Centrifuge and numerical modeling of h-type anti-slide pile reinforced soil-rock mixture slope

Due to the loose structure,high porosity and high permeability of soil-rock mixture slope,the slope is unstable and may cause huge economic losses and casualties.The h-type anti-slide pile is regarded as an effective means to prevent the instability of soilrock mixture slope.In this paper,a centrifuge model test was conducted to investigate the stress distribution of the h-type anti-slide pile and the evolution process of soil arching during the loading.A numerical simulation model was built based on the similar relationship between the centrifuge model and the prototype to investigate the influence factors of the pile spacing,anchored depth,and crossbeam stiffness,and some recommendations were proposed for its application.The results show that the bending moment distribution of the rear pile exhibits Wshaped,while for the front pile,its distribution resembles V-shaped.The soil arching evolution process during loading is gradually dissipated from bottom to top and from far to near.During the loading,the change of bending moment can be divided into three stages,namely,the stabilization stage,the slow growth stage,and the rapid growth stage.In engineering projects,the recommended values of the pile spacing,anchored depth,and crossbeam stiffness are 4.0d,2.0d,and 2.0EI,where d and EI are the diameter and bending stiffness of the h-type anti-slide pile respectively.

Optimized Design of H-Type Vertical Axis Wind Airfoil at Multiple Angles of Attack

Numerical simulations are conducted to improve the energy acquisition efficiency of H-type vertical axis wind turbines through the optimization of the related blade airfoil aerodynamic performance.The Bézier curve is initi-ally used tofit the curve profile of a NACA2412 airfoil,and the moving asymptote algorithm is then exploited to optimize the design of the considered H-type vertical-axis wind-turbine blade airfoil for a certain attack angle.The results show that the maximum lift coefficient of the optimized airfoil is 8.33%higher than that of the original airfoil.The maximum lift-to-drag ratio of the optimized airfoil exceeds the maximum lift-to-drag ratio of the ori-ginal airfoil by 11.22%.Moreover,the power coefficient is increased by 12.19%and the torque coefficient of the wind turbine is significantly improved.

Equalities between h-type Indices and Definitions of Rational h-type Indicators

Purpose: To show for which publication-citation arrays h-type indices are equal and to reconsider rational h-type indices. Results for these research questions fill some gaps in existing basic knowledge about h-type indices.Design/methodology/approach: The results and introduction of new indicators are based on well-known definitions.Findings: The research purpose has been reached: answers to the first questions are obtained and new indicators are defined. Research limitations: h-type indices do not meet the Bouyssou-Marchant independence requirement.Practical implications: On the one hand, more insight has been obtained for well-known indices such as the h-and the g-index and on the other hand, simple extensions of existing indicators have been added to the bibliometric toolbox. Relative rational h-type indices are more useful for individuals than the existing absolute ones.Originality/value: Answers to basic questions such as "when are the values of two h-type indices equal" are provided. A new rational h-index is introduced.

Correlation analysis of carotid intima media thickness and function in patients with H-type hypertension and acute cerebral infarction

