BACKGROUND Porocarcinoma is a rare type of skin cancer that originates from sweat gland tumors.It is an aggressive malignant skin cancer that is difficult to diagnose clinically owing to its rarity and similarity to s...BACKGROUND Porocarcinoma is a rare type of skin cancer that originates from sweat gland tumors.It is an aggressive malignant skin cancer that is difficult to diagnose clinically owing to its rarity and similarity to squamous cell carcinoma(SCC).CASE SUMMARY This case involved a 92-year-old woman,a farmer by profession,presented with an exophytic and verrucous mass on her left palm that had formed 2 years prior and caused chronic pain and frequent bleeding.Initially,the patient was diagnosed with SCC using a punch biopsy;however,a repeat biopsy with addi-tional immunohistochemical tests was performed for porocarcinoma.Ultimately,the patient was diagnosed with porocarcinoma and reconstruction was planned using a full-thickness skin graft.After treatment,the range of motion of the palm was preserved,and the aesthetic outcome was favorable.At 6 mo of follow-up,the patient was satisfied with the outcome.CONCLUSION Porocarcinoma is commonly misdiagnosed as SCC;therefore,clinicians should consider porocarcinomas when evaluating mass-like lesions on the hands.展开更多
目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组...目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组在对照组的基础上采用皮瓣综合护理干预,比较两组手部功能恢复[采用总主动活动度(Total active motion,TAM)系统评价]、术后并发症、日常生活能力[采用Barthel指数评定量表(Barthel index,BI)评估]和外形满意度。结果:干预2周后,观察组TAM优良率高于对照组,术后并发症总发生率低于对照组,BI评分高于对照组,患者对皮瓣外形的满意度评分高于对照组,差异均有统计学意义(P<0.05)。结论:皮瓣综合护理可有效加快手部软组织缺损术后功能快速恢复,减少并发症发生,提高日常生活能力和外形满意度。展开更多
The Air Force Health Study (AFHS), also called the Ranch Hand Study, investigated the impact of exposure to dioxin the toxic contaminant in Agent Orange on health, survival, and reproductive outcomes of male Air Force...The Air Force Health Study (AFHS), also called the Ranch Hand Study, investigated the impact of exposure to dioxin the toxic contaminant in Agent Orange on health, survival, and reproductive outcomes of male Air Force Vietnam War veterans. It was concluded that available reproductive outcome data did not provide support for an adverse association with paternal dioxin exposure. A more extensive set of AFHS data was used to reassess this conclusion, restricting to the case of birth defects in children fathered after the start of the first Vietnam War tour. Analyses started by repeating published analyses, followed by assessing decisions made in those analyses, for example, of excluding participants with dioxin levels below the detectable limit, using a threshold of 10 parts per trillion for a high dioxin level, and not adjusting for multiple conceptions/children of the same participant. Using data for all participants with measured dioxin levels, both veterans who served in Operation Ranch Hand and other non-Ranch Hand veterans, and after accounting for correlation within children of the same participant, the occurrence for children fathered after the start of the first tour of a major defect, a non-major defect, and multiple defects depended significantly on participants having a high dioxin level. These conclusions were not changed by consideration of covariates. In contrast to prior published analyses, the more extensive AFHS data provided support for an adverse effect of paternal dioxin exposure on birth defects. However, the study had many limitations that could have affected the conclusions.展开更多
文摘BACKGROUND Porocarcinoma is a rare type of skin cancer that originates from sweat gland tumors.It is an aggressive malignant skin cancer that is difficult to diagnose clinically owing to its rarity and similarity to squamous cell carcinoma(SCC).CASE SUMMARY This case involved a 92-year-old woman,a farmer by profession,presented with an exophytic and verrucous mass on her left palm that had formed 2 years prior and caused chronic pain and frequent bleeding.Initially,the patient was diagnosed with SCC using a punch biopsy;however,a repeat biopsy with addi-tional immunohistochemical tests was performed for porocarcinoma.Ultimately,the patient was diagnosed with porocarcinoma and reconstruction was planned using a full-thickness skin graft.After treatment,the range of motion of the palm was preserved,and the aesthetic outcome was favorable.At 6 mo of follow-up,the patient was satisfied with the outcome.CONCLUSION Porocarcinoma is commonly misdiagnosed as SCC;therefore,clinicians should consider porocarcinomas when evaluating mass-like lesions on the hands.
文摘目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组在对照组的基础上采用皮瓣综合护理干预,比较两组手部功能恢复[采用总主动活动度(Total active motion,TAM)系统评价]、术后并发症、日常生活能力[采用Barthel指数评定量表(Barthel index,BI)评估]和外形满意度。结果:干预2周后,观察组TAM优良率高于对照组,术后并发症总发生率低于对照组,BI评分高于对照组,患者对皮瓣外形的满意度评分高于对照组,差异均有统计学意义(P<0.05)。结论:皮瓣综合护理可有效加快手部软组织缺损术后功能快速恢复,减少并发症发生,提高日常生活能力和外形满意度。
文摘The Air Force Health Study (AFHS), also called the Ranch Hand Study, investigated the impact of exposure to dioxin the toxic contaminant in Agent Orange on health, survival, and reproductive outcomes of male Air Force Vietnam War veterans. It was concluded that available reproductive outcome data did not provide support for an adverse association with paternal dioxin exposure. A more extensive set of AFHS data was used to reassess this conclusion, restricting to the case of birth defects in children fathered after the start of the first Vietnam War tour. Analyses started by repeating published analyses, followed by assessing decisions made in those analyses, for example, of excluding participants with dioxin levels below the detectable limit, using a threshold of 10 parts per trillion for a high dioxin level, and not adjusting for multiple conceptions/children of the same participant. Using data for all participants with measured dioxin levels, both veterans who served in Operation Ranch Hand and other non-Ranch Hand veterans, and after accounting for correlation within children of the same participant, the occurrence for children fathered after the start of the first tour of a major defect, a non-major defect, and multiple defects depended significantly on participants having a high dioxin level. These conclusions were not changed by consideration of covariates. In contrast to prior published analyses, the more extensive AFHS data provided support for an adverse effect of paternal dioxin exposure on birth defects. However, the study had many limitations that could have affected the conclusions.
