Nationwide epidemiological surveys of idiopathic sudden sensorineural hearing loss(SSNHL) have been performed five times by the Research Committee of the Ministry of Health and Welfare or the Ministry of Health, Welfa...Nationwide epidemiological surveys of idiopathic sudden sensorineural hearing loss(SSNHL) have been performed five times by the Research Committee of the Ministry of Health and Welfare or the Ministry of Health, Welfare and Labour in Japan. These surveys included patients who had SSNHL in 1972, 1987, 1993, 2001, and 2012. Using the criteria for the grading of hearing loss in SSNHL or the criteria for grading the degree of hearing recovery after SSNHL established by the Research Committee, we compared the outcomes of SSNHL between the five nationwide surveys. The results revealed that the outcomes of SSNHL have not changed in the past 40 years. In 1972, 88% of patients received steroids, but none received prostaglandin E1(PGE1). The use of PGE1 has increased since the 1980 s, but its effect on SSNHL may not be significant. Intratympanic steroid injection has been introduced recently for the treatment of SSNHL, but it does not seem to be used widely in Japan. Intratympanic therapy that can reduce the total amount of steroids administered will be used more frequently if the true effects and indications for this therapy are known. Elucidation of the etiologies of SSNHL and development of treatments specific for these etiologies are expected.展开更多
【目的】探讨纯中医规范化综合治疗短病程突发性聋(简称突聋)的临床疗效及其影响因素。【方法】对516例采用纯中医规范化综合治疗的短病程突聋住院患者(中医组)的临床资料进行回顾性分析,并与《中国突发性聋分型治疗的多中心临床研究》...【目的】探讨纯中医规范化综合治疗短病程突发性聋(简称突聋)的临床疗效及其影响因素。【方法】对516例采用纯中医规范化综合治疗的短病程突聋住院患者(中医组)的临床资料进行回顾性分析,并与《中国突发性聋分型治疗的多中心临床研究》的1024例患者(西医组)的疗效进行对照,分析患者性别、耳别、年龄、耳聋程度、听力曲线类型、伴随症状(耳鸣、眩晕、耳闷)及中医证型对疗效的影响。【结果】(1)基线资料比较:与西医组相比,中医组低频下降型占比较低,全聋型占比较高,治疗难度相对较大,而疗程缩短近2/3(12.60 d vs 30.00 d)。(2)疗效分析:中医组516例患者中,痊愈175例,显效121例,有效90例,无效130例,总有效率为74.80%,与西医组1024例相比,无论总体疗效还是按听力曲线分类统计疗效,差异均无统计学意义(P>0.05)。(3)疗效影响因素分析:听力曲线类型与突聋疗效关系密切(P<0.001),低频下降型疗效最好,全聋型疗效最差;耳聋程度越轻,痊愈可能性越大(P<0.001);无眩晕者疗效优于伴眩晕者(P<0.001);青少年患者疗效较中老年好(P<0.05);中医证型与疗效无关(P>0.05)。【结论】纯中医规范化综合治疗短病程突聋疗效较好,与西医常规治疗相比可能具有一定的优势;听力曲线类型、耳聋程度、是否伴随眩晕及年龄是影响疗效的相关因素。展开更多
文摘Nationwide epidemiological surveys of idiopathic sudden sensorineural hearing loss(SSNHL) have been performed five times by the Research Committee of the Ministry of Health and Welfare or the Ministry of Health, Welfare and Labour in Japan. These surveys included patients who had SSNHL in 1972, 1987, 1993, 2001, and 2012. Using the criteria for the grading of hearing loss in SSNHL or the criteria for grading the degree of hearing recovery after SSNHL established by the Research Committee, we compared the outcomes of SSNHL between the five nationwide surveys. The results revealed that the outcomes of SSNHL have not changed in the past 40 years. In 1972, 88% of patients received steroids, but none received prostaglandin E1(PGE1). The use of PGE1 has increased since the 1980 s, but its effect on SSNHL may not be significant. Intratympanic steroid injection has been introduced recently for the treatment of SSNHL, but it does not seem to be used widely in Japan. Intratympanic therapy that can reduce the total amount of steroids administered will be used more frequently if the true effects and indications for this therapy are known. Elucidation of the etiologies of SSNHL and development of treatments specific for these etiologies are expected.
文摘【目的】探讨纯中医规范化综合治疗短病程突发性聋(简称突聋)的临床疗效及其影响因素。【方法】对516例采用纯中医规范化综合治疗的短病程突聋住院患者(中医组)的临床资料进行回顾性分析,并与《中国突发性聋分型治疗的多中心临床研究》的1024例患者(西医组)的疗效进行对照,分析患者性别、耳别、年龄、耳聋程度、听力曲线类型、伴随症状(耳鸣、眩晕、耳闷)及中医证型对疗效的影响。【结果】(1)基线资料比较:与西医组相比,中医组低频下降型占比较低,全聋型占比较高,治疗难度相对较大,而疗程缩短近2/3(12.60 d vs 30.00 d)。(2)疗效分析:中医组516例患者中,痊愈175例,显效121例,有效90例,无效130例,总有效率为74.80%,与西医组1024例相比,无论总体疗效还是按听力曲线分类统计疗效,差异均无统计学意义(P>0.05)。(3)疗效影响因素分析:听力曲线类型与突聋疗效关系密切(P<0.001),低频下降型疗效最好,全聋型疗效最差;耳聋程度越轻,痊愈可能性越大(P<0.001);无眩晕者疗效优于伴眩晕者(P<0.001);青少年患者疗效较中老年好(P<0.05);中医证型与疗效无关(P>0.05)。【结论】纯中医规范化综合治疗短病程突聋疗效较好,与西医常规治疗相比可能具有一定的优势;听力曲线类型、耳聋程度、是否伴随眩晕及年龄是影响疗效的相关因素。
