A green heterogeneous catalyst for Heck reaction-chitosan-immobilized palladium complex was prepared. The catalyst exhibits high activity and stereoselectivity under the moderate reaction conditions. The catalyst can ...A green heterogeneous catalyst for Heck reaction-chitosan-immobilized palladium complex was prepared. The catalyst exhibits high activity and stereoselectivity under the moderate reaction conditions. The catalyst can be separated easily from the reaction mixture and reused after washing. Under the suitable reaction conditions, the cross-coupling of iodobenzene (ArI) with acrylic acid (AA) or acrylate can be achieved 93.3% or 99% yield of trans-cinnamic acid or trans-cinnamic ester.展开更多
Macroporous magnetic poly(GMA-EGDMA-DVB) microspheres synthesized by suspension polymerization were used as supports for palladium catalyst.The results showed the novel magnetic catalyst can promote Heck reaction of a...Macroporous magnetic poly(GMA-EGDMA-DVB) microspheres synthesized by suspension polymerization were used as supports for palladium catalyst.The results showed the novel magnetic catalyst can promote Heck reaction of aryl halides with acrylic acid efficiently without an inert atmosphere.In addition,the novel catalyst can be conveniently recovered by applying an external magnet and reused at least five times without significant loss of its activity.展开更多
A ligand-free Heck reaction catalyzed by in situ-generated palladium nanoparticles in PEG-400 has been developed.This catalytic system is a simple and active protocol for the Heck reaction of aryl halides under mild c...A ligand-free Heck reaction catalyzed by in situ-generated palladium nanoparticles in PEG-400 has been developed.This catalytic system is a simple and active protocol for the Heck reaction of aryl halides under mild conditions.Comparative experiments demonstrated that the Heck reaction catalyzed by the palladium nanoparticles in situ-generated under the Heck reaction conditions was carried out much quicker than that by the in ex situ-generated ones.展开更多
Highly efficient palladium-catalyzed Heck coupling of aryl nonaflates with electron-rich vinyl ethers, and enamides is described. These reactions afforded exclusively the branched products in good yields. The results ...Highly efficient palladium-catalyzed Heck coupling of aryl nonaflates with electron-rich vinyl ethers, and enamides is described. These reactions afforded exclusively the branched products in good yields. The results indicated that aryl nonaflates are effective alternative to the frequently employed aryl triflates.展开更多
Polymer and polymer were obtained by the polymerization of (R)-6,6'-dibromo-2,2'-binaphtho-20-crown-6 (M-1) and (R)-6,6'-dibromo-2,2'-di(methoxyethoxymethyloxy)-1,1'-binaphthyl (M-2) with p-divinyl...Polymer and polymer were obtained by the polymerization of (R)-6,6'-dibromo-2,2'-binaphtho-20-crown-6 (M-1) and (R)-6,6'-dibromo-2,2'-di(methoxyethoxymethyloxy)-1,1'-binaphthyl (M-2) with p-divinylbenzene under Pd- catalyzed Heck reaction. The UV, fluorescence and CD spectra of polymer are similar due to the same linkers present in their polymer chain. Polymers can emit strong blue fluorescence and are expected to have potential applications in polarized blue-light emitting sensors. The chiral conjugated polymers exhibit a strong Cotton effect in their circular dichroism (CD) spectra, indicating a high rigidity of polymer backbone.展开更多
The substituted phenanthrene-9-carboxyaldehydes are very important intermediates for the syntheses of phenanthroindolizidine and phenanthroquinolizidine alkaloids. The novel title compound was prepared from the reacti...The substituted phenanthrene-9-carboxyaldehydes are very important intermediates for the syntheses of phenanthroindolizidine and phenanthroquinolizidine alkaloids. The novel title compound was prepared from the reaction of 5 steps starting from the condensation of 3-methoxyl-4-methyl-phenylacetic acid and 4-(benzyloxy)-2-iodobenzaldehyde, followed by esterification, cyclization, reduction, and oxidation. A new method for the preparation of phenanthrene ring via palladium-catalyzed intramolecular Heck reaction was described. The title compound was characterized by IR, ^1H NMR, ^13C NMR, elemental analysis, and MS.展开更多
The Heck coupling reactions of aryl halides and olefins were performed under the microwave assistance. Interestingly, the ultralow concentration of transition metals (in ppb) coming from the reactants could catalyze t...The Heck coupling reactions of aryl halides and olefins were performed under the microwave assistance. Interestingly, the ultralow concentration of transition metals (in ppb) coming from the reactants could catalyze the Heck coupling reactions under microwave irradiation, without addition of any catalysts, ligands and phase-transfer agents. The influences of bases, solvents and temperature were discussed, and the reaction rate was enhanced largely in the mixed solvents of NMP and water due to the solubility of base in water.展开更多
