Plasma hemoglobin concentration was related to estimated glomerular filtration rate in elderly patients with ischemic cardiomyopathy

Objectives To study the relationship between plasma hemoglobin concentration and estimated glomerular filtration rate （eGFR） in elderly patients with ischemic cardiomyopathy （ICM）.Methods Clinical data of patients with coronary heart disease who were discharged from The First Affiliated Hospital,Chongqing Medical University between 2005 and 2007 were analyzed retrospectively. Echocardiography results,plasma hemoglobin and creatinine concentration were abstracted from the medical records.The study included 235 Chinese Hart patients with age 60 years and older with angiography confirmed coronary heart disease,silent myocardial ischemia or angina pectoris,of whom 154 had ICM defined as left ventricular end-diastolic diameter （LVDd）,male≥56 mm,female≥51 mm （63. 51±7.70 mm） measured by M-mode echocardiography.The differences in plasma hemoglobin concentration were analyzed retrospec- tively between patients with and without ICM,and between patients with an eGFR【60 ml·min-1·1.73m-2 and those with an eGFR≥60 ml·min-1·1.73m-2.Results There were no significant differences in plasma hemoglobin concentration and eGFR between ICM and non-ICM group (118.49±20.52 g·L-1 vs.115.80±23.32 g·L-1 and 75.13±24.21 ml·min-1·1.73m-2 vs.79.09±28.41 ml·min- 1·1.73m-2,respectively,both P】0.05).However,in both ICM and non-ICM groups,plasma hemoglobin concentration was lower in those with an eGFR【60 ml·min-1·1.73m-2 compared with compared with those with an eGFR≥60 ml·min-1·1.73m-2 group (112. 29±18.61 g·L-1 vs.119.92±20.74L-1,P【0.05);plasma hemoglobin concentration was related positively to eGFR.Conclusions There were no significant changes in plasma hemoglobin concentration and eGFR;however,plasma hemoglobin concentration was related to eGFR significantly positively in elderly patients with ICM due to coronary heart

Prediction of the severity of colorectal lesion by fecal hemoglobin concentration observed during previous test in the French screening program

BACKGROUND The rate of positive tests using fecal immunochemical test(FIT)does not decrease with subsequent campaigns,but the positive predictive value of advanced neoplasia significantly decreases in subsequent campaign after a first negative test.A relationship between the fecal hemoglobin concentration(Fhb)and the opportunity to detect a colorectal cancer in subsequent campaign has been shown.AIM To predict the severity of colorectal lesions based on Fhb measured during previous colorectal cancer screening campaign.METHODS This etiological study included 293750 patients aged 50-74,living in Auvergne-Rhone-Alpes(France).These patients completed at least two FIT[test_((-1))and test_((0))]between June 2015 and December 2019.Delay between test_((-1))and test_((0))was>1year and test_((-1))result was negative(<150 ngHb/mL).The severity of colorectal lesions diagnosed at test_((0))was described according to Fhb measured at test_((-1))[Fhb_((-1))].The relationship between the severity classified in seven ordinal categories and the predictive factors was analyzed in an ordered multivariate polytomous regression model.RESULTS The test_((0))positive rate was 4.0%,and the colonoscopy completion rate was 97.1%in 11594 patients who showed a positive test_((0)).The colonoscopy detection rate was 77.7%in those 11254 patients who underwent a colonoscopy.A total of 8748 colorectal lesions were detected(including 2182 low-risk-polyps,2400 high-riskpolyp,and 502 colorectal cancer).The colonoscopy detection rate varied significantly with Fhb_((-1))[0 ngHb/mL:75.6%,(0-50 ngHb/mL):77.3%,(50-100 ngHb/mL):88.7%,(100-150 ngHb/mL):90.3%;P=0.001].People with a Fhb_((-1))within(100-150 ngHb/mL)(P=0.001)were 2.6(2.2;3.0)times more likely to have a high severity level compared to those having a Fhb_((-1))value of zero.This risk was reduced by 20%in patients aged 55-59 compared to those aged<55[adjusted odds ratio:0.8(0.6;1.0)].CONCLUSION The study showed that higher Fhb_((-1))is correlated to an increased risk of severity of colorectal lesions.This risk of severity increased among first-time participants(age<55)and the elderly(≥70).To avoid the loss of chance in these age groups,the FIT positivity threshold should be reduced to 100 ngHb/mL.The other alternative would be to reduce the time between the two tests in these age groups from the current 2 years to 1 year.

