The Pre-Diagnosis History of Gynecologic Tumors in Children

Introduction: Gynecologic tumors represent less than 5% of all solid tumors in children. Patients and Method: Through a prospective and descriptive study over 4-years, we included girls aged less than 15 years admitted for a gynecologic tumor. We collected and analyzed the medical data, and paid particular attention to the pre-diagnosis history. Results: Eleven girls met our criteria with a mean age of 8.5 years (2 - 13 years). Abdominal pain, abdominal distension or protrusion of a vaginal mass was the main symptoms. The patients were seen at least by one doctor outside the surgical structure [1] [2] [3]. Four of eleven were received by two different doctors before carrying out the evocative radiological assessment. The average consultation delay was 7-months (24 hours to 18 months). There were nine ovarian tumors and two vaginal tumors. The histological study revealed five of eleven (45%) malignant tumors. Conclusion: Gynecological tumors in children are rare. However, there is a significant proportion of malignant tumors. All doctors can be confronted with it and should not delay the radiological assessment.

Innovative insights into extrachromosomal circular DNAs in gynecologic tumors and reproduction

Originating but free from chromosomal DNA,extrachromosomal circular DNAs(eccDNAs)are organized in circular form and have long been found in unicellular and multicellular eukaryotes.Their biogenesis and function are poorly understood as they are characterized by sequence homology with linear DNA,for which few detection methods are available.Recent advances in high-throughput sequencing technologies have revealed that eccDNAs play crucial roles in tumor formation,evolution,and drug resistance as well as aging,genomic diversity,and other biological processes,bringing it back to the research hotspot.Several mechanisms of eccDNA formation have been proposed,including the breakage-fusion-bridge(BFB)and translocation-deletion-amplification models.Gynecologic tumors and disorders of embryonic and fetal development are major threats to human reproductive health.The roles of eccDNAs in these pathological processes have been partially elucidated since the first discovery of eccDNA in pig sperm and the double minutes in ovarian cancer ascites.The present review summarized the research history,biogenesis,and currently available detection and analytical methods for eccDNAs and clarified their functions in gynecologic tumors and reproduction.We also proposed the application of eccDNAs as drug targets and liquid biopsy markers for prenatal diagnosis and the early detection,prognosis,and treatment of gynecologic tumors.This review lays theoretical foundations for future investigations into the complex regulatory networks of eccDNAs in vital physiological and pathological processes.

Application of traditional Chinese medicine acupoint needle embedding combined with emotional nursing in patients with gynecological malignant tumors

BACKGROUND Few relevant literature reports on applying acupoint press-needle embedding combined with emotional nursing in patients with a gynecological malignant tumor.AIM To explore the effect of traditional Chinese medicine acupoint needle embedding combined with emotional nursing on chemotherapy-related nausea and vomiting(CINV),cancer-related fatigue(CRF)and psychological state in patients with gynecological malignant tumors.METHODS Retrospective analysis of the clinical information of 84 patients with gynecological malignant tumors treated in our hospital from August 2020 to December 2022 Led to the development of an observation group(n=42)and a control group(n=42)based on various nursing approaches.Ondansetron hydrochloride injection was administered to the individuals in the control group.However,the observation group received emotional nursing based on the control group and acupoint pressneedle embedding of traditional Chinese medicine.Patients in both groups received the chemotherapy regimen of paclitaxel liposome+carbo-platin/cisplatin.For four weeks,both groups intervened.The CINV grade,quality of life,CRF,psychological status and sleep quality scores of the two groups before and RESULTS After intervention,the degree of CINV in the observation group was significantly better than that in the control group.After intervention,the scores of each dimension and total score of FLIE scale were significantly higher than those in the control group.After intervention,the scores of each dimension and total score of Piper Fatigue Scale were significantly lower than those in the control group(P<0.05).After intervention,the scores of avoidance and yield dimensions in the observation group were significantly lower than those in the control group,and the scores of confrontation dimension were significantly higher than those in the control group(P<0.05).After intervention,the sleep quality score of the observation group was significantly lower than that of the control group,and the Karnofsky Performance Status scale score was significantly higher than that of the control group(P<0.05).CONCLUSION The acupuncture point needle embedding of traditional Chinese medicine combined with emotional nursing can further reduce the incidence of chemotherapy-related nausea and vomiting in patients with gynecological malignant tumors,improve the quality of life and the degree of CRF,alleviate the bad psychological state,adopt a positive way to face the disease and treatment,and improve the quality of sleep and quality of life.

