent for 28 consecutive days.After the intervention,serum and ovarian tissue were collected from rats in each group.The morphological structure of rat ovarian tissue was observed after HE staining.Serum AMH level was determined by ELISA.The expressions of Bcl-2,Bax and VEGF in ovarian tissue were detected by IHC.The apoptosis of granulosa cells in ovary was observed by TUNEL.Results:Compared to the normal group,the growth follicles in the model group were reduced and the atretic follicles were increased.Serum AMH level was significantly decreased(P<0.01).The expression of Bax protein in ovarian tissue was increased(P<0.01).The protein expressions of Bcl-2 and VEGF were decreased(P<0.01,P<0.05),and the apoptosis rate of follicular granulosa cells in ovarian tissue was increased(P<0.01).Compared to the molding group,the serum AMH level in the TCM dose groups was increased to varying degrees,and the change of the AMH in high-dose group was the most significant(P<0.05).The expression of Bax protein in ovarian tissue decreased(P<0.05),while the expression of Bcl-2 and VEGF protein increased(P<0.05,P<0.05).The apoptosis rate of follicular granulosa cells in ovarian tissue was decreased in the high dose group(P<0.05).Conclusion:Daodi Tongguan Decoction can improve the histological morphology of ovary and relieve ovarian injury,and its mechanism may be related to improving the sex hormone level of POF model rats,reducing the expression level of Bax protein in ovarian tissue,increasing the expression level of Bcl-2 and VEGF protein in ovarian tissue,and reducing the apoptosis rate of follicular granulosa cells in ovarian tissue.

Three-Dimensional Water Quality Model Based on FVCOM for Total Load Control Management in Guan River Estuary,Northern Jiangsu Province

Guan River Estuary and adjacent coastal area(GREC) suffer from serious pollution and eutrophicational problems over the recent years.Thus,reducing the land-based load through the national pollutant total load control program and developing hydrodynamic and water quality models that can simulate the complex circulation and water quality kinetics within the system,including longitudinal and lateral variations in nutrient and COD concentrations,is a matter of urgency.In this study,a three-dimensional,hydrodynamic,water quality model was developed in GREC,Northern Jiangsu Province.The complex three-dimensional hydrodynamics of GREC were modeled using the unstructured-grid,finite-volume,free-surface,primitive equation coastal ocean circulation model(FVCOM).The water quality model was adapted from the mesocosm nutrients dynamic model in the south Yellow Sea and considers eight compartments:dissolved inorganic nitrogen,soluble reactive phosphorus(SRP),phytoplankton,zooplankton,detritus,dissolved organic nitrogen(DON),dissolved organic phosphorus(DOP),and chemical oxygen demand.The hydrodynamic and water quality models were calibrated and confirmed for 2012 and 2013.A comparison of the model simulations with extensive dataset shows that the models accurately simulate the longitudinal distribution of the hydrodynamics and water quality.The model can be used for total load control management to improve water quality in this area.

Land Use Change and Driving Forces in Guangzhou City during 1996- 2012

Based on the statistical data of land use change,from the perspective of sustainable use,we use literature inquiry,statistical analysis,GIS spatial analysis and dynamic degree model of land use,to analyze the land use change characteristics,land use amount and spatial distribution characteristics in Guangzhou City during 1996- 2012,and further elaborate the driving forces of land use change to get the basic law of land use change in Guangzhou City. The results show that the construction land was rapidly expanded,causing a significant reduction in arable land( from 129286 ha in 1996 to 84567 ha in 2012); in construction land,the land for residential,industrial and mining use and transportation land dramatically increased,and the single dynamic degree of transportation land was close to 7. 1%. In comparison with other developed cities,it is found that economic factors and policy factors are important factors affecting land use change in Guangzhou City,and the growth rate of economic density of land was high in Tianhe District and Yuexiu District. From the perspective of sustainable use,the future land use in Guangzhou City needs to better coordinate the relationship between various types of land,between socio-economic development and coordinated land use development,between environmental protection and land development and utilization. Through a series of land consolidation activities,it is necessary to strengthen the protection of farmland,improve the intensive and economical use of construction land,improve the ecological environment,and coordinate development of urban and rural areas,to ultimately achieve sustainable land use in Guangzhou City.

“Tong Guan Li Qiao” Acupuncture Therapy on Post-Stroke Dysphagia

The differences between the“Tong Guan Li Qiao”acupuncture therapy and the conventional and current other acupuncture methods for poststroke dysphagia are as follows:first,it adheres to the basic idea of "Xing Nao Kai Qiao"acupuncture therapy in selecting and combining acupoints,centers on the brain,and combines the dysphagia symptoms of the mouth,tongue,and throat-related orifices with the root cause of"brain";second,thereare strictand standard requirements intheacupuncture operation,that is,manipulation quantification.In addition to standardized twirling,lifting,and thrusting,the techniques of deep needling on the acupoints in the neck region,blood-letting puncturing at the posterior wallof the pharynx,and theneedling sensation of"like a fishbone getting stuck in the throat"are all unique.

