Objective:To investigate the role of T help 17 cells(Th17)and STAT3-VEGF pathway in pathogenesis of psoriasis.Methods:A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected.The ratio of T...Objective:To investigate the role of T help 17 cells(Th17)and STAT3-VEGF pathway in pathogenesis of psoriasis.Methods:A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected.The ratio of Th17/IL-17 cell in peripheral blood were detected by flow cytometric analysis;STAT3 and VEGF concentrations were measured hy immunohistochemistry and Western blot.Results:The expression of Th17 in peripheral blood were significantly increased in psoriasis[(1.76±0.88)%]compared with controls[(0.48±0.27)%](P<0.05).Th17 related cytokine STAT3 and VEGF were significantly increased in psoriasis compared with controls(P<0.05),and were positively correlated the expression of Th17.Conclusions:The expressions of Th17,STAT3 and VEGF are elevated in psoriasis,which suggests Th17 cells have a potential role in the pathogenesis of psoriasis by STAT3-VEGF pathway.展开更多
强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性进行性自身免疫性疾病,发病早、病程长、致残率高,且好发于青少年。因此AS早期诊断和治疗至关重要。近年来,研究表明AS发病可能与辅助性T细胞(T help cell,Th)亚群有关。Th细胞亚群...强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性进行性自身免疫性疾病,发病早、病程长、致残率高,且好发于青少年。因此AS早期诊断和治疗至关重要。近年来,研究表明AS发病可能与辅助性T细胞(T help cell,Th)亚群有关。Th细胞亚群分泌促炎抑炎细胞因子失衡,机体免疫功能受损,致AS发病。当前一些针对Th细胞亚群的药物运用于临床,虽取得一定疗效,但未取得预期理想效果,因此进一步深化Th细胞亚群的研究将为揭示AS发病机制并制定相应的免疫治疗策略提供新的理论依据和思路。展开更多
基金supported by Guangdong Medical Research Project(NoB2012240)
文摘Objective:To investigate the role of T help 17 cells(Th17)and STAT3-VEGF pathway in pathogenesis of psoriasis.Methods:A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected.The ratio of Th17/IL-17 cell in peripheral blood were detected by flow cytometric analysis;STAT3 and VEGF concentrations were measured hy immunohistochemistry and Western blot.Results:The expression of Th17 in peripheral blood were significantly increased in psoriasis[(1.76±0.88)%]compared with controls[(0.48±0.27)%](P<0.05).Th17 related cytokine STAT3 and VEGF were significantly increased in psoriasis compared with controls(P<0.05),and were positively correlated the expression of Th17.Conclusions:The expressions of Th17,STAT3 and VEGF are elevated in psoriasis,which suggests Th17 cells have a potential role in the pathogenesis of psoriasis by STAT3-VEGF pathway.
文摘炎性关节病包括一大类以外周关节炎为主要表现的风湿性疾病,如类风湿关节炎(rheumatoid arthritis,RA)、脊柱关节病(spondyloarthropathy,SpA)及其相关的关节炎,如强直性脊柱炎(ankylosingspondylitis,AS)、银屑病关节炎(psoriaticarthritis,PsA)和炎症性肠病关节炎等。免疫细胞在他们的发病过程中起了重要作用。近年又发现了一种以分泌IL-17为主的辅助性T细胞17(Thelpcell 17,Th17),其介导炎症反应。调节性T细胞(regulatory T cells,Treg)是一类具有免疫抑制作用的T细胞亚群。Th17与Treg细胞在分化过程中是密切相关的,多种细胞因子参与了他们的发育分化过程,Th17/Treg细胞的平衡对维持正常免疫应答、防止自身免疫性疾病具有重要意义。
文摘强直性脊柱炎(ankylosing spondylitis,AS)是一种慢性进行性自身免疫性疾病,发病早、病程长、致残率高,且好发于青少年。因此AS早期诊断和治疗至关重要。近年来,研究表明AS发病可能与辅助性T细胞(T help cell,Th)亚群有关。Th细胞亚群分泌促炎抑炎细胞因子失衡,机体免疫功能受损,致AS发病。当前一些针对Th细胞亚群的药物运用于临床,虽取得一定疗效,但未取得预期理想效果,因此进一步深化Th细胞亚群的研究将为揭示AS发病机制并制定相应的免疫治疗策略提供新的理论依据和思路。
