Two major causes of human aging include protein misfolding and free radicals. Protein misfolding occurs when proteins which are synthesized by cells do not have the proper amino acid sequence or do not achieve the cor...Two major causes of human aging include protein misfolding and free radicals. Protein misfolding occurs when proteins which are synthesized by cells do not have the proper amino acid sequence or do not achieve the correct three-dimensional configuration to function properly. Peer-reviewed scientific literature explains how these processes contribute to many age-associated diseases. A few examples include cancer, heart disease, dementias including Parkinson’s and Alzheimer’s </span><span style="font-family:Verdana;">diseases, and arthritis. This article reviews how protein misfolding can be slowed and even reversed by appropriate nutrition, potentially slowing and reversing these diseases. One cause of misfolding is mRNA translation occurring too rapidly for proper chaperone binding or protein folding. A second cause is deficiency of amino acids so improper tRNA binding occurs. A third cause is free radicals. They cause mutations promoting misfolding and cancer, and oxidize lipoproteins causing plaque in circulation promoting heart disease and stroke. Nutrients with proven actions will contribute to longer healthspans for our aging population. Healthspan is the number of healthy years before chronic or terminal diseases substantially impair the quality of life. This can be done especially by slowing and reversing these three causes of PM. Niacin, quercetin, EGCG, alpha-lipoic acid, N-acetyl-carnitine, tyrosine and cysteine address protein misfolding. Vitamin C and glutathione trap free radicals. Vitamin K amplifies free radical cancer killing by vitamin C and activates decalcification enzymes which remove calcium deposits in the circulatory system and strengthen bones. Apigenin activates the pathway of caloric restriction and induces cancer cell apoptosis. This article provides citations and explanations of the progress showing new ways to maintain health as we age. For convenience and cost savings, many of these ingredients can be consumed in supplement form, taken twice a day to maintain water-soluble nutrient levels.展开更多
The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous st...The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK,oral nitazoxanide protects against experimental hyperlipidemia,hepatic steatosis,and atherosclerosis.Here,we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 pathway.Additionally,both nitazoxanide and tizoxanide improve high glucose-induced shortening of C.elegans lifespan.Nitazoxanide has been a clinical drug with a good safety profile,we suggest that it is a novel anti-aging drug.展开更多
Human lifespan and life expectancy have increased worldwide,but the number of years that we spend free of chronic or debilitating disorders,known as healthspan,has not shifted along with increased lifespan.This unfavo...Human lifespan and life expectancy have increased worldwide,but the number of years that we spend free of chronic or debilitating disorders,known as healthspan,has not shifted along with increased lifespan.This unfavourable trend presents a tremendous global social-economical problem.We propose a model of promoting optimal human health with proactive,holistic interventions across the lifespan,which require multi-disciplinary,innovative approaches to research and care.We contend that this is the only hope that we have to face the challenges of population growth and aging,as well as the upward trend in non-communicable disease prevalence.展开更多
At the 2017 Linus Pauling meeting, it was announced that based on metabolomic analysis, vitamin K at levels far above the daily value activates a variety of enzymes that are beneficial. The enzymes have been shown to ...At the 2017 Linus Pauling meeting, it was announced that based on metabolomic analysis, vitamin K at levels far above the daily value activates a variety of enzymes that are beneficial. The enzymes have been shown to remove calcium where it harms our health, deposit it where it benefits bone, may reduce hip fractures, and decrease calcification of the circulatory system, reducing by 50% the risk of heart disease and high blood pressure. Linus Pauling demonstrated that vitamin C can kill cancer cells. One form of vitamin K regenerates vitamin C so that it is even more effective at killing cancer cells. I previously reported a trial that determined an oral dosage of vitamin C that produces a concentration in the bladder able to kill recurring non-invasive muscle carcinoma cells. Nature in 1999 published an article on foods that reduce the risk of cancer. Since then there is additional evidence that nutrients can extend the human healthspan. Other nutrients are effective at reducing the risk of cancer, such as the active ingredient in cruciferous vegetables. These nutrients that reduce the risk of cancer and improve health are GRAS. They are safe and likely to substantially reduce the risk of cancer, heart disease, hip fractures, and other undesirable conditions. While research on treating cancer dominates media attention, pharmaceutical development, and Federal funding, it is likely that people can prevent cancer by consuming nutrients that have been shown to kill human cancer cells.展开更多