A genetic adaptive pattern-low hemoglobin concentration in the himalayan highlanders

Mean hemoglobin(Hb) concentration of about 3 500 subjects derived from 17 studies of Himalayan highlanders(Tibetans, Sherpas, and Ladakhis) was compared with lowlanders(Chinese Han, Indian Tamils) lived in the Himalayas, and European climbers during Everest expeditions as well as Andean natives. The results found that Hb concentration in Himalayan highlanders was systemically lower than those reported for Andean natives and lowland immigrants. These comparative data demonstrated that a healthy native population may successfully reside at high altitude without a significant elevation in Hb, and the lower Hb levels of Himalayan highlanders than those of migrated lowlanders and Andean natives are an example of favourable adaptation over the generations. In addition, excessive polycythemia has frequently been used as a marker of chronic mountain sickness(CMS). Altitude populations who have a higher Hb concentration also have a higher incidence of CMS. The low Hb in Himalayans suggested as showing adaptation over many generations in Tibetan stock. Recent work in Tibet, suggested that Tibetans there may have adapted to high altitude as a result of evolutionary pressure selecting for genes which give an advantage at altitude. All of the population genomic and statistical analysis indicated that EPAS1 and EGLN1 are mostly likely responsible for high altitude adaptation and closely related to low Hb concentration in Tibetans. These data supported the hypothesis that Himalayan highlanders have evolved a genetically different erythropoietic response to chronic hypoxia by virtue of their much longer exposure to high altitude.

Drinking pattern and its relation to hemoglobin concentration in local brew consumers from the Kathmandu Region

The study was conducted to determine the hemoglobin concentration in alcohol consumers(home made brew-Chang) and compare it with non-alcoholics healthy subjects.Hemoglobin(Hb) concentration was determined in 2053 alcoholic consumers(males: 1056;females: 997) and was compared with 1 027(males: 623;females: 404) healthy non-alcoholic control subjects.The Hb concentration in alcoholic male and female were 13.42 ± 2.14 g/dL and 12.19 ± 1.55 g/dL compared with control showing 14.43 ± 1.07 g/dL and 12.73 ± 1.41 g/dL in males and females respectively.The differences in Hb concentration between alcoholic and non-alcoholic consumers were highly significant in both genders with a P value of 0.000 674 in males and 0.004 732 in females.Alcohol Use Disorders Identification test(AUDIT) scores was advocated to alcoholic consumers to test the severity of drunkenness and disorders related to it.A total of 887 males and 663 females crossed the cut-off limits of ≥8 AUDIT scores showing the addiction towards drinking habits of local brew.

Hemoglobin concentration of intestinal parasites infested children in Okada, Edo state, Nigeria

Anemia in children is defined by the World Health Organization as a hemoglobin concentration below 11 g/dl for children (0.5-5.0 yrs) and12 g/dl for teens (12-15 yrs). 4 ml of venous blood sample was collected in EDTA container. Of the total of three hundred and thirty four (334) subjects, one hundred and fifty two (152) were Females and one hundred and eighty two (182) were Males. Intestinal parasite assessment was done by Direct Smear technique and Formol-Ether concentration methods. Hemoglobin concentration was analyzed using Cyanmethaemoglobin method. Thirty (30) subjects were infested with Ascaris lumbricoides (single infestation), Ninety Five (95) subjects were infested with Ascaris lumbricoides and Hookworm (Double infestation) and Forty Two (42) subjects were infested with Ascaris lumbricoides, Hookworm, Entamoeba histolytica and Trichuris trichiura (Multiple infestation). The Mean ± Standard Deviation of Hemoglobin concentration of the various infestation types against the control subject shows a statistically significant decrease

Socio-Economic Status and Hemoglobin Concentration of Type 2 Diabetes Mellitus Patients Attending Diabetic Clinic in Benin City, Nigeria

The aim of this study is to determine the Socio Economic Status and Red Blood Cell Hemoglobin concentration alteration in type 2 Diabetes mellitus patients attending Diabetic Clinic in Benin City, Nigeria. The sample population consists of 142 subjects, 71 of patients were known in Type 2 Diabetes mellitus already on drugs and were confirmed to be Diabetic using Glucose oxidase method while the other 71 subjects were age matched apparently healthy control subject on routine check up, they were confirmed to be non Diabetic using the Glucose oxidase method. Hemoglobin concentrations were done using the Cyanmethemoglobin method. Those under the low income Socio-Economic status had the highest incidence of type 2 Diabetes mellitus (49%) of the Diabetic population, closely followed by the middle income Socio-Economic status (35%) of the Diabetic populations. The Mean ± S.D of Hemoglobin concentration of control subjects against Mean ± S.D of Hemoglobin concentration of the various Socio-Economic status of Males and Females type 2 Diabetes mellitus patient show a statistically significant decrease

