Refractory lipoatrophy treated with autologous whole blood injection:A case report

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and hyperpigmentation.Although cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this condition.CASE SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months earlier.There had been only subtle improvement at the margins after fractional CO2 laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was initiated.One month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in discoloration.CONCLUSION Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

Preliminary Study on Transgenesis by Injecting Exogenous DNA into Zygote Cytoplasm of Buffalo

[Objective] This study aimed to investigate the feasibility of transgenesis by injecting exogenous DNA into zygote cytoplasm of Buffalo. [Method] Buffalo oocytes were randomly divided into two groups 20-22 h after in vitro maturation. One group of oocytes was introduced with about 7.5 pl of 50 μg/ml DNA solution containing linear EGFP fragment by cytoplasmic injection 7-10 h or 18-20 h after in vitro fertilization （IVF）; the other group of oocytes was introduced with mixture of a single buffalo sperm and about 7.5 pl of 50 μg/ml DNA solution containing linear EGFP fragment by cytoplasmic injection （generally called ICSI-Mediated Gene Transfer, ICSI-Tr）. Expression of exogenous DNA was observed and recorded during the process of embryonic development. [Result] Early embryonic gene expression efficiency and blastocyst gene expression efficiency in IVF injection group showed no significant difference compared with that in ICSI-Tr group （P0.05）. In addition, the cleavage rate and early embryonic gene expression efficiency in IVF injection group were significantly higher with injection at 7-10 h post IVF than that at 18-20 h post IVF （P0.05）. [Conclusion] These results indicate that transgenic buffalo embryos can be generated by injecting exogenous DNA into cytoplasm of IVF oocytes, and the optimal injection time is 7-10 h post IVF.

Rectifier Configurations Based on Harmonic Injecting and Counteracting Principle

On the basis of detailed analysis of a novel harmonic counteracting method which can be used to effectively compensate the supply line harmonic currents of a passive single phase diode bridge rectifier, this paper presents two simpler single phase diode bridge rectifier configurations and their alternatives which can achieve low supply line current THD(total harmonic distortion) too. Moreover, this paper also proposes a few passive hamonic counteracting networks for multi single phase rectifiers which are connected in parallel.

An optimization of injecting system in die casting

After many years of development, die casting technology of metallic materials has been matured. In this paper,the lower-support and its injecting system were created with commercial software. And then the simulation softwareFLOW3D was applied to study the flow behavior of the melt during injection filling process. Both temperature field anddefect distribution were simulated. Based on these results, the better injecting system with two additional overflows wasadopted.

Polymer light-emitting devices using poly(ethylene oxide) as an electron injecting layer

The performance of polymer light emitting devices(PLEDs)based on polyvinyl carbazole(PVK)is improved by introducing a nanoscale interfacial thin layer,made of poly(ethylene oxide)(PEO),between the calcium cathode and the PVK emissive layer.It is believed that the PEO layer plays a key role in enhancing the device performance.In comparison to the device with Ca/Al as the cathode,the performance of the PLED with PEO/Ca/Al cathode,including the driving voltage,luminance efficiency is significantly improved.These improvements are attributed to the introduction of a thin layer of PEO that can lower the interfacial barrier and facilitate electron injection.

Mixing and Vaporization Process of Injecting Water in Hydrogenation Unit

Injecting water into the main pipeline is a common method to prevent the ammonium salt corrosion in hydrogenation units.The use of spray nozzle can enhance the effects of washing ammonium salt and reduce the risk of ammonium salt corrosion.The droplet atomization and evaporation model were used to investigate the mixing process of injecting water and gas-oil mixture in a high-pressure environment.The effects of some key parameters including fluid velocity,temperature,and droplet volume fraction on the mixing and vaporization process were analyzed.Numerical simulation results show that with the increase of injecting water flow rate,the fluid velocity increases and the temperature decreases continuously.When the mass flow rate of injecting water is 1.5 t/h,the droplet has the maximum evaporation efficiency and the volume fraction reaches a minimum value.Besides,with the increase of atomization angle and droplet size,the mean velocity and the temperature of fluid decrease continuously.The increase of atomization angle or the decrease of droplet size will accelerate the evaporation process of droplets and reduce the droplet volume fraction,which indicates that the droplet slip velocity and the contact area are the key factors affecting the droplet evaporation rate.

Poloidal rotation induced by injecting lower hybrid waves in tokamak plasma edge

The poloidal rotation of the magnetized edge plasma in tokamak driven by the ponderomotive force which is generated by injecting lower hybrid wave(LHW) electric field has been studied. The LHW is launched from a waveguide in the plasma edge, and by Brambilla's grill theory, analytic expressions for the wave electric field in the slab model of an inhomogeneous cold plasma have been derived. It is shown that a strong wave electric field will be generated in the plasma edge by injecting LH wave of the power in MW magnitude, and this electric field will induce a poloidal rotation with a sheared poloidal velocity.

