To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular autonomic nervous systems in essential hypertensive (EH) patients by comparing heart rate variability (HRV) and blood pressure va...To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular autonomic nervous systems in essential hypertensive (EH) patients by comparing heart rate variability (HRV) and blood pressure variability (BPV) in EH patients with or without type 2 diabetes mellitus (T2DM). Simultaneous 24-h recordings of ambulatory ECG and blood pressure monitoring were performed in 36 male old patients with simple EH and 33 male old patients with EH combined with T2DM. HRV analysis included time domain parameters such as SDNN, SDANN, SDNNi, rMSSD and pNN50, and total spectral power (TP) of HRV, which mainly consists of VLF, LF and HF component along with LF/HF ratio, was also obtained. The value of ambulatory blood pressure was represented as the mean blood pressure (mean systolic/mSBP, diastolic/mDBP and pulse pressure/mPP) during different periods (24 h/24 h, day time/d and night time/n). Standard deviation (SD) as well as coefficient of variance (CV) of blood pressure during each above-mentioned period were obtained to reflect the long-term BPV. Our result showed that SDNN, SDNNi, SDANN, rMSSD, PNN50, TP and HF of HRV in cases of EH with T2DM were all significantly lower than those in simple EH subjects (P〈0.05). No significant differences in VLF or LF was found between the two groups (P〉0.05), while LF/HF ratio was significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.01). Moreover, dmSBP, 24 h-mPP and dmPP were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while nmSBP, 24 h-mSBP, 24 h-mDBP, dmDBP, nmDBP or nmPP showed no significant difference between this two groups of patients (P〉0.05). And dSBPSD, dSBPCV and 24 h-SBPSD were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while the other BPV indexes showed no significant difference between this two groups (P〉0.05). It is concluded that the cardiovascular autonomic nervous systems in EH patients was further impaired by T2DM, displaying lowering of HRV and enlargement of BPV, which in turn induced abnormal structural and functional changes of cardiovascular systems. Therefore, improving cardiovascular autonomic nervous systems might reduce the occurrence of cardiovascular complications in the EH patients with IGM.展开更多
Assessing the dynamics of heart rate fluctuations can provide valuable information about heart status. In this study, regularity of heart rate variability (HRV) of heart failure patients and healthy persons using th...Assessing the dynamics of heart rate fluctuations can provide valuable information about heart status. In this study, regularity of heart rate variability (HRV) of heart failure patients and healthy persons using the concept of singular value decomposition entropy (SvdEn) is analyzed. SvdEn is calculated from the time series using normalized singular values. The advantage of this method is its simplicity and fast computation. It enables analysis of very short and non-stationary data sets. The results show that SvdEn of patients with congestive heart failure (CHF) shows a low value (SvdEn: 0.056±0.006, p 〈 0.01) which can be completely separated from healthy subjects. In addition, differences of SvdEn values between day and night are found for the healthy groups. SvdEn decreases with age. The lower the SvdEn values, the higher the risk of heart disease. Moreover, SvdEn is associated with the energy of heart rhythm. The results show that using SvdEn for discriminating HRV in different physiological states for clinical applications is feasible and simple.展开更多
Objective: To evaluate the changes of human heart rate (HR) and heart rate variability (HRV) during and after moxa smoke inhalation and to investigate the effects of moxa smoke on human autonomic nervous system. Metho...Objective: To evaluate the changes of human heart rate (HR) and heart rate variability (HRV) during and after moxa smoke inhalation and to investigate the effects of moxa smoke on human autonomic nervous system. Methods: 24 healthy volunteers were exposed to moxa smoke with their HRV parameters measured before, during and after the moxa smoke inhalation. Results: The healthy volunteers exposed to moxa smoke had significant reductions in HR and also significant changes in HRV parameters. Conclusions: Moxa smoke can improve the autonomic nervous system activity. The inhalation of moxa smoke will induce a depressant effect on human body.展开更多