Objective:To explore the correlation of carotid intima media thickness with function in patients with H-type hypertension and acute cerebral infarction.Methods:A total of 150 patients with acute cerebral infarction who were admitted in our hospital from June, 2016 to June, 2017 were included in the study and divided into H-type hypertension group (H-type hypertension merged with acute cerebral infarction, Hcy≥10 μmol/L), non-H-type hypertension group (non- H-type hypertension merged with acute cerebral infarction, Hcy≥10 μmol/L), and the control group (no hypertension but with acute cerebral infarction) according to Hcy level and whether being suffered from hypertension or not with 50 cases in each group. Moreover, 50 healthy individuals who came for physical examinations were served as the healthy group. The morning fasting peripheral venous blood was collected at physical examination time for patients in the healthy group and after admission for patients with acute cerebral infarction. Hcy, sICAM-1, MCP-1, and YKL-40 were detected. The color Doppler ultrasound diagnostic apparatus was used to detect IMT, distensibility, and stiffness. Results: Hcy, MCP-1, sICAM-1, and YKL-40 levels in H-type hypertension group, non-H-type hypertension group, and the control group were significantly higher than those in the healthy group. Hcy, MCP-1, sICAM-1, and YKL-40 levels in H-type hypertension group and non-H-type hypertension group were significantly higher than those in the control group. Hcy, MCP-1, sICAM-1, and YKL-40 levels in H-type hypertension group were significantly higher than those in non-H-type hypertension group. IMT and stiffness in H-type hypertension group, non-H-type hypertension group, and the control group were significantly greater than those in the healthy group, while distensibility was significantly less than that in the healthy group. IMT and stiffness in H-type hypertension group and non-H-type hypertension group were significantly greater than those in the control group, while distensibility was significantly less than that in the control group. IMT and stiffness in H-type hypertension group were significantly greater than those in non-H-type hypertension group, while distensibility was significantly less than that in non-H-type hypertension group.Conclusions: Hcy can directly affect carotid AS, increase carotid IMT, and promote the occurrence of hypertension merged with acute cerebral infarction;therefore, positive monitoring of serum Hcy level and IMT thickness in patients with hypertension and acute cerebral infarction and early intervention are of great significance in reducing the occurrence of carotid AS, delaying the progression of carotid AS, and preventing hypertension and acute cerebral infarction.

Effect of folic acid combined with routine drugs on Hcy metabolism, inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis

Objective:To explore the effect of folic acid combined with routine drugs on Hcy metabolism, inflammatory response and plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis.Methods: A total of 68 patients with H-type hypertension complicated by carotid atherosclerosis who received treatment in our hospital between January 2014 and September 2016 were collected and divided into control group (n=34) and observation group (n=34) according to random number table. The control group received routine therapy and the observation group received folic acid combined with routine drug therapy. The differences in Hcy metabolism, inflammatory response and plaque properties were compared between the two groups of patients before and after treatment.Results:Before treatment, differences in serum Hcy contents, pro-inflammatory and anti-inflammatory mediator contents, and ultrasound plaque property parameter levels were not statistically significant between two groups of patients. After treatment, serum Hcy content of observation group was lower than that of control group;serum pro-inflammatory factors IL-1, IL-6, IL-8 and CRP contents were lower than those of control group;serum anti-inflammatory factors IL-4, IL-10 and IL-13 contents were lower than those of control group;ultrasound plaque property parameter strain value was lower than that of control group while plaque strain rate was higher than that of control group.Conclusion:Folic acid treatment based on routine treatment can effectively accelerate the Hcy metabolism, reduce systemic inflammatory response and increase the plaque stability in patients with H-type hypertension complicated by carotid atherosclerosis.

Relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis

Objective:To study the relationship between serum inflammatory response cytokines and the change of plaque properties in patients with H-type hypertension complicated by carotid atherosclerosis.Methods: Patients who were diagnosed with H-type hypertension complicated by carotid atherosclerosis in Yulin Hospital of Traditional Chinese Medicine between May 2014 and December 2016 were selected as group A, patients with H-type hypertension complicated by carotid atherosclerosis and normal Hcy levels were selected as group B, patients with carotid atherosclerosis and normal blood pressure levels and Hcy levels were selected as group C, and healthy volunteers during the same period were selected as control group. Serum levels of inflammatory response cytokines and plaque property-related cytokines were detected.Results: Serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A, group B and group C were significantly higher than those of group D, serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A and group B were significantly higher than those of group C, and serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A were significantly higher than those of group B;serum Hcy, sICAM-1, MCP-1, YKL-40, IL-6, PTX3, FGF23, MMP9 and Caspase-3 levels of group A with vulnerable plaques were significantly higher than those of patients with stable plaques. Serum Hcy, sICAM-1, MCP-1, YKL-40 and IL-6 levels of group A were positively correlated with PTX3, FGF23, MMP9 and Caspase-3 levels.Conclusion: Serum inflammatory response cytokine secretion increases in patients with H-type hypertension complicated by carotid atherosclerosis, and it can result in the change in plaque properties and the decrease in stability.

