Multicenter Clinical Randomized Controlled Trial and Network Pharmacology Analysis of Zhenzhu Qingyuan Granules for the Treatment of Gastroesophageal Reflux Disease

Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.

How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review

Purpose:The study aimed to examine the reporting completeness of randomized controlled trials(RCTs)of non-pharmacological interventions following concussion.Methods:We searched MEDLINE,Embase,PsycInfo,CINAHL,and Web of Science up to May 2022.Two reviewers independently screened studies and assessed reporting completeness using the Template for Intervention Description and Replication(TIDieR),Consensus on Exercise Reporting Template(CERT),and international Consensus on Therapeutic Exercise aNd Training(i-CONTENT)checklists.Additional information was sought my study authors where reporting was incomplete.Risk of bias(ROB)was assessed with the Cochrane ROB-2 Tool.RCTs examining non-pharmacological interventions following concussion.Results:We included 89 RCTs(n=53 high ROB)examining 11 different interventions for concussion:sub-symptom threshold aerobic exercise,cervicovestibular therapy,physical/cognitive rest,vision therapy,education,psychotherapy,hyperbaric oxygen therapy,transcranial magnetic stimulation,blue light therapy,osteopathic manipulation,and head/neck cooling.Median scores were:TIDieR 9/12(75%;interquartile range(IQR)=5;range:5-12),CERT 17/19(89%;IQR=2;range:10-19),and i-CONTENT 6/7(86%;IQR=1;range:5-7).Percentage of studies completely reporting all items was TIDieR 35%(31/89),CERT 24%(5/21),and i-CONTENT 10%(2/21).Studies were more completely reported after publication of TIDieR(t_(87)=2.08;p=0.04)and CERT(t_(19)=2.72;p=0.01).Reporting completeness was not strongly associated with journal impact factor(TIDieR:rs=0.27;p=0.01;CERT:r_(s)=-0.44;p=0.06;i-CONTENT:r_(s)=-0.17;p=0.48)or ROB(TIDieR:rs=0.11;p=0.31;CERT:rs=0.04;p=0.86;i-CONTENT:rs=0.12;p=0.60).Conclusion:RCTs of non-pharmacological interventions following concussion demonstrate moderate to good reporting completeness,but are often missing key components,particularly modifications,motivational strategies,and qualified supervisor.Reporting completeness improved after TIDieR and CERT publication,but publication in highly cited journals and low ROB do not guarantee reporting completeness.

Power-Sharing Enhancement Using Harmonized Membership Fuzzy Logic Droop Control Based Micro-Grid

The contribution of Renewable Energy Resources(RER)in the process of power generation is significantly high in the recent days since it paves the way for overcoming the issues like serious energy crisis and natural contamination.This paper deals with the renewable energy based micro-grid as it is regarded as the apt solution for integrating the RER with the electrical frameworks.As thefixed droop coefficients in conventional droop control approaches have caused various limitations like low power-sharing and sudden drops of grid voltage in the Direct Current(DC)side,the Harmonized Membership Fuzzy Logic(MFL)droop control is employed in this present study.This proposed droop control for the hybrid PV-wind-battery system with MFL assists in achieving proper power-sharing and minimizing Total Harmonic Distortion(THD)in the emer-gency micro-grid.It eradicates the deviations in voltage and frequency with itsflexible and robust operation.The THD is reduced and attains the value of 3.1%compared to the traditional droop control.The simulation results of harmo-nized MFL droop control are analogized with the conventional approaches to vali-date the performance of the proposed method.In addition,the experimental results provided by the Field Programmable Gate Array(FPGA)based laboratory setup built using a solar photovoltaic(PV)and wind Permanent Magnet Synchro-nous Generator(PMSG)reaffirms the design.

Topology Optimization for Harmonic Excitation Structures with Minimum Length Scale Control Using the Discrete Variable Method

Continuumtopology optimization considering the vibration response is of great value in the engineering structure design.The aimof this studyis toaddress the topological designoptimizationof harmonic excitationstructureswith minimumlength scale control to facilitate structuralmanufacturing.Astructural topology design based on discrete variables is proposed to avoid localized vibration modes,gray regions and fuzzy boundaries in harmonic excitation topology optimization.The topological design model and sensitivity formulation are derived.The requirement of minimum size control is transformed into a geometric constraint using the discrete variables.Consequently,thin bars,small holes,and sharp corners,which are not conducive to the manufacturing process,can be eliminated from the design results.The present optimization design can efficiently achieve a 0–1 topology configuration with a significantly improved resonance frequency in a wide range of excitation frequencies.Additionally,the optimal solution for harmonic excitation topology optimization is not necessarily symmetric when the load and support are symmetric,which is a distinct difference fromthe static optimization design.Hence,one-half of the design domain cannot be selected according to the load and support symmetry.Numerical examples are presented to demonstrate the effectiveness of the discrete variable design for excitation frequency topology optimization,and to improve the design manufacturability.