我国西北地区49例Hb G Coushatta的分布——东北亚古代游牧民族的遗传标志

本文报道49例Hb G Coushatta在我国西北部的分布情况。新疆和甘肃的发生率为0.57‰和0.43‰,高于陕西的发生率0.07‰。维吾尔、哈萨克、柯尔克孜和回族的发生率为0.66‰—1.74‰,高于汉族的发生率0.45‰。Hb G Coushatta基因流呈由北向南和向西漂移和特点,结合国内外有关资料进行分析,这种变异体起源于东北亚地区,为古代游牧民族的遗传标志。

Hb Lepore-BW伴发IVS-Ⅱ-654杂合变异的诊断及产前筛查的临床意义

目的:鉴定四川地区罕见Hb Lepore-BW伴发IVS-Ⅱ-654杂合变异的病例。方法:采用血常规和血红蛋白电泳方法分析先证者及其父母的外周血和孕妇脐血的血常规参数、血红蛋白A;(HbA;)和血红蛋白F(HbF);采用地中海贫血基因检测和Sanger测序方法分析并鉴定先证者及其父母和孕妇脐血的血红蛋白突变。结果:检测到先证者为Hb Lepore-BW伴发IVS-Ⅱ-654杂合突变,其父亲为Hb Lepore-BW杂合突变,其母亲和脐血均为IVS-Ⅱ-654杂合突变。结论:本研究鉴定出一例罕见Hb Lepore-BW伴发IVS-Ⅱ-654杂合突变。此突变临床表现为中间型β地贫。血红蛋白电泳结合血常规检查是产前筛查的必要手段。

急性有机磷农药中毒患者血细胞数Hb和CRP浓度的变化及意义

目的 探讨急性有机磷农药中毒患者血细胞数、血红蛋白和C -反应蛋白浓度的变化及临床意义。方法 把35例中毒患者分为轻、中和重度中毒 3组 ,在入院 1、3、7d分别采集静脉血 4mL ,作红细胞 (RBC)、血红蛋白 (Hb)、白细胞(WBC)、中性粒细胞 (N)、血小板 (PLT)及C -反应蛋白 (CRP)浓度检测。并与对照组进行对比分析。结果 各中毒组第 1日检测上述各项指标均有不同程度的升高 ,且中毒越重 ,升高越显著 ;中毒第 3日 ,各中毒组RBC数和Hb浓度均明显下降 ,随中毒的严重程度而下降更显著。PLT数则随中毒程度而明显升高 ,中、重度中毒组与对照组比较差异显著 (P <0 .0 1或P <0 .0 0 1) ;WBC、N和CRP浓度随中毒的程度而显示不同的变化 ,中度中毒组较中毒第 1日有所下降 ,而重度中毒组则呈现出上升趋势 ;中毒第 7日 ,中度中毒组除PLT和N仍显示升高外 ,其余各项均基本恢复正常 ;重度中毒组除RBC和Hb较第 3日更进一步降低外 ,其余各项呈上升趋势 ,与对照组比较差异显著 (P <0 .0 1或P <0 .0 0 1)。结论 对急性有机磷农药中毒患者动态观察血细胞数、Hb和CRP浓度的变化 ,对判定中毒程度和了解病情变化有重要临床意义。