Correlation between serum Hcy content and coronary atherosclerosis severity in patients with H-type hypertension and coronary heart disease

Objective:To analyze the correlation between serum Hcy content and coronary atherosclerosis severity in patients with H-type hypertension and coronary heart disease. Methods: 48 patients with H-type hypertension and coronary heart disease were selected as observation group, and 57 patients with normal hypertension and coronary heart disease were selected as control group. Echocardiography was used to determine coronary lesion parameters, enzyme-linked immunosorbent assay (ELISA) was used to determine serum levels of homocysteine (Hcy) and coronary heart disease-related indexes, and the correlation between Hcy levels and coronary heart disease was further analyzed. Results:Serum Hcy level of observation group was higher than that of control group (P<0.05), absolute GLPSS value and E/A value under echocardiography were less than those of control group while E-DT and E/e value were higher than those of control group (P<0.05);serum adiponectin (APN) level was lower than that of control group while P-selectin, asymmetric dimethylarginine (ADMA), oxidized high-density lipoprotein (OX-HDL), MMP-2, MMP-9, lipoprotein-associated phospholipase A2 (Lp-PLA2) and Resistin levels were higher than those of control group (P<0.05);Hcy was negatively correlated with absolute GLPSS value, E/A value and APN level, and was positively correlated with E-DT value, E/e value as well as P-selectin, ADMA, OX-HDL, MMP-2, MMP-9, Lp-PLA2 and Resistin levels (P<0.05). Conclusions:There is direct correlation between serum Hcy levels and the severity of coronary heart disease in patients with H-type hypertension and coronary heart disease, it can be a reliable way to early screen for coronary heart disease and evaluate the illness, and it is also a new target of coronary heart disease intervention.

Study on the correlation of carotid IMT with Hcy, Cyst-C, UA, and Lp(a) in middle-aged patients with H-type hypertension

Objective:To explore the correlation of carotid IMT (cIMT) with Hcy, Cyst-C, UA, and Lp(a) in middle-aged patients with H-type hypertension.Methods:A total of 120 middle-aged patients with H-type hypertension who were admitted in our hospital from July, 2015 to July, 2016 were included in the study. The color Doppler ultrasound diagnostic apparatus was used for the two-dimensional ultrasound examination. The patients were divided into the normal group, thickening group, and plaque group with 40 cases in each group according to the atherosclerosis (AS). The full automatic biochemical analyzer was used to detect the plasma Hcy, Cyst-C, UA, Scr, Bun, TC, TG, LDL-C, and HDL-C. Emulsion turbidity method was used to detect Lp(a).Results:With the thickening of cIMT, Hcy, Cyst-C, Lp(a), and UA levels were elevated, while HDL-C level was reduced.Conclusions:The serum Hcy, Cyst-C, UA, and Lp(a) levels in middle-aged patients with H-type hypertension are positively correlated with cIMT, are the independent risk factors for developing AS, and can be served as the early indicators to estimate the occurrence and development of AS.

Experimental Research on Resistance Characteristics of H-type Elliptical Finned Tube Bundles

阻力特性是换热器的基本特性之一，流体横掠换热管产生的绕流扰动是换热器阻力恶化的主要因素。为分析前排绕流对后排阻力的影响规律，分别对管排数2-10不等的换热管进行阻力特性试验研究，同时为定量分析管排数对阻力特性的影响规律，定义了管排阻力修正系数，并根据实验数据给出了其在不同管排数下的取值，具有重要的工程意义；同时基于冷态阻力特性试验台进行实验研究，得到κ=1及κ=1.6的经典椭圆管的阻力特性公式Eu，并研究不同管型及布置方式对其的影响规律。

LOCAL ESTIMATE ABOUT SCHRODINGER MAXIMAL OPERATOR ON H-TYPE GROUPS

Let ? be full Laplacian on H-type group G. Then for every compact set D ■ G,a local estimate of the Schr¨odinger maximal operator holds, that is, ∫_(D)sup |e^(it?)f(x)|~2dx ■||f ||_(H^s)~2, s >1/2.We also show that the above inequality fails when s < 1/4.

