[Objectives]To observe the effect of Jianpi Xiaowei Decoction on gastric function and quality of life in elderly patients with chronic atrophic gastritis(CAG)of liver-stomach heat stagnation type.[Methods]Seventy-two ...[Objectives]To observe the effect of Jianpi Xiaowei Decoction on gastric function and quality of life in elderly patients with chronic atrophic gastritis(CAG)of liver-stomach heat stagnation type.[Methods]Seventy-two elderly patients with CAG of liver-stomach stagnation-heat type were randomly divided into study group and control group.The two groups were treated with Jianpi Xiaowei Decoction and Rabeprazole Enteric-coated Tablets respectively.The curative effect of TCM syndromes,serum pepsinogen I and II(PG-I and PG-II),gastrin-17(G-17)and quality of life(SF-36 table)scores of gastric function indicators before and after treatment were observed.[Results]After treatment,the total effective rate of the study group was 97.22%(35/36),which was significantly higher than that of the control group 77.78%(28/36)(P<0.05).Before treatment,there was no significant difference in the levels of gastric function indicators between the two groups(P>0.05).After treatment,the indicators of the study group were significantly lower than those of the control group(t=12.239,6.010,5.928,10.420,P<0.05).Before treatment,there was no significant difference in SF-36 scores between the two groups(P>0.05).After treatment,the SF-36 scores in the study group were significantly lower than those in the control group(t=3.520,10.335,11.300,9.693,P<0.05).[Conclusions]Jianpi Xiaowei Decoction can achieve significant curative effect in the treatment of CAG with liver and stomach stagnation heat type in the elderly,and can significantly improve the key gastrointestinal hormone levels and quality of life of elderly patients.It is worthy of promotion in the same clinical cases.展开更多
Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network...Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.展开更多
Gastroesophageal reflux disease (GERD) is a high-incidence digestive system disease. Western medicine mainly uses drugs such as proton pump inhibitors to inhibit gastric acid secretion, but some patients are accompani...Gastroesophageal reflux disease (GERD) is a high-incidence digestive system disease. Western medicine mainly uses drugs such as proton pump inhibitors to inhibit gastric acid secretion, but some patients are accompanied by symptoms such as non-acid reflux and gas reflux, which cannot effectively treat the disease. It is necessary to actively explore other treatment schemes. Traditional Chinese medicine (TCM) has a long history of research on gastroesophageal reflux disease, which emphasizes the treatment based on syndrome differentiation as a whole. Through the treatment of various and multi-component TCM prescriptions, the patient’s body condition can be adjusted, and the treatment effect on gastroesophageal reflux disease is reliable, which has obvious therapeutic advantages. To further clarify the treatment of gastroesophageal reflux disease, this study reviewed and analyzed the research progress of the treatment of liver disease with modified prescriptions, and the report is as follows.展开更多
目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模...目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模)、针-药对照组(桑枇消痤颗粒+毫火针)、药-模对照组(桑枇消痤颗粒+石膏倒模),每组50例,均每周治疗1次,持续治疗4周。观察3组患者的临床疗效,比较3组治疗前后皮疹情况及生活质量[皮肤病生活质量指数量表(dermatology quality of life index,DLQI)],统计不良反应发生情况与复发率。结果:治疗4周后,针-药-模治疗组临床有效率高于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。3组患者皮疹情况评分、DLQI评分与治疗前比较均降低,且针-药-模治疗组低于针-药对照组及药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。治疗期间,3组患者不良反应发生情况比较,差异无统计学意义;结束治疗后2个月,针-药-模治疗组复发率低于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。结论:与“药-模”及“针-药”治疗相比,“针-药-模”相结合的综合治疗方法在粉刺病肺胃热蕴证的治疗中临床疗效更为显著,有效改善患者皮疹情况,提高生活质量,减少复发,安全性可靠。展开更多
基金Supported by National Natural Science Foundation of China (82374546)The Ninth Batch of Suzhou Gusu Health Key Talents Project (GSWS2023015).