前额叶Oxy-Hb峰值浓度与达峰时间在不同程度脑卒中后抑郁状态病人中的变化

目的通过对不同程度的脑卒中后抑郁(post stroke depression,PSD)病人脑部前额叶功能激活变化特点的观察,进一步探讨能否利用近红外光脑成像技术(functional near-infrared spectroscopy,f NIRS)协助早期识别及辅助诊断脑卒中后抑郁状态奠定一定的研究基础。方法应用近红外光脑成像系统对脑卒中后抑郁状态病人(轻度抑郁组27例,中度抑郁组19例,重度抑郁组18例)和脑卒中后未出现抑郁或情绪不稳的病人(对照组29例)在执行语义言语流畅任务(verbal fluency task,VFT)时,测定前额叶脑组织氧合血红蛋白(oxygenate hemoglobin,Oxy-Hb)峰值浓度和达峰时间,并进行比较分析,对相关结果进行统计学分析。结果轻度抑郁组病人Oxy-Hb峰值浓度为(0.29±0.17)mmol·L^(-1)·mm,达峰时间为(74.27±24.12)s,中度抑郁组病人Oxy-Hb峰值浓度为(0.17±0.11)mmol·L^(-1)·mm,达峰时间为(95.14±70.35)s,重度抑郁组病人Oxy-Hb峰值浓度为(0.16±0.30)mmol·L^(-1)·mm,达峰时间为(125.95±25.68)s;轻度抑郁组病人两方面与对照组差异均无统计学意义(P>0.05);中度抑郁组病人仅在Oxy-Hb峰值浓度方面与对照组差异有统计学意义(P<0.05);只有重度抑郁组病人在以上两方面与对照组差异均有统计学意义(P<0.05)。结论 Oxy-Hb峰值浓度是一个较为敏感的指标,可用于中度、重度PSD病人的观察,达峰时间只对重度病人适用,对于轻度病人上述两个指标均不适用;PSD后抑郁程度不同的病人,具有的抑郁情绪症状不同,而呈现出前额叶功能激活下降状态的生物学特征也有差异,重度抑郁状态的病人前额叶有氧代谢功能失调情况更严重,表现更为典型,这将为进一步研究将近红外光脑成像检查作为PSD早期识别及辅助诊断的一种检查方法奠定一定的研究基础。

慢性乙型肝炎患者血清HBsAg浓度与HBV DNA定量及HBeAg滴度的关系分析

目的:定量检测慢性乙型肝炎(CHB)患者血清中乙肝病毒(HBV)表面抗原(HBs Ag)、e抗原(HBe Ag)浓度、HBV DNA、丙氨酸氨基转移酶(ALT)等4项指标,并探讨之间的关系。方法:收集437例CHB患者HBs Ag阳性血清,应用化学发光微粒子免疫分析法定量检测HBV血清学标志物和荧光定量聚合酶链反应检测HBV DNA载量。结果:将HBs Ag按浓度由低到高依次分为5组,并分别与HBV DNA、HBe Ag和ALT比较分析。统计结果显示,不同HBs Ag浓度组之间HBV DNA定量水平差异有显著性意义(F=119.753,P<0.01),组间两两分别比较,各组之间差异有显著性意义(P<0.01);不同HBs Ag浓度组间HBe Ag滴度的比较,差异有显著性意义(F=175.457,P<0.01),各组间两两比较,差异有显著性意义(P<0.01)。不同HBs Ag浓度组间ALT水平的比较,差异无统计学意义(F=2.545,P=0.056)。结论:HBs Ag在高浓度时(>10 000IU/ml)与HBV DNA的关联性较高,当HBs Ag浓度达到1 000IU/ml以上时与HBe Ag有较高的关联性,而HBs Ag浓度与血清ALT活性无关联性。所以在HBs Ag浓度下降后,坚持检测HBs Ag、HBV DNA及HBe Ag,将对治疗方案的调整和监测疗效提供更加全面的参考依据。

全自动血红蛋白电泳与Hb-F碱变性试验在β地中海贫血中的应用及评价

目的 评价全自动血红蛋白琼脂糖凝胶电泳与Hb—F碱变性试验在口地中海贫血中的应用。方法 采用全自动血红蛋白琼脂糖凝胶电泳仪进行血红蛋白（Hb）电泳，测定Hb—A2及Hb-F含量，同时采用Hb—F碱变性试验对同一标本进行Hb—F含量测定．比较两种方法对Hb—F含量的检测结果。结果 检测了30例临床标本，发现Hb—A2增高者（含量〉4％）5侧，阳性率〉16．7％，测定Hb-A2的批内CV〈6％，批间〈9％。同时检测出Hb-F含量增高3例。对于Hb-F碱变性试验测得Hb—F含量增高者（含量〉3．1％），通过全自动琼脂糖凝胶电泳可以分辨出HbF区带，并且能进行定量扫描，测出的Hb—F含量与Hb-F碱变性试验测得Hb—F含量基本一致；如果Hb—F碱变性试验测得Hb-F含量在正常范围内（1.0％～3.0％），电泳就不能分辨出HbF区带。结论 全自动血红蛋白琼脂糖凝胶电泳法能够分辨出Hb—A2及Hb—F异常增高者，为β地中海贫血的诊断提供重要的数据。

