Micro-mobile heat pipe-cooled nuclear power plants are promising candidates for distributed energy resource power genera-tors and can be flexibly deployed in remote places to meet increasing electric power demands.How...Micro-mobile heat pipe-cooled nuclear power plants are promising candidates for distributed energy resource power genera-tors and can be flexibly deployed in remote places to meet increasing electric power demands.However,previous steady-state simulations and experiments have deviated significantly from actual micronuclear system operations.Hence,a transient analysis is required for performance optimization and safety assessment.In this study,a hardware-in-the-loop(HIL)approach was used to investigate the dynamic behavior of scaled-down heat pipe-cooled systems.The real-time features of the HIL architecture were interpreted and validated,and an optimal time step of 500 ms was selected for the thermal transient.The power transient was modeled using point kinetic equations,and a scaled-down thermal prototype was set up to avoid mod-eling unpredictable heat transfer behaviors and feeding temperature samples into the main program running on a desktop PC.A series of dynamic test results showed significant power and temperature oscillations during the transient process,owing to the inconsistency of the rapid nuclear reaction rate and large thermal inertia.The proposed HIL approach is stable and effective for further studying of the dynamic characteristics and control optimization of solid-state small nuclear-powered systems at an early prototyping stage.展开更多
Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life ...Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.展开更多
As friction, intrinsic steady-state nonlinearity poses a challenging dilemma to the control system of 3-DOF （three degree of freedom） flight simulator, a novel hybrid control strategy of nonlinear PID （proportional...As friction, intrinsic steady-state nonlinearity poses a challenging dilemma to the control system of 3-DOF （three degree of freedom） flight simulator, a novel hybrid control strategy of nonlinear PID （proportionalintegral-derivative） with additional FFC （feed-forward controller） is proposed, and the hardware-in-the-loop simulation results are also given. Based on the description of 3-DOF flight simulator, a novel nonlinear PID theory is well introduced. Then a nonlinear PID controller with additional FFC is designed. Subsequently, the loop structure of 3-DOF flight simulator is also designed. Finally, a series of hardware-in-the-loop simulation experiments are undertaken to verify the feasibility and effectiveness of the proposed nonlinear PID controller with additional FFC for 3-DOF flight simulator.展开更多
[Objective] The present study was conducted to evaluate the cold resis-tance of four cherry cultivars under different chil ing stresses. [Method] Four cultivars of Cerasus, Early-mahapphala, Red light, Lapins and Kash...[Objective] The present study was conducted to evaluate the cold resis-tance of four cherry cultivars under different chil ing stresses. [Method] Four cultivars of Cerasus, Early-mahapphala, Red light, Lapins and Kashgar Kukan were selected as the experimental materials, and the changes of the relative electric conductivity （REC）, proline （PRO） content, malondialdehyde （MDA） content, superoxide dismu-tase （SOD） activity and peroxidase （POD） activity of dormant branches of the four cherry cultivars under low temperature stress were investigated. [Result] The REC of the four cherry cultivars was Kashgar kukan 〉 Red light 〉 Early-mahapphala 〉Lapins, while the MDA content was Kashgar kukan 〉 Early-mahapphala 〉 Red light 〉Lapins, both showed a rising trend in the four cultivars with the aggravating of the low temperature stress. The PRO content, POD and SOD activities of al cultivars were precisely contrary to their REC and MDA content, as al of them exhibited a sequence as Lapins 〉 Red light 〉 Early-mahapphala 〉 Kashgar kukan in al culti-vars, and got a trend of first rising and then declining. [Conclusion] Therefore, our final evaluation of cold resistance of the four cherry cultivars was Lapins 〉 Red light 〉 Early-mahapphala 〉 Kashgar kukan.展开更多
Nowadays validation of anti-lock braking systems（ABS） relies mainly on a large amount of road tests.An alternative means with higher efficiency is employing the hardware-in-the-loop simulation（HILS） system to subs...Nowadays validation of anti-lock braking systems（ABS） relies mainly on a large amount of road tests.An alternative means with higher efficiency is employing the hardware-in-the-loop simulation（HILS） system to substitute part of road tests for designing,testing,and tuning electronic control units（ECUs） of ABS.Most HILS systems for ABS use expensive digital signal processor hardware and special purpose software,and some fail-safe functions with regard to wheel speeds cannot be evaluated since artificial wheel speed signals are usually provided.In this paper,a