Synthesis and characterization of H-type amphiphilic liquid crystalline block copolymers by ATRP

H-type amphiphilic liquid crystalline block copolymers containing azobenzene were synthesized by atom transfer radical polymerization (ATRP). Macroinitiators prepared by the esterification between poly(ethylene oxide) (PEG) and 2,2-dichloroacetyl chloride were utilized to initiate the polymerization of 6-[4-(4-ethoxyphenylazo)phenoxy]hexyl methacrylate (M6C). The resulting macroinitiators and block copolymers were characterized by 1H NMR, gel permeation chromatography (GPC). Polarizing optical microscopy (POM) and differential scanning calorimetry (DSC) preliminarily revealed the liquid crystalline property of these block copolymers. This series of liquid crystalline block copolymers are promising in some areas, such as optical data storage, optical switch, and molecular devices.

Catalytic Synthesis of Hexyl-naphthalene over H-type Zeolites

H-type zeolites(HY, Hβ, and HM) were synthesized and characterized by XRD, NH_ 3 -TPD, and Py-IR. Selectively catalytic alkylation of naphthalene with n-hexanol to hexyl-naphthalene over the zeolites was carried out. The experimental results show that the catalytic activities of the zeolites are mainly determined by their acid properties and pore structures. The larger the pore diameter is, the higher the catalytic activity is. NH_ 3 -TPD profiles show that Hβ and HM have lower acid strengths than HY. HY has both the highest activity and highest selectivity for the hexyl-naphthalene. Higher reaction temperatures and longer reaction time are beneficial to the production of β-hexyl-naphthalene over the HY zeolite.

Effect of H-type Aggregation on the Photoelectric Conversion of Tetrasulfonated Phthalocyanine Adsorbed on Nanostructured TiO_2 Electrode

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HEAT KERNELS AND HARDY'S UNCERTAINTY PRINCIPLE ON H-TYPE GROUPS

This article obtains an explicit expression of the heat kernels on H-type groups and then follow the estimate of heat kernels to deduce the Hardy's uncertainty principle on the nilpotent Lie groups.

