A novel hasubanan alkaloid has been isolated along with the known aknadinine from the fresh roots of Stephania sutchenensis.Its structure has been established as 1—nitroaknadinine from detailed spectral studies and c...A novel hasubanan alkaloid has been isolated along with the known aknadinine from the fresh roots of Stephania sutchenensis.Its structure has been established as 1—nitroaknadinine from detailed spectral studies and confirmed by chemical correlation with aknadinine.The novel alkaloid is the first nitro-hasubanan and also the first example of naturally occurring nitro—alkaloids.展开更多
Two unusual nitro-substituted hasubanan-type alkaloids, stephalonines J (1) and K (2), together with ten known alkaloids, protostephanine, dehydrostephanine, (-)-stephanine, (-)-isolaureline, R-roemeroline, ...Two unusual nitro-substituted hasubanan-type alkaloids, stephalonines J (1) and K (2), together with ten known alkaloids, protostephanine, dehydrostephanine, (-)-stephanine, (-)-isolaureline, R-roemeroline, (+)-pronuciferine, ( +)-stephafine, ( + )-N-acetylstephafine, ( + )-lirioferine, and ( + )-norlirioferine, were isolated from the whole plant of Stephania longa. Their structures were characterized mainly by spectroscopic methods including IR, MS, and NMR experiments, and the structures of 1 and 2 were further confirmed through chemical correlations with the known alkaloids stephalonines A (1a) and B (2a), respectively.展开更多
Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS,...Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D (1) was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.展开更多
文摘A novel hasubanan alkaloid has been isolated along with the known aknadinine from the fresh roots of Stephania sutchenensis.Its structure has been established as 1—nitroaknadinine from detailed spectral studies and confirmed by chemical correlation with aknadinine.The novel alkaloid is the first nitro-hasubanan and also the first example of naturally occurring nitro—alkaloids.
基金Project supported by the National Natural Science Foundation of China (No. 30025044), Shanghai Municipal Scientific Foundation (No. 04XD 14019), and the Foundation from the Ministry of Science and Technology (No. 2002CB512807) of China.
文摘Two unusual nitro-substituted hasubanan-type alkaloids, stephalonines J (1) and K (2), together with ten known alkaloids, protostephanine, dehydrostephanine, (-)-stephanine, (-)-isolaureline, R-roemeroline, (+)-pronuciferine, ( +)-stephafine, ( + )-N-acetylstephafine, ( + )-lirioferine, and ( + )-norlirioferine, were isolated from the whole plant of Stephania longa. Their structures were characterized mainly by spectroscopic methods including IR, MS, and NMR experiments, and the structures of 1 and 2 were further confirmed through chemical correlations with the known alkaloids stephalonines A (1a) and B (2a), respectively.
基金Science and Technology Commission of China(2012CB722601)Science and Technology Department of Guizhou Province(QKHZYZ[2011]5085)
文摘Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D (1) was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.