According to the original works of an ancient Chinese medicine book"Treatise on Spleen and Stomach"(Detailed Analysis of Spleen and Stomach Diseases;1249 C.E.)written by Li Dongyuan(1180-1251 C.E),and relate...According to the original works of an ancient Chinese medicine book"Treatise on Spleen and Stomach"(Detailed Analysis of Spleen and Stomach Diseases;1249 C.E.)written by Li Dongyuan(1180-1251 C.E),and related explanations of later physicians,the efficacy and application of Ginseng(Ginseng Radix et Rhizoma)in related prescriptions were investigated from the aspects of dosage,usage and treatment methods.Ginseng appeared in 27 named prescriptions,including 20 decoctions,4 pill and 3 powder.In terms of dosage and usage,the common dosage of Ginseng is five points,mainly decoction.Most of the processing methods are"Fuju"(Bite up the medicine with your mouth so it can be taken.)and decoction with water.In terms of treatment methods,Ginseng is used in the sweet temperature and heat removing method and Nourishes Qi and Eliminates Evils Method(build your body to cure disease)in Li Dongyuan's"Treatise on Spleen and Stomach".Explaining Sweet Temperature Heat Removal Method(Use sweet and warm medicines to treat Qi-deficiency fever or Blood-deficiency fever;there are many reasons for fever,and cold and cooling medicines with heat-clearing effect are generally used for treatment.Use bitter cold medicine,so as not to consume the body's Yang.)takes Buzhong Yiqi Decoction(BYD)as an example,and explaining the Nourishes Qi and Eliminates Evils Method takes Mahuang-renshen-shaoyao decoction as an example.At the same time,"Treatise on Spleen and Stomach"matured in the Jin and Yuan Dynasties(1115-1368 C.E.).Its system of weights and measures,terminology and medical theory are quite different from those of modern Chinese medicine.Therefore,when researching the dosage,usage and treatment methods of Ginseng,we will explore the controversial points,and explain them by using modern Chinese medicine theory,so as to guide the clinical medication more accurately.展开更多
OBJECTIVE: To investigate the expression of and interleukin-12(IL-12) and interferon-γ(IFN-γ) in relation to the pathology of damp-heat of spleen-stomach syndrome(DHSS) induced by Helicobacter pylori(H. pylori) infe...OBJECTIVE: To investigate the expression of and interleukin-12(IL-12) and interferon-γ(IFN-γ) in relation to the pathology of damp-heat of spleen-stomach syndrome(DHSS) induced by Helicobacter pylori(H. pylori) infection.METHODS: In total, 114 individual gastric mucosal specimens including 83 DHSS, 19 spleen-qi deficiency syndrome(SQD) and 12 from healthy volunteers(CON) were collected by gastroscopy. To explore the relationship between the two syndromes and H. pylori infection, individual samples were tested using rapid urease and methylene blue tests. Hematoxylin and eosin stained sections were examined to grade for the degree of inflammation and inflammatory activity, and expression of IL-12 and IFN-γ was investigated by immunohistochemistry.RESULTS: Statistically significant differences in the degree of inflammation and inflammatory activity were observed between the groups of specimens:DHSS, SQD and CON(P < 0.05). Additionally, greater intestinal metaplasia(IM) and dysplasia were observed in the DHSS group, especially those with H.pylori infection. Expression of both IFN-γ and IL-12 was higher in DHSS samples infected with H. pylori than in uninfected samples