The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some vo...The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some voice alarm if the HRV is abnormal.Then it is decided whether to see a doctor at a convenient time for further diagnosis.The instrument has a feature of voice guidance that can save keyboard steps,which extends the scope of use.All people,old and young,the blind and the deaf,can use it by themselves.展开更多
In previous studies by the same research group it has been shown in post-stroke patients that the autonomic system can be affected by acupuncture. Within this study, teleacupuncture between China and Austria is used f...In previous studies by the same research group it has been shown in post-stroke patients that the autonomic system can be affected by acupuncture. Within this study, teleacupuncture between China and Austria is used for quantifying the effects of heart rate variability (HRV) in Chinese patients suffering from depression. In 22 Chinese depression patients (17 f, 5 m;mean age ± SD 52.3 ± 10.6 years;range 31 - 70 years) electrocardiographic signals before, during and after acupuncture at the acupoint Jianshi (PC 5) were recorded in Harbin and analyzed in Graz using teleacupuncture via internet. HRV data were analyzed in the time and frequency domain and a protocol from Austria was sent to the team in China immediately after the treatment and recording session. Mean heart rate decreased significantly (p < 0.001) during and after acupuncture, whereas total HRV increased significantly during (p < 0.034) and after (p < 0.001) acupuncture, always immediately following manual needle stimulation. Furthermore, there is a marked decrease in balance between sympathetic and parasympathetic activity (low frequency/high frequency HRV ratio) during treatment. This study shows that HRV could be a useful parameter for quantifying clinical effects of acupuncture on the autonomic nervous system. Teleacupuncture between China and Austria over a distance of more than 8,500 km has been successfully used.展开更多
Background: The effect of traffic related emissions on Heart Rate Variability (HRV) has been previously demonstrated. However, the results of different studies on the relationship between ambient pollutants and specif...Background: The effect of traffic related emissions on Heart Rate Variability (HRV) has been previously demonstrated. However, the results of different studies on the relationship between ambient pollutants and specifically carbon monoxide (CO) on HRV are inconclusive and appear to reflect personal differences. The differences in methodology including breathing style and participants under study can possibly attribute to this variability. The aim of the present study is to assess the effect of the breathing route (Nasal/Oral) on the relationship between CO concentration and HRV. Methodology: Forty healthy participants (25 females, 15 males) between the ages of 15 - 50 years were included in the study. The participants strolled in a central bus station, staying for 10 minutes in three designated locations alternating nasal and oral breathing. CO concentration and HRV were continuously monitored. Frequency (LnLF, LnHF, LnLF/HF) and time domain (LnSDNN, LnRMSSD) HRV indices were computed. Analysis: MANCOVA, with HRV indices being the dependent variables and CO, gender and age being the independent variables was employed. Results: Significant interaction effects between breathing route and CO, and breathing route and gender on HRV (LnLF/HF) were found (p = 0.04 and 0.01 respectively). Both CO and age were found to affect LnSDNN and LnRMSSD. Conclusion: Breathing route emerges as a possible modifier of the relationship between air pollution and HRV and thus contributes to interpersonal differences obtained in studies investigating the effect of environmental pollution and HRV.展开更多
Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynapt...Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynaptically perigenual Anterior Cingulate Cortex (pACC, BA 33), insula, amigdala, hypothalamus and connected branches of the Autonomic Nervous System (ANS) involved in stressorevoked cardiovascular reactivity. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both, and, consequently, an increase in systolic/stroke volume, total vascular impedance/resistance and heart rate, a decrease of baroreflex sensitivity, i.e., an increase in blood pressure/arterial tension. Objectives and Aims: The present work aims, using TMS and accordingly to Gianaros modeling, based on functional neuroimaging studies and previous neuroanatomical data from animal models, to probe the connectivity of brain systems involved in stressor-evoked cardiovascular reactivity and to explore TMS potential as a tool for detection and stratification of individual differences concerning this reactivity and hemorreological risk factors correlated with the development of Coronary Heart Disease (CHD). Methods: Both subjects, a 52 years old male and a 40 years old female with previous increased Low Frequency (LF)/High Frequency (HF) Heart Rate Variability (HRV) ratios (respectively, 4.209/3.028) without decompensated cardiorespiratory symptoms, gave informed consent, and ethico-legal issues have been observed. Electroencephalographic (EEG) monitoring has been performed for safety purposes. Immediately after administration, over the mPFC, of 15 pulses of rTMS, during 60 second, with an inductive electrical current, at the stimulating coil, of 85.9 Ampère per μsecond and 66 Ampère per μsecond, respectively, for male and female subjects (a “figure-of-eight” coil and magnetic stimulator MagLite, Dantec/Medtronic, have been used), HRV spectrum analysis (cStress software) has been performed (during 5 minutes, in supine position). Results: In both subjects, LF power, HF power and LF/HF ratio results, before and after rTMS administration, pointed towards sympathetic attenuation and parasympathetic augmentation (respectively, in male/female subject: decreased LF power—65.1 nu/69.3 nu, before rTMS;56.1 nu/41.6 nu, after rTMS;increased HF power—15.5 nu/22.9 nu, before rTMS;30.9 nu/45.5 nu, after rTMS). Conclusions: In this preliminary investigation, the existence of a link between “mind” and heart’s function has been put in evidence, through a reversible “virtual” lesion, of brain systems involved in cardiovascular control, caused by TMS. Repetitive TMS over mPFC decreased brain function involved in stressorevoked cardiovascular reactivity, suggesting the importance of TMS in the management of stress-related cardiovascular disorders.展开更多
目的探讨肥胖合并重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的心率变异性(heart rate variability,HRV)特征。方法回顾性分析2018年4月至2022年5月在西安交通大学第二附属医院行多导睡...目的探讨肥胖合并重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的心率变异性(heart rate variability,HRV)特征。方法回顾性分析2018年4月至2022年5月在西安交通大学第二附属医院行多导睡眠(polysomnography,PSG)监测确诊为重度OSAHS的78例患者,根据身体质量(body mass index,BMI)将患者分为肥胖并重度OSAHS组(n=43)和非肥胖并重度OSAHS组(n=35)。所有患者行PSG监测同时接受24 h动态心电图监测,进行HRV指标的组间差异分析及与临床指标的相关性分析。结果基础指标及PSG指标分析结果显示,与非肥胖并重度OSAHS组相比,肥胖并重度OSAHS组体质量、BMI、颈围、腰围、呼吸暂停低通气指数(apnea hypopnea index,AHI)显著升高。组间HRV分析结果显示,与非肥胖并重度OSAHS组相比,肥胖并重度OSAHS组的24 h正常R-R间期标准差(standard deviation of R-R interval,SDNN)、5 min R-R间期均值标准差(standard deviation of the averages of 5-minute R-R intervals,SDANN)、三角指数(triangle index,TI)、心率减速力(deceleration capacity of heart rate,DC)、清醒期SDNN及睡眠高频功率明显降低(P<0.05)。相关性结果显示肥胖并重度OSAHS患者中相邻R-R间期差值均方根(root mean square of the difference of adjacent R-R interval,rMSSD)与高血压病程呈负相关,TI、DC与AHI呈负相关。经校正颈围和腰围后的线性回归分析显示SDNN、SDANN、rMSSD与收缩压相关(P<0.05)。结论肥胖并重度OSAHS患者存在HRV指标下降,自主神经功能受到损害,心血管疾病的发生风险增加。展开更多
Previous studies have found that drivers’physiological conditions can deteriorate under noise conditions,which poses a potential hazard when driving.As a result,it is crucial to identify the status of drivers when ex...Previous studies have found that drivers’physiological conditions can deteriorate under noise conditions,which poses a potential hazard when driving.As a result,it is crucial to identify the status of drivers when exposed to different noises.However,such explo-rations are rarely discussed with short-term physiological indicators,especially for rail transit drivers.In this study,an experiment involving 42 railway transit drivers was conducted with a driving simulator to assess the impact of noise on drivers’physiological responses.Considering the individuals’heterogeneity,this study introduced drivers’noise annoyance to measure their self-noise-adaption.The variances of drivers’heart rate variability(HRV)along with different noise adaptions are explored when exposed to different noise conditions.Several