Heck reaction is one of the most important carbon-carbon bond forming reactions with wide applications in organic synthesis.Considerable advances of enantioselective Heck reaction have been achieved in the past decade...Heck reaction is one of the most important carbon-carbon bond forming reactions with wide applications in organic synthesis.Considerable advances of enantioselective Heck reaction have been achieved in the past decades.This review focuses on recent development of catalytic asymmetric Heck reaction and reductive Heck reaction,which covers intermolecular and intramolecular versions since 2011.The article is organized in terms of the cat-alysts and olefin substrates.展开更多
A series of magnetically recyclable Pd/Fe3O4@γ-Al2O3 catalysts were synthesized using the superparamagnetic Fe3O4@γ-Al2O3 core-shell microspheres as the supporter and nano-Pd particles assembled on γ-Al2O3 shell as...A series of magnetically recyclable Pd/Fe3O4@γ-Al2O3 catalysts were synthesized using the superparamagnetic Fe3O4@γ-Al2O3 core-shell microspheres as the supporter and nano-Pd particles assembled on γ-Al2O3 shell as the active catalytic component. The structure of the catalysts was characterized by X-ray diffraction (XRD), transmission electron microscopy iTEM), N2 adsorptiondesorption and vibrating sample magnetometer (VSM). The catalytic activity and the recyclability properties of the catalysts for the Heck coupling reaction with aryl bromides and the olefins were investigated. The results show that the microspheres of the magnetic Pd/Fe304@γ-Al2O3 catalysts were about 400 nm and the nano-Pd particles assembled on γ-Al2O3 shell were about 3-4 nm in size. The saturation magnetization (MS) of the magnetic catalysts was sufficiently high to allow magnetic separations. In the Heck coupling reactions, the magnetic Pd/Fe304@γ-Al2O3 catalysts exhibited good catalytic activity and recyclability. With Pd/Fe304@γ-Al2O3 (0.021 mol%) catalyst, the bromobenzene conversion and product yield reached about 96.8% and 91.2%, respectively, at 120℃ and in 14 h. After being recycled for six times, the conversion of bromobenzene and the recovery of the catalyst were about 80% and 90%, respectively. The nano-Pd particles were kept well dispersed in the used Pd/Fe304@γ-Al2O3 catalysts.展开更多
A new method for the preparation of SBA-15-supported palladium catalyst for Heck reaction in supercritical carbon dioxide was presented.The newly formed SBA-15-supported palladium catalyst(Ph-SBA-15-PPh_3-Pd) exhibi...A new method for the preparation of SBA-15-supported palladium catalyst for Heck reaction in supercritical carbon dioxide was presented.The newly formed SBA-15-supported palladium catalyst(Ph-SBA-15-PPh_3-Pd) exhibited high catalytic activity for the Heck reaction of 4-nitrobromobenzene with methyl acrylate.The catalyst can be reused several times without a loss of activity.展开更多
1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs.A new and effective method for the synthesis of 4-trifluoromethylated 1,3-b...1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs.A new and effective method for the synthesis of 4-trifluoromethylated 1,3-butadiene through the fluorinated Heck reaction catalyzed by Pd(0)is described.Without additives,1-chloro-3,3,3-trifluoropropene(an inexpensive CF3 structural unit that is harmless to ozone)reacts with enamide to synthesize 4-trifluoromethylated 1,3-butadienes with good yield,high regioselectivity and chemical selectivity,and strong tolerance of substrate functional groups such as alkynes,aldehyde,and ester groups.展开更多
Water-soluble diol-functionalized imidazolium ionic liquid 1, prepared from 2,2-bis(1-methyl-methyl-imida- zolium)propane-l,3-diol bromide, potassium hydroxide, and malononitrile, was used as an efficient phosphine-...Water-soluble diol-functionalized imidazolium ionic liquid 1, prepared from 2,2-bis(1-methyl-methyl-imida- zolium)propane-l,3-diol bromide, potassium hydroxide, and malononitrile, was used as an efficient phosphine-free ligand for palladium-catalyzed arylation of aryl halides with acrylates in aqueous phase under mild conditions. It was found that the synergistic coordinating action of diol-functionalized imidazolium cation with CN-containing anion played the key role in improving the activity and stability of the catalyst.展开更多
