We investigated the potential value of prostate-specific antigen half-life （PSAHL） and decreasing velocity （PSAVd） to predict progression-free survival （PFS） and overall survival （OS） in Chinese patients with ...We investigated the potential value of prostate-specific antigen half-life （PSAHL） and decreasing velocity （PSAVd） to predict progression-free survival （PFS） and overall survival （OS） in Chinese patients with prostate cancer. A total of 153 patients treated with hormonal therapy were included in the study. Of these, 78 patients progressed to hormone- refractory prostate cancer （HRPC） and 24 patients died by the end of follow-up. PSAHL was defined as the time during which prostate-specific antigen （PSA） concentration became half of the initial value during the first hormonal therapy. PSAVd reflected the decreasing velocity of PSA during the first hormonal therapy. PFS was defined as the interval from the beginning of hormonal therapy to HRPC. Cox proportional hazards regression analysis was used to evaluate whether PSAHL and PSAVd were significantly associated with PFS and OS. The median PSAHL and PSAVd were 0.50 months and 33.8 ng mL^-1 per month. The median PFS and OS were 22.7 months （95% confidence interval [CI], 22.0-29.6 months） and 43.5 months （95% CI, 37.9-48.4 months）, respectively. On univariate and multivariate analysis, long PSAHL （〉 0.5 months）, metastatic disease, high biopsy Gleason scores （〉 8） and high nadir PSA （〉 0.4 ng mL^-1） were all found to be significantly associated with short PFS. Long PSAHL, high nadir PSA and short PSA doubling time （PSADT 〈 2.0 months） were significantly associated with short OS. There were no significant relationships between PSAVd and either PFS or OS. Thus, PSAHL is a promising new independent predictor of survival. Patients with long PSAHL were identified as those at high risk for a relatively short PFS and OS.展开更多
Based on the newest experimentally extracted nuclear density distributions for double-magic nucleus208Pb(Tarbert et al. in Phys Rev Lett 112:242502, 2014),the sensitivity of α-decay half-life to nuclear skin thicknes...Based on the newest experimentally extracted nuclear density distributions for double-magic nucleus208Pb(Tarbert et al. in Phys Rev Lett 112:242502, 2014),the sensitivity of α-decay half-life to nuclear skin thickness is explored in the vicinity of the shell closure region around208 Pb, i.e., isotopes of Z ? 82 and isotones of N ? 126.With the two-parameter Fermi(2PF) density distributions and an analytically derived formula, the α-decay half-life is found to be closely related to the magnitude of nuclear skin thickness. For a decays to the Z ? 82 isotopes, the α-decay half-life is found to decrease with the increasing neutron skin thickness, while the opposite behavior is found for a decays to the N ? 126 isotones. Therefore, it could be a possible way to extract the nuclear skin thickness from measured α-decay half-lives.展开更多
Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and ...Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and antibody-like fragments are being evaluated clinically. Production of antibody fragments can be efficient and their compact size can allows for better tissue extravasation into solid tumors than full antibodies. Unfortunately, a key limitation of antibody fragments for systemic use is their short half-life in circulation. Prolonging their circulation half-life can be accomplished clinically by the covalent conjugation of the antibody fragment to the water-soluble polymer, poly(ethylene glycol) (PEG). Many polymers and strategies are also being pursued to increase antibody fragment half-life.展开更多
The neutrons have been captured by Erbium nuclei which were received by using clinical electron linear accelerator. In this experiment, the possibility of the neutron capture process has been observed because of emitt...The neutrons have been captured by Erbium nuclei which were received by using clinical electron linear accelerator. In this experiment, the possibility of the neutron capture process has been observed because of emitted neutrons appearing in the experimental area. In particular,neutron capture of ^(170)Er nucleus has been observed. After the neutron capture of ^(170)Er nucleus, the unstable ^(171)Er has been formed and decayed into the ^(171)Tm. By using this reaction path, some transition energies of ^(171)Tm obtained from the residual activity measurements and the half-life of ^(171)Er have been determined, and they are in agreement with adopted values in the literature.展开更多
In this paper,by considering the electrons in different external environments,including neutral atoms,a metal,and an extremely strong magnetic-field environment,the screened a-decay half-lives of the a emitters with p...In this paper,by considering the electrons in different external environments,including neutral atoms,a metal,and an extremely strong magnetic-field environment,the screened a-decay half-lives of the a emitters with proton number Z = 52–105 are systematically calculated.In the external environment,the decay energy and the interaction potential between a particle and daughter nucleus are both changed due to the electron screening effect and their variations are both very important for the electron screening effect.Besides,the electron screening effect is found to be closely related to the decay energy and its proton number.展开更多