and in the CON(P <0.05) but not in the SQD(P > 0.05) groups. Intriguingly, in gastric specimens exhibiting IM and dysplasia, IL-12 translocated from the nucleus into the cytoplasm.CONCLUSION: Our findings suggest that IL-12 and IFN-γ are involved in DHSS pathology, but not in SQD, acting as healthy-Qi. DHSS is not just the consequence of those two cytokines but results from the cross-talk between a number of cytokines and/or other proteins, which may warrant further investigation in DHSS patients infected with H. pylori.展开更多
目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模...目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模)、针-药对照组(桑枇消痤颗粒+毫火针)、药-模对照组(桑枇消痤颗粒+石膏倒模),每组50例,均每周治疗1次,持续治疗4周。观察3组患者的临床疗效,比较3组治疗前后皮疹情况及生活质量[皮肤病生活质量指数量表(dermatology quality of life index,DLQI)],统计不良反应发生情况与复发率。结果:治疗4周后,针-药-模治疗组临床有效率高于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。3组患者皮疹情况评分、DLQI评分与治疗前比较均降低,且针-药-模治疗组低于针-药对照组及药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。治疗期间,3组患者不良反应发生情况比较,差异无统计学意义;结束治疗后2个月,针-药-模治疗组复发率低于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。结论:与“药-模”及“针-药”治疗相比,“针-药-模”相结合的综合治疗方法在粉刺病肺胃热蕴证的治疗中临床疗效更为显著,有效改善患者皮疹情况,提高生活质量,减少复发,安全性可靠。展开更多
肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应...肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应密切相关。脾胃虚弱,炎症始生,郁化促炎,脑肠互损,气血运行不畅,肠腑痰浊内生,气滞痰凝血瘀,初未能成积聚,留滞不去,乃成积聚。从现代生物学角度而言,辅助性T细胞(T helper cell,Th)17/调节性T细胞(regulatory T cell,Treg)介导的促炎因子与抗炎因子释放,影响肠道微环境内肠道菌群结构的动态平衡,通过神经免疫等上传至大脑中枢,脑肠相互作用,在内外因的刺激下,其中某一环境平衡失调,就会造成局部和整体的失衡,诱发炎症逐步发展至不可控状态,驱动基因突变形成癌症。围绕“虚、郁、滞、瘀”核心病机,从健运脾胃入手,缓解炎症,行滞化瘀,未癌先治炎,阻断炎-癌转化,能为肠道炎-癌转化疾病的临床防治提供思路借鉴。展开更多
文摘According to the original works of an ancient Chinese medicine book"Treatise on Spleen and Stomach"(Detailed Analysis of Spleen and Stomach Diseases;1249 C.E.)written by Li Dongyuan(1180-1251 C.E),and related explanations of later physicians,the efficacy and application of Ginseng(Ginseng Radix et Rhizoma)in related prescriptions were investigated from the aspects of dosage,usage and treatment methods.Ginseng appeared in 27 named prescriptions,including 20 decoctions,4 pill and 3 powder.In terms of dosage and usage,the common dosage of Ginseng is five points,mainly decoction.Most of the processing methods are"Fuju"(Bite up the medicine with your mouth so it can be taken.)and decoction with water.In terms of treatment methods,Ginseng is used in the sweet temperature and heat removing method and Nourishes Qi and Eliminates Evils Method(build your body to cure disease)in Li Dongyuan's"Treatise on Spleen and Stomach".Explaining Sweet Temperature Heat Removal Method(Use sweet and warm medicines to treat Qi-deficiency fever or Blood-deficiency fever;there are many reasons for fever,and cold and cooling medicines with heat-clearing effect are generally used for treatment.Use bitter cold medicine,so as not to consume the body's Yang.)takes Buzhong Yiqi Decoction(BYD)as an example,and explaining the Nourishes Qi and Eliminates Evils Method takes Mahuang-renshen-shaoyao decoction as an example.At the same time,"Treatise on Spleen and Stomach"matured in the Jin and Yuan Dynasties(1115-1368 C.E.).Its system of weights and measures,terminology and medical theory are quite different from those of modern Chinese medicine.Therefore,when researching the dosage,usage and treatment methods of Ginseng,we will explore the controversial points,and explain them by using modern Chinese medicine theory,so as to guide the clinical medication more accurately.