社区H型高血压患者药物基因作用靶点多态性分布及叶酸联合维生素D干预效果研究

背景H型高血压严重影响着人们的健康及生活质量,目前临床上治疗高血压主要根据患者症状和临床经验选择药物,降压效果不理想,急需探寻降压药物基因分布的多态性,为高血压患者进行个体化用药指导。目的探讨济南市社区H型高血压药物作用靶点基因多态性分布及叶酸联合维生素D的干预作用,为该地区开展高血压医防融合精准医疗提供参考依据。方法2020年6月—2022年6月随机抽取山东省济南市槐荫区20家街道办事处社区卫生服务中心200例血压控制不佳的高血压患者为研究对象,治疗前首先进行5类常用抗高血压药物[利尿剂、β受体阻滞剂、血管紧张素转化酶抑制剂(ACEI)、钙离子通道抑制剂(CCB)、血管紧张素Ⅱ受体拮抗剂(ARB)]相关高血压个体化用药基因位点的基因多态性检测。将患者随机分为基因导向治疗组(基因组)与基因导向协同叶酸、维生素D治疗组(基因导向组),每组100例。基因组根据检测的高血压基因作用位点的特点调整用药;基因导向组在基因组治疗方案的基础上同时服用叶酸、维生素D。干预初始(M0)、干预3个月(M3)、干预6个月(M6)时采集患者晨间未服用降压药物情况下坐位收缩压和舒张压。记录患者患病情况、不良反应发生情况、脑卒中发生情况,进行基因测序,检测血清同型半胱氨酸(Hcy)浓度。采用Pearson相关性分析或Spearman秩相关分析探究性别、年龄、收缩压、舒张压与Hcy的相关性。结果研究对象性别(r_(s)=-0.463)、收缩压(r=0.181)、舒张压(r=0.188)与Hcy水平有相关性(P<0.05)。5类抗高血压药物基因作用靶点中,与药物代谢酶基因多态性位点相关的分别是CYP3A5(A6986G)、CYP2C9(c.1075A>C)、CYP2D6(c.100C>T),与药物作用靶点敏感性基因多态性位点相关的是ADRB1、ACEI(I/D)、AGTR1、NPPA。基因组A6986G:CYP3A5*1/*1(AA)、ACEI(I/D):D/D、c.100 C>T:CYP2D6*1/*1(CC)患者M3、M6舒张压低于M0,A6986G:CYP3A5a1/a3(AG)、ADRB1 c.1165 G>C:GG、c.1075 A>C:CYP2C9*1/*3(AC)、c.1075 A>C:CYP2C9*3/*3(CC)患者M6舒张压低于M0,A6986G:CYP3A5*3/*3(GG)、ADRB1 c.1165 G>C:CC、ACEI(I/D):I/I、c.1075 A>C:CYP2C9*1/*1(AA)、AGTR1 c.1166 A>C:AA、NPPA T2238C:TT、c.100 C>T:CYP2D6*10/*10(TT)患者M3、M6收缩压、舒张压低于M0,ADRB1 c.1165 G>C:GC、ACEI(I/D):I/D、c.100 C>T:CYP2D6*1/*10(CT)患者M6收缩压低于M0,M3、M6舒张压低于M0,差异有统计学意义(P<0.05)。Hcy水平组间比较结果显示,M3、M6基因导向组Hcy水平低于基因组,差异有统计学意义(P<0.05)。组内比较结果显示,基因组M6 Hcy水平低于M0,基因导向组M3、M6 Hcy水平低于M0,M6 Hcy水平低于M3,差异有统计学意义(P<0.05)。收缩压、舒张压组间比较结果显示,M3、M6基因导向组收缩压、舒张压低于基因组,差异有统计学意义(P<0.05)。组内比较结果显示,基因组、基因导向组M6收缩压、舒张压低于M0,M6收缩压低于M3,差异有统计学意义(P<0.05)。结论社区H型高血压患者中存在高血压药物相关基因多态性的表达差异,个体化用药效果显著;叶酸联合维生素D协同治疗更能显著降低H型高血压水平。

叶酸联合依那普利治疗老年H型高血压的效果及对血管内皮功能和Hcy水平的影响

目的 观察叶酸联合依那普利治疗老年H型高血压的效果及对血管内皮功能和同型半胱氨酸(Hcy)水平的影响。方法 选取2019年10月—2020年10月昆明医科大学第一附属医院收治的老年H型高血压患者82例,根据随机数字表法分为观察组和对照组,每组41例。对照组予马来酸依那普利片治疗,观察组在对照组基础上加用叶酸片治疗,2组均治疗3个月。比较2组临床疗效,治疗前后血压情况、血管内皮损伤指标[一氧化氮(NO)、血管内皮素(ET-1)]、颈动脉内—中膜厚度(IMT)、血清Hcy、血浆可溶性细胞间黏附分子-1(sICAM-1)水平及不良反应。结果 观察组治疗总有效率为95.12%,高于对照组的78.05%(χ^(2)=5.145,P=0.023)。治疗3个月后,2组收缩压、舒张压低于治疗前,且观察组低于对照组(P<0.01);2组NO水平较治疗前升高,ET-1水平较治疗前降低,且观察组升高/降低幅度大于对照组(P<0.01);2组IMT较治疗前减小,血清Hcy、血浆sICAM-1水平较治疗前降低,且观察组低于对照组(P<0.01)。观察组与对照组不良反应总发生率均为4.88%,差异无统计学意义(P>0.05)。结论 叶酸联合依那普利治疗老年H型高血压疗效显著,控制血压效果更佳,并能改善血管内皮损伤,降低Hcy水平及心脑血管疾病的发病风险,且不良反应发生率低。