The coordination mode of IL-supported diols used as phosphine-free ligands for palladium catalyzed Heck reaction has been investigated by tuning their compositions. The difference in coordination of these IL-supported...The coordination mode of IL-supported diols used as phosphine-free ligands for palladium catalyzed Heck reaction has been investigated by tuning their compositions. The difference in coordination of these IL-supported diols with metal Pd in Heck reaction was related to the changes of the cation rings, leading to the different activities of Pd catalyst in the reaction. The experimental results indicated that the activities of Pd catalyst were affected mainly by n-electron density of the cation rings. Compared to pyridinium and piperidinium cations, imidazolium cations showed the best coordination to metal Pd. In the meantime, C-2 hydrogen and the length of alkyl side chains had impacts on the coordination as well.展开更多
A novel Heck reaction catalyst consisting of a palladium(ll) complex of meso-tetra(p- hydroxyphenyl)porphyrin (MTP) and cross-linked chloromethylated polystyrene microspheres (PMs) was successfully prepared vi...A novel Heck reaction catalyst consisting of a palladium(ll) complex of meso-tetra(p- hydroxyphenyl)porphyrin (MTP) and cross-linked chloromethylated polystyrene microspheres (PMs) was successfully prepared via covalent ether bonds between the chloride groups in the PMs and the hydroxyl groups in MTP. The catalyst was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES). This polystyrene-supported palladium-complex was an efficient heterogeneous catalyst for cross-coupling of aryl iodides with ethyl acrylate. The reaction of iodobenzene and ethyl acrylate under N2 at 100 °C and a catalyst concentration of 0.1% gave a gas chromatography product yield of 99.8%, which is much higher than that achieved using a free palladium(II) complex of MTP as the catalyst (41.3%). The catalyst was recycled up to six times without significant loss of catalytic activity. These results suggest that the immobilized palladium(II) MTP catalyst has potential applications in synthetic and industrial chemistry.展开更多
Well-dispersed palladium nanoparticles immobilized onto modified silica (Si02-pr-NH-cyanuric-SH) have been prepared in some facile steps. The catalyst exhibits high catalytic activity in the Heck reaction, and can b...Well-dispersed palladium nanoparticles immobilized onto modified silica (Si02-pr-NH-cyanuric-SH) have been prepared in some facile steps. The catalyst exhibits high catalytic activity in the Heck reaction, and can be easily recovered and reused without significant loss of its activity in several runs.展开更多
Cyclopalladated ferrocenylimine has been found to be a type of excellent phosphine-free catalyst for Heck reactions in neat water with both higher yields and turnover numbers than those reported in the literature up t...Cyclopalladated ferrocenylimine has been found to be a type of excellent phosphine-free catalyst for Heck reactions in neat water with both higher yields and turnover numbers than those reported in the literature up to now. Some commercial emulsifying agents, including the commonly used quaternary ammonium salts, have been proved to be excellent additives in the catalysis of the reactions. Not only aromatic iodide, but also aromatic bromide could be coupled with the olefins. All reactions were able to be conducted in air under refluxing condition.展开更多
Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reactio...Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reaction of aryl halides with electron-deficient olefins. The coupling reaction of awl halide bearig different functional groups with olefin derivatives took place and the corresponding products were isolated in good to excellent yields under optimal conditions. The procedure exhibits good functional group tolerance and wide substrate scope. This Mizoroki-Heck reaction was further achieved using Pd(OAc)2 and 3,5-di-isopropyl-1H-1,2,4-diazaphospholes as combined catalyst, which provide the convenient and alternative method in organic synthesis展开更多
文摘A green heterogeneous catalyst for Heck reaction-chitosan-immobilized palladium complex was prepared. The catalyst exhibits high activity and stereoselectivity under the moderate reaction conditions. The catalyst can be separated easily from the reaction mixture and reused after washing. Under the suitable reaction conditions, the cross-coupling of iodobenzene (ArI) with acrylic acid (AA) or acrylate can be achieved 93.3% or 99% yield of trans-cinnamic acid or trans-cinnamic ester.