Prospect of research and clinical application of arsenic compounds in chemotherapy for gynecological malignant tumors

Arsenic compounds,including various arsenic-containing compounds such as intravenous use of arsenic trioxide(ATO)and an oral tetra-arsenic tetra-sulfide(As4S4)-containing formula named the Realgar-Indigo naturalis formula(RIF).RIF,also known as Compound Huangdai Tablets,which exert anti-tumor effects through a variety of mechanisms,such as the induction of programmed cell death,induction of G1 or G2/M phase arrest,epigenetic regulation of miRNAs,and suppression of cancer stem cell properties.International multicenter clinical studies have shown that ATO and RIF have anti-tumorigenic effects on hematological tumors and some solids.Arsenic compounds also been used in the treatment of cervical cancer,endometrial cancer,ovarian cancer,especially advanced drug-resistant ovarian cancer.This article introduces the progress of ATO in combination chemotherapy,such as ATO with paclitaxel,adriamycin,cisplatin,etc in solid tumors and gynecological malignant tumors.The side effects associated with arsenic treatment,including cardiac disorders,skin and bone marrow suppression,etc.are also discussed in this review.Oral arsenic drugs also have a good therapeutic effect,it may be an outpatient oral chemotherapy new model for RIF to treatment recurrent ovarian cancer.

Molecular targeted therapy of gynecological malignanttumors: the development and challenge, from laboratory toclinic

More and more molecular drugs based on targeted therapy have been utilized in the treatment of gynecologic cancer,especially in ovarian cancer.In this article,we systematically review the current targeted therapeutic trials running in clinic.Large,randomized trials have been conducted in the treatment of ovarian cancer,endometrial cancer and cervical cancer by using small molecule,antisense,mutational gene as well as antibodies.Other planned or ongoing trials currently targeted at molecular markers which may play important roles in gynecological carcinogenesis and progression suggest that combination chemotherapy with molecular targeted therapy will ultimately be an important option.

A STUDY ON THE SERUM PREGNANCY ZONE PROTEIN LEVELS IN PREGNANT WOMEN AND PATIENTS WITH GYNECOLOGICAL TUMORS

In this study, the serum levels of the pregnancy zone protein (PZP) were determined by PZP-single radial immunodiffusion in 708 cases of normal pregnancy, 207 with abormal pregnancy and 188 with gynecological tumors. The results indicated that serum PZP levels in the normal pregnancy was detectable 5 weeks after gestation. It increased with the advance of gestational weeks, and reached a peak level in week 40. The serum PZP levels in 81.7% of patients with threatened abortion but not aborted were within the normal range, and also mostly in those with pregnancy-nduced hypertension, intrauterine growth retardation (IUGR), anencepbalus and ectopic pregnancy; the serum PZP levels in 51.6% of patients with invasive moles and 80.0% with choriocarcinoma, respectively, were lower than in normal controls. In gynaecological tumors, the serum PZP levels were significantly higher in patients with ovarian carcinomas than in those with other ovarian tumors (P<0.01), and in those with endometrial or cervical carcinoma than in those with uterine myomas (P<0.01). These results suggest that measuring the serum PZP levels may be used as an important reference index to observe threatened abortion and to identify trophoblastic diseases and gynecological tumors.

Wrist-Ankle Acupuncture and Ginger Moxibustion for Preventing Gastrointestinal Reactions to Chemotherapy:A Randomized Controlled Trial

Objective： To evaluate the effects of wrist-ankle acupuncture combined with ginger moxibustion against gastrointestinal tract reactions （nausea, vomiting, and constipation） to chemotherapy in cancer patients. Methods： A total of 60 patients with gynecological tumors treated by chemotherapy were randomly divided into two groups. The treatment group （30 cases） underwent wrist-ankle acupuncture and ginger moxibustion, whereas tropisetron hydrochloride and dexamethasone were intravenously administered to the control group （30 cases） during chemotherapy. Results： The frequency of nausea in the treatment group was significantly less than that of the control group from the 2nd to the 5th day of chemotherapy （P〈0.01）. The anti-emetic effect in the treatment group was significantly better than that in the control group on the 3rd day of therapy （P〈0.05）. The incidence rate of constipation was significantly lower in the treatment group than that in the control group （P〈0.01）. Furthermore, the cost of therapy for the treatment group was significantly lower than that of the control group （P〈0.01）. Only 1 patient manifested a post-acupuncture side effect in the form of subcutaneous blood stasis. Conclusion： Wrist-ankle acupuncture combined with ginger moxibustion could prevent gastrointestinal tract reactions to chemotherapy in cancer patients. In addition, the proposed method had fewer side effects, lower cost, and less risk.