Botanical,quality control,phytochemistry,pharmacology and toxicity characteristics of Corydalis bungeana Turcz.:a review

Corydalis bungeana Turcz.(CB)is a medicinal herb with significant medicinal value in traditional Chinese medicine.This paper reviews the progress of research on CB’s botany,quality control,phytochemistry,pharmacology and toxicity.The plant’s information was gathered from scientific databases such as PubMed,GeenMedical,Springer Link(https://link.springer.com),Chinese National Knowledge Infrastructure,Pharmacopoeia and Flora.Currently,137 phytochemicals have been identified and isolated from CB,including alkaloids,flavonoids,amino acids,terpenoids,coumarins and organic acids.In addition,many phytochemicals reported various antiinflammatory,antibacterial,antiviral,antitumor,analgesic,hepatoprotective,immunomodulatory,neuromodulatory,and lipid reduction activities.However,the study of its toxicity is still at the preliminary exploration stage and needs further intensive exploration.Herein,we provide an in-depth investigation of the progress of CB to elucidate the underlying mechanisms of activity of CB extracts and its major components,deliver valuable resources and information for further research and rational drug use,and explore the potential research directions and prospects of CB.

Harm of Hail to Crops and Countermeasures of Artificial Hail Suppression in Ulanqab City

Hail is one of meteorological disasters affecting crop growth in Ulanqab City.It happens frequently from May to September,and this period is also the main growing season of crops.In this period,hail will cause damage to crops,make farmland soil harden,and bring varying degrees of harm to agricultural production.Artificial hail suppression is an important scientific and technological means for disaster prevention and mitigation.It is necessary to strengthen the monitoring,analysis and forecast of severe convection weather,intensify the release of early warning information of hail weather,provide accurate and reliable real-time information for the implementation of artificial hail suppression operations,strengthen the implementation of artificial weather modification,effectively carry out artificial hail suppression operations,and avoid and reduce the impact of hail disaster.

Determination of Total Flavonoids in Acanthopanax senticosus(Rupr. et Maxim.) Harms by Enzymolysis and Its Technological Optimization

In order to optimize the ultrasonic extraction technique for the total flavonoid of leaf yellows plus, the contents of 21 leaf yellows plus total flavonoid from four regions in Heilongjiang Province were comparatively analyzed. The ultrasonic extraction technology was optimized by Box-Behnken response surface method, and the total flavonoid content of 21 kinds of Acanthopanax senticosus(Rupr. et Maxim.) Harms from different producing areas were analyzed by cluster analysis. The optimal process conditions were determined as ultrasonic time 30 min, solid-liquid ratio 1 : 12 and ultrasonic power 250 W, and the average yield of the total flavonoid was 1.453 mg·g^ (-1). By optimizing the ultrasonic-assisted extraction method, the total flavonoid content from different producing areas was compared in the experiment, which provided certain data support for the optimization of the extraction process in the future and laid a certain theoretical foundation for the quality analysis of Chinese medicinal materials.

Clinical study on microscopic syndrome differentiation and traditional Chinese medicine treatment for liver stomach disharmony in chronic gastritis

BACKGROUND Chronic gastritis(CG)is a common gastrointestinal disorder characterized by inflammation of the stomach lining.Liver-stomach disharmony(LSD)syndrome is believed to contribute to CG symptoms.AIM To evaluate the efficacy and safety of microcosmic syndrome differentiation and Chinese herbal medicine(CHM)treatment in patients with CG and LSD syndrome.METHODS Sixty-four patients with CG and LSD syndrome were randomly divided into two groups:The treatment group received CHM based on microcosmic syndrome differentiation and the control group received conventional Western medicine.The treatment course lasted 12 wk.The primary outcome was improvement in dyspeptic symptoms,measured using the Nepean Dyspepsia Index.The secondary outcomes included the improvement rate of endoscopic findings,histopathological findings,and microcosmic syndrome scores and the incidence of adverse events.RESULTS After 12 wk of treatment,the treatment group showed significantly greater improvement in dyspeptic symptoms than the control group(93.75%vs 65.63%,P<0.01).The treatment group also showed a significantly higher improvement rate in endoscopic findings than the control group(81.25%vs 53.13%,P<0.05).The improvement rates of histopathological findings and microcosmic syndrome scores were not significantly different between the two groups(P>0.05).No serious adverse events were observed in either group.CONCLUSION Microcosmic syndrome differentiation and CHM treatment can effectively improve dyspeptic symptoms and endoscopic findings in patients with CG and LSD syndrome and have a good safety profile.Further studies with larger sample sizes and longer follow-up periods are required to confirm the long-term efficacy and mechanism of action of this treatment.