Topological and Historical Considerations for Infectious Disease Transmission among Injecting Drug Users in Bushwick, Brooklyn (USA)

Recent interest by physicists in social networks and disease transmission factors has prompted debate over the topology of degree distributions in sexual networks. Social network researchers have been critical of “scale-free” Barabasi-Albert approaches, and largely rejected the preferential attachment, “rich-get-richer” assumptions that underlie that model. Instead, research on sexual networks has pointed to the importance of homophily and local sexual norms in dictating degree distributions, and thus disease transmission thresholds. Injecting Drug User (IDU) network topologies may differ from the emerging models of sexual networks, however. Degree distribution analysis of a Brooklyn, NY, IDU network indicates a different topology than the spanning tree configurations discussed for sexual networks, instead featuring comparatively short cycles and high concurrency. Our findings suggest that IDU networks do in some ways conform to a “scale-free” topology, and thus may represent “reservoirs” of potential infection despite seemingly low transmission thresholds.

Cross-upgrading of biomass hydrothermal carbonization and pyrolysis for high quality blast furnace injection fuel production:Physicochemical characteristics and gasification kinetics analysis

The paper proposes a biomass cross-upgrading process that combines hydrothermal carbonization and pyrolysis to produce high-quality blast furnace injection fuel.The results showed that after upgrading,the volatile content of biochar ranged from 16.19%to 45.35%,and the alkali metal content,ash content,and specific surface area were significantly reduced.The optimal route for biochar pro-duction is hydrothermal carbonization-pyrolysis(P-HC),resulting in biochar with a higher calorific value,C=C structure,and increased graphitization degree.The apparent activation energy(E)of the sample ranges from 199.1 to 324.8 kJ/mol,with P-HC having an E of 277.8 kJ/mol,lower than that of raw biomass,primary biochar,and anthracite.This makes P-HC more suitable for blast furnace injection fuel.Additionally,the paper proposes a path for P-HC injection in blast furnaces and calculates potential environmental benefits.P-HC of-fers the highest potential for carbon emission reduction,capable of reducing emissions by 96.04 kg/t when replacing 40wt%coal injec-tion.

Estimating the Size of an Injecting Drug User Population

This article describes a sampling and estimation scheme for estimating the size of an injecting drug user (IDU) population by combining classical sampling and respondent-driven sampling procedures. It is designed to use the information from harm reduction programs, especially, Needle Exchange Programs (NEPs). The approach involves using respondent-driven sampling design to collect a sample of injecting drug users who appear at site of NEP in a certain period of time and to obtain retrospective self-report data on the number of friends among the IDUs and number of needles exchanged for each sampled injecting drug user. A methodology is developed to estimate the size of injecting drug users who have ever used the NEP during the fixed period of time, and which allows us to estimate the proportion of injecting drug users in using NEP. The size of the IDU population is estimated by dividing the total number of IDUs who using NEPs during the period of time by the estimated proportion of IDUs in the group. The technique holds promise for providing data needed to answer questions such as “What is the size of an IDU population in a city?” and “Is that size changing?” and better understand the dynamics of the IDU population. The methodology described here can also be used to estimate size of other hard-to-reach population by using information from harm reduction programs.

HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China

Objective The mode of human immunodeficiency virus(HIV) transmission via injection drug use(IDU)still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.Methods We performed a molecular epidemiological investigation of infections across Guangxi from2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.Results Among the 535 subjects, CRF08_BC(57.4%), CRF01_AE(28.4%), and CRF07_BC(10.7%) were the top 3 HIV strains;72.6% of infections were linked to other provinces in the transmission network;93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces,predominantly Guangdong and Yunnan;92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.Conclusion HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces.Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.

Sintering products molded by injecting ceramic and metal powders

The injection molding products with different volume ratios of ZrO2 ceramic powder to 316L stainless steel powder were prepared. Properties and structure of the products were characterized by X-ray diffraction（XRD）, scanning electron microscope（SEM） and transmission electron microscope （TEM）. The results show that the compressive stress exists in the products and the bend strength reaches 300MPa. ZrO2 phase and stainless steel phase are uniform in samples. The toughness of ceramic increases with the increasing the content of stainless steel. Through TEM study of the interface, some crystalline orientation relationships are determined.