文摘Macroporous magnetic poly(GMA-EGDMA-DVB) microspheres synthesized by suspension polymerization were used as supports for palladium catalyst.The results showed the novel magnetic catalyst can promote Heck reaction of aryl halides with acrylic acid efficiently without an inert atmosphere.In addition,the novel catalyst can be conveniently recovered by applying an external magnet and reused at least five times without significant loss of its activity.
基金The authors thank the financial support from State Key Laboratory of Fine Chemicals(No.KF0801)Science Research Foundation of DUT,Graduate Student Education Reform Fund of DUTthe National Natural Science Foundation of China(No.20976024).
文摘A ligand-free Heck reaction catalyzed by in situ-generated palladium nanoparticles in PEG-400 has been developed.This catalytic system is a simple and active protocol for the Heck reaction of aryl halides under mild conditions.Comparative experiments demonstrated that the Heck reaction catalyzed by the palladium nanoparticles in situ-generated under the Heck reaction conditions was carried out much quicker than that by the in ex situ-generated ones.
基金the Renmin University of China and the National Natural Science Foundation of China(Nos.20542009 and 20672139)for financial support.
文摘Highly efficient palladium-catalyzed Heck coupling of aryl nonaflates with electron-rich vinyl ethers, and enamides is described. These reactions afforded exclusively the branched products in good yields. The results indicated that aryl nonaflates are effective alternative to the frequently employed aryl triflates.
文摘Polymer and polymer were obtained by the polymerization of (R)-6,6'-dibromo-2,2'-binaphtho-20-crown-6 (M-1) and (R)-6,6'-dibromo-2,2'-di(methoxyethoxymethyloxy)-1,1'-binaphthyl (M-2) with p-divinylbenzene under Pd- catalyzed Heck reaction. The UV, fluorescence and CD spectra of polymer are similar due to the same linkers present in their polymer chain. Polymers can emit strong blue fluorescence and are expected to have potential applications in polarized blue-light emitting sensors. The chiral conjugated polymers exhibit a strong Cotton effect in their circular dichroism (CD) spectra, indicating a high rigidity of polymer backbone.
文摘The substituted phenanthrene-9-carboxyaldehydes are very important intermediates for the syntheses of phenanthroindolizidine and phenanthroquinolizidine alkaloids. The novel title compound was prepared from the reaction of 5 steps starting from the condensation of 3-methoxyl-4-methyl-phenylacetic acid and 4-(benzyloxy)-2-iodobenzaldehyde, followed by esterification, cyclization, reduction, and oxidation. A new method for the preparation of phenanthrene ring via palladium-catalyzed intramolecular Heck reaction was described. The title compound was characterized by IR, ^1H NMR, ^13C NMR, elemental analysis, and MS.
文摘The Heck coupling reactions of aryl halides and olefins were performed under the microwave assistance. Interestingly, the ultralow concentration of transition metals (in ppb) coming from the reactants could catalyze the Heck coupling reactions under microwave irradiation, without addition of any catalysts, ligands and phase-transfer agents. The influences of bases, solvents and temperature were discussed, and the reaction rate was enhanced largely in the mixed solvents of NMP and water due to the solubility of base in water.