HiLog:OpenHarmony的高性能日志系统

日志是计算机系统中记录事件状态信息的的重要载体,日志系统负责计算机系统的日志生成、收集和输出.OpenHarmony是新兴的、面向全设备、全场景的开源操作系统.在所述工作之前,包括日志系统在内OpenHarmony有许多关键子系统尚未构建,而OpenHarmony的开源特性使第三方开发者可以为其贡献核心代码.为了解决Open Harmony日志系统缺乏的问题,主要开展如下工作:(1)分析当今主流日志系统的技术架构和优缺点;(2)基于OpenHarmony操作系统的异构设备互联特性设计HiLog日志系统模型规范;(3)设计并实现第1个面向OpenHarmony的日志系统HiLog,并贡献到OpenHarmony主线;(4)对HiLog日志系统的关键指标进行测试和对比试验.实验数据表明,在基础性能方面,HiLog和Log的日志写入阶段吞吐量分别为1500 KB/s和700 KB/s,相比Android日志系统吞吐量提升114%;在日志持久化方面,HiLog可以3.5%的压缩率进行持久化,并且丢包率小于6‰,远低于Log.此外,HiLog还具备数据安全、流量控制等新型实用能力.

Distorted Waveform Balancing Using an Artificial Bee Colony (ABC) Based Optimal Control for Mitigating Total Harmonics in Single Phase Inverter

The main objective of this paper is to reduce the total harmonics in a single phase voltage source inverter using Artificial Bee Colony (ABC) optimization technique for critical load applications. Single phase inverter is a non-linear load using power electronic components causing distortions in the load voltage and current wave patterns from the sinusoidal waveforms due to harmonics. The mapping state space model for a full bridge voltage source inverter was developed using output load resistance. An optimal ABC technique has been designed and optimized values are estimated using a full bridge voltage controlled inverter using Proportional Integral Algorithm. The MATLAB/SIMULINK tool and Experimental setup were implemented and their THD values were estimated. Also this ABC scheme is compared with the previous results such as PI Algorithm, Fuzzy logic controller and Neuro-fuzzy controllers. From the simulation and experimental results using ABC algorithm, it is observed that the total harmonics are mitigated considerably compared to previous results with respect to the power quality standards such as IEEE-519 and IEC 61000.

Prevention of Harmful Algal Blooms by Control of Growth Parameters

Harmful Algal Blooms (HAB) were investigated to prevent the outbreak of HAB in both freshwater and seawater. Parameters inducing HAB were volcanic eruption, sunlight, aeolian dust, environmental factors (current, pH, dissolved oxygen, food web, turbulence, growth phase), enzyme, iron, nutrients (carbon, nitrogen, phosphorus, sulfur, silicon, minerals) while the critical growth parameter for the outbreak of HAB was iron (Fe). HAB development was halted in freshwater and seawater due to the sulfur compounds (H2S, sulfates) inducing the deficiency of the dissolved Fe in the water. The atomic ratio of N/P is commonly known to be 16/1 in freshwater and 176/1 in seawater for HAB. Therefore, nitrogen can be a relatively limiting factor in seawater while phosphorus in freshwater. HAB could be prevented by control of growth parameters such as pH, temperature, sunlight, turbulence, nitrogen, phosphorus, iron, and sulfur compounds prior to reaching the early exponential phase of algal growth.