Influence analysis of flow rule in mine fire during injecting inert gases

According to the action law of gas flow during injecting inert gases as the research main line, and hydromechanics and thermodynamics theories, the characteristic of gas delamination that was caused by injecting inert gases to closed fire zone was analyzed. The criterion was brought forward, which could scale disappearing probability of turbulent state. Formation mechanism of gas layer in turbulent state was discussed primarily. Simultaneously, the condition was pointed out, which could makc the gas in turbulent state by injecting different gases. The mathematical model about dynamic changes of oxygen and methane concentration in the process of injecting gases was erected. The mixture mechanism about injecting different flow inert gases and flammable gas layer in closed fire zone was revealed.

A Probabilistic Trust Model and Control Algorithm to Protect 6G Networks against Malicious Data Injection Attacks in Edge Computing Environments

Future 6G communications are envisioned to enable a large catalogue of pioneering applications.These will range from networked Cyber-Physical Systems to edge computing devices,establishing real-time feedback control loops critical for managing Industry 5.0 deployments,digital agriculture systems,and essential infrastructures.The provision of extensive machine-type communications through 6G will render many of these innovative systems autonomous and unsupervised.While full automation will enhance industrial efficiency significantly,it concurrently introduces new cyber risks and vulnerabilities.In particular,unattended systems are highly susceptible to trust issues:malicious nodes and false information can be easily introduced into control loops.Additionally,Denialof-Service attacks can be executed by inundating the network with valueless noise.Current anomaly detection schemes require the entire transformation of the control software to integrate new steps and can only mitigate anomalies that conform to predefined mathematical models.Solutions based on an exhaustive data collection to detect anomalies are precise but extremely slow.Standard models,with their limited understanding of mobile networks,can achieve precision rates no higher than 75%.Therefore,more general and transversal protection mechanisms are needed to detect malicious behaviors transparently.This paper introduces a probabilistic trust model and control algorithm designed to address this gap.The model determines the probability of any node to be trustworthy.Communication channels are pruned for those nodes whose probability is below a given threshold.The trust control algorithmcomprises three primary phases,which feed themodel with three different probabilities,which are weighted and combined.Initially,anomalous nodes are identified using Gaussian mixture models and clustering technologies.Next,traffic patterns are studied using digital Bessel functions and the functional scalar product.Finally,the information coherence and content are analyzed.The noise content and abnormal information sequences are detected using a Volterra filter and a bank of Finite Impulse Response filters.An experimental validation based on simulation tools and environments was carried out.Results show the proposed solution can successfully detect up to 92%of malicious data injection attacks.

Remission of Abdominal Colic During Enteroscopy by Injecting Vitamin K_3 into Zusanli Acupoint

In 1970s,sedatives or spasmolytics needed to beadministered 30 minutes prior to performingenteroscopy to relieve abdominal colic during theexamination.Owing to the improvement in operatingskills,such drugs are no more used today.However,anumber of patients still suffer from abdominal coliccaused by irritated colon in the process ofenteroscopy.For severe cases,the operator has nochoice but to suspend the examination.To find a

Study on Rotational Effects of Modern Turbine Blade on Coolant Injecting Nozzle Position with Film Cooling and Vortex Composite Performance

The flow structure of the vortex cooling is asymmetrical compared to the traditional gas turbine leading edge cooling,such as the impingement cooling and the axial flow cooling.This asymmetrical property will affect the cooling performance in the blade leading edge,whereas such effects are not found in most of the studies on vortex cooling due to the neglect of the mainstream flow in the airfoil channel.This study involves the mainstream flow field and the rotational effects based on the profile of the GE E3 blade to reveal the mechanism of the asymmetrical flow structure effects.The nozzle position on the characteristics of the vortex and film composite cooling in the turbine rotating blade leading edge is numerically investigated.The cool-ant injecting nozzles are set at the side of the pressure surface(PS-side-in)vs.that is set at the side of the suction surface(SS-side-in)to compare the cooling characteristics at the rotating speed range of 0–4000 rpm with fluid and thermal conjugate approach.Results show that the nozzle position presents different influences under low and higher rotational speeds.As for the mainstream flow,rotation makes the stagnation line move from the pressure surface side to the suction surface side,which changes the coolant film attachment on the blade leading edge surface.The position of nozzles,however,indicates limited influence on the coolant film flow.As for the internal channel vortex flow characteristics,the coolant injected from the nozzles forms a high-velocity region near the target wall,which brings about enhancing convective heat transfer.The flow direction of the vortex flow near the internal channel wall is opposite and aligns with the direction of Coriolis force in both the PS-side-in and SS-side-in,respectively.Therefore,the Coriolis force augments the convective heat transfer intensity of the vortex cooling in the internal channel in SS-side-in while weakening the internal heat transfer in PS-side-in.Such effects become more intense with higher rotational speed.The blade surface temperature decreases as the Coriolis force increases the internal heat transfer intensity.The SS-side-in suggests a superior composite cooling performance under the relatively higher rotating speed.The SS-side-in structure is recommended in the gas turbine blade leading edge running at a higher rotating speed.