H型高血压:我国脑卒中一级预防的关键

H型高血压是伴有血中同型半胱氨酸(Hcy)升高(血清Hcy浓度≥10μmol/L)的高血压。Hcy与高血压协同增加心脑血管疾病尤其是脑卒中的风险。我国高血压患者中约75%是H型高血压,与我国人群特点密切相关,早期筛查并诊断H型高血压患者,并开展精准防治对降低高血压患者脑卒中风险至关重要。降压基础上补充叶酸可有效降低高血压患者脑卒中风险,不同人群补充叶酸预防脑卒中的效果并不相同,筛查成本获益比更高的人群可明显提高防治效率。随着H型高血压概念的提出,越来越多的学者针对其开展研究,为理解相关机制提供了有价值的线索,有必要开展进一步的深入研究,拓展和补充H型高血压相关理论。

南宁市某社区空巢老年H型高血压病人居家服药依从性及其影响因素

目的:了解南宁市社区空巢老年H型高血压病人服药依从性及影响因素。方法:2022年7月—2023年1月选取南宁市西乡塘区某社区卫生服务中心450例空巢老年H型高血压病人为调查对象,采用一般资料调查表、Morisky服药依从性量表进行调查,分析影响病人服药依从性的因素。结果:450例社区空巢老年H型高血压病人的服药依从性评分为3.00(2.00,3.00)分,服药依从性好297例,差153例;Logistic回归分析结果显示:年龄、服药种类和居住类型是影响空巢老年H型高血压病人服药依从性的因素(均P<0.05)。结论:社区空巢老年H型高血压病人服药依从性处于中等水平,医护人员应重点关注年龄较大、服药种类较多、独居的病人。

H型高血压患者自我管理能力现状及其相关影响因素分析

目的:分析H型高血压患者自我管理能力现状及其相关影响因素。方法:选取2020年1月—2021年6月赣州市人民医院收治的82例H型高血压患者作为研究对象,评估所有患者的自我管理能力情况,设计基线资料调查表,详细统计所有患者的基线资料,比较不同资料特征H型高血压患者的自我管理能力评分情况,分析H型高血压患者自我管理能力的影响因素。结果:经评估82例H型高血压患者的自我管理能力评分为(121.43±12.69)分。不同年龄、受教育程度、家庭关怀度、社会支持、自我效能的H型高血压患者自我管理能力评分比较,差异有统计学意义(t=4.957、5.619、3.521,P<0.05;F=33.855、26.451,P<0.05)。年龄大、受教育程度低、家庭关怀度低、社会支持低下、自我效能低下均是H型高血压患者自我管理能力的影响因素。结论:H型高血压患者自我管理能力可能与年龄大、受教育程度低、家庭关怀度低、社会支持低下、自我效能低下有关,应加强患者的健康教育与心理疏导,同时,家属应给予患者必要的支持,以提高患者的自我管理能力。

马来酸依那普利叶酸片治疗H型高血压的效果及对脑卒中的预防作用

目的:分析马来酸依那普利叶酸片治疗H型高血压的效果及对脑卒中的预防作用。方法:选取2013年4月—2020年6月梧州市红十字会医院心内科治疗的H型高血压患者201例为研究对象,随机分为观察组(101例)和对照组(100例)。对照组口服厄贝沙坦片治疗,观察组口服马来酸依那普利叶酸片治疗。比较两组血压、血清同型半胱氨酸(Hcy)、不良反应发生情况、脑卒中发生率。结果:治疗前后,两组收缩压(SBP)、舒张压(DBP)水平比较,差异无统计学意义(P>0.05);治疗后,两组SBP、DBP水平低于治疗前,差异有统计学意义(P<0.05)。治疗前,两组Hcy水平比较,差异无统计学意义(P>0.05);治疗后,两组Hcy水平低于治疗前,观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组脑卒中发生率低于对照组,差异有统计学意义(P=0.049)。结论:马来酸依那普利叶酸片治疗H型高血压患者可有效降低血压、Hcy水平及脑卒中发生率。