machine learning approaches(support vector machine,K-nearest neighbour and random forest)were then used to classify their physiological status under different noise conditions according to the HRV and drivers’self-noise adaptions.Results indicate that the volume of traffic noise negatively affects drivers’performance in their routines.Drivers with different noise adaptions but exposed to a fixed noise were found with discrepant HRV,demonstrating that noise adaption is highly associated with drivers’physiological status under noises.It is also found that noise adaption inclusion could raise the accuracy of classifications.Overall,the random forests classifier performed the best in identifying the physiological status when exposed to noise conditions for drivers with different noise adaptions.展开更多
Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable rea...Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable real-time detection of exercise intensity and mitigate the risks of harmfrom excessive exercise, a exercise intensity monitoring system based on the heart rate variability(HRV) from electrocardiogram (ECG) signal and linear features from phonocardiogram (PCG)signal is proposed. The main contributions include: First, accurate analysis of HRV is crucial forsubsequent exercise intensity detection. To enhance HRV analysis, we propose an R-peak detectorbased on encoder-decoder and temporal convolutional network (TCN). Experimental resultsdemonstrate that the proposed R-peak detector achieves an F1 score exceeding 0.99 on real high-intensity exercise ECG datasets. Second, an exercise fatigue monitoring system based on multi-signal feature fusion is proposed. Initially, utilizing the proposed R-peak detector for HRV extractionin exercise intensity detection,which outperforms traditional algorithms, with the system achieving a classification performance of 0.933 sensitivity, 0.802 specificity, and 0.960 accuracy. To further improve the system, we combine HRV with the linear features of PCG. Our exercise intensitydetection system achieves 90.2% specificity, 96.7% recall, and 98.1% accuracy in five-fold cross-validation.展开更多
文摘To investigate the effects of impaired glucose metabolism (IGM) on cardiovascular autonomic nervous systems in essential hypertensive (EH) patients by comparing heart rate variability (HRV) and blood pressure variability (BPV) in EH patients with or without type 2 diabetes mellitus (T2DM). Simultaneous 24-h recordings of ambulatory ECG and blood pressure monitoring were performed in 36 male old patients with simple EH and 33 male old patients with EH combined with T2DM. HRV analysis included time domain parameters such as SDNN, SDANN, SDNNi, rMSSD and pNN50, and total spectral power (TP) of HRV, which mainly consists of VLF, LF and HF component along with LF/HF ratio, was also obtained. The value of ambulatory blood pressure was represented as the mean blood pressure (mean systolic/mSBP, diastolic/mDBP and pulse pressure/mPP) during different periods (24 h/24 h, day time/d and night time/n). Standard deviation (SD) as well as coefficient of variance (CV) of blood pressure during each above-mentioned period were obtained to reflect the long-term BPV. Our result showed that SDNN, SDNNi, SDANN, rMSSD, PNN50, TP and HF of HRV in cases of EH with T2DM were all significantly lower than those in simple EH subjects (P〈0.05). No significant differences in VLF or LF was found between the two groups (P〉0.05), while LF/HF ratio was significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.01). Moreover, dmSBP, 24 h-mPP and dmPP were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while nmSBP, 24 h-mSBP, 24 h-mDBP, dmDBP, nmDBP or nmPP showed no significant difference between this two groups of patients (P〉0.05). And dSBPSD, dSBPCV and 24 h-SBPSD were all significantly higher in EH with T2DM patients than in simple EH subjects (P〈0.05), while the other BPV indexes showed no significant difference between this two groups (P〉0.05). It is concluded that the cardiovascular autonomic nervous systems in EH patients was further impaired by T2DM, displaying lowering of HRV and enlargement of BPV, which in turn induced abnormal structural and functional changes of cardiovascular systems. Therefore, improving cardiovascular autonomic nervous systems might reduce the occurrence of cardiovascular complications in the EH patients with IGM.