Shenqi Fuzheng injection alleviates chemotherapy-induced cachexia by restoring glucocorticoid signaling in hypothalamus

Chemotherapy-induced cachexia(CIC)is a debilitating condition characterized by weight loss,muscle atrophy,and anorexia[1].While peripheral mechanisms of cachexia have been extensively studied,the involvement of the central nervous system(CNS)in CIC is often overlooked.Chemotherapeutic drugs cause stress responses and inflammation,which may impact the hypothalamus and disrupt systemic energy and neuroendocrine functions.Understanding hypothalamic roles in regulating these processes can provide insights into CIC's mechanisms and aid in developing novel therapies.

Stabilizing subgrades of transport structures by injecting solidifying solutions in cold regions

Transport structures built throughout the period from 1960 to 1980 in permafrost regions based on the principle of permafrost preservation are subject to deformations.In many cases,the reason is a gradual change in temperature and their subgrade condition within the active zone due to the structures'technogenic impact.Design solutions for the fifty-year-old structures fail to ensure in all cases their reliable operation at the present time.The greatest danger to the reliable operation of railway lines in cold regions is uneven deformations of bridges,which are barrier places.Therefore,the solution to this problem is urgent especially due to the necessity of increase carrying capacity.The purpose of this study is to increase reliability of bridge operation in cold regions through strengthening the subgrade by reinforcement with injection of solidifying solutions.The problem of uneven deformations due to permafrost degradation is considered using the example of a railway bridge located in the northern line of the Krasnoyarsk railway.Deformations of the bridge abutments began immediately after the construction was completed and the bridge was open for traffic-since 1977.Permafrost degradation was developing more actively straight under the abutments due to higher thermal conductivity of the piles concrete.Notably,thawing intensity of frozen soils under the bridge abutments is uneven due to its orientation to the cardinal points.The analysis of archive materials and results of the geodetic survey made it possible to systematize the features of augmenting deformations of each abutment over time.The engineering-geological survey with drilling wells near the abutments ensured determination of soil characteristics,both in the frozen and thawed states.Thermometric wells were arranged to measure temperatures.The analysis and systematization of the data obtained allowed us to develop geotechnical models for each abutment of the bridge.The peculiarity of these models is allowance for changes in the strength and deformation characteristics of the soil calculated layers depending on changes in temperature and the soil condition.Thus,different calculated geological elements with the corresponding strength and deformation characteristics were identified in the soil layers of the same origin.The analysis of the systematized geodetic data allowed us to confirm adequacy of the developed geotechnical models.Studies carried out using geotechnical models made it possible to predict improvement of physical and mechanical characteristics of the subgrade to prevent further growth deformations of the bridge abutments.The method of reinforcement by injection is proposed.Injecting a solution under pressure leads to strengthening of weakened thawed soils and improving their physical and mechanical properties.This research theoretically substantiates and develops the geotechnical models of the reinforced pier footing of bridge abutments by injection of solidifying solutions.The models take into account the reinforcement parameters and elements for the case in question.The influence of reinforcement on the change in physical and mechanical properties of the soil mass is determined.

Personalized laparoscopic radical resection of gallbladder cancer by staining of the liver draining area through ICG injection into the cholecystic artery

Gallbladder cancer(GBC)is a common malignant tumor often diagnosed in advanced stages.Surgery is among the most important treatments for GBC.Radical resection of GBC involves removal of the gallbladder and the gallbladder bed[liver segments(S)4b and 5],and hepatoduodenal ligament regional lymphadenectomy.The main GBC metastasis modes are blood and lymph node metastases.The scope of resection/wedge resection or regular S4b and S5 hepatectomy for blood metastasis is a matter of debate.A variety of hepatectomy methods have been proposed for T2 stage GBC,but no consensus has been reached regarding the scope of radical resection.Currently,the liver resection range is determined by branches of the portal vein.S4b and S5 hepatectomy is determined according to the liver portal vein branch perfusion area,but the rationale for liver resection for GBC is to eliminate potential metastasis from the cystic vein reflux area to the liver.In the case described herein,we used a novel technique and theoretical framework to conduct laparoscopic radical resection of gallbladder cancer(LRRGC)facilitated by staining of the liver draining area with an indocyanine green(ICG)injection into the cholecystic artery.

Does HSP27 injection induce glaucoma damage in mice?

In a further aging society,excellent eyesight is an integral part of overall well-being and quality of life.Preserving good vision is crucial to maintaining mobility,independence,and mental health.There can be several reasons for visual impairment in elderly people,these include age-related macular degeneration,the leading cause of vision loss among older adults,cataract,glaucoma,diabetic retinopathy,retinal detachment,and others.