Effect of condensation latent heat release on the relative vorticity tendency in extratropical cyclones:a case study

Taking an extratropical cyclone that produced extreme precipitation as the research object,this paper calculates the contribution of condensation latent heat release(LHR)to relative vorticity tendency based on the complete-form vertical vorticity tendency equation.The results show that the heating rate of convectional condensation LHR can reach up to about 40 times that of stable condensation LHR.Both the stable and convectional heating centers are higher than 700 hPa,which would cause∂Q/∂z>0 and a positive vorticity source in the lower troposphere.The vertical gradient of stable condensation LHR contributes little to the growth of relative vorticity,while the relative vorticity tendency associated with the vertical gradient of convectional condensation LHR can be an order of magnitude higher than the former.The positive vorticity source is always located right below the latent heating center,and its maximum value can always be found in the lower troposphere.Convectional LHR is the primary factor for cyclone development from the perspective of diabatic heating.The horizontal gradient of total condensation LHR can contribute about 65%of the actual vorticity growth,but the effect of the vertical gradient of convectional condensation(LHR)can reach twice as much.The adiabatic heating from LHR can cause vorticity tendency directly.However,it can also change the vertical and horizontal gradient of potential temperature,which can further induce vorticity tendency.

Calcium-sensing receptor: A new target for therapy of diarrhea

Management of acute diarrhea remains a global challenge, particularly in resource-limiting countries. Oral rehydration solution (ORS), a passive rehydrating therapy developed approximately 40 years ago, remains the mainstay treatment. Although ORS is effective for hydration, since it does not inhibit enterotoxin-mediated excessive secretion, reduced absorption and compromised barrier function - the primary mechanisms of diarrhea, ORS does not offer a rapid relief of diarrhea symptom. There are a few alternative therapies available, yet the use of these drugs is limited by their expense, lack of availability and/or safety concerns. Novel anti-diarrheal therapeutic approaches, particularly those simple affordable therapies, are needed. This article explores intestinal calcium-sensing receptor (CaSR), a newly uncovered target for therapy of diarrhea. Unlike others, targeting this host antidiarrheal receptor system appears “all-inclusive”: it is anti-secretory, pro-absorptive, anti-motility, and anti-inflammatory. Thus, activating CaSR reverses changes of both secretory and inflammatory diarrheas. Considering its unique property of using simple nutrients such as calcium, polyamines, and certain amino acids/oligopeptides as activators, it is possible that through targeting of CaSR with a combination of specific nutrients, novel oral rehydrating solutions that are inexpensive and practical to use in all countries may be developed.