Alcohol hangover:impairments in behavior and bioenergetics in central nervous system

Alcohol hangover(AH)is defined as the temporary state after alcohol binge-like drinking,starting when EtOH is absent in plasma.Results from our laboratory have shown behavioral impairments and mitochon-drial dysfunction in an experimental model of AH in mice.Our model consisted in a single i.p.injection of EtOH(3.8 g/kg BW)or saline solution in male and female mice,sacrificing the animals 6 hours after injection.Motor and affective behavior together with mitochondrial function and free radical production were evaluated in brain cortex and cerebellum during AH.Results showed that hangover animals exhibited a significant reduction in neuromus-cular coordination,motor strength and locomotion together with a loss of gait stability and walking deficiencies.Moreover,an increment in anxiety-like behavior together with fear-related phenotype and depression signs were observed.In relation to bioenergetics metabolism,AH induced a reduction in oxygen uptake,inhibition of respira-tory complexes,changes in mitochondrial membrane permeability,decrease in transmembrane potential,increase in O2•-and H2O2 production and impairment in nitric oxide metabolism.All together our data suggest that the phys-iopathological state of AH involves behavioral impairments and mitochondrial dysfunction in mouse brain cortex and cerebellum showing the long lasting effects of acute EtOH exposure in CNS.

A Bioprocessed Black Rice Bran Glutathione-Enriched Yeast Extract Protects Rats and Mice against Alcohol-Induced Hangovers

Human and animal alcohol-induced hangovers are caused by adverse effects of acetaldehyde formed in vivo by the enzymatic oxidation of ethyl alcohol to acetaldehyde. This study aims to determine the effect of the combination of a bioprocessed black rice bran (BRB-F) and glutathione-enriched yeast extract (GEYE) on hangovers as tested in rats and mice. Because analysis by HPLC showed that the content of the biologically active rice bran compound γ-oryzanol as well as of the antioxidant reduced glutathione were unaffected during the preparation of tablets containing 100 mg/kg of the bran formulation, the tablets were then administered orally to rats. The results showed decreased blood concentrations of both alcohol and acetaldehyde compared to the control group. Additional behavior experiments using the Rota-rod and wire tests in mice confirmed that the food formulation relieved hangover behavior caused by alcohol. It seems that the combination of BRB-F and GEYE can effectively control hangovers in rodents caused by alcohol intake. Mechanistic aspects of the hangover and anti-hangover effects of alcohol-derived acetaldehyde are similar to browning-type reactions between the aldehyde group of glucose and proteins, the antibiotic effects of cinnamaldehyde against pathogenic bacteria, the adverse effects of the heat-induced food toxin acrylamide, and the alkali-induced formation of the unnatural amino acid lysinoalanine.

Prickly Pear May Be Hangover Preventative

避免宿醉,来点仙人果吧!大醉一场或许还蛮爽的,不过第二天醒来后宿醉的痛苦有几人能受得了。在贪杯前先来点仙人果精华可以预防宿醉。模仿一句广告词,“有了仙人果,第二天舒服一点儿”。

5,000 Years of Booze and the Hangover That Comes With It

with Spring Festival coming up,we at The World of Chinese,like many over the New Year,hit the bottle pretty hard.Ginger dug through history books and will have a look at drinking and prohibition in ancient China,complete with drunken despots,merry ministers and plastered poets.It’s hard to imagine,especially on the subway on a Friday night。

Christmas: A $157 Million Hangover

本文出语惊人,圣诞节是怎样一个节日?本文下了这样的定义:Chrhtmas is one of Britain's most unhealthy times of the year.乍见此句,觉得不可理解,读完全文,便觉得有理。笔者很自然地想到国人的春节。我们是否能说:Spring Festival is one of China's most unhealthy times of the year.

Acute ethanol-related nervous system injuries

Acute ethanol intoxication has a diversity of clinical pictures that extend from mere euphoria to severe neurological impairment culminating in coma. Although the majority of cases have a reversible and benign course, the situation needs a careful medical monitoring. Authors describe pharmacological aspects of the acute ethanol intoxication, with organs and systems affected during the consumption of exaggerated quantities. Correlations between blood alcohol concentration and neurological symptomatology are given, and a brief discussion of the criteria for the acute intoxication is made. The fact that this occurrence has been of little attention is due not only to the reversibility of the majority of symptoms, but also because that medical research has been ever since focused more on chronic diseases related to alcohol abuse, withdrawal syndrome and recently with hangover as an independent situation. With no specific antidote actually at hand, treatment is symptom-oriented and the pharmacological armamentarium is richer when it comes to dealing with withdrawal, abstinence and other chronic complications of ethanol abuse.