基金the National Natural Science Foundation of China(Nos.21702184,21772175,and 91956117)is gratefully acknowledged.
文摘Heck reaction is one of the most important carbon-carbon bond forming reactions with wide applications in organic synthesis.Considerable advances of enantioselective Heck reaction have been achieved in the past decades.This review focuses on recent development of catalytic asymmetric Heck reaction and reductive Heck reaction,which covers intermolecular and intramolecular versions since 2011.The article is organized in terms of the cat-alysts and olefin substrates.
基金Financial support from the National Natural Science Foundation of China (No.21173018)
文摘A series of magnetically recyclable Pd/Fe3O4@γ-Al2O3 catalysts were synthesized using the superparamagnetic Fe3O4@γ-Al2O3 core-shell microspheres as the supporter and nano-Pd particles assembled on γ-Al2O3 shell as the active catalytic component. The structure of the catalysts was characterized by X-ray diffraction (XRD), transmission electron microscopy iTEM), N2 adsorptiondesorption and vibrating sample magnetometer (VSM). The catalytic activity and the recyclability properties of the catalysts for the Heck coupling reaction with aryl bromides and the olefins were investigated. The results show that the microspheres of the magnetic Pd/Fe304@γ-Al2O3 catalysts were about 400 nm and the nano-Pd particles assembled on γ-Al2O3 shell were about 3-4 nm in size. The saturation magnetization (MS) of the magnetic catalysts was sufficiently high to allow magnetic separations. In the Heck coupling reactions, the magnetic Pd/Fe304@γ-Al2O3 catalysts exhibited good catalytic activity and recyclability. With Pd/Fe304@γ-Al2O3 (0.021 mol%) catalyst, the bromobenzene conversion and product yield reached about 96.8% and 91.2%, respectively, at 120℃ and in 14 h. After being recycled for six times, the conversion of bromobenzene and the recovery of the catalyst were about 80% and 90%, respectively. The nano-Pd particles were kept well dispersed in the used Pd/Fe304@γ-Al2O3 catalysts.
基金National Natural Science Foundation of China(No.20603005)the Specialized Research Fund for the Doctoral Program of Higher Education(No.20090041110012) for their financial support
文摘A new method for the preparation of SBA-15-supported palladium catalyst for Heck reaction in supercritical carbon dioxide was presented.The newly formed SBA-15-supported palladium catalyst(Ph-SBA-15-PPh_3-Pd) exhibited high catalytic activity for the Heck reaction of 4-nitrobromobenzene with methyl acrylate.The catalyst can be reused several times without a loss of activity.
基金the financial support by the National Natural Science Foundation of China(No.GZ1645)the Shaanxi Provincial Natural Science Basic Research Program(No.2021JLM-30)the Doctoral Scientific Research Foundation of Xi'an Polytechnic University(No.107020336).
文摘1,3-Butadiene plays a key role in modern synthetic chemistry and biochemistry because it is a key intermediate in the synthesis of many drugs.A new and effective method for the synthesis of 4-trifluoromethylated 1,3-butadiene through the fluorinated Heck reaction catalyzed by Pd(0)is described.Without additives,1-chloro-3,3,3-trifluoropropene(an inexpensive CF3 structural unit that is harmless to ozone)reacts with enamide to synthesize 4-trifluoromethylated 1,3-butadienes with good yield,high regioselectivity and chemical selectivity,and strong tolerance of substrate functional groups such as alkynes,aldehyde,and ester groups.
基金the National Natural Science Foundation of China (No. 20676033), the China Post- doctoral Science Foundation (No. 20070410169) and the Shanghai Leading Academic Discipline Project (No. B507) for financial support.
文摘Water-soluble diol-functionalized imidazolium ionic liquid 1, prepared from 2,2-bis(1-methyl-methyl-imida- zolium)propane-l,3-diol bromide, potassium hydroxide, and malononitrile, was used as an efficient phosphine-free ligand for palladium-catalyzed arylation of aryl halides with acrylates in aqueous phase under mild conditions. It was found that the synergistic coordinating action of diol-functionalized imidazolium cation with CN-containing anion played the key role in improving the activity and stability of the catalyst.