文摘[Objectives]To observe the effect of Jianpi Xiaowei Decoction on gastric function and quality of life in elderly patients with chronic atrophic gastritis(CAG)of liver-stomach heat stagnation type.[Methods]Seventy-two elderly patients with CAG of liver-stomach stagnation-heat type were randomly divided into study group and control group.The two groups were treated with Jianpi Xiaowei Decoction and Rabeprazole Enteric-coated Tablets respectively.The curative effect of TCM syndromes,serum pepsinogen I and II(PG-I and PG-II),gastrin-17(G-17)and quality of life(SF-36 table)scores of gastric function indicators before and after treatment were observed.[Results]After treatment,the total effective rate of the study group was 97.22%(35/36),which was significantly higher than that of the control group 77.78%(28/36)(P<0.05).Before treatment,there was no significant difference in the levels of gastric function indicators between the two groups(P>0.05).After treatment,the indicators of the study group were significantly lower than those of the control group(t=12.239,6.010,5.928,10.420,P<0.05).Before treatment,there was no significant difference in SF-36 scores between the two groups(P>0.05).After treatment,the SF-36 scores in the study group were significantly lower than those in the control group(t=3.520,10.335,11.300,9.693,P<0.05).[Conclusions]Jianpi Xiaowei Decoction can achieve significant curative effect in the treatment of CAG with liver and stomach stagnation heat type in the elderly,and can significantly improve the key gastrointestinal hormone levels and quality of life of elderly patients.It is worthy of promotion in the same clinical cases.
基金National Administration of Traditional Chinese Medicine Evidence-Based Capacity Building Project(2019XZZXXH005)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2022ZY2022)+1 种基金Henan Provincial Top Talents Cultivation Project in Traditional Chinese Medicine Discipline of Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talents Project(Zhongjing Project)(Henan Health TraditionalMedicine Letter[2021]No.15)Special Project on Traditional Chinese Medicine Scientific Research of Health Commission of Henan Province(2023ZY2062).
文摘Objective To evaluate the clinical efficacy and safety of Zhenzhu Qingyuan Granules through a clinical randomized controlled trial and to analyze the potential action targets and pathways of this formula using network pharmacology.Methods Patients with gastroesophageal reflux disease(GERD)of liver–stomach stagnant heat pattern who met the inclusion and exclusion criteria were randomly divided into the control group and the observation group.The control group received oral rabeprazole,whereas the observation group were given Zhenzhu Qingyuan Granules in addition to the rabeprazole.The treatment duration was 8 weeks.Clinical efficacy was observed in both groups after 8 weeks.Network pharmacology was used to analyze the action targets of ZhenzhuQingyuanGranules and the genes related to GERD,and core targets were inferred.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were conducted to explore the potential mechanisms of this formula.Results The clinical research results showed that the total effective rate in the treatment group was 92.68%,compared with 70.00%in the control group,with a statistically significant difference(p<0.05).After treatment,both Chinese medicine syndrome score and endoscopic score improved in both groups compared with before treatment(p<0.05),and the treatment group showed greater improvement than the control group(p<0.05).Network pharmacology identified effective components of Zhenzhu Qingyuan Granules for treating GERD,including quercetin,luteolin,andβ-sitosterol,with potential action targets such as tumor protein 53(TP53),protein kinase B(AKT1),and tumor necrosis factor.Conclusion Zhenzhu Qingyuan Granules can significantly improve clinical symptoms in patients with GERD of liver–stomach stagnated heat pattern,enhance clinical efficacy,and have high safety.This formula may exert therapeutic effects through multiple targets and pathways.
文摘Gastroesophageal reflux disease (GERD) is a high-incidence digestive system disease. Western medicine mainly uses drugs such as proton pump inhibitors to inhibit gastric acid secretion, but some patients are accompanied by symptoms such as non-acid reflux and gas reflux, which cannot effectively treat the disease. It is necessary to actively explore other treatment schemes. Traditional Chinese medicine (TCM) has a long history of research on gastroesophageal reflux disease, which emphasizes the treatment based on syndrome differentiation as a whole. Through the treatment of various and multi-component TCM prescriptions, the patient’s body condition can be adjusted, and the treatment effect on gastroesophageal reflux disease is reliable, which has obvious therapeutic advantages. To further clarify the treatment of gastroesophageal reflux disease, this study reviewed and analyzed the research progress of the treatment of liver disease with modified prescriptions, and the report is as follows.
文摘目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模)、针-药对照组(桑枇消痤颗粒+毫火针)、药-模对照组(桑枇消痤颗粒+石膏倒模),每组50例,均每周治疗1次,持续治疗4周。观察3组患者的临床疗效,比较3组治疗前后皮疹情况及生活质量[皮肤病生活质量指数量表(dermatology quality of life index,DLQI)],统计不良反应发生情况与复发率。结果:治疗4周后,针-药-模治疗组临床有效率高于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。3组患者皮疹情况评分、DLQI评分与治疗前比较均降低,且针-药-模治疗组低于针-药对照组及药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。治疗期间,3组患者不良反应发生情况比较,差异无统计学意义;结束治疗后2个月,针-药-模治疗组复发率低于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。结论:与“药-模”及“针-药”治疗相比,“针-药-模”相结合的综合治疗方法在粉刺病肺胃热蕴证的治疗中临床疗效更为显著,有效改善患者皮疹情况,提高生活质量,减少复发,安全性可靠。