文摘Two major causes of human aging include protein misfolding and free radicals. Protein misfolding occurs when proteins which are synthesized by cells do not have the proper amino acid sequence or do not achieve the correct three-dimensional configuration to function properly. Peer-reviewed scientific literature explains how these processes contribute to many age-associated diseases. A few examples include cancer, heart disease, dementias including Parkinson’s and Alzheimer’s </span><span style="font-family:Verdana;">diseases, and arthritis. This article reviews how protein misfolding can be slowed and even reversed by appropriate nutrition, potentially slowing and reversing these diseases. One cause of misfolding is mRNA translation occurring too rapidly for proper chaperone binding or protein folding. A second cause is deficiency of amino acids so improper tRNA binding occurs. A third cause is free radicals. They cause mutations promoting misfolding and cancer, and oxidize lipoproteins causing plaque in circulation promoting heart disease and stroke. Nutrients with proven actions will contribute to longer healthspans for our aging population. Healthspan is the number of healthy years before chronic or terminal diseases substantially impair the quality of life. This can be done especially by slowing and reversing these three causes of PM. Niacin, quercetin, EGCG, alpha-lipoic acid, N-acetyl-carnitine, tyrosine and cysteine address protein misfolding. Vitamin C and glutathione trap free radicals. Vitamin K amplifies free radical cancer killing by vitamin C and activates decalcification enzymes which remove calcium deposits in the circulatory system and strengthen bones. Apigenin activates the pathway of caloric restriction and induces cancer cell apoptosis. This article provides citations and explanations of the progress showing new ways to maintain health as we age. For convenience and cost savings, many of these ingredients can be consumed in supplement form, taken twice a day to maintain water-soluble nutrient levels.
基金supported by the National Natural Science Foundation of China(Nos.82373864 and 82170472).
文摘The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous studies find that nitazoxanide and its metabolite tizoxanide induce mild mitochondrial uncoupling and activate cellular AMPK,oral nitazoxanide protects against experimental hyperlipidemia,hepatic steatosis,and atherosclerosis.Here,we demonstrate that both nitazoxanide and tizoxanide extend the lifespan and healthspan of Caenorhabditis elegans through Akt/AMPK/sir 2.1/daf16 pathway.Additionally,both nitazoxanide and tizoxanide improve high glucose-induced shortening of C.elegans lifespan.Nitazoxanide has been a clinical drug with a good safety profile,we suggest that it is a novel anti-aging drug.
基金supported by the Healthspan Institute Initiative of University of Virginia.
文摘Human lifespan and life expectancy have increased worldwide,but the number of years that we spend free of chronic or debilitating disorders,known as healthspan,has not shifted along with increased lifespan.This unfavourable trend presents a tremendous global social-economical problem.We propose a model of promoting optimal human health with proactive,holistic interventions across the lifespan,which require multi-disciplinary,innovative approaches to research and care.We contend that this is the only hope that we have to face the challenges of population growth and aging,as well as the upward trend in non-communicable disease prevalence.
文摘At the 2017 Linus Pauling meeting, it was announced that based on metabolomic analysis, vitamin K at levels far above the daily value activates a variety of enzymes that are beneficial. The enzymes have been shown to remove calcium where it harms our health, deposit it where it benefits bone, may reduce hip fractures, and decrease calcification of the circulatory system, reducing by 50% the risk of heart disease and high blood pressure. Linus Pauling demonstrated that vitamin C can kill cancer cells. One form of vitamin K regenerates vitamin C so that it is even more effective at killing cancer cells. I previously reported a trial that determined an oral dosage of vitamin C that produces a concentration in the bladder able to kill recurring non-invasive muscle carcinoma cells. Nature in 1999 published an article on foods that reduce the risk of cancer. Since then there is additional evidence that nutrients can extend the human healthspan. Other nutrients are effective at reducing the risk of cancer, such as the active ingredient in cruciferous vegetables. These nutrients that reduce the risk of cancer and improve health are GRAS. They are safe and likely to substantially reduce the risk of cancer, heart disease, hip fractures, and other undesirable conditions. While research on treating cancer dominates media attention, pharmaceutical development, and Federal funding, it is likely that people can prevent cancer by consuming nutrients that have been shown to kill human cancer cells.