基金Acknowledgement We acknowledge the Natural Science Foundation of China (Grant 20676033), China Postdoctoral Science Foundation (Grant 20070410169) and Shanghai Leading Academic Discipline Project (Project Number: B507) for financial support.
文摘The coordination mode of IL-supported diols used as phosphine-free ligands for palladium catalyzed Heck reaction has been investigated by tuning their compositions. The difference in coordination of these IL-supported diols with metal Pd in Heck reaction was related to the changes of the cation rings, leading to the different activities of Pd catalyst in the reaction. The experimental results indicated that the activities of Pd catalyst were affected mainly by n-electron density of the cation rings. Compared to pyridinium and piperidinium cations, imidazolium cations showed the best coordination to metal Pd. In the meantime, C-2 hydrogen and the length of alkyl side chains had impacts on the coordination as well.
基金financially supported by the National Natural Science Foundation of China(21106162)the National Key Natural Science Foundation of China(21136009)+1 种基金the National High Technology Research and Development Program of China (2009CB219904)the State Key Laboratory of Chemical Engineering(SKL-ChE-11A04)
文摘A novel Heck reaction catalyst consisting of a palladium(ll) complex of meso-tetra(p- hydroxyphenyl)porphyrin (MTP) and cross-linked chloromethylated polystyrene microspheres (PMs) was successfully prepared via covalent ether bonds between the chloride groups in the PMs and the hydroxyl groups in MTP. The catalyst was characterized using scanning electron microscopy, Fourier-transform infrared spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES). This polystyrene-supported palladium-complex was an efficient heterogeneous catalyst for cross-coupling of aryl iodides with ethyl acrylate. The reaction of iodobenzene and ethyl acrylate under N2 at 100 °C and a catalyst concentration of 0.1% gave a gas chromatography product yield of 99.8%, which is much higher than that achieved using a free palladium(II) complex of MTP as the catalyst (41.3%). The catalyst was recycled up to six times without significant loss of catalytic activity. These results suggest that the immobilized palladium(II) MTP catalyst has potential applications in synthetic and industrial chemistry.
文摘Well-dispersed palladium nanoparticles immobilized onto modified silica (Si02-pr-NH-cyanuric-SH) have been prepared in some facile steps. The catalyst exhibits high catalytic activity in the Heck reaction, and can be easily recovered and reused without significant loss of its activity in several runs.
基金Project supported by the National Natural Science Foundation of China(No.20072034)and the Natural Science Foundation of Henan Province(No.004030100).
文摘Cyclopalladated ferrocenylimine has been found to be a type of excellent phosphine-free catalyst for Heck reactions in neat water with both higher yields and turnover numbers than those reported in the literature up to now. Some commercial emulsifying agents, including the commonly used quaternary ammonium salts, have been proved to be excellent additives in the catalysis of the reactions. Not only aromatic iodide, but also aromatic bromide could be coupled with the olefins. All reactions were able to be conducted in air under refluxing condition.
基金Financial support from Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(No. 2015157)Teaching Reform Project of Shanxi Normal University(No. SD2014JGKT-52)Undergraduate Training Programs for Innovation and Entrepreneurship of Modern College of Arts and Sciences, Shanxi Normal University(No. WL2015CXCY-YJ-26)
文摘Four novel palladium((Ⅱ)) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H- 1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki- Heck reaction of aryl halides with electron-deficient olefins. The coupling reaction of awl halide bearig different functional groups with olefin derivatives took place and the corresponding products were isolated in good to excellent yields under optimal conditions. The procedure exhibits good functional group tolerance and wide substrate scope. This Mizoroki-Heck reaction was further achieved using Pd(OAc)2 and 3,5-di-isopropyl-1H-1,2,4-diazaphospholes as combined catalyst, which provide the convenient and alternative method in organic synthesis