Pharmacokinetics of Controlled Release and Immediate Release Morphine Sulphate Tablets after a Single Dose and Multiple Doses in Chinese Volunteers

The pharmacokinetics of morphine sulphate was studied in 10 Chinese healthy volunteers after a single oral dose. Blood samples were collected before and after administration of controlled release tablets (CRMS, 30 mg) and immediate release tablets (IRMS, 20 mg). The plasma concentration of morphine was determined by GC MS. The pharmacokinetic parameters of controlled release tablets and immediate release tablets were calculated∶ C max was 19.38±3.80 and 21.27±6.21 ng/ml, t max was 2.36 ±0.37 h and 0.56±0.16 h, t 1/2β was 3.53±0.87 and 3.03±0.74 h, AUC was 145.15±17.65 and 93.08±16.65 ng/ml, respectively. The steady state plasma concentration of morphine sulphate in cancer patients after multiple doses was achieved, C max of CRMS and IRMS was 27.43±0.33 ng/ml and 22.68±0.16 ng/ml, C min of CRMS and IRMS was 19.45±1.44 ng/ml and 18.14±0.49 ng/ml, respectively.

Fuzzy Controller Based 3Phase 4Wire Shunt Active Filter for Mitigation of Current Harmonics with Combined p-q and Id-Iq Control Strategies

As more and more variable frequency drives (VFDs), electronic ballasts, battery chargers, and static Var compensators are installed in facilities, the problems related to harmonics are expected to get worse. As a result Active power filter (APF) gains much more attention due to excellent harmonic compensation. But still the performance of the active filter seems to be in contradictions with different control strategies. This paper presents detailed analysis to compare and elevate the performance of two control strategies for ex-tracting reference currents of shunt active filters under balanced, un-balanced and non-sinusoidal conditions by using Fuzzy controller. The well known methods, instantaneous real active and reactive power method (p-q) and active and reactive current method (id-iq) are two control methods which are extensively used in active filters. Extensive Simulations are carried out with fuzzy controller for both p-q and Id-Iq methods for different voltage conditions and adequate results were presented. Simulation results validate the superior per-formance of active and reactive current control strategy (id-iq) with fuzzy controller over active and reactive power control strategy (p-q) with fuzzy controller.

Empirical Study on Improving Customer Satisfaction of Retail Pharmacies by Using Quality Control Circle

Objective To study the effect of quality control circle(QCC)activities on customer satisfaction of retail pharmacies so as to improve the level of customer management.Methods After choosing the theme of improving customer satisfaction research(CSR)in pharmacies,Gantt chart,questionnaire,fishbone diagram and other tools were applied in the“endeavor circle”to find out the factors affecting the theme.Then corresponding countermeasures were made and implemented to verify them in different stages.Meanwhile,the radar map and other technologies were used to compare the changes of CSR and circle members’growth before and after the activities.Results and Conclusion Sales clerk’s lack of drug knowledge,serious shortage of drugs,incapability of establishing a good relationship with customers and the lack of after-sales service were identified as the main factors.After implementing corresponding countermeasures,the target achievement rate was 116.12%,and the progress rate was 19.02%.Besides,customer satisfaction increased from 79.54%to 94.67%and the team growth value of circle members increased from 3.29 to 5.83,with significant tangible and intangible effects.QCC activities in retail pharmacies can not only standardize pharmaceutical service mode,but also improve the overall competence of sales clerks.The key factors and management methods for CSR improvement obtained from QCC activities will provide reference for the customer management of retail pharmacies.

Sustainable Utilization of Agricultural Straw for Harmful Algal Blooms Control:A Review

The use of agricultural straw for algal bloom control has been studied for more than 30 years.In this article,we have reviewed the promising potentials of using agricultural straw as source of anti-algal agents,including the effectiveness of each major straw type so far used in this regard,and the investigated algal species.Various pre-treatment methods have also been widely reviewed.Significant progress has been made in natural product chemistry and molecular biology with regards to agricultural straw,especially in relation to the extraction of antialgal allelochemicals,degradation processes of agricultural straws and the mechanisms through which these inhibitions occur.The development of biotechnologies using agricultural straw to successfully inhibit growth of bloom forming algae has been generally accepted as environmentally friendly.The current research status and that of the future should include isolation and discovery of antialgal allelochemicals,development of models that would illustrate the sequence of physiologic events that match the species-specific inhibitor phenomenon,and products fit in the field applications.

Instantaneous Active and Reactive Power and Current Strategies for Current harmonics cancellation in 3-ph 4wire SHAF With both PI and Fuzzy Controllers

Control strategies for extracting the three-phase reference currents for shunt active power filters are compared, evaluating their performance under different source conditions with PI and Fuzzy Controllers in MATLAB/Simulink environment When the supply voltages are balanced and sinusoidal, the two control strategies are converge to the same compensation characteristics;However, the supply voltages are distorted and/or un-balanced sinusoidal, these control strategies result in different degrees of compensation in harmonics. The compensation capabilities are not equivalent, with p - q control strategy unable to yield an adequate solution when source voltages are not ideal. Extensive simulations are carried out with PI controller and also with Fuzzy controller for both p-q and Id-Iq control strategies under different main voltages. Extensive Simulations are carried out with PI as well as fuzzy controller for both p-q and Id - Iq control strategies by considering different voltage conditions and adequate results were presented. On owing Id - Iq method with fuzzy logic controller gives away an out-standing performance under any voltage conditions (balanced, un-balanced, balanced and non-sinusoidal).

