超脉冲点阵CO_(2)激光联合5%米诺地尔酊治疗斑秃疗效分析

目的:研究超脉冲点阵CO_(2)激光联合5%米诺地尔酊治疗斑秃对患者外观美观度及毛发镜检查结果的影响。方法:选取2021年1月-2023年1月延安市人民医院收治的斑秃患者110例分为外用5%米诺地尔治疗的对照组(55例)和联合10600 nm超脉冲点阵CO_(2)激光治疗的观察组(55例),分组方法为随机抽签法,均治疗6周,后随访6个月。统计两组治疗6周后的临床疗效、随访期间复发情况及治疗期间不良反应发生情况,比较两组斑秃改善情况、外观美观度及治疗前和治疗6周后免疫、炎症指标、毛发镜检查、心理状态、脱发严重程度、生活质量。结果:治疗6周后,观察组总有效率为96.36%,高于对照组81.82%(P<0.05);随访期间,观察组复发率为9.09%,低于对照组23.64%(P<0.05)。观察组毳毛长出时间、毳毛变黑时间短于对照组,治疗6周后新发生长面积、美观度评分高于对照组(P<0.05)。两组治疗6周后外周血CD3^(+)、CD4^(+)水平、CD4^(+)/CD8^(+)、毛发密度、毛囊密度与治疗前比较,升高,观察组高于对照组(P<0.05);外周血CD8^(+)、血清肿瘤坏死因子α(TNF-α)水平、毳毛率及焦虑自评量表(Self-rating anxiety scale,SAS)、抑郁自评量表(Self-rating depression scale,SDS)评分、脱发严重程度评分工具(Severity of alopecia tool,SALT)、皮肤病生活质量指数(Dermatology life quality index,DLQI)评分与治疗前比较,降低,观察组低于对照组(P<0.05)。治疗期间,观察组总不良反应发生率为14.55%,对照组总不良反应发生率为9.09%,组间比较差异无统计学意义(P>0.05)。结论:超脉冲点阵CO_(2)激光联合5%米诺地尔酊可有效改善斑秃,提高患者生活质量,且复发风险低,安全性良好。

A MICROBEAM SYSTEM OF HIGH ENERGY IONS AT FUDAN UNIVERSITY

Particle induced X- ray emission (PIXE) and Rutherford backscattering spectrometry (RBS) have been used extensively for analytical purpose because of their quantitative accuracy, reliability, simplicity and capability of non- destructive and multielement analysis. When these techniques are combined with a scanning microbeam system and a data acquisition system, three dimensional distribution of elemental composition can be displayed. Samples analyzed so far at Fudan University include a microelectronic circuit and some biological and archaeological samples. The PIXE and RBS spectra and the secondary electron images have been measured.