low-cost ABS HILS test bench is developed and used for validating the anti-lock braking performance and tuning control parameters of ABS controllers.Another important merit of the proposed test bench is that it can comprehensively evaluate the fail-safe functions with regard to wheel speed signals since real tone rings and sensors are integrated in the bench.A 5-DOF vehicle model with consideration of longitudinal load transfer is used to calculate tire forces,wheel speeds and vehicle speed.Each of the four real-time wheel speed signal generators consists of a servo motor plus a ring gear,which has sufficient dynamic response ability to emulate the rapid changes of the wheel speeds under strict braking conditions of very slippery roads.The simulation of braking tests under different road adhesion coefficients using the HILS test bench is run,and results show that it can evaluate the anti-lock braking performance of ABS and partly the fail-safe functions.This HILS system can also be used in such applications as durability test,benchmarking and comparison between different ECUs.The test bench developed not only has a relatively low cost,but also can be used to validate the wheel speed-related ECU design and all its fail-safe functions,and a rapid testing and proving platform with a high efficiency for research and development of the automotive ABS is therefore provided.展开更多
A ground-based hardware-in-the-loop （HIL） simulation system with hydraulically driven Stewart platform for spacecraft docking simulation is presented. The system is used for simulating docking process of the on-orbi...A ground-based hardware-in-the-loop （HIL） simulation system with hydraulically driven Stewart platform for spacecraft docking simulation is presented. The system is used for simulating docking process of the on-orbit spacecraft. Principle and structure of the six-degree-of-freedom simulation system are introduced. The docking process dynamic of the vehicles is modeled. Experiment results and mathematical simulation data are compared to validating the simulation system. The comparisons of the results prove that the simulation system proposed can effectively simulate the on-orbit docking process of the spacecraft.展开更多
Beer fermentation process is a complex biochemical reaction process.It is the most important to control temperature of the wort in fermentation tank in accordance with the beer fermentation temperature curve so as to ...Beer fermentation process is a complex biochemical reaction process.It is the most important to control temperature of the wort in fermentation tank in accordance with the beer fermentation temperature curve so as to ensure the completion of fermentation.The controlled object is characterized by large inertia,long time delay and mutual coupling of three temperature areas.Based on this,a temperature control method for beer fermentation system is designed.Using digital incremental proportion integration differentiation （PID） control algorithm,the controlled quantity is transmitted to the controlled object after diagonal matrix decoupling.This simulation system can be completed in laboratory using VB and Kingview software,so it has the features of good security and low cost.It is very suitable for experimental teaching.展开更多
基金This work was financially supported by the National Key R&D Program of China(No.2020YFB1901900)National Natural Science Foundation of China(No.12275175)+2 种基金Special Fund for Strengthening Industry of Shanghai(No.GYQJ-2018-2-02)Shanghai Rising Star Program(No.21QA1404200)the LingChuang Research Project of the China National Nuclear Corporation.
文摘Micro-mobile heat pipe-cooled nuclear power plants are promising candidates for distributed energy resource power genera-tors and can be flexibly deployed in remote places to meet increasing electric power demands.However,previous steady-state simulations and experiments have deviated significantly from actual micronuclear system operations.Hence,a transient analysis is required for performance optimization and safety assessment.In this study,a hardware-in-the-loop(HIL)approach was used to investigate the dynamic behavior of scaled-down heat pipe-cooled systems.The real-time features of the HIL architecture were interpreted and validated,and an optimal time step of 500 ms was selected for the thermal transient.The power transient was modeled using point kinetic equations,and a scaled-down thermal prototype was set up to avoid mod-eling unpredictable heat transfer behaviors and feeding temperature samples into the main program running on a desktop PC.A series of dynamic test results showed significant power and temperature oscillations during the transient process,owing to the inconsistency of the rapid nuclear reaction rate and large thermal inertia.The proposed HIL approach is stable and effective for further studying of the dynamic characteristics and control optimization of solid-state small nuclear-powered systems at an early prototyping stage.