红细胞外HbA_2与HbA间的相互作用

1.为了阐明血红蛋白A_2现象的发生机制,研究了红细胞外Hb A_2与HbA有无相互作用。结果表明,这些血红蛋白在离开红细胞后仍能发生相互作用。 2.我们是用交叉电泳来验证这个问题,主要实验结果如下: (1)单向交叉电泳结果表明,溶血液HbA穿过另一溶血液的Hb A_2时,出现明显的交叉电泳图象。 (2)双向交叉电泳实验使上述结果更加明确。 (3)用提纯的Hb A做实验,证实了Hb A与Hb A_2间的相互作用。 (4)血浆白蛋白穿过Hb A_2、Hb A及CA时,没有看到交叉电泳图象。说明Hb A与Hb A_2之间的作用是特异的。 4.初步结论,不仅在缸细胞中Hb A_2是与Hb A结合存在,就是在离开红细胞的条件下,这两种血红蛋白之间仍能发生相互作用。我们认为,这就是血红蛋白A_2现象的发生机制,很可能如此。

低分子肝素对慢性病贫血患者Hb和C反应蛋白水平影响的初步研究

目的初步研究低分子肝素(LMWH)在治疗慢性病贫血(ACD)患者中的临床意义。方法对90例伴有血栓形成或血浆D-二聚体很高而有血栓形成倾向的ACD患者应用LMWH(4 000U/天,7～15天)治疗,并测定治疗前后Hb和C-反应蛋白(CRP)水平以观察它们的变化情况,同时分析其临床意义。结果①贫血组治疗前Hb水平为93.51±15.55g/L,明显低于治疗后的100.95±12.97g/L,差异有统计学意义(t=2.527 8,P<0.05)。②无贫血组治疗前Hb水平为133.09±10.69g/L,与治疗后的135.57±13.09g/L比较差异无统计学意义(t=0.7417,P>0.05)。③治疗前贫血组CRP为49.31±39.07mg/L,明显高于治疗后的29.73±39.07mg/L,差异有统计学意义(t=2.483 4,P<0.05)。④无贫血组治疗前CRP水平为18.08±16.77mg/L,与治疗后的18.24±12.31mg/L比较差异无统计学意义(t=0.023 7,P>0.05)。⑤治疗前后CRP水平与Hb水平均呈负相关(分别为r=-0.425 9,P<0.01和r=-0.234 7,P<0.05)。结论LMWH上调ACD患者的Hb水平,可以改善患者的贫血,可能机制是下调CRP水平。

HemoCue Hb 201+分析仪测定血红蛋白结果的可比性研究

目的：评估便携式HemoCue Hb 201＋分析仪急性失血后输血的指导意义。方法选择2013年6月~2015年5月间深圳市第二人民医院全麻术中因急性失血可能需要输血的患者共208例，血标本采集后，分别采用HemoCue Hb 201＋分析仪及SYSMEX XE-2100型血细胞分析仪测定同一标本的Hb，所测得的数据进行相关分析，并采用Bland-Altman 法评价两种检验方法的一致性。结果 HemoCue Hb 201＋分析仪和中心实验室SYSMEX XE-2100全自动血液分析仪测得的Hb具有良好的相关性（y =15.9297＋0.8086x， r=0.888，P＜0.001）。两种方法检测Hb差值95%的一致性限度超出临床可接受范围。结论 HemoCue Hb 201＋分析仪在急性失血后Hb的检测具有较好的准确性，并且迅捷，对术中输血具有良好的指导意义；但与标准方法的一致性尚有不足，二者不能相互取代。

MCV、MCH联合Hb电泳在地中海贫血干预中的意义探讨

目的:探讨常用的地中海贫血筛查方法红细胞平均体积(MCV)、平均红细胞血红蛋白含量(MCH)、血红蛋白(Hb)电泳检测在地中海贫血诊断中的应用。方法:对5 000例儿童进行血细胞分析,红细胞平均体积(MCV)下降(MCV<80 fl)且平均红细胞血红蛋白含量(MCH)<27 pg实施血红蛋白电泳检测,Hb电泳异常者再进行基因诊断。结果:5 000例受检者中,MCV、MCH下降609例(占12.18%),血红蛋白电泳检测异常者460例(占9.2%),基因确诊285例,其中α-地贫168例,β-地贫114例,α-地贫复合β-地贫3例。结论:MCV、MCH、Hb电泳检测地中海贫血操作简便,灵敏度和特异度高,且价格低廉,易被大众接受,适合在基层医院推广。