MeV/u 18O ions were used to bombard natural uranium targets, and the heavy neutron-rich isotope 237Th was produced via multi-nucleon transfer reaction and dissipative fragmentation of the heavy target. A relatively fa...MeV/u 18O ions were used to bombard natural uranium targets, and the heavy neutron-rich isotope 237Th was produced via multi-nucleon transfer reaction and dissipative fragmentation of the heavy target. A relatively fast radiochemical procedure was used to separate thorium from the mixture of uranium and complex reaction products. The chemically separated thorium fractions were studied by the 7-ray spectroscopic method. The behaviors of the growth and decay of 853.7 and 865.0 keV-γrays of 237Pa decay were observed. The half-life of 237Th was determined to be 4.69±0.60 nun.展开更多
The experiment adopts complex coacervation to prepare microcapsules. Through the experimental comparison, soybean protein isolated-maltodextrin is determined as the wall material for the experimental preparation of th...The experiment adopts complex coacervation to prepare microcapsules. Through the experimental comparison, soybean protein isolated-maltodextrin is determined as the wall material for the experimental preparation of the microcapsules of kiwi fruit seed oil. This paper researched the effects of wall material concentration, core wall ratio and other factors on complex coacervation of kiwi fruit seed oil microcapsules embedding rate, determining that the best wall material concentration is 1%, core wall ratio is 1:1, and the optimum pH ratio is 3.0, temperature is 40°C, and the optimum curing time is 6 hours. The experiment carried out half life research on the microcapsules prepared by the complex coacervation of kiwi fruit seed oil microcapsule. By calculation: the degradation rate constant of kiwi fruit seed oil microcapsules prepared by complex coacervation is 2.793. According to the regression equation it can calculate the half life of kiwi fruit seed oil microcapsules is 18.58 months, about a year and a half.展开更多
3D-QSAR studies of persistent organic pollutants(POPs)screening for atmosphere persistence were performed by comparative molecular field analysis(CoMFA)and comparative molecular similarity index analysis(CoMSIA)method...3D-QSAR studies of persistent organic pollutants(POPs)screening for atmosphere persistence were performed by comparative molecular field analysis(CoMFA)and comparative molecular similarity index analysis(CoMSIA)methods.The mean and maximum half-life estimations for degradation in air of 49 UNEP POPs and possible POPs were modeled.Both groups’data have been modeled to obtain an average estimate and a predictive value for ranking and screening purposes.CoMFA and CoMSIA models have given cross-validation regre...展开更多
文摘We investigated the potential value of prostate-specific antigen half-life （PSAHL） and decreasing velocity （PSAVd） to predict progression-free survival （PFS） and overall survival （OS） in Chinese patients with prostate cancer. A total of 153 patients treated with hormonal therapy were included in the study. Of these, 78 patients progressed to hormone- refractory prostate cancer （HRPC） and 24 patients died by the end of follow-up. PSAHL was defined as the time during which prostate-specific antigen （PSA） concentration became half of the initial value during the first hormonal therapy. PSAVd reflected the decreasing velocity of PSA during the first hormonal therapy. PFS was defined as the interval from the beginning of hormonal therapy to HRPC. Cox proportional hazards regression analysis was used to evaluate whether PSAHL and PSAVd were significantly associated with PFS and OS. The median PSAHL and PSAVd were 0.50 months and 33.8 ng mL^-1 per month. The median PFS and OS were 22.7 months （95% confidence interval [CI], 22.0-29.6 months） and 43.5 months （95% CI, 37.9-48.4 months）, respectively. On univariate and multivariate analysis, long PSAHL （〉 0.5 months）, metastatic disease, high biopsy Gleason scores （〉 8） and high nadir PSA （〉 0.4 ng mL^-1） were all found to be significantly associated with short PFS. Long PSAHL, high nadir PSA and short PSA doubling time （PSADT 〈 2.0 months） were significantly associated with short OS. There were no significant relationships between PSAVd and either PFS or OS. Thus, PSAHL is a promising new independent predictor of survival. Patients with long PSAHL were identified as those at high risk for a relatively short PFS and OS.
基金supported by the National Natural Science Foundation of China(Nos.11175085,11235001,11375086,and 11120101005)the 973 Program of China(No.2013CB834400)+1 种基金the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Open Project Program of the State Key Laboratory of Theoretical Physics,Institute of Theoretical Physics,Chinese Academy of Sciences,China(No.Y5KF141CJ1)
文摘Based on the newest experimentally extracted nuclear density distributions for double-magic nucleus208Pb(Tarbert et al. in Phys Rev Lett 112:242502, 2014),the sensitivity of α-decay half-life to nuclear skin thickness is explored in the vicinity of the shell closure region around208 Pb, i.e., isotopes of Z ? 82 and isotones of N ? 126.With the two-parameter Fermi(2PF) density distributions and an analytically derived formula, the α-decay half-life is found to be closely related to the magnitude of nuclear skin thickness. For a decays to the Z ? 82 isotopes, the α-decay half-life is found to decrease with the increasing neutron skin thickness, while the opposite behavior is found for a decays to the N ? 126 isotones. Therefore, it could be a possible way to extract the nuclear skin thickness from measured α-decay half-lives.