文摘目的 探讨不同助听模式的语前聋儿童听觉言语康复效果、家庭生活质量及两者间的相关性。方法 选取2020年3月至2020年7月在安徽医科大学第一附属医院行人工耳蜗植入术的语前聋儿童75例,其中58例符合纳排标准且连续随访1年而被纳入研究,按助听模式将儿童分为单侧人工耳蜗植入组(CI)21例,双耳双模式组(CI+HA)8例,双侧人工耳蜗植入组(BCI)29例。采用听觉能力分级标准(categories of auditory performance,CAP)评分、言语可懂度分级标准(speech intelligibility rate,SIR)评分、父母版言语空间特性量表(speech,spatial and qualities of hearing scale-parent's version,SSQ-P)评分及听力植入体儿童的家庭生活质量表(children using hearing implants quality of life,CuHI Qol)评估患儿听觉言语能力和家庭生活质量。结果 术前CI组、CI+HA组、BCI组CAP评分、SIR评分、SSQ-P评分比较,差异无统计学意义(P>0.05);术后3、6、12个月BCI组CAP评分、SIR评分、SSQ-P评分均高于CI+HA组,差异均有统计学意义(P<0.05);CI+HA组CAP评分、SIR评分、SSQ-P评分均高于CI组,差异均有统计学意义(P<0.05)。CI组、CI+HA组、BCI组言语感知评分、空间听力评分、听力音质评分、SSQ-P评分组间效应、时间效应、交互效应比较,差异均有统计学意义(P<0.05)。随时间延长,CI组、CI+HA组、BCI组SSQ-P评分均呈逐渐递增趋势。CI组、CI+HA组、BCI组不同时间点CuHI Qol评分时间效应比较,差异均有统计学意义(P<0.05),但组间效应、交互效应比较,差异均无统计学意义(P>0.05)。随时间推移,CI组、CI+HA组、BCI组家庭生活质量也越来越高。术后6个月,BCI组家庭生活质量最高,术后12个月,CI+HA组家庭生活质量评分上升明显。CuHI Qol评分与CAP评分、SIR评分、SSQ-P评分呈正相关,差异均有统计学意义(P<0.05)。结论 BCI具备双耳信息整合功能,空间听力优势较双耳双模式及单侧CI更明显,是极佳的助听补偿方式。术后听觉言语康复效果越好,家庭生活质量也越高。
基金supported by the National Natural Science Foundation of China,Nos.81730033,82171193(to XG)the Key Talent Project for Strengthening Health during the 13^(th)Five-Year Plan Period,No.ZDRCA2016069(to XG)+1 种基金the National Key R&D Program of China,No.2018YFC2001901(to XG)Jiangsu Provincial Medical Key Discipline,No.ZDXK202232(to XG)。
文摘Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of patients.To date,there are no viable treatment options for postoperative cognitive dysfunction.The identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future research.To identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial fracture.The dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub gene.Therefore,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re surgery.Mice were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning tests.In addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western blotting.Treatment with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expression compared with vehicle treatment.Intraperitoneal administration of the specific ERK inhibitor PD98059 diminished the effects of recombinant chitinase-3-like protein 1.Collectively,our findings suggest that recombinant chitinase-3-like protein 1 ameliorates surgery-induced cognitive decline by attenuating neuroinflammation via M2 microglial polarization in the hippocampus.Therefore,recombinant chitinase-3-like protein1 may have therapeutic potential fo r postoperative cognitive dysfunction.
基金the National Natural Science Foundation of China (60604009)Aeronautical Science Foundationof China(2006ZC51039)Beijing NOVA Program (2007A017).
文摘As friction, intrinsic steady-state nonlinearity poses a challenging dilemma to the control system of 3-DOF （three degree of freedom） flight simulator, a novel hybrid control strategy of nonlinear PID （proportionalintegral-derivative） with additional FFC （feed-forward controller） is proposed, and the hardware-in-the-loop simulation results are also given. Based on the description of 3-DOF flight simulator, a novel nonlinear PID theory is well introduced. Then a nonlinear PID controller with additional FFC is designed. Subsequently, the loop structure of 3-DOF flight simulator is also designed. Finally, a series of hardware-in-the-loop simulation experiments are undertaken to verify the feasibility and effectiveness of the proposed nonlinear PID controller with additional FFC for 3-DOF flight simulator.