基金Project supported by the National Natural Science Foundation of China (Grant No.30540025)
文摘Assessing the dynamics of heart rate fluctuations can provide valuable information about heart status. In this study, regularity of heart rate variability (HRV) of heart failure patients and healthy persons using the concept of singular value decomposition entropy (SvdEn) is analyzed. SvdEn is calculated from the time series using normalized singular values. The advantage of this method is its simplicity and fast computation. It enables analysis of very short and non-stationary data sets. The results show that SvdEn of patients with congestive heart failure (CHF) shows a low value (SvdEn: 0.056±0.006, p 〈 0.01) which can be completely separated from healthy subjects. In addition, differences of SvdEn values between day and night are found for the healthy groups. SvdEn decreases with age. The lower the SvdEn values, the higher the risk of heart disease. Moreover, SvdEn is associated with the energy of heart rhythm. The results show that using SvdEn for discriminating HRV in different physiological states for clinical applications is feasible and simple.
文摘Objective: To evaluate the changes of human heart rate (HR) and heart rate variability (HRV) during and after moxa smoke inhalation and to investigate the effects of moxa smoke on human autonomic nervous system. Methods: 24 healthy volunteers were exposed to moxa smoke with their HRV parameters measured before, during and after the moxa smoke inhalation. Results: The healthy volunteers exposed to moxa smoke had significant reductions in HR and also significant changes in HRV parameters. Conclusions: Moxa smoke can improve the autonomic nervous system activity. The inhalation of moxa smoke will induce a depressant effect on human body.
基金supported by the National Nature Science Foundation of China(60804034)Nature Science Foundation of Shandong Province(ZR2009GQ006)+3 种基金the Project of Science and Technology of Qingdao Economic and Technological Development Area(2009-2-39)"Taishan Scholarship"Construction Engineering,Innovation Project Special Fund for PostDoctors of Shandong Province(201002028)SDUST Research Fund(2010KYJQ105)the Project of Shandong Province Higher Educational Science and Technology Program(J11LG53)
文摘The measuring instrument which uses Sunplus SPCE061A MCU as the controller is a practical intelligent household heart rate meter.It can serve all people timely and effectively to detect the heart rate.It rings some voice alarm if the HRV is abnormal.Then it is decided whether to see a doctor at a convenient time for further diagnosis.The instrument has a feature of voice guidance that can save keyboard steps,which extends the scope of use.All people,old and young,the blind and the deaf,can use it by themselves.
文摘In previous studies by the same research group it has been shown in post-stroke patients that the autonomic system can be affected by acupuncture. Within this study, teleacupuncture between China and Austria is used for quantifying the effects of heart rate variability (HRV) in Chinese patients suffering from depression. In 22 Chinese depression patients (17 f, 5 m;mean age ± SD 52.3 ± 10.6 years;range 31 - 70 years) electrocardiographic signals before, during and after acupuncture at the acupoint Jianshi (PC 5) were recorded in Harbin and analyzed in Graz using teleacupuncture via internet. HRV data were analyzed in the time and frequency domain and a protocol from Austria was sent to the team in China immediately after the treatment and recording session. Mean heart rate decreased significantly (p < 0.001) during and after acupuncture, whereas total HRV increased significantly during (p < 0.034) and after (p < 0.001) acupuncture, always immediately following manual needle stimulation. Furthermore, there is a marked decrease in balance between sympathetic and parasympathetic activity (low frequency/high frequency HRV ratio) during treatment. This study shows that HRV could be a useful parameter for quantifying clinical effects of acupuncture on the autonomic nervous system. Teleacupuncture between China and Austria over a distance of more than 8,500 km has been successfully used.
文摘Background: The effect of traffic related emissions on Heart Rate Variability (HRV) has been previously demonstrated. However, the results of different studies on the relationship between ambient pollutants and specifically carbon monoxide (CO) on HRV are inconclusive and appear to reflect personal differences. The differences in methodology including breathing style and participants under study can possibly attribute to this variability. The aim of the present study is to assess the effect of the breathing route (Nasal/Oral) on the relationship between CO concentration and HRV. Methodology: Forty healthy participants (25 females, 15 males) between the ages of 15 - 50 years were included in the study. The participants strolled in a central bus station, staying for 10 minutes in three designated locations alternating nasal and oral breathing. CO concentration and HRV were continuously monitored. Frequency (LnLF, LnHF, LnLF/HF) and time domain (LnSDNN, LnRMSSD) HRV indices were computed. Analysis: MANCOVA, with HRV indices being the dependent variables and CO, gender and age being the independent variables was employed. Results: Significant interaction effects between breathing route and CO, and breathing route and gender on HRV (LnLF/HF) were found (p = 0.04 and 0.01 respectively). Both CO and age were found to affect LnSDNN and LnRMSSD. Conclusion: Breathing route emerges as a possible modifier of the relationship between air pollution and HRV and thus contributes to interpersonal differences obtained in studies investigating the effect of environmental pollution and HRV.