文摘Antibodies are currently the fastest growing class of therapeutic proteins. When antibody fragments are included, there are over thirty-five antibody-based medicines approved for human therapy. Many more antibody and antibody-like fragments are being evaluated clinically. Production of antibody fragments can be efficient and their compact size can allows for better tissue extravasation into solid tumors than full antibodies. Unfortunately, a key limitation of antibody fragments for systemic use is their short half-life in circulation. Prolonging their circulation half-life can be accomplished clinically by the covalent conjugation of the antibody fragment to the water-soluble polymer, poly(ethylene glycol) (PEG). Many polymers and strategies are also being pursued to increase antibody fragment half-life.
基金supported by the Sinop University Scientific Research Projects Coordination Unit.Project Number:FEF-1901-14-04,2014
文摘The neutrons have been captured by Erbium nuclei which were received by using clinical electron linear accelerator. In this experiment, the possibility of the neutron capture process has been observed because of emitted neutrons appearing in the experimental area. In particular,neutron capture of ^(170)Er nucleus has been observed. After the neutron capture of ^(170)Er nucleus, the unstable ^(171)Er has been formed and decayed into the ^(171)Tm. By using this reaction path, some transition energies of ^(171)Tm obtained from the residual activity measurements and the half-life of ^(171)Er have been determined, and they are in agreement with adopted values in the literature.
基金supported by the National Natural Science Foundation of China(Nos.11175085,11235001,11375086,and 11120101005)by the 973 Program of China(No.2013CB834400)+1 种基金by the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)by the Open Project Program of the State Key Laboratory of Theoretical Physics,Institute of Theoretical Physics,Chinese Academy of Sciences,China(No.Y5KF141CJ1)
文摘In this paper,by considering the electrons in different external environments,including neutral atoms,a metal,and an extremely strong magnetic-field environment,the screened a-decay half-lives of the a emitters with proton number Z = 52–105 are systematically calculated.In the external environment,the decay energy and the interaction potential between a particle and daughter nucleus are both changed due to the electron screening effect and their variations are both very important for the electron screening effect.Besides,the electron screening effect is found to be closely related to the decay energy and its proton number.
基金Supported by the National Natural Science Foundation of China (10075063), Major State Basic Research Development Program (G20000
文摘MeV/u 18O ions were used to bombard natural uranium targets, and the heavy neutron-rich isotope 237Th was produced via multi-nucleon transfer reaction and dissipative fragmentation of the heavy target. A relatively fast radiochemical procedure was used to separate thorium from the mixture of uranium and complex reaction products. The chemically separated thorium fractions were studied by the 7-ray spectroscopic method. The behaviors of the growth and decay of 853.7 and 865.0 keV-γrays of 237Pa decay were observed. The half-life of 237Th was determined to be 4.69±0.60 nun.
文摘The experiment adopts complex coacervation to prepare microcapsules. Through the experimental comparison, soybean protein isolated-maltodextrin is determined as the wall material for the experimental preparation of the microcapsules of kiwi fruit seed oil. This paper researched the effects of wall material concentration, core wall ratio and other factors on complex coacervation of kiwi fruit seed oil microcapsules embedding rate, determining that the best wall material concentration is 1%, core wall ratio is 1:1, and the optimum pH ratio is 3.0, temperature is 40°C, and the optimum curing time is 6 hours. The experiment carried out half life research on the microcapsules prepared by the complex coacervation of kiwi fruit seed oil microcapsule. By calculation: the degradation rate constant of kiwi fruit seed oil microcapsules prepared by complex coacervation is 2.793. According to the regression equation it can calculate the half life of kiwi fruit seed oil microcapsules is 18.58 months, about a year and a half.
基金supported by the Scientific ResearchFoundation for the Returned Overseas Chinese Scholars,State Education Ministry,the National Natural ScienceFoundation of China(No.30470918).
文摘3D-QSAR studies of persistent organic pollutants(POPs)screening for atmosphere persistence were performed by comparative molecular field analysis(CoMFA)and comparative molecular similarity index analysis(CoMSIA)methods.The mean and maximum half-life estimations for degradation in air of 49 UNEP POPs and possible POPs were modeled.Both groups’data have been modeled to obtain an average estimate and a predictive value for ranking and screening purposes.CoMFA and CoMSIA models have given cross-validation regre...