基金Supported by the Science and Technology Supporting Project in Xinjiang Uygur Autonomous Region(201291123)~~
文摘[Objective] The present study was conducted to evaluate the cold resis-tance of four cherry cultivars under different chil ing stresses. [Method] Four cultivars of Cerasus, Early-mahapphala, Red light, Lapins and Kashgar Kukan were selected as the experimental materials, and the changes of the relative electric conductivity （REC）, proline （PRO） content, malondialdehyde （MDA） content, superoxide dismu-tase （SOD） activity and peroxidase （POD） activity of dormant branches of the four cherry cultivars under low temperature stress were investigated. [Result] The REC of the four cherry cultivars was Kashgar kukan 〉 Red light 〉 Early-mahapphala 〉Lapins, while the MDA content was Kashgar kukan 〉 Early-mahapphala 〉 Red light 〉Lapins, both showed a rising trend in the four cultivars with the aggravating of the low temperature stress. The PRO content, POD and SOD activities of al cultivars were precisely contrary to their REC and MDA content, as al of them exhibited a sequence as Lapins 〉 Red light 〉 Early-mahapphala 〉 Kashgar kukan in al culti-vars, and got a trend of first rising and then declining. [Conclusion] Therefore, our final evaluation of cold resistance of the four cherry cultivars was Lapins 〉 Red light 〉 Early-mahapphala 〉 Kashgar kukan.
基金supported by National Natural Science Foundation of China(Grant No.50908008)National Hi-tech Research and Development Program of China(863Program,Grant No.2009AA11Z216)
文摘Nowadays validation of anti-lock braking systems（ABS） relies mainly on a large amount of road tests.An alternative means with higher efficiency is employing the hardware-in-the-loop simulation（HILS） system to substitute part of road tests for designing,testing,and tuning electronic control units（ECUs） of ABS.Most HILS systems for ABS use expensive digital signal processor hardware and special purpose software,and some fail-safe functions with regard to wheel speeds cannot be evaluated since artificial wheel speed signals are usually provided.In this paper,a low-cost ABS HILS test bench is developed and used for validating the anti-lock braking performance and tuning control parameters of ABS controllers.Another important merit of the proposed test bench is that it can comprehensively evaluate the fail-safe functions with regard to wheel speed signals since real tone rings and sensors are integrated in the bench.A 5-DOF vehicle model with consideration of longitudinal load transfer is used to calculate tire forces,wheel speeds and vehicle speed.Each of the four real-time wheel speed signal generators consists of a servo motor plus a ring gear,which has sufficient dynamic response ability to emulate the rapid changes of the wheel speeds under strict braking conditions of very slippery roads.The simulation of braking tests under different road adhesion coefficients using the HILS test bench is run,and results show that it can evaluate the anti-lock braking performance of ABS and partly the fail-safe functions.This HILS system can also be used in such applications as durability test,benchmarking and comparison between different ECUs.The test bench developed not only has a relatively low cost,but also can be used to validate the wheel speed-related ECU design and all its fail-safe functions,and a rapid testing and proving platform with a high efficiency for research and development of the automotive ABS is therefore provided.
文摘A ground-based hardware-in-the-loop （HIL） simulation system with hydraulically driven Stewart platform for spacecraft docking simulation is presented. The system is used for simulating docking process of the on-orbit spacecraft. Principle and structure of the six-degree-of-freedom simulation system are introduced. The docking process dynamic of the vehicles is modeled. Experiment results and mathematical simulation data are compared to validating the simulation system. The comparisons of the results prove that the simulation system proposed can effectively simulate the on-orbit docking process of the spacecraft.
基金Shandong Province Department of Education Science and Technology Program(No.J05C11)
文摘Beer fermentation process is a complex biochemical reaction process.It is the most important to control temperature of the wort in fermentation tank in accordance with the beer fermentation temperature curve so as to ensure the completion of fermentation.The controlled object is characterized by large inertia,long time delay and mutual coupling of three temperature areas.Based on this,a temperature control method for beer fermentation system is designed.Using digital incremental proportion integration differentiation （PID） control algorithm,the controlled quantity is transmitted to the controlled object after diagonal matrix decoupling.This simulation system can be completed in laboratory using VB and Kingview software,so it has the features of good security and low cost.It is very suitable for experimental teaching.