不同海拔高度居住一年的青年Hb和RBC─SOD的变化

我们对在喀喇昆仑山海拔3700、5200、5380m三地区居住一年的青年进行Hb和RBC—SOD检测，并以平原（海拔1400m）健康青年做对照。结果：随海拔高度升高Hb递增，RBC－SOD活力逐步下降，差异非常显著（P＜0．01或＜0．001）。作者认为RBC—SOD活力下降与高原低氧、低气压、强紫外线、强电离辐射、营养素缺乏等有密切关系。

基于Hb/α-ZrP生物纳米复合物的亚硝酸盐传感器

本研究利用插层组装手段,制备了Hb/α-ZrP生物纳米复合物,并构建了一个基于Hb/α-ZrP的亚硝酸盐生物传感器。该Hb/α-ZrP二元复合物经过X-射线粉末衍射、扫描电子显微镜、红外光谱及圆二色谱表征,结果表明血红蛋白(Hb)以单层形式插入α-磷酸锆(α-ZrP)层间,并且,插入α-ZrP层间后,Hb的蛋白构型仍然相当程度地被保持。以这种Hb/α-ZrP复合物修饰的玻炭电极,实现了Hb的直接电子传递性能,对亚硝酸盐具有良好的响应,线性范围为1.0×10-6～2.0×10-5M,检测下限为1.54×10-7M。

Hb Bart's定量分析在α地贫筛查中的应用

目的:研究不同α地贫基因类型与Hb Bart’s血红蛋白条带的对应关系。方法:收集2020年1-12月在湖北省新生儿疾病筛查中心进行毛细管电泳的新生儿地中海贫血筛查的样本信息,对电泳结果判读为病理曲线的对象采用PCR-导流杂交法或PCR-NGS法进行基因分型鉴定。比对患者的α地贫基因检测结果与Hb Bart’s血红蛋白的关系,并进行统计学分析。结果:不同α地贫突变类型的Hb Bart’s血红蛋白条带存在显著性差异,Hb Bart’s含量从高到低依次为--^(SEA)/-α^(3.7)复合杂合突变、--^(SEA)/αα单杂合缺失型,-α^(3.7)/-α^(3.7),-α^(3.7)/-α;复合杂合突变、α^(QS)α/αα,α^(CS)α/αα单杂合点突变型、-α^(3.7)/αα及-α^(4.2)/αα单杂合缺失型,各组之间差异存在统计学意义。结论:不同基因型的α地贫Hb Bart’s含量有极显著性差异,Hb Bart’s含量在α地贫筛查及基因类型的鉴别中有较高的应用价值。

新生儿异常Hb Q的家系分析

目的报道新生儿异常Hb Q的家系分析结果,进而加强医务人员对Hb Q患者及其他异常Hb携带者的重视。方法采集患者家系成员的外周血标本,行血常规检测、血红蛋白(Hb)电泳、变性珠蛋白小体(Heinz小体)试验及α、β地中海贫血基因检测。结果5例先证者及其父或母MCV、MCH均降低,4例先证者及其父或母α基因型均为-α^(4.2)/αα;1例先证者α基因型为--SEA/-α^(4.2),其父及母α基因型分别为--SEA/αα、-α^(4.2)/αα。4例先证者的Hb电泳在S区含有(19.2-24.0)%的区带,Hb Bart's:(0.3-1.4)%,Hb A:(8.1-21.0)%,Hb F:(59.3-67.4)%。其父或母为异常Hb Q1含量:(27.9-29.1)%,Hb A:(68.2-69.7)%,Hb A2:(1.7-1.9),Hb Q2:(0.7-0.8)%。1例先证者Hb电泳在S区含有46.3%的区带,Hb Bart's:26.9%,Hb F:25.7%,未见Hb A,且Heinz小体试验阳性,阳性率为0.5%。其父Heinz小体试验阳性。其母为异常Hb Q1含量:28.5%,Hb A:69.1%,Hb A2:1.7%,Hb Q2:0.7%。结论根据家系遗传和地贫基因分析,推断上述5例先证者及其父或母的异常血红蛋白均为α链变异的Hb Q连锁静止型α^(4.2)地贫。此5例家系的报道提升了医务人员对异常血红蛋白复合α地中海贫血的认知,对优生优育与遗传咨询具有重要指导意义。