Iron is an indispensable trace element in mammals and performs several important physiological functions in the body.Dynamic equilibrium in iron metabolism exists.Iron uptake,storage,and output are in equilibrium as w...Iron is an indispensable trace element in mammals and performs several important physiological functions in the body.Dynamic equilibrium in iron metabolism exists.Iron uptake,storage,and output are in equilibrium as well.Several laboratory animal models have shown that iron deficiency and deposition can lead to a variety of functional disorders.Cardiac diseases caused by iron deposition in laboratory animal models are caused by abnormal oxidative stress,electrophysiological changes,iron metabolism-related gene defects,myocardial cell apoptosis,fibrosis,ferroptosis,and other causes.This review discusses the causes of heart disease related to iron deposition in laboratory animal models to illustrate further the impact of effective iron removal therapy on cardiac disease associated with iron deposition.In addition,this review demonstrates the possibility of elucidating the precise molecular mechanism of iron abnormality in heart diseases in experimental animal models and the feasibility of using iron abnormality as a target for developing new therapeutic drugs for the treatment of heart disease.展开更多
基金supported by the National Natural Science Foundation of China(No.31900502&81903448)the Henan Medical Science and Technology Joint Building Program(No.LHGJ20190229&LHGJ20190265)+1 种基金the Natural Science Foundation of Henan Province(212300410275)the Key R&D and promotion Special Projects of Henan Province(No.212102310194).
文摘Iron is an indispensable trace element in mammals and performs several important physiological functions in the body.Dynamic equilibrium in iron metabolism exists.Iron uptake,storage,and output are in equilibrium as well.Several laboratory animal models have shown that iron deficiency and deposition can lead to a variety of functional disorders.Cardiac diseases caused by iron deposition in laboratory animal models are caused by abnormal oxidative stress,electrophysiological changes,iron metabolism-related gene defects,myocardial cell apoptosis,fibrosis,ferroptosis,and other causes.This review discusses the causes of heart disease related to iron deposition in laboratory animal models to illustrate further the impact of effective iron removal therapy on cardiac disease associated with iron deposition.In addition,this review demonstrates the possibility of elucidating the precise molecular mechanism of iron abnormality in heart diseases in experimental animal models and the feasibility of using iron abnormality as a target for developing new therapeutic drugs for the treatment of heart disease.