文摘Introduction: Transcranial Magnetic Stimulation (TMS) is a non-invasive technique for brain stimulation. Repetitive TMS (rTMS) over the medial Prefrontal Cortex (mPFC), Broadman Area 10 (BA10) may stimulate transynaptically perigenual Anterior Cingulate Cortex (pACC, BA 33), insula, amigdala, hypothalamus and connected branches of the Autonomic Nervous System (ANS) involved in stressorevoked cardiovascular reactivity. Stressors are associated with an increase in sympathetic cardiac control, a decrease in parasympathetic control, or both, and, consequently, an increase in systolic/stroke volume, total vascular impedance/resistance and heart rate, a decrease of baroreflex sensitivity, i.e., an increase in blood pressure/arterial tension. Objectives and Aims: The present work aims, using TMS and accordingly to Gianaros modeling, based on functional neuroimaging studies and previous neuroanatomical data from animal models, to probe the connectivity of brain systems involved in stressor-evoked cardiovascular reactivity and to explore TMS potential as a tool for detection and stratification of individual differences concerning this reactivity and hemorreological risk factors correlated with the development of Coronary Heart Disease (CHD). Methods: Both subjects, a 52 years old male and a 40 years old female with previous increased Low Frequency (LF)/High Frequency (HF) Heart Rate Variability (HRV) ratios (respectively, 4.209/3.028) without decompensated cardiorespiratory symptoms, gave informed consent, and ethico-legal issues have been observed. Electroencephalographic (EEG) monitoring has been performed for safety purposes. Immediately after administration, over the mPFC, of 15 pulses of rTMS, during 60 second, with an inductive electrical current, at the stimulating coil, of 85.9 Ampère per μsecond and 66 Ampère per μsecond, respectively, for male and female subjects (a “figure-of-eight” coil and magnetic stimulator MagLite, Dantec/Medtronic, have been used), HRV spectrum analysis (cStress software) has been performed (during 5 minutes, in supine position). Results: In both subjects, LF power, HF power and LF/HF ratio results, before and after rTMS administration, pointed towards sympathetic attenuation and parasympathetic augmentation (respectively, in male/female subject: decreased LF power—65.1 nu/69.3 nu, before rTMS;56.1 nu/41.6 nu, after rTMS;increased HF power—15.5 nu/22.9 nu, before rTMS;30.9 nu/45.5 nu, after rTMS). Conclusions: In this preliminary investigation, the existence of a link between “mind” and heart’s function has been put in evidence, through a reversible “virtual” lesion, of brain systems involved in cardiovascular control, caused by TMS. Repetitive TMS over mPFC decreased brain function involved in stressorevoked cardiovascular reactivity, suggesting the importance of TMS in the management of stress-related cardiovascular disorders.
文摘目的探讨肥胖合并重度阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)患者的心率变异性(heart rate variability,HRV)特征。方法回顾性分析2018年4月至2022年5月在西安交通大学第二附属医院行多导睡眠(polysomnography,PSG)监测确诊为重度OSAHS的78例患者,根据身体质量(body mass index,BMI)将患者分为肥胖并重度OSAHS组(n=43)和非肥胖并重度OSAHS组(n=35)。所有患者行PSG监测同时接受24 h动态心电图监测,进行HRV指标的组间差异分析及与临床指标的相关性分析。结果基础指标及PSG指标分析结果显示,与非肥胖并重度OSAHS组相比,肥胖并重度OSAHS组体质量、BMI、颈围、腰围、呼吸暂停低通气指数(apnea hypopnea index,AHI)显著升高。组间HRV分析结果显示,与非肥胖并重度OSAHS组相比,肥胖并重度OSAHS组的24 h正常R-R间期标准差(standard deviation of R-R interval,SDNN)、5 min R-R间期均值标准差(standard deviation of the averages of 5-minute R-R intervals,SDANN)、三角指数(triangle index,TI)、心率减速力(deceleration capacity of heart rate,DC)、清醒期SDNN及睡眠高频功率明显降低(P<0.05)。相关性结果显示肥胖并重度OSAHS患者中相邻R-R间期差值均方根(root mean square of the difference of adjacent R-R interval,rMSSD)与高血压病程呈负相关,TI、DC与AHI呈负相关。经校正颈围和腰围后的线性回归分析显示SDNN、SDANN、rMSSD与收缩压相关(P<0.05)。结论肥胖并重度OSAHS患者存在HRV指标下降,自主神经功能受到损害,心血管疾病的发生风险增加。
基金supported by the Sichuan Mineral Resources Research Center(Gr ant No.SCKCZY2023-ZC010)the Gansu Tec h-nological Innovation Guidance Plan(Grant No.22CX8JA142)+2 种基金the Sc hool Enter prise Cooperation Program of Southwest Jiao-tong Univ ersity(Grant No.LG-YY-CW-2020010)the Open Fund of Key Laboratory of Flight Techniques and Flight Safety(Grant No.FZ2021KF05)the Key Research Base of Humanistic and Social Sciences of Deyang-Psychology and Behavior Science Research Center(Grant No.XLYXW2023202).
文摘Previous studies have found that drivers’physiological conditions can deteriorate under noise conditions,which poses a potential hazard when driving.As a result,it is crucial to identify the status of drivers when exposed to different noises.However,such explo-rations are rarely discussed with short-term physiological indicators,especially for rail transit drivers.In this study,an experiment involving 42 railway transit drivers was conducted with a driving simulator to assess the impact of noise on drivers’physiological responses.Considering the individuals’heterogeneity,this study introduced drivers’noise annoyance to measure their self-noise-adaption.The variances of drivers’heart rate variability(HRV)along with different noise adaptions are explored when exposed to different noise conditions.Several machine learning approaches(support vector machine,K-nearest neighbour and random forest)were then used to classify their physiological status under different noise conditions according to the HRV and drivers’self-noise adaptions.Results indicate that the volume of traffic noise negatively affects drivers’performance in their routines.Drivers with different noise adaptions but exposed to a fixed noise were found with discrepant HRV,demonstrating that noise adaption is highly associated with drivers’physiological status under noises.It is also found that noise adaption inclusion could raise the accuracy of classifications.Overall,the random forests classifier performed the best in identifying the physiological status when exposed to noise conditions for drivers with different noise adaptions.
基金the National Natural Science Foundation of China(No.62301056)the Fundamental Research Funds for Central Universities(No.2022QN005).
文摘Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable real-time detection of exercise intensity and mitigate the risks of harmfrom excessive exercise, a exercise intensity monitoring system based on the heart rate variability(HRV) from electrocardiogram (ECG) signal and linear features from phonocardiogram (PCG)signal is proposed. The main contributions include: First, accurate analysis of HRV is crucial forsubsequent exercise intensity detection. To enhance HRV analysis, we propose an R-peak detectorbased on encoder-decoder and temporal convolutional network (TCN). Experimental resultsdemonstrate that the proposed R-peak detector achieves an F1 score exceeding 0.99 on real high-intensity exercise ECG datasets. Second, an exercise fatigue monitoring system based on multi-signal feature fusion is proposed. Initially, utilizing the proposed R-peak detector for HRV extractionin exercise intensity detection,which outperforms traditional algorithms, with the system achieving a classification performance of 0.933 sensitivity, 0.802 specificity, and 0.960 accuracy. To further improve the system, we combine HRV with the linear features of PCG. Our exercise intensitydetection system achieves 90.2% specificity, 96.7% recall, and 98.1% accuracy in five-fold cross-validation.