基金Supported by Natural Science Foundation-funded Project:Research on the NF-KB Pathway and Micro-ecology Alteration Based on Helicobacter Pylori Correlated Gastric Disease(No.30772689)Natural Science Foundation-funded Project:Progression of Diverse Syndromes on Mi RNAs and Gene Polymorphism of Inflammatory Cytokines in Helicobacter Pylori Correlated Gastric Disease Based on Pathogenic Toxin(No.81373563)
文摘OBJECTIVE: To investigate the expression of and interleukin-12(IL-12) and interferon-γ(IFN-γ) in relation to the pathology of damp-heat of spleen-stomach syndrome(DHSS) induced by Helicobacter pylori(H. pylori) infection.METHODS: In total, 114 individual gastric mucosal specimens including 83 DHSS, 19 spleen-qi deficiency syndrome(SQD) and 12 from healthy volunteers(CON) were collected by gastroscopy. To explore the relationship between the two syndromes and H. pylori infection, individual samples were tested using rapid urease and methylene blue tests. Hematoxylin and eosin stained sections were examined to grade for the degree of inflammation and inflammatory activity, and expression of IL-12 and IFN-γ was investigated by immunohistochemistry.RESULTS: Statistically significant differences in the degree of inflammation and inflammatory activity were observed between the groups of specimens:DHSS, SQD and CON(P < 0.05). Additionally, greater intestinal metaplasia(IM) and dysplasia were observed in the DHSS group, especially those with H.pylori infection. Expression of both IFN-γ and IL-12 was higher in DHSS samples infected with H. pylori than in uninfected samples and in the CON(P <0.05) but not in the SQD(P > 0.05) groups. Intriguingly, in gastric specimens exhibiting IM and dysplasia, IL-12 translocated from the nucleus into the cytoplasm.CONCLUSION: Our findings suggest that IL-12 and IFN-γ are involved in DHSS pathology, but not in SQD, acting as healthy-Qi. DHSS is not just the consequence of those two cytokines but results from the cross-talk between a number of cytokines and/or other proteins, which may warrant further investigation in DHSS patients infected with H. pylori.
文摘目的:探究“针-药-模”结合治疗粉刺病肺胃热蕴证的临床效果。方法:收集2020年10月—2022年9月上海市嘉定区中医医院皮肤科门诊收治的粉刺病肺胃热蕴证患者150例,根据随机数字表法将其分为针-药-模治疗组(桑枇消痤颗粒+毫火针+石膏倒模)、针-药对照组(桑枇消痤颗粒+毫火针)、药-模对照组(桑枇消痤颗粒+石膏倒模),每组50例,均每周治疗1次,持续治疗4周。观察3组患者的临床疗效,比较3组治疗前后皮疹情况及生活质量[皮肤病生活质量指数量表(dermatology quality of life index,DLQI)],统计不良反应发生情况与复发率。结果:治疗4周后,针-药-模治疗组临床有效率高于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。3组患者皮疹情况评分、DLQI评分与治疗前比较均降低,且针-药-模治疗组低于针-药对照组及药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。治疗期间,3组患者不良反应发生情况比较,差异无统计学意义;结束治疗后2个月,针-药-模治疗组复发率低于针-药对照组、药-模对照组,差异有统计学意义;针-药对照组与药-模对照组比较,差异无统计学意义。结论:与“药-模”及“针-药”治疗相比,“针-药-模”相结合的综合治疗方法在粉刺病肺胃热蕴证的治疗中临床疗效更为显著,有效改善患者皮疹情况,提高生活质量,减少复发,安全性可靠。
文摘肠道从正常黏膜至癌变病程较为漫长,始于炎性状态,进展至癌前病变和癌前状态,终于结肠癌,简称结肠炎-癌转化类疾病。在肠道炎-癌转化类疾病进程中,所呈现“虚、郁、滞、瘀”核心病机与机体的神经、免疫状态以及平衡失调诱发的炎症反应密切相关。脾胃虚弱,炎症始生,郁化促炎,脑肠互损,气血运行不畅,肠腑痰浊内生,气滞痰凝血瘀,初未能成积聚,留滞不去,乃成积聚。从现代生物学角度而言,辅助性T细胞(T helper cell,Th)17/调节性T细胞(regulatory T cell,Treg)介导的促炎因子与抗炎因子释放,影响肠道微环境内肠道菌群结构的动态平衡,通过神经免疫等上传至大脑中枢,脑肠相互作用,在内外因的刺激下,其中某一环境平衡失调,就会造成局部和整体的失衡,诱发炎症逐步发展至不可控状态,驱动基因突变形成癌症。围绕“虚、郁、滞、瘀”核心病机,从健运脾胃入手,缓解炎症,行滞化瘀,未癌先治炎,阻断炎-癌转化,能为肠道炎-癌转化疾病的临床防治提供思路借鉴。
