1—NITROAKNADININE,A NOVEL NITRO—HASUBANAN ALKALOID FROM STEPHANIA SUTCHUEN ENSIS

A novel hasubanan alkaloid has been isolated along with the known aknadinine from the fresh roots of Stephania sutchenensis.Its structure has been established as 1—nitroaknadinine from detailed spectral studies and confirmed by chemical correlation with aknadinine.The novel alkaloid is the first nitro-hasubanan and also the first example of naturally occurring nitro—alkaloids.

A New Hasubanan Alkaloid from Stephania hernandifolia

Objective To study the chemical constituents of Stephania hernandifolia. Methods Various chromato- graphic techniques were used to isolate the constituents, and the structures were elucidated on the basis of HR-EI-MS, 1D-NMR and 2D-NMR spectral analyses. Results A hasubanan alkaloid, hernsubanine D （1） was isolated from the whole plants of S. hernandifolia. The compound was screened for the cytotoxic activity against two human cancer cell lines in vitro. Conclusion Compound 1 is a new compound without cytotoxicity against A549 and K562 cells.

莲花烷类生物碱化学成分和药理活性研究进展

莲花烷类生物碱属于异喹啉类吗啡型生物碱,主要存在于防己科千金藤属植物中,目前已发现70余个。其药理活性主要表现在抗HBV、与δ-阿片受体结合、抗单纯疱疹病毒等方面。为了更好地开发利用莲花烷类生物碱,本文综述了其化学成分与药理活性的研究进展。

Two Unusual Nitro-substituted Hasubanan-type Alkaloids from Stephania longa

Two unusual nitro-substituted hasubanan-type alkaloids, stephalonines J （1） and K （2）, together with ten known alkaloids, protostephanine, dehydrostephanine, （-）-stephanine, （-）-isolaureline, R-roemeroline, （＋）-pronuciferine, （ ＋）-stephafine, （ ＋ ）-N-acetylstephafine, （ ＋ ）-lirioferine, and （ ＋ ）-norlirioferine, were isolated from the whole plant of Stephania longa. Their structures were characterized mainly by spectroscopic methods including IR, MS, and NMR experiments, and the structures of 1 and 2 were further confirmed through chemical correlations with the known alkaloids stephalonines A （1a） and B （2a）, respectively.

钯催化分子内Heck型插羰串联环化反应及在复杂天然产物全合成中的应用

钯催化分子内Heck型插羰串联反应在复杂分子的合成中有着广泛的应用.近年来,本课题组开发了一种高效构筑全碳环骨架的钯催化分子内Heck型插羰串联环化反应.本文将从该合成方法学的建立、不同底物类型的扩展及反应机理的探究等方面对该串联环化反应进行详细介绍.在此基础上,利用该串联环化反应作为关键步骤,通过对环化前体中所包含双键类型的调节,成功实现了三尖杉二萜类天然产物、莲花烷类生物碱及加兰他敏类生物碱的全合成.

桐叶千金藤中莲花烷类生物碱的研究

目的：研究桐叶千金藤Stephania hernandifolia中的莲花烷类生物碱。方法：桐叶千金藤全草用95%乙醇溶液加热回流提取,减压回收乙醇,浓缩液加水稀释后经酸碱处理,石油醚、氯仿萃取,得生物总碱。生物总碱利用正相硅胶、反相Rp-18、微孔吸附树脂CHP20P、Sephadex LH-20等柱色谱方法分离和纯化,通过理化性质和光谱数据进行结构鉴定。结果：从桐叶千金藤中分离得到9个莲花烷类生物碱,分别为aknadinine（1）,longanone（2）,stephasunoline（3）,N-methylstephuline（4）,epistephamiersine（5）,prostephabyssine（6）,aknadilactam（7）,dihydroepistephamiersine（8）,hasubanonine（9）。结论：化合物2~8为首次从该植物中分离得到。

桐叶千金藤中的一个新莲花烷型生物碱(英文)

采用多种柱色谱方法从桐叶千金藤Stephania hernandifolia Walp中分离得到1个新的莲花烷型生物碱—桐叶莲花碱E(1)和2个已知化合物—对羟基苯甲醛(2)和(-)-丁香树脂酚(3)。通过光谱学数据分析鉴定了这些化合物的结构。其中,化合物2和3为首次从该属植物中分离鉴定。