Control Design for Harmonic Disturbance Rejection for Robot Manipulators with Bounded Inputs

Currently most of control methods are of one degree of freedom（1-DOF） control structure for the robot systems which are affected by unmeasurable harmonic disturbances,at the same time in order to obtain perfect disturbance attenuation level,the controller gain must be increased.In practice,however,for robotic actuators,there are physical constraints that limit the amplitude of the available torques.This paper considers the problem of tracking control under input constraints for robot manipulators which are affected by unmeasurable harmonic disturbances.A new control scheme is proposed for the problem,which is composed of a parameter-dependent nonlinear observer and a tracking controller.The parameter-dependent nonlinear observer,designed based on the internal model principle,can achieve an estimation and compensation of a class of harmonic disturbances with unknown frequencies.The tracking controller,designed via adaptive control techniques,can make the systems asymptotically track the desired trajectories.In the control design,the continuous piecewise differentiable increasing function is used to limit control input amplitude,such that the control input saturation is avoided.The Lyapunov stability of closed loop systems is analyzed.To validate proposed control scheme,simulation results are provided for a two link horizontal robot manipulator.The simulation results show that the proposed control scheme ensures asymptotic tracking in presence of an uncertain external disturbance acting on the system.An important feature of the methodology consists of the fact that the designed controller is of 2-DOF control structure,namely,it has the ability to overcome the conflict between controller gain and robustness against external disturbances in the traditional 1 -DOF control structure framework.

STUDY ON SENSOR-BASED CONTROL METHOD FOR HARMONIC DRIVE SYSTEM

A new type of robust traje ctory tracking control for harmonic using joint torque sensor and joint acceleration sensor information is concerned with.Joint torque sensor information is used to compensate the uncertainty of link and load parameters. Joint acceleration feedback control will enhace the robustness of the driving system, resist the dynamic uncertainties and disturbing torque acted on the joint axis within definite bandwidth, improve the joint tracking performance, and resist the vibration of the load side of the harmonic drive system. Experimental studies are carried out and comparison of several controllers , such as PD and sensor- based control, the experimental results clearly illustrate the effectiveness of the proposed methods.

<i>Houttuynia cordata</i>Thunb: A Review of Phytochemistry and Pharmacology and Quality Control

Houttuynia cordata Thunb is an important medicinal plant widely distributed in East Asia. The collected information is an attempt to cover recent developments in the pharmacology, phytochemistry and quality control of this species. During the past several decades, the medicinally important phyto-constituents have been identified including essential oil, flavonoids and other polyphenols, fatty acids and alkaloids. A survey of the literatures shows H. cordata possesses a variety of pharmacological activities including antiviral, antitumor, antimicrobial, anti-inflammatory, and antioxidative effects. Little attempt has been done to review the techniques used for its quality control. Future efforts should concentrate more on in vitro, in vivo studies and clinical trials in order to confirm traditional wisdom in the light of a rational phytotherapy. The information summarized here is intended to serve as a reference tool to practitioners in the fields of ethnopharmacology and natural products chemistry.

Development of chromatographic technologies for the quality control of Traditional Chinese Medicine in the Chinese Pharmacopoeia

As an important branch of medicine, Traditional Chinese Medicine(TCM) has been applied for the treatment of diseases for thousands of years in China and other countries in East Asia. The Chinese Pharmacopoeia(ChP) is a drug code formulated by the Chinese government, and it includes a special volume for the monographs of TCM, which plays an important role in ensuring the quality of drugs. The use of quality control technology has always been a complex and important factor in TCM. Owing to the chemical diversity of TCM, chromatography technology has been proven to be a comprehensive strategy for the assessment of the overall quality of TCM and has become the main analytical method in the ChP.This article provides an overview of the classical and modern chromatographic technologies applied in the ChP, and summarizes the advantages and disadvantages of each technique in the TCM monographs.In 2020, the new edition of the Ch P(the 2020 edition) has been implemented at the end of 2020. This paper also contains a brief introduction about the application of chromatographic technologies in the new edition of the ChP.