Probe into the Logic and Rhetoric of Propriety in The Book of Songs :Taking “Guan Ju” as the Core Example

The Book of Songs is a book of propriety passing on rites and teaching people by the form of poetry with unique logic and rhetoric.“Guan Ju”is the most typical poem deducing the propriety of humans from the laws of nature,which is acceptable,convinced and obeyed by the people naturally,friendly and eloquently.Therefore,the logic and rhetoric in The Book of Songs can be reconciled and self-consistent in the poetic thinking of the unity of heaven and humans.

Guan Sheng Yuan (Group) Co. Ltd.

Guan Sheng Yuan was founded in 1918. As a famous, time-honoured brand enterprise of China’s national industry, it has a history of about 80 years. Since 1993 when it was re-estab-lished in accordance with the demand for the modern enterprise system, the Guan Sheng Yuan (Group) Co. Ltd.

Preliminary Study on Heavy Metal Pollution Status of Farmland Soil at Two Sides of Cheng-Guan Expressway

The heavy metal content of the farmland soil at two sides of Cheng-Guan Expressway is measured to make a preliminary evaluation on its heavy metal pollution status.After digestion and volume fixation of the soil samples collected,measure the Cu,Zn,Cd,Pb and Cr content with atomic absorption spectrophotometry and evaluate the measured data according to Level Two of National Soil Environmental Quality Standard to obtain the contamination status.Cu,Zn and Cd content of the farmland soil for sections of Cheng-Guan Expressway goes beyond Level Two of National Soil Environmental Quality Standard,while the Pb and Cr content meets Level Two of National Soil Environmental Quality Standard.Pb and Cr content of the farmland soil at two sides of Cheng-Guan Expressway is in safe state,while the Cu,Zn and Cd content is in a mild contamination state.Cu,Zn and Cd are the main pollution elements.

A Study on Yang Xianyi and Gladys Yang’s Translation of“Guan Ju”

The Book of Songs,as the first collection of poems in China,is of great significance for understanding the culture of China’s pre-Qin Dynasty and plays an important role in the history of Chinese literature.Confucius once said,“If you do not study The Book of Songs,you cannot speak”.However,poem translation is of great difficulty and importance during cultural exchange.On the one hand,translators should strike the balance between the original poem’s beauty and readers’understanding.This paper aims to offer suggestions upon how to render Chinese poems into English by analyzing Yang Xianyi and Gladys Yang’s translation of“Guan Ju”,the first poem of The Book of Songs.

Differentiation and Analysis of Nephrotoxicity Between Caulis Clematidis Armandii(Chuan Mu Tong)and Aristolochia Manshuriensis(Guan Mu Tong)

Mutong is a kind of medicine for promoting water circulation and drenching.There are many kinds of Aristolochia manshuriensis(Guan Mu Tong),which are commonly used in clinic,such as Mutong,Caulis Clematidis Armandii(Chuan Mu Tong)and Mutong.After the event of"Longdan Xiegan pill",the doctor made Chuanmu general taboo,or replaced it with other drugs,or did not dare to use it for a long time,which affected the clinical effect.This paper discusses the toxicity of Mutong.

Congratulations for the 80th birthday of academician Chunyun Guan and great achievement in scientific research and life time teaching

Professor Chunyun Guan,born in Jingzhou, Hubei Province in 1938, is an academician of the Chinese Academy of Engineering, chairman of the Academic Committee of Hunan Agricultural University,and the former president of the University.Throughout his career, leading his research team, Prof.Guan has been working tirelessly in the fields of rapeseed genetics and breeding as well as high-yield and high-efficiency cultivation system.

guan溪蜜柚

丰产素在琯溪蜜柚上的应用内蒙古呼和浩特市精细化工厂生产的丰洲牌丰产素是动植物细胞赋活增进剂，该产品以天然原料为主，产品内所含硝基钠类有机化合物，低毒、分解快，无积累，无副作用，可促进新陈代谢，加速细胞分裂，并含适量氮磷钾等常量、微量元素，营养搭配合理...

Improve Labor Contract System, Safeguard Lawful Rights and Interests of Laborers——An interview with Prof. Guan Huai of Law School of Renmin University of China

EDITOR＇S NOTE： The Draft Labor Contract Law of the People＇s Republic of China has been completed and was published for soliciting comments on March 20. In a short period of one month, 191,849 pieces of comments and opinions were received. Prior to the promulgation of the law, this reporter interviewed Mr. Guan Huai, a noted Chinese expert in labor law, professor of the Law School of the Renmin University of China and law advisor to the All-China Federation of Trade Unions.