Study on Heart-protecting Musk Pill (麝香保心丸)in Improving Myocardial IschemiaEvaluated by Nuclear Myocardial Imaging

The effect of Heart-protecting Musk Pill(HMP) on blood perfusion of the ischemic myocardi-um by intravenous dipyridamole 99mTc-sestamibi single photon emission computerized tomography (99mTc-MIBISPECT) in 17 patients with coronary heart disease was observed. Results showed that sublingual admin-istration of HMP prior to injection of dipyridamole could remit the cardiac symptoms induced by dipyridamole,such as angina, chest distress, etc. with a remission rate of 85% . HMP could also improve the SPECT imagedefect significantly, 8 of 11 cases with reversible image defects and 4 of 6 irreversible image defects wereimproved. It suggested that HMP could improve the blood perfusion of the ischemic myocardium, the total ef-fective rate was70 . 59 % . No adverse reaction was found.

麝香保心丸联合硝酸异山梨醇酯片治疗冠心病心绞痛的疗效观察

目的探讨麝香保心丸联合硝酸异山梨醇酯片(消心痛)治疗冠心病心绞痛的疗效及其对血脂的影响。方法选取冠心病心绞痛患者100例,随机分为两组,治疗组口服麝香保心丸,每次2粒,每日3次,消心痛每次5 mg,每日3次,对照组50例单用硝酸异山梨醇酯片(消心痛)治疗。每次10 mg,每日3次。两组疗程均为2月。观察临床疗效、心电图、治疗前后血脂变化情况。结果治疗组临床症状改善及心电图改善率、血脂改善情况明显优于对照组(P<0.05)。且没有明显的毒副作用,值得大力推广。结论麝香保心丸联合消心痛是一种安全、有效的治疗冠心病心绞痛的药物。联合应用比单用消心痛更有效。

麝香保心丸和消心痛防治冠心病心绞痛的对比性研究

为了比较麝香保心丸和消心痛对防治冠心病心绞痛患者的疗效,本文观察了66例冠心病心绞痛患者,将他们随机分为麝香保心丸治疗组(30例)和消心痛对照组(30例)。心绞痛发作时首先舌下含服麝香保心丸2粒,然后以麝香保心丸2粒,3次1d;对照组则含服消心痛10 mg,然后以消心痛10 mg,3次/d,疗程均为四周。结果发现,含服麝香保心丸和消心痛均能迅速缓解心绞痛发作,对缺血性ST段压低和T波倒置,总有效率治疗组达93.3％和96.7％,对照组均达96.7％,两药疗效相当。经过四周冶疗两药均可显著降低心绞痛发作频率和硝酸甘油消耗量,改善心绞痛分级。治疗组心电图总有效率达93.9％～96.7％,24 h动态心电图显示两药均可明显改善缺血负荷,与对照组比较差别有显著性(420±271,411±291 VS 664±324 mm×min P值均小于0.05)。超声心动图示麝香保心丸可缩小左室收缩末和舒张末容积指数,并改善心功能。麝香保心丸副